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CL2014002339A1 - Forma cristalina c de succinato de ester dipropilcarbamoilmetilo del acido 3-(3-{2-[(e)-3,5-diamino-6-cloro-pirazina-2-carbonilimino]-1,3,8-triaza-espiro[4.5]decano-8-carbonil}-bencenosulfonilamino)-propionico; composicion farmaceutica y dispositivo de inhalacion que la comprende; y su uso para el tratamiento de enfermedades respiratorias tales como epoc y asma. - Google Patents

Forma cristalina c de succinato de ester dipropilcarbamoilmetilo del acido 3-(3-{2-[(e)-3,5-diamino-6-cloro-pirazina-2-carbonilimino]-1,3,8-triaza-espiro[4.5]decano-8-carbonil}-bencenosulfonilamino)-propionico; composicion farmaceutica y dispositivo de inhalacion que la comprende; y su uso para el tratamiento de enfermedades respiratorias tales como epoc y asma.

Info

Publication number
CL2014002339A1
CL2014002339A1 CL2014002339A CL2014002339A CL2014002339A1 CL 2014002339 A1 CL2014002339 A1 CL 2014002339A1 CL 2014002339 A CL2014002339 A CL 2014002339A CL 2014002339 A CL2014002339 A CL 2014002339A CL 2014002339 A1 CL2014002339 A1 CL 2014002339A1
Authority
CL
Chile
Prior art keywords
dipropylcarbamoylmethyl
epoc
carbonylimino
benzenesulfonylamino
triaza
Prior art date
Application number
CL2014002339A
Other languages
English (en)
Inventor
Tufilli Nicola
Howsham Catherine
Linderberg Christian
Perlberg Anett
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48237169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014002339(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2014002339A1 publication Critical patent/CL2014002339A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CL2014002339A 2012-03-19 2014-09-03 Forma cristalina c de succinato de ester dipropilcarbamoilmetilo del acido 3-(3-{2-[(e)-3,5-diamino-6-cloro-pirazina-2-carbonilimino]-1,3,8-triaza-espiro[4.5]decano-8-carbonil}-bencenosulfonilamino)-propionico; composicion farmaceutica y dispositivo de inhalacion que la comprende; y su uso para el tratamiento de enfermedades respiratorias tales como epoc y asma. CL2014002339A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261612727P 2012-03-19 2012-03-19

Publications (1)

Publication Number Publication Date
CL2014002339A1 true CL2014002339A1 (es) 2014-12-19

Family

ID=48237169

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014002339A CL2014002339A1 (es) 2012-03-19 2014-09-03 Forma cristalina c de succinato de ester dipropilcarbamoilmetilo del acido 3-(3-{2-[(e)-3,5-diamino-6-cloro-pirazina-2-carbonilimino]-1,3,8-triaza-espiro[4.5]decano-8-carbonil}-bencenosulfonilamino)-propionico; composicion farmaceutica y dispositivo de inhalacion que la comprende; y su uso para el tratamiento de enfermedades respiratorias tales como epoc y asma.

Country Status (34)

Country Link
US (1) US8809340B2 (es)
EP (1) EP2828261B1 (es)
JP (1) JP6134378B2 (es)
KR (1) KR101686311B1 (es)
CN (1) CN104302648B (es)
AR (1) AR090371A1 (es)
AU (1) AU2013237073B2 (es)
CA (1) CA2865536C (es)
CL (1) CL2014002339A1 (es)
CO (1) CO7071138A2 (es)
CY (1) CY1117410T1 (es)
DK (1) DK2828261T3 (es)
EA (1) EA023716B1 (es)
EC (1) ECSP14023397A (es)
ES (1) ES2565811T3 (es)
GT (1) GT201400200A (es)
HR (1) HRP20160420T1 (es)
HU (1) HUE028761T2 (es)
IN (1) IN2014DN07461A (es)
JO (1) JO3184B1 (es)
MA (1) MA37391B1 (es)
MX (1) MX352185B (es)
MY (1) MY165082A (es)
NZ (1) NZ629032A (es)
PE (1) PE20142352A1 (es)
PH (1) PH12014502064B1 (es)
PL (1) PL2828261T3 (es)
SG (1) SG11201405105TA (es)
SI (1) SI2828261T1 (es)
TN (1) TN2014000369A1 (es)
TW (1) TWI608006B (es)
UA (1) UA114904C2 (es)
WO (1) WO2013140319A1 (es)
ZA (1) ZA201406238B (es)

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CA2635581C (en) 2005-12-28 2017-02-28 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9050339B2 (en) 2010-09-17 2015-06-09 Novartis Ag Pyrazine derivatives as ENaC blockers
JP6746569B2 (ja) 2014-10-07 2020-08-26 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶

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