CL2013003073A1 - Compuestos derivados de pirrolotriazinona o imidazotriazinona, inhibidores de pi3k; composicion farmaceutica que los comprende; combinacion farmaceutica; utiles en el tratamiento de enfermedades respiratorias, inflamatorias, autoinmune, neurologica, cancer, entre otras. - Google Patents
Compuestos derivados de pirrolotriazinona o imidazotriazinona, inhibidores de pi3k; composicion farmaceutica que los comprende; combinacion farmaceutica; utiles en el tratamiento de enfermedades respiratorias, inflamatorias, autoinmune, neurologica, cancer, entre otras.Info
- Publication number
- CL2013003073A1 CL2013003073A1 CL2013003073A CL2013003073A CL2013003073A1 CL 2013003073 A1 CL2013003073 A1 CL 2013003073A1 CL 2013003073 A CL2013003073 A CL 2013003073A CL 2013003073 A CL2013003073 A CL 2013003073A CL 2013003073 A1 CL2013003073 A1 CL 2013003073A1
- Authority
- CL
- Chile
- Prior art keywords
- useful
- treatment
- pyrrolotriazinone
- imidazotriazinone
- neurological
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000012828 PI3K inhibitor Substances 0.000 title 1
- 230000001363 autoimmune Effects 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- IJYHVZICHKCLMQ-UHFFFAOYSA-N imidazo[4,5-d]triazin-4-one Chemical compound O=C1N=NN=C2N=CN=C12 IJYHVZICHKCLMQ-UHFFFAOYSA-N 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title 1
- BEBRHYJBTAMGRW-UHFFFAOYSA-N pyrrolo[3,2-d]triazin-4-one Chemical compound O=C1N=NN=C2C=CN=C12 BEBRHYJBTAMGRW-UHFFFAOYSA-N 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 239000013066 combination product Substances 0.000 abstract 1
- 229940127555 combination product Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Immunology (AREA)
- Diabetes (AREA)
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- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE FÓRMULA (1), DONDE RL A R5, RA Y RB SON COMO SE DESCRIBEN EN LA MEMORIA DESCRIPTIVA Y PLIEGO DE REIVINDICACIONES; ASÍ COMO LAS COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN; UN PRODUCTO DE COMBINACIÓN; Y EL USO DE LOS COMPUESTOS COMO INHIBIDORES DE FOSFOINOSITIDO 3-QUINASAS (PI3KS), ÚTILES EN LA PREPARACIÓN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES TALES COMO LEUCEMIA, LINFOMA Y TUMORES SÓLIDOS, ARTRITIS REUMATOIDE, ENTRE OTRAS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11382124A EP2518070A1 (en) | 2011-04-29 | 2011-04-29 | Pyrrolotriazinone derivatives as PI3K inhibitors |
| US201161502550P | 2011-06-29 | 2011-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013003073A1 true CL2013003073A1 (es) | 2014-02-21 |
Family
ID=44484054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013003073A CL2013003073A1 (es) | 2011-04-29 | 2013-10-24 | Compuestos derivados de pirrolotriazinona o imidazotriazinona, inhibidores de pi3k; composicion farmaceutica que los comprende; combinacion farmaceutica; utiles en el tratamiento de enfermedades respiratorias, inflamatorias, autoinmune, neurologica, cancer, entre otras. |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US9340547B2 (es) |
| EP (2) | EP2518070A1 (es) |
| JP (1) | JP5903160B2 (es) |
| KR (1) | KR20140021622A (es) |
| CN (1) | CN103649089B (es) |
| AR (1) | AR086144A1 (es) |
| AU (1) | AU2012247491B2 (es) |
| BR (1) | BR112013023876A2 (es) |
| CA (1) | CA2826197A1 (es) |
| CL (1) | CL2013003073A1 (es) |
| CO (1) | CO6801747A2 (es) |
| CR (1) | CR20130543A (es) |
| CY (1) | CY1116871T1 (es) |
| DK (1) | DK2702061T3 (es) |
| EA (1) | EA024350B1 (es) |
| ES (1) | ES2545853T3 (es) |
| GT (1) | GT201300266A (es) |
| HR (1) | HRP20151153T1 (es) |
| HU (1) | HUE026041T2 (es) |
| IL (1) | IL227764A (es) |
| ME (1) | ME02210B (es) |
| MX (1) | MX336214B (es) |
| MY (1) | MY171553A (es) |
| PE (1) | PE20141193A1 (es) |
| PH (1) | PH12013502059A1 (es) |
| PL (1) | PL2702061T3 (es) |
| PT (1) | PT2702061E (es) |
| RS (1) | RS54270B1 (es) |
| SG (1) | SG194084A1 (es) |
| SI (1) | SI2702061T1 (es) |
| SM (1) | SMT201500270B (es) |
| TW (2) | TWI535720B (es) |
| UA (1) | UA111197C2 (es) |
| UY (1) | UY34051A (es) |
| WO (1) | WO2012146666A1 (es) |
| ZA (1) | ZA201305612B (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2518070A1 (en) | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
| AU2012354094C1 (en) | 2011-12-15 | 2015-10-15 | Novartis Ag | Use of inhibitors of the activity or function of PI3K |
| WO2014015523A1 (en) * | 2012-07-27 | 2014-01-30 | Hutchison Medipharma Limited | Novel heteroaryl and heterocycle compounds, compositions and methods |
| AP2015008328A0 (en) | 2012-10-16 | 2015-03-31 | Almirall Sa | Pyrrolotriazinone derivatives as pi3k inhibitors |
| KR20150079745A (ko) * | 2012-11-08 | 2015-07-08 | 리젠 파마슈티컬스 소시에떼 아노님 | Pde4 억제제 및 pi3 델타 또는 이중 pi3 델타-감마 키나아제 억제제를 함유하는 약제학적 조성물 |
| KR20150084992A (ko) * | 2012-11-16 | 2015-07-22 | 머크 샤프 앤드 돔 코포레이션 | 인간 포스파티딜이노시톨 3-키나제 델타의 퓨린 억제제 |
| WO2014082230A1 (zh) * | 2012-11-28 | 2014-06-05 | 上海希迈医药科技有限公司 | 吡咯并三嗪类衍生物、其制备方法及其在医药上的应用 |
| WO2014087208A2 (en) * | 2012-12-06 | 2014-06-12 | Enaltec Labs Pvt. Ltd. | A process of preparing alcaftadine |
| AU2013364068B2 (en) | 2012-12-21 | 2016-10-20 | Gilead Calistoga Llc | Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors |
| AU2013364070B2 (en) * | 2012-12-21 | 2016-10-27 | Gilead Calistoga Llc | Isoquinolinone or quinazolinone phosphatidylinositol 3-kinase inhibitors |
| UY35332A (es) * | 2013-02-15 | 2014-11-28 | Almirall Sa | Derivados de pirrolotriazina como inhibidores de pi3k |
| CN105308034B (zh) * | 2013-06-14 | 2017-10-31 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
| CN105658648B (zh) * | 2013-08-13 | 2020-03-17 | 加利福尼亚大学董事会 | 脱氧胞苷激酶抑制剂 |
| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
| NZ763326A (en) * | 2014-04-08 | 2023-04-28 | Incyte Holdings Corp | Treatment of b-cell malignancies by a combination jak and pi3k inhibitor |
| WO2015181053A1 (en) * | 2014-05-27 | 2015-12-03 | Almirall, S.A. | Medical use |
| NZ726055A (en) | 2014-06-13 | 2018-04-27 | Gilead Sciences Inc | Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors |
| AU2015274696B2 (en) | 2014-06-13 | 2018-09-27 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| CA2952044C (en) * | 2014-06-13 | 2019-01-29 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| CU24428B1 (es) | 2014-07-04 | 2019-06-04 | Lupin Ltd | Derivados de quinolizinona como inhibidores de pi3k |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| AU2015341186B2 (en) * | 2014-11-01 | 2019-11-14 | Fochon Biosciences, Ltd. | Certain protein kinase inhibitors |
| CN107207444B (zh) | 2014-11-26 | 2020-07-24 | 武田药品工业株式会社 | 二环化合物 |
| CN105712998B (zh) * | 2014-12-05 | 2019-12-13 | 上海润诺生物科技有限公司 | 氮杂吲哚类衍生物、其制备方法及其在医药上的应用 |
| GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
| GB201514758D0 (en) * | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
| WO2017160930A1 (en) * | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2018130443A1 (de) | 2017-01-10 | 2018-07-19 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
| US12011437B1 (en) | 2017-06-07 | 2024-06-18 | Arcutis Biotherapeutics, Inc. | Roflumilast formulations with an improved pharmacokinetic profile |
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