CL2013002895A1 - Compuestos derivados de 7,8-dihidro-5h-pteridin-6-ona, utiles como intermediarios en la sintesis de compuestos derivados de pteridinona (divisional de la solicitud 3123-2005). - Google Patents
Compuestos derivados de 7,8-dihidro-5h-pteridin-6-ona, utiles como intermediarios en la sintesis de compuestos derivados de pteridinona (divisional de la solicitud 3123-2005).Info
- Publication number
- CL2013002895A1 CL2013002895A1 CL2013002895A CL2013002895A CL2013002895A1 CL 2013002895 A1 CL2013002895 A1 CL 2013002895A1 CL 2013002895 A CL2013002895 A CL 2013002895A CL 2013002895 A CL2013002895 A CL 2013002895A CL 2013002895 A1 CL2013002895 A1 CL 2013002895A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds derived
- pteridinone
- pteridin
- divisional
- dihydro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- UGYZVBUANICGLW-UHFFFAOYSA-N 7,8-dihydro-5h-pteridin-6-one Chemical compound C1=NC=C2NC(=O)CNC2=N1 UGYZVBUANICGLW-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- CIZZUEUKGNBQPP-UHFFFAOYSA-N ethyl 2-anilino-7-oxo-8-phenylpteridine-6-carboxylate Chemical compound N1=C2N(C=3C=CC=CC=3)C(=O)C(C(=O)OCC)=NC2=CN=C1NC1=CC=CC=C1 CIZZUEUKGNBQPP-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004058337A DE102004058337A1 (de) | 2004-12-02 | 2004-12-02 | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013002895A1 true CL2013002895A1 (es) | 2014-03-14 |
Family
ID=35923724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002895A CL2013002895A1 (es) | 2004-12-02 | 2013-10-09 | Compuestos derivados de 7,8-dihidro-5h-pteridin-6-ona, utiles como intermediarios en la sintesis de compuestos derivados de pteridinona (divisional de la solicitud 3123-2005). |
Country Status (34)
| Country | Link |
|---|---|
| US (9) | US7238807B2 (es) |
| EP (2) | EP2436685B1 (es) |
| JP (1) | JP5164574B2 (es) |
| KR (2) | KR101362131B1 (es) |
| CN (3) | CN101065381B (es) |
| AR (1) | AR053100A1 (es) |
| AU (1) | AU2005311308B2 (es) |
| BR (1) | BRPI0518601A2 (es) |
| CA (1) | CA2588857C (es) |
| CL (1) | CL2013002895A1 (es) |
| CY (1) | CY1113625T1 (es) |
| DE (1) | DE102004058337A1 (es) |
| DK (2) | DK1819706T3 (es) |
| EA (1) | EA012624B1 (es) |
| ES (2) | ES2548680T3 (es) |
| HR (1) | HRP20120980T1 (es) |
| HU (1) | HUE027689T2 (es) |
| IL (1) | IL183568A (es) |
| ME (1) | ME01470B (es) |
| MX (1) | MX2007006549A (es) |
| MY (1) | MY147459A (es) |
| NO (1) | NO20072283L (es) |
| NZ (1) | NZ556182A (es) |
| PE (2) | PE20090488A1 (es) |
| PL (2) | PL1819706T3 (es) |
| PT (1) | PT1819706E (es) |
| RS (1) | RS52533B (es) |
| SG (2) | SG141461A1 (es) |
| SI (1) | SI1819706T1 (es) |
| TW (1) | TWI362391B (es) |
| UA (1) | UA89390C2 (es) |
| UY (1) | UY29233A1 (es) |
| WO (1) | WO2006058876A1 (es) |
| ZA (1) | ZA200703368B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861422B2 (en) * | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| US7759485B2 (en) * | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004058337A1 (de) * | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| US7439358B2 (en) * | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| NZ570530A (en) | 2006-02-14 | 2011-09-30 | Vertex Pharma | Pharmaceutical compositions comprising 6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4)diazepine derivatives |
| JP4958461B2 (ja) * | 2006-03-30 | 2012-06-20 | 富士フイルム株式会社 | 近赤外吸収色素含有硬化性組成物 |
| WO2008093075A2 (en) | 2007-02-01 | 2008-08-07 | Astrazeneca Ab | 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors |
| EP2185559A1 (en) * | 2007-08-03 | 2010-05-19 | Boehringer Ingelheim International GmbH | Crystalline form of a dihydropteridione derivative |
| EP2100894A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
| CN102020643A (zh) | 2009-09-22 | 2011-04-20 | 上海恒瑞医药有限公司 | 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用 |
| CN103492391A (zh) | 2009-09-25 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法 |
| MX2012003484A (es) | 2009-09-25 | 2012-04-20 | Vertex Pharma | Metodos para preparar derivados de pirimidina utiles como inhibidores de proteina cinasa. |
| US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
| US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
| AR085406A1 (es) | 2011-02-25 | 2013-09-25 | Takeda Pharmaceutical | Oxazinopteridinas y oxazinopteridinonas n-sustituidas |
| US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
| TW201414734A (zh) | 2012-07-10 | 2014-04-16 | Takeda Pharmaceutical | 氮雜吲哚衍生物 |
| JP2016525532A (ja) | 2013-07-26 | 2016-08-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 骨髄異形成症候群の処置 |
| TW201620904A (zh) | 2014-01-09 | 2016-06-16 | 武田藥品工業有限公司 | 氮雜吲哚衍生物 |
| US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4032639A (en) * | 1976-03-22 | 1977-06-28 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension |
| US4182872A (en) * | 1976-03-22 | 1980-01-08 | American Home Products Corporation | 4-(Lower)alkyl-1-(o-nitrophenyl)piperazine-2-carboxylic acid chemical intermediates |
| NL8303657A (nl) | 1983-10-24 | 1985-05-17 | Pharmachemie Bv | Voor injectie geschikte, stabiele, waterige, zoutzuur bevattende oplossing van cisplatine, alsmede werkwijze ter bereiding daarvan. |
| DE3537761A1 (de) * | 1985-10-24 | 1987-04-30 | Bayer Ag | Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure |
| EP0347146B1 (en) | 1988-06-16 | 1993-09-01 | Smith Kline & French Laboratories Limited | Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
| FR2645152B1 (fr) * | 1989-03-30 | 1991-05-31 | Lipha | 3h-pteridinones-4, procedes de preparation et medicaments les contenant |
| US5043270A (en) | 1989-03-31 | 1991-08-27 | The Board Of Trustees Of The Leland Stanford Junior University | Intronic overexpression vectors |
| CA2029651C (en) | 1989-11-17 | 2000-06-06 | David D. Davey | Tricyclic pteridinones and a process for their preparation |
| US5198547A (en) | 1992-03-16 | 1993-03-30 | South Alabama Medical Science Foundation, Usa | Process for N5-formylating tetrahydropteridines |
| TW274550B (es) * | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
| EP1195372A1 (en) | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
| CO4410190A1 (es) | 1994-09-19 | 1997-01-09 | Lilly Co Eli | 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| EP0825979B1 (en) * | 1995-05-19 | 2001-01-03 | Novartis AG | Process for the catalytic hydrogenation of aromatic nitro compounds |
| US5698556A (en) * | 1995-06-07 | 1997-12-16 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
| HU226167B1 (hu) | 1996-09-23 | 2008-05-28 | Lilly Co Eli | Olanzapin-dihidrát D, elõállítása és az azt tartalmazó gyógyszerkészítmények |
| AP2001002068A0 (en) * | 1998-08-11 | 2001-03-31 | Pfizer Prod Inc | Substituted 1,8-naphthyridin-4(1H)-ones as phosphodiesterase 4 inhibitors. |
| NZ516872A (en) | 1999-09-15 | 2003-10-31 | Warner Lambert Co | Pteridinones as kinase inhibitors |
| GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| CA2401368A1 (en) | 2000-03-06 | 2001-09-27 | Warner-Lambert Company | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
| DE10018783A1 (de) | 2000-04-15 | 2001-10-25 | Fresenius Kabi De Gmbh | Lagerstabile Infusionslösung des Ciprofloxacins mit verringertem Säuregehalt |
| US20020183292A1 (en) * | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
| DE10058119A1 (de) * | 2000-11-22 | 2002-05-23 | Bayer Ag | Pepinotan-Kit |
| US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| WO2002076954A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| WO2002076985A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| US20030055026A1 (en) * | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| US6806272B2 (en) * | 2001-09-04 | 2004-10-19 | Boehringer Ingelheim Pharma Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| JP3876254B2 (ja) | 2001-09-04 | 2007-01-31 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 新規なジヒドロプテリジノン、その製造方法及びその医薬組成物としての使用 |
| ATE526013T1 (de) * | 2001-12-14 | 2011-10-15 | Merck Serono Sa | Verfahren zur herbeiführung einer ovulation über einen nicht-polypeptid-camp-spiegel-modulator |
| RU2004135533A (ru) | 2002-05-03 | 2005-07-20 | Шеринг Акциенгезельшафт (De) | Тиазолидиноны и их применение в качестве ингибиторов polo- подобной киназы |
| RU2296758C2 (ru) | 2002-08-08 | 2007-04-10 | Смитклайн Бичем Корпорейшн | Производные тиофена |
| US6862422B2 (en) * | 2003-02-12 | 2005-03-01 | Kabushiki Kaisha Toshiba | Image forming apparatus and image forming method having pressing members for pressing a belt-like member |
| HRP20050735B1 (hr) | 2003-02-26 | 2013-08-31 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Dihidropteridinoni, metoda za njihovu proizvodnju i upotrebu u obliku lijekova |
| US6861422B2 (en) * | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| US20040180898A1 (en) * | 2003-03-03 | 2004-09-16 | Bang-Chi Chen | Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines |
| JP2006523224A (ja) | 2003-03-26 | 2006-10-12 | ワイス | 免疫原性組成物および方法 |
| WO2004093848A2 (en) | 2003-04-14 | 2004-11-04 | Vectura Ltd | Dry power inhaler devices and dry power formulations for enhancing dosing efficiency |
| EP1708715A1 (de) * | 2004-01-17 | 2006-10-11 | Boehringer Ingelheim International GmbH | Verwendung von substituierten pteridinen zur behandlung von atemwegserkrankungen |
| DE102004002557A1 (de) * | 2004-01-17 | 2005-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
| DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| DE102004034623A1 (de) * | 2004-07-16 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 6-Formyl-tetrahydropteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US7759485B2 (en) | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| US20060035903A1 (en) | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| WO2006021547A1 (de) * | 2004-08-26 | 2006-03-02 | Boehringer Ingelheim International Gmbh | Pteridinone als plk (polo like kinase) inhibitoren |
| EP1784406A1 (de) * | 2004-08-27 | 2007-05-16 | Boehringer Ingelheim International GmbH | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| DE102004058337A1 (de) * | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
| JP2009503014A (ja) | 2005-08-03 | 2009-01-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系疾患の治療におけるジヒドロプテリジノン |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| US20090023733A1 (en) | 2006-03-07 | 2009-01-22 | Peter Cage | Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them |
| EP2185559A1 (en) | 2007-08-03 | 2010-05-19 | Boehringer Ingelheim International GmbH | Crystalline form of a dihydropteridione derivative |
-
2004
- 2004-12-02 DE DE102004058337A patent/DE102004058337A1/de not_active Withdrawn
-
2005
- 2005-11-22 US US11/284,836 patent/US7238807B2/en not_active Ceased
- 2005-11-29 SI SI200531631T patent/SI1819706T1/sl unknown
- 2005-11-29 UA UAA200706986A patent/UA89390C2/ru unknown
- 2005-11-29 CN CN2005800406546A patent/CN101065381B/zh not_active Expired - Fee Related
- 2005-11-29 BR BRPI0518601-3A patent/BRPI0518601A2/pt not_active IP Right Cessation
- 2005-11-29 KR KR1020077015136A patent/KR101362131B1/ko not_active Expired - Fee Related
- 2005-11-29 RS RS20120519A patent/RS52533B/sr unknown
- 2005-11-29 ME MEP-2012-124A patent/ME01470B/me unknown
- 2005-11-29 CN CN201010593286.0A patent/CN102093361B/zh not_active Expired - Fee Related
- 2005-11-29 PL PL05823799T patent/PL1819706T3/pl unknown
- 2005-11-29 DK DK05823799.1T patent/DK1819706T3/da active
- 2005-11-29 HR HRP20120980TT patent/HRP20120980T1/hr unknown
- 2005-11-29 HU HUE11189691A patent/HUE027689T2/hu unknown
- 2005-11-29 EA EA200701164A patent/EA012624B1/ru not_active IP Right Cessation
- 2005-11-29 EP EP11189691.6A patent/EP2436685B1/de not_active Expired - Lifetime
- 2005-11-29 SG SG200802431-7A patent/SG141461A1/en unknown
- 2005-11-29 SG SG201000003-2A patent/SG158848A1/en unknown
- 2005-11-29 CN CN2010105934512A patent/CN102070637B/zh not_active Expired - Fee Related
- 2005-11-29 ES ES11189691.6T patent/ES2548680T3/es not_active Expired - Lifetime
- 2005-11-29 WO PCT/EP2005/056291 patent/WO2006058876A1/de not_active Ceased
- 2005-11-29 PT PT58237991T patent/PT1819706E/pt unknown
- 2005-11-29 MX MX2007006549A patent/MX2007006549A/es active IP Right Grant
- 2005-11-29 EP EP05823799A patent/EP1819706B1/de not_active Expired - Lifetime
- 2005-11-29 PL PL11189691T patent/PL2436685T3/pl unknown
- 2005-11-29 NZ NZ556182A patent/NZ556182A/en not_active IP Right Cessation
- 2005-11-29 JP JP2007543838A patent/JP5164574B2/ja not_active Expired - Lifetime
- 2005-11-29 AU AU2005311308A patent/AU2005311308B2/en not_active Ceased
- 2005-11-29 UY UY29233A patent/UY29233A1/es not_active Application Discontinuation
- 2005-11-29 DK DK11189691.6T patent/DK2436685T3/en active
- 2005-11-29 ES ES05823799T patent/ES2395829T3/es not_active Expired - Lifetime
- 2005-11-29 CA CA2588857A patent/CA2588857C/en not_active Expired - Fee Related
- 2005-11-29 KR KR1020127028659A patent/KR101395591B1/ko not_active Expired - Fee Related
- 2005-11-30 PE PE2009000418A patent/PE20090488A1/es not_active Application Discontinuation
- 2005-11-30 PE PE2005001388A patent/PE20061061A1/es not_active Application Discontinuation
- 2005-11-30 MY MYPI20055607A patent/MY147459A/en unknown
- 2005-12-01 TW TW094142312A patent/TWI362391B/zh not_active IP Right Cessation
- 2005-12-02 AR ARP050105040A patent/AR053100A1/es unknown
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2007
- 2007-04-25 ZA ZA200703368A patent/ZA200703368B/xx unknown
- 2007-05-03 NO NO20072283A patent/NO20072283L/no not_active Application Discontinuation
- 2007-05-16 US US11/749,207 patent/US20070213534A1/en not_active Abandoned
- 2007-05-16 US US11/749,212 patent/US20070213530A1/en not_active Abandoned
- 2007-05-16 US US11/749,205 patent/US20070213529A1/en not_active Abandoned
- 2007-05-16 US US11/749,210 patent/US20070213531A1/en not_active Abandoned
- 2007-05-16 US US11/749,203 patent/US20070213528A1/en not_active Abandoned
- 2007-05-16 US US11/749,208 patent/US20070219369A1/en not_active Abandoned
- 2007-05-16 US US11/749,206 patent/US7626019B2/en active Active
- 2007-05-31 IL IL183568A patent/IL183568A/en not_active IP Right Cessation
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2010
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2012
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2013
- 2013-10-09 CL CL2013002895A patent/CL2013002895A1/es unknown
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