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CL2013002874A1 - Metodo para tratar condiciones asociadas con la activacion del complemento dependiente de serino proteasa 2 asociada a la lactina de union a membrana (masp-2) mediante un agente inhibidor de masp-2, preferentemente u anticuerpo anti-(masp-2). - Google Patents

Metodo para tratar condiciones asociadas con la activacion del complemento dependiente de serino proteasa 2 asociada a la lactina de union a membrana (masp-2) mediante un agente inhibidor de masp-2, preferentemente u anticuerpo anti-(masp-2).

Info

Publication number
CL2013002874A1
CL2013002874A1 CL2013002874A CL2013002874A CL2013002874A1 CL 2013002874 A1 CL2013002874 A1 CL 2013002874A1 CL 2013002874 A CL2013002874 A CL 2013002874A CL 2013002874 A CL2013002874 A CL 2013002874A CL 2013002874 A1 CL2013002874 A1 CL 2013002874A1
Authority
CL
Chile
Prior art keywords
masp
lactin
antibody
inhibitor
activation
Prior art date
Application number
CL2013002874A
Other languages
English (en)
Inventor
Gregory A Demopulos
Tom Dudler
Hans-Wilhelm Schwaeble
Original Assignee
Omeros Corp
Univ Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp, Univ Leicester filed Critical Omeros Corp
Publication of CL2013002874A1 publication Critical patent/CL2013002874A1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biophysics (AREA)
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CL2013002874A 2011-04-08 2013-10-07 Metodo para tratar condiciones asociadas con la activacion del complemento dependiente de serino proteasa 2 asociada a la lactina de union a membrana (masp-2) mediante un agente inhibidor de masp-2, preferentemente u anticuerpo anti-(masp-2). CL2013002874A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161473698P 2011-04-08 2011-04-08

Publications (1)

Publication Number Publication Date
CL2013002874A1 true CL2013002874A1 (es) 2014-03-07

Family

ID=46966283

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013002874A CL2013002874A1 (es) 2011-04-08 2013-10-07 Metodo para tratar condiciones asociadas con la activacion del complemento dependiente de serino proteasa 2 asociada a la lactina de union a membrana (masp-2) mediante un agente inhibidor de masp-2, preferentemente u anticuerpo anti-(masp-2).

Country Status (17)

Country Link
US (5) US8951522B2 (es)
EP (3) EP3964233A1 (es)
JP (4) JP5937197B2 (es)
KR (6) KR20220044616A (es)
CN (3) CN103781492A (es)
AU (1) AU2012239889B2 (es)
BR (1) BR112013025917A2 (es)
CA (4) CA3076975C (es)
CL (1) CL2013002874A1 (es)
DK (2) DK3287142T3 (es)
ES (2) ES2683307T3 (es)
IL (3) IL228758B (es)
MX (3) MX339002B (es)
NZ (5) NZ709997A (es)
PL (1) PL3287142T3 (es)
RU (2) RU2743409C2 (es)
WO (1) WO2012139081A2 (es)

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SMT201800253T1 (it) * 2012-04-06 2018-07-17 Omeros Corp Composizioni e metodi per inibire masp-1 e/o masp-3 per il trattamento di emoglobinuria parossistica notturna
PT2861246T (pt) * 2012-06-18 2021-04-05 Univ Leicester Composições e métodos para inibir masp-1 e/ou masp-2 e/ou masp-3 para o tratamento de várias doenças e perturbações
CN110818798A (zh) 2012-10-25 2020-02-21 美国比奥维拉迪维股份有限公司 抗补体C1s抗体和其用途
RS63212B1 (sr) 2012-11-02 2022-06-30 Bioverativ Usa Inc Antikomplementna c1s antitela i njihove primene
US20140363433A1 (en) 2013-03-15 2014-12-11 Omeros Corporation Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
NZ629682A (en) * 2013-03-15 2017-03-31 Omeros Corp Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
SI3057993T1 (sl) * 2013-10-17 2021-03-31 Omeros Corporation Postopki za zdravljenje bolezenskih stanj, povezanih z aktivacijo komplementov, odvisnih od MASP-2
WO2015070041A1 (en) * 2013-11-08 2015-05-14 Icahn School Of Medicine At Mount Sinai Methods for monitoring kidney dysfunction
PL3154561T3 (pl) 2014-06-12 2019-12-31 Ra Pharmaceuticals, Inc. Modulowanie aktywności dopełniacza
HRP20211824T1 (hr) 2015-01-28 2022-03-04 Ra Pharmaceuticals, Inc. Modulatori aktivnosti komplementa
HUE061076T2 (hu) 2015-04-06 2023-05-28 Bioverativ Usa Inc Humanizált anti-C1s ellenanyagok alkalmazási eljárások
KR102432062B1 (ko) * 2015-11-09 2022-08-12 오메로스 코포레이션 Masp-2 의존성 보체 활성화와 관련된 질병의 치료 방법
RS60134B1 (sr) 2015-12-16 2020-05-29 Ra Pharmaceuticals Inc Modulatori aktivnosti komplementa
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JP6682653B2 (ja) 2016-01-05 2020-04-15 ユニバーシティー オブ レスター 線維症の阻害を必要とする対象において線維症を阻害するための方法
BR112018069732A2 (pt) 2016-03-31 2019-02-05 Omeros Corporation métodos para prevenir, tratar, reverter e/ou retardar angiogênese em um sujeito mamífero, para tratar um sujeito que sofre de uma doença ou condição angiogênica ocular e para inibir angiogênese do tumor
UY37376A (es) * 2016-08-26 2018-03-23 Amgen Inc Construcciones de arni para inhibir expresión de asgr1 y métodos para su uso
JOP20170170B1 (ar) 2016-08-31 2022-09-15 Omeros Corp صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق
DK3525583T3 (da) 2016-10-12 2025-10-27 Bioverativ Usa Inc Anti-c1s-antistoffer og fremgangsmåder til anvendelse deraf
JOP20190068A1 (ar) * 2016-10-13 2019-04-01 Omeros Corp طرق لتقليل البول البروتيني في خاضع بشري يعاني من الاعتلال الكلوي a الناتج عن الجلوبيولين المناعي
BR112019011053A2 (pt) 2016-12-07 2019-10-15 Ra Pharmaceuticals Inc moduladores da atividade do complemento
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