CL2011003247A1 - Compuesto {5-[4-(1,1-dioxo-1-tiomorfolin-4-ilmetil)-fenil]-[1,2,4]triazolo[1,5-a]piridin-2-il}-amida de acido ciclopropanocarboxilico, con actividad inhibidora de jak1 y jak2; composicion farmaceutica; y uso en el tratamiento de enfermedades inflamatorias, autoinmunitarias, proliferativas, entre otras. - Google Patents
Compuesto {5-[4-(1,1-dioxo-1-tiomorfolin-4-ilmetil)-fenil]-[1,2,4]triazolo[1,5-a]piridin-2-il}-amida de acido ciclopropanocarboxilico, con actividad inhibidora de jak1 y jak2; composicion farmaceutica; y uso en el tratamiento de enfermedades inflamatorias, autoinmunitarias, proliferativas, entre otras.Info
- Publication number
- CL2011003247A1 CL2011003247A1 CL2011003247A CL2011003247A CL2011003247A1 CL 2011003247 A1 CL2011003247 A1 CL 2011003247A1 CL 2011003247 A CL2011003247 A CL 2011003247A CL 2011003247 A CL2011003247 A CL 2011003247A CL 2011003247 A1 CL2011003247 A1 CL 2011003247A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- pharmaceutical composition
- treatment
- jak1
- thiomorpholin
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- QMMBWINEFXQCKF-UHFFFAOYSA-N NC1=NN2C(C3=CC=C(CN(CC4)CCS4(=O)=O)C=C3)=CC=CC2=N1.OC(C1CC1)=O Chemical compound NC1=NN2C(C3=CC=C(CN(CC4)CCS4(=O)=O)C=C3)=CC=CC2=N1.OC(C1CC1)=O QMMBWINEFXQCKF-UHFFFAOYSA-N 0.000 title 1
- 230000001363 autoimmune Effects 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 101150079478 jak1 gene Proteins 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REVELA UN COMPUESTO DE FORMULA (I) CAPAZ DE INHIBIR JAK; ESTE COMPUESTO PUEDE PREPARARSE COMO UNA COMPOSICIÓN FARMACÉUTICA, Y PUEDE USARSE PARA LA PREVENCIÓN Y EL TRATAMIENTO DE UNA DIVERSIDAD DE AFECCIONES EN MAMÍFEROS, QUE INCLUYEN HUMANOS, QUE ABARCAN, A MODO DE EJEMPLO, SIN LIMITACIÓN, AFECCIONES INFLAMATORIAS, ENFERMEDADES AUTOINMUNITARIAS, ENFERMEDADES PROLIFERATIVAS, RECHAZO DE TRASPLANTES, ENFERMEDADES QUE INVOLUCRAN EL DETERIORO DEL RECAMBIO DE CARTÍLAGO, MALFORMACIONES CONGÉNITAS DEL CARTÍLAGO Y ENFERMEDADES ASOCIADOS CON LA HIPERSECRECION DEL IL6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22068809P | 2009-06-26 | 2009-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011003247A1 true CL2011003247A1 (es) | 2012-04-13 |
Family
ID=42562363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011003247A CL2011003247A1 (es) | 2009-06-26 | 2011-12-21 | Compuesto {5-[4-(1,1-dioxo-1-tiomorfolin-4-ilmetil)-fenil]-[1,2,4]triazolo[1,5-a]piridin-2-il}-amida de acido ciclopropanocarboxilico, con actividad inhibidora de jak1 y jak2; composicion farmaceutica; y uso en el tratamiento de enfermedades inflamatorias, autoinmunitarias, proliferativas, entre otras. |
Country Status (43)
Families Citing this family (88)
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| JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
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| EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| WO2013063331A1 (en) * | 2011-10-26 | 2013-05-02 | Stein Emily A | Agents, methods, and devices for affecting nerve function |
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