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CL2011001496A1 - Compuestos derivados de 2-piridin-2-il-pirazol-3(2h)-ona, activadores de hif; composicion farmaceutica que los comprende; procedimiento de preparacion de estos; y su uso en el tratamiento de enfermedades cardiacas perifericas de origen isquemico, entre otras. - Google Patents

Compuestos derivados de 2-piridin-2-il-pirazol-3(2h)-ona, activadores de hif; composicion farmaceutica que los comprende; procedimiento de preparacion de estos; y su uso en el tratamiento de enfermedades cardiacas perifericas de origen isquemico, entre otras.

Info

Publication number
CL2011001496A1
CL2011001496A1 CL2011001496A CL2011001496A CL2011001496A1 CL 2011001496 A1 CL2011001496 A1 CL 2011001496A1 CL 2011001496 A CL2011001496 A CL 2011001496A CL 2011001496 A CL2011001496 A CL 2011001496A CL 2011001496 A1 CL2011001496 A1 CL 2011001496A1
Authority
CL
Chile
Prior art keywords
pyrazol
pyridin
treatment
pharmaceutical composition
preparation procedure
Prior art date
Application number
CL2011001496A
Other languages
English (en)
Inventor
Jean-Michael Altenburger
Valerie Fossey
Stephane Illiano
Geraldine Manette
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0807474A external-priority patent/FR2940651B1/fr
Priority claimed from FR0904092A external-priority patent/FR2949466A1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CL2011001496A1 publication Critical patent/CL2011001496A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)

Abstract

Compuestos derivados de 2-piridin-2-il-pirazol-3(2h)ona, activadores de hif; procedimiento de preparación; medicamento; composición farmacéutica; y su uso para el tratamiento o profilaxis de isquemia de miembros inferiores, insuficiencia cardíaca, angina de pecho, infarto de miocardio, hipertensión pulmonar, entre otras.
CL2011001496A 2008-12-29 2011-06-17 Compuestos derivados de 2-piridin-2-il-pirazol-3(2h)-ona, activadores de hif; composicion farmaceutica que los comprende; procedimiento de preparacion de estos; y su uso en el tratamiento de enfermedades cardiacas perifericas de origen isquemico, entre otras. CL2011001496A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0807474A FR2940651B1 (fr) 2008-12-29 2008-12-29 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif
FR0904092A FR2949466A1 (fr) 2009-08-28 2009-08-28 Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif

Publications (1)

Publication Number Publication Date
CL2011001496A1 true CL2011001496A1 (es) 2011-10-28

Family

ID=42008610

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011001496A CL2011001496A1 (es) 2008-12-29 2011-06-17 Compuestos derivados de 2-piridin-2-il-pirazol-3(2h)-ona, activadores de hif; composicion farmaceutica que los comprende; procedimiento de preparacion de estos; y su uso en el tratamiento de enfermedades cardiacas perifericas de origen isquemico, entre otras.

Country Status (35)

Country Link
US (1) US8541455B2 (es)
EP (1) EP2382205B1 (es)
JP (1) JP5734870B2 (es)
KR (1) KR20110099786A (es)
CN (1) CN102333769B (es)
AR (1) AR074915A1 (es)
AU (1) AU2009334569B2 (es)
BR (1) BRPI0924060A8 (es)
CA (1) CA2748411A1 (es)
CL (1) CL2011001496A1 (es)
CO (1) CO6400141A2 (es)
CR (1) CR20110361A (es)
CY (1) CY1115368T1 (es)
DK (1) DK2382205T3 (es)
EA (1) EA019591B1 (es)
EC (1) ECSP11011155A (es)
ES (1) ES2481042T3 (es)
HR (1) HRP20140680T1 (es)
IL (1) IL213789A (es)
MA (1) MA32976B1 (es)
MX (1) MX2011007054A (es)
MY (1) MY179093A (es)
NZ (1) NZ593751A (es)
PA (1) PA8856201A1 (es)
PE (1) PE20120416A1 (es)
PL (1) PL2382205T3 (es)
PT (1) PT2382205E (es)
SG (1) SG172803A1 (es)
SI (1) SI2382205T1 (es)
SM (1) SMT201400097B (es)
TN (1) TN2011000267A1 (es)
TW (1) TWI482763B (es)
UY (1) UY32369A (es)
WO (1) WO2010076524A2 (es)
ZA (1) ZA201104783B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2382215T3 (da) 2008-12-29 2014-10-27 Sanofi Sa Derivater af 2-pyridin-2-yl-pyrazol-3(2h)-on, fremstilling og terapeutisk anvendelse heraf
WO2012133783A1 (ja) * 2011-03-31 2012-10-04 キッセイ薬品工業株式会社 ベンジルピラゾール誘導体の製造方法およびその製造中間体
TW201400470A (zh) * 2012-03-30 2014-01-01 Daiichi Sankyo Co Ltd ４－烷醇胺－３－吡唑哢衍生物
PE20151860A1 (es) * 2013-03-29 2015-12-16 Takeda Pharmaceutical Derivados de 6-(5-hidroxi-1h-pirazol-1-il)nicotinamida y su uso como inhidores de la phd
DE102016223133A1 (de) 2016-11-23 2018-05-24 Deere & Company Geschwindigkeitskontrolle einer Erntemaschine
CN121085892A (zh) * 2020-03-20 2025-12-09 阿克比治疗有限公司 Phd抑制剂化合物、组合物和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4023488A1 (de) * 1990-07-24 1992-01-30 Bayer Ag 1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
AU2004275694B2 (en) 2003-06-30 2008-03-06 Bizbiotech Co., Ltd. Compounds, compositions and methods
DE102005019712A1 (de) * 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
TW200808793A (en) 2006-03-07 2008-02-16 Smithkline Beecham Corp Prolyl hydroxylase inhibitors
CA2666603C (en) 2006-10-16 2013-08-06 Pfizer Products Inc. Therapeutic pyrazolyl thienopyridines and uses thereof for treating tgf.beta. mediated conditions
DE102006050516A1 (de) * 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
KR20100016617A (ko) 2007-05-18 2010-02-12 바이엘 쉐링 파마 악티엔게젤샤프트 과증식성 장애 및 혈관형성 관련 질환의 치료에 유용한 저산소증 유도성 인자 （ｈｉｆ）의 억제제

Also Published As

Publication number Publication date
AR074915A1 (es) 2011-02-23
CN102333769A (zh) 2012-01-25
SI2382205T1 (sl) 2014-08-29
ZA201104783B (en) 2012-09-26
NZ593751A (en) 2013-08-30
ES2481042T3 (es) 2014-07-29
US8541455B2 (en) 2013-09-24
WO2010076524A3 (fr) 2010-08-26
SG172803A1 (en) 2011-08-29
MY179093A (en) 2020-10-27
MA32976B1 (fr) 2012-01-02
PL2382205T3 (pl) 2014-09-30
EA019591B1 (ru) 2014-04-30
CO6400141A2 (es) 2012-03-15
ECSP11011155A (es) 2011-07-29
SMT201400097B (it) 2014-09-08
TW201028391A (en) 2010-08-01
EP2382205A2 (fr) 2011-11-02
PE20120416A1 (es) 2012-05-08
AU2009334569B2 (en) 2016-02-25
WO2010076524A2 (fr) 2010-07-08
MX2011007054A (es) 2011-11-29
US20110294788A1 (en) 2011-12-01
TWI482763B (zh) 2015-05-01
JP5734870B2 (ja) 2015-06-17
CA2748411A1 (fr) 2010-07-08
BRPI0924060A2 (pt) 2015-07-07
KR20110099786A (ko) 2011-09-08
EA201170899A1 (ru) 2012-02-28
IL213789A (en) 2014-11-30
BRPI0924060A8 (pt) 2015-09-29
IL213789A0 (en) 2011-07-31
HRP20140680T1 (hr) 2014-10-10
PA8856201A1 (es) 2010-07-27
PT2382205E (pt) 2014-07-28
AU2009334569A1 (en) 2011-07-21
CN102333769B (zh) 2014-08-27
CR20110361A (es) 2011-09-20
JP2012513976A (ja) 2012-06-21
CY1115368T1 (el) 2017-01-04
EP2382205B1 (fr) 2014-04-23
DK2382205T3 (da) 2014-07-28
TN2011000267A1 (fr) 2012-12-17
UY32369A (es) 2010-07-30

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