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CL2009000019A1 - Compuestos derivados de aril sulfonamida que contienen o-sulfato u o-fosfato; procedimiento de preparacion; composicion farmaceutica que los comprende; y uso como profarmacos para incrementar la semivida de circulacion de compuestos inhibidores de la produccion de beta-amiloide, utiles en el tratamiento del alzheimer y cancer. - Google Patents

Compuestos derivados de aril sulfonamida que contienen o-sulfato u o-fosfato; procedimiento de preparacion; composicion farmaceutica que los comprende; y uso como profarmacos para incrementar la semivida de circulacion de compuestos inhibidores de la produccion de beta-amiloide, utiles en el tratamiento del alzheimer y cancer.

Info

Publication number
CL2009000019A1
CL2009000019A1 CL2009000019A CL2009000019A CL2009000019A1 CL 2009000019 A1 CL2009000019 A1 CL 2009000019A1 CL 2009000019 A CL2009000019 A CL 2009000019A CL 2009000019 A CL2009000019 A CL 2009000019A CL 2009000019 A1 CL2009000019 A1 CL 2009000019A1
Authority
CL
Chile
Prior art keywords
compounds
sulfate
phosphate
alzheimer
beta
Prior art date
Application number
CL2009000019A
Other languages
English (en)
Inventor
Appavu Chandrasekaran
Li David Zenan
Dane Springer
Sayed Elmarakby
Iii Anthony F Kreft
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CL2009000019A1 publication Critical patent/CL2009000019A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composición farmacéutica que comprende un compuesto derivado de aril sulfonamida que contiene o-sulfato y o-fosfato; compuesto derivado de aril sulfonamida que contiene o-sulfato y o-fosfato; procedimiento de preparación; y uso como inhibidor de la producción de beta-amiloide en el tratamiento del Alzheimer y cáncer.
CL2009000019A 2008-01-11 2009-01-07 Compuestos derivados de aril sulfonamida que contienen o-sulfato u o-fosfato; procedimiento de preparacion; composicion farmaceutica que los comprende; y uso como profarmacos para incrementar la semivida de circulacion de compuestos inhibidores de la produccion de beta-amiloide, utiles en el tratamiento del alzheimer y cancer. CL2009000019A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1089408P 2008-01-11 2008-01-11

Publications (1)

Publication Number Publication Date
CL2009000019A1 true CL2009000019A1 (es) 2009-05-22

Family

ID=40467169

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000019A CL2009000019A1 (es) 2008-01-11 2009-01-07 Compuestos derivados de aril sulfonamida que contienen o-sulfato u o-fosfato; procedimiento de preparacion; composicion farmaceutica que los comprende; y uso como profarmacos para incrementar la semivida de circulacion de compuestos inhibidores de la produccion de beta-amiloide, utiles en el tratamiento del alzheimer y cancer.

Country Status (6)

Country Link
US (1) US20090181932A1 (es)
AR (1) AR070120A1 (es)
CL (1) CL2009000019A1 (es)
PA (1) PA8811701A1 (es)
TW (1) TW200934482A (es)
WO (1) WO2009089237A1 (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889061A (en) * 1997-10-15 1999-03-30 Wisconsin Alumni Research Foundation Conformationally restricted polyamines
US6657070B2 (en) * 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
SG128491A1 (en) * 2000-12-13 2007-01-30 Wyeth Arqule Inc Heterocyclic sulfonamide inhibitors of beta amyloid production
RU2321394C2 (ru) * 2002-06-11 2008-04-10 Уайт Замещенные фенилсульфонамидные ингибиторы продуцирования бета-амилоида
RU2342374C2 (ru) * 2003-03-31 2008-12-27 Уайт Фтор- и трифторалкилсодержащие гетероциклические сульфонамидные ингибиторы образования бета-амилоида и их производные
CA2552558A1 (en) * 2004-01-16 2005-08-11 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
PE20080169A1 (es) * 2006-02-17 2008-04-11 Wyeth Corp Metodo para preparar alcoholes sustituidos con sulfonamidas y sus compuestos intermedios
US7550629B2 (en) * 2006-04-21 2009-06-23 Wyeth Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
TW200848019A (en) * 2007-03-06 2008-12-16 Wyeth Corp Aryl sulfonamides useful for modulation of the progesterone receptor
WO2009012205A1 (en) * 2007-07-16 2009-01-22 Wyeth Inhibitors of beta amyloid production

Also Published As

Publication number Publication date
US20090181932A1 (en) 2009-07-16
PA8811701A1 (es) 2009-08-26
WO2009089237A1 (en) 2009-07-16
AR070120A1 (es) 2010-03-17
TW200934482A (en) 2009-08-16

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