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CL2008003928A1 - Compuestos derivados de n-6-heterociclo-imidazo-[1,2-a]-piridin-2-carboxamida sustituidos; procedimiento de preparacion; composicion farmaceutica; utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas, inflamatorias, epilepsia, osteoporosis, tumores malignos, entre otras. - Google Patents

Compuestos derivados de n-6-heterociclo-imidazo-[1,2-a]-piridin-2-carboxamida sustituidos; procedimiento de preparacion; composicion farmaceutica; utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas, inflamatorias, epilepsia, osteoporosis, tumores malignos, entre otras.

Info

Publication number
CL2008003928A1
CL2008003928A1 CL2008003928A CL2008003928A CL2008003928A1 CL 2008003928 A1 CL2008003928 A1 CL 2008003928A1 CL 2008003928 A CL2008003928 A CL 2008003928A CL 2008003928 A CL2008003928 A CL 2008003928A CL 2008003928 A1 CL2008003928 A1 CL 2008003928A1
Authority
CL
Chile
Prior art keywords
epilepsy
osteoporosis
neurodegenerative
prevention
useful
Prior art date
Application number
CL2008003928A
Other languages
English (en)
Inventor
Jean-Francois Peyronel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CL2008003928A1 publication Critical patent/CL2008003928A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPUESTOS DE LA FÓRMULA (I) DONDE R1, R2, R3, R4, Y-X, SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA Y PLIEGO DE REIVINDICACIONES; PROCEDIMIENTO DE PREPARACIÓN; COMPOSICIÓN FARMACÉUTICA; ÚTILES EN EL TRATAMIENTO Y/O PREVENCIÓN DE ENFERMEDADES NEURODEGENERATIVAS, INFLAMATORIAS, EPILEPSIA, OSTEOPOROSIS, TUMORES MALIGNOS, ENTRE OTRAS.
CL2008003928A 2008-01-02 2008-12-30 Compuestos derivados de n-6-heterociclo-imidazo-[1,2-a]-piridin-2-carboxamida sustituidos; procedimiento de preparacion; composicion farmaceutica; utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas, inflamatorias, epilepsia, osteoporosis, tumores malignos, entre otras. CL2008003928A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0800005A FR2925903B1 (fr) 2008-01-02 2008-01-02 DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
CL2008003928A1 true CL2008003928A1 (es) 2010-02-12

Family

ID=39745373

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003928A CL2008003928A1 (es) 2008-01-02 2008-12-30 Compuestos derivados de n-6-heterociclo-imidazo-[1,2-a]-piridin-2-carboxamida sustituidos; procedimiento de preparacion; composicion farmaceutica; utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas, inflamatorias, epilepsia, osteoporosis, tumores malignos, entre otras.

Country Status (24)

Country Link
US (2) US8314109B2 (es)
EP (1) EP2225240B1 (es)
JP (1) JP5258899B2 (es)
KR (1) KR101600635B1 (es)
CN (1) CN101959884B (es)
AR (1) AR070074A1 (es)
AU (1) AU2008351928B2 (es)
BR (1) BRPI0821458A2 (es)
CA (1) CA2710947C (es)
CL (1) CL2008003928A1 (es)
CO (1) CO6331309A2 (es)
EA (1) EA019122B1 (es)
FR (1) FR2925903B1 (es)
IL (1) IL206669A (es)
MA (1) MA32527B1 (es)
ME (1) ME01157B (es)
MX (1) MX2010007353A (es)
MY (1) MY155468A (es)
NZ (1) NZ586474A (es)
SG (1) SG187408A1 (es)
TW (1) TWI432432B (es)
UY (1) UY31589A1 (es)
WO (1) WO2009106750A2 (es)
ZA (1) ZA201004644B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2925907B1 (fr) * 2008-01-02 2010-10-15 Sanofi Aventis DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US20150126530A1 (en) * 2011-10-21 2015-05-07 Torrent Pharmaceuticals Limited Novel Substituted Imidazopyrimidines as Gpbar1 Receptor Modulators
KR101716993B1 (ko) 2012-12-25 2017-03-15 닛뽕소다 가부시키가이샤 할로겐화 아닐린 및 그 제조 방법
CN108295074B (zh) * 2018-02-01 2020-08-28 华中农业大学 一种噻二唑并三嗪类化合物在制备单胺氧化酶抑制剂中的用途
KR102819183B1 (ko) 2019-03-29 2025-06-13 한미약품 주식회사 퓨로피리미딘 화합물의 산 부가염의 결정형

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2638161B1 (fr) * 1988-10-24 1991-01-11 Centre Nat Rech Scient Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
IE904346A1 (en) * 1989-12-04 1991-06-05 Searle & Co IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY
US20060233771A1 (en) * 2002-09-24 2006-10-19 Ernesto Arenas Methods for promoting dopaminergic neuronal development by using ng4a-subfamily and wnt-ligands
AU2003290734A1 (en) * 2002-11-27 2004-06-23 Eli Lilly And Company Novel compounds as pharmaceutical agents
WO2004103991A1 (en) * 2003-05-20 2004-12-02 'chemical Diversity Research Institute', Ltd. 2-substituted piperidines, focused library and a pharmaceutical compound
DE102005019181A1 (de) * 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
FR2903107B1 (fr) * 2006-07-03 2008-08-22 Sanofi Aventis Sa Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2903108B1 (fr) * 2006-07-03 2008-08-29 Sanofi Aventis Sa Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique.
FR2903106B1 (fr) * 2006-07-03 2010-07-30 Sanofi Aventis Utilisations de 2-benzoyl-imidazopyridines en therapeutique

Also Published As

Publication number Publication date
ZA201004644B (en) 2011-11-30
IL206669A0 (en) 2010-12-30
AU2008351928B2 (en) 2013-11-21
MA32527B1 (fr) 2011-08-01
CA2710947C (fr) 2016-04-12
US8691990B2 (en) 2014-04-08
SG187408A1 (en) 2013-02-28
NZ586474A (en) 2012-06-29
CO6331309A2 (es) 2011-10-20
UY31589A1 (es) 2009-08-03
EP2225240B1 (fr) 2014-01-22
IL206669A (en) 2015-07-30
KR101600635B1 (ko) 2016-03-07
MY155468A (en) 2015-10-15
TW200934780A (en) 2009-08-16
KR20100109940A (ko) 2010-10-11
JP2011508760A (ja) 2011-03-17
US20130041152A1 (en) 2013-02-14
EA019122B1 (ru) 2014-01-30
CA2710947A1 (fr) 2009-09-03
EP2225240A2 (fr) 2010-09-08
FR2925903A1 (fr) 2009-07-03
MX2010007353A (es) 2010-08-18
FR2925903B1 (fr) 2011-01-21
HK1148016A1 (en) 2011-08-26
ME01157B (me) 2013-03-20
CN101959884A (zh) 2011-01-26
TWI432432B (zh) 2014-04-01
EA201070814A1 (ru) 2011-02-28
CN101959884B (zh) 2013-02-27
AR070074A1 (es) 2010-03-10
US20100317675A1 (en) 2010-12-16
BRPI0821458A2 (pt) 2015-06-16
AU2008351928A1 (en) 2009-09-03
WO2009106750A2 (fr) 2009-09-03
WO2009106750A3 (fr) 2010-02-25
US8314109B2 (en) 2012-11-20
JP5258899B2 (ja) 2013-08-07

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