CL2008003582A1 - Uso de una composicion farmaceutica que contiene cisteamina o cistamina en la preparacion de un medicamento util para el tratamiento de una enfermedad de higado graso no alcholico (nafld) o esteatohepatitis no alcoholica (nash). - Google Patents
Uso de una composicion farmaceutica que contiene cisteamina o cistamina en la preparacion de un medicamento util para el tratamiento de una enfermedad de higado graso no alcholico (nafld) o esteatohepatitis no alcoholica (nash).Info
- Publication number
- CL2008003582A1 CL2008003582A1 CL2008003582A CL2008003582A CL2008003582A1 CL 2008003582 A1 CL2008003582 A1 CL 2008003582A1 CL 2008003582 A CL2008003582 A CL 2008003582A CL 2008003582 A CL2008003582 A CL 2008003582A CL 2008003582 A1 CL2008003582 A1 CL 2008003582A1
- Authority
- CL
- Chile
- Prior art keywords
- nafld
- cystamine
- nash
- alcoholic
- preparation
- Prior art date
Links
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229960003151 mercaptamine Drugs 0.000 title abstract 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 title 2
- OOTFVKOQINZBBF-UHFFFAOYSA-N cystamine Chemical compound CCSSCCN OOTFVKOQINZBBF-UHFFFAOYSA-N 0.000 title 1
- 229940099500 cystamine Drugs 0.000 title 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000004930 Fatty Liver Diseases 0.000 abstract 1
- 206010019708 Hepatic steatosis Diseases 0.000 abstract 1
- 208000010706 fatty liver disease Diseases 0.000 abstract 1
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Uso de un producto de cisteamina para preparar un medicamento para tratar hígado graso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99151707P | 2007-11-30 | 2007-11-30 | |
| US8539708P | 2008-07-31 | 2008-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008003582A1 true CL2008003582A1 (es) | 2009-04-03 |
Family
ID=40679016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008003582A CL2008003582A1 (es) | 2007-11-30 | 2008-12-01 | Uso de una composicion farmaceutica que contiene cisteamina o cistamina en la preparacion de un medicamento util para el tratamiento de una enfermedad de higado graso no alcholico (nafld) o esteatohepatitis no alcoholica (nash). |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US7994226B2 (es) |
| EP (2) | EP2636404B1 (es) |
| JP (3) | JP5583022B2 (es) |
| KR (1) | KR20100091219A (es) |
| CN (2) | CN104825430B (es) |
| AR (1) | AR069500A1 (es) |
| AU (1) | AU2008329628B2 (es) |
| BR (1) | BRPI0819690B8 (es) |
| CA (1) | CA2706768C (es) |
| CL (1) | CL2008003582A1 (es) |
| CY (1) | CY1114126T1 (es) |
| DK (1) | DK2214480T3 (es) |
| ES (1) | ES2417179T3 (es) |
| HR (1) | HRP20130590T1 (es) |
| IL (2) | IL205909B (es) |
| MX (2) | MX360827B (es) |
| MY (1) | MY156316A (es) |
| NZ (1) | NZ585732A (es) |
| PL (1) | PL2214480T3 (es) |
| PT (1) | PT2214480E (es) |
| RU (1) | RU2498795C2 (es) |
| SG (1) | SG10201403200RA (es) |
| TW (2) | TWI535435B (es) |
| WO (1) | WO2009070781A1 (es) |
| ZA (1) | ZA201003670B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2535044T1 (sl) | 2006-01-27 | 2020-06-30 | The Regents Of The University Of California | Cisteamin bitartrat in cistamin z enterično oblogo |
| EP2636404B1 (en) | 2007-11-30 | 2019-03-20 | The Regents of The University of California | Methods of Treating Non-Alcoholic Steatohepatitis (Nash) Using Cysteamine Products |
| JP5800368B2 (ja) * | 2010-05-19 | 2015-10-28 | 興和株式会社 | 非アルコール性脂肪性肝炎の予防及び/又は治療剤 |
| CA2801336C (en) * | 2010-06-08 | 2020-01-28 | Mahesh Kandula | Cysteamine derivatives and their use in the treatment of nash |
| ES2565487T3 (es) * | 2010-07-28 | 2016-04-05 | Orchid Chemicals And Pharmaceuticals Ltd | Compuestos de difeniléter para su uso en el tratamiento de enfermedades hepáticas |
| WO2014045293A1 (en) * | 2012-09-24 | 2014-03-27 | Krisani Bioscience (P) Ltd. | Fatty acid amides with a cysteamine or an acetylated cysteamine group and uses thereof |
| US20130085075A1 (en) * | 2011-06-06 | 2013-04-04 | Meso Scale Technologies, Llc | Diagnostic methods for liver disorders |
| MX360979B (es) * | 2011-09-16 | 2018-11-22 | Galectin Therapeutics Inc | Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y de la enfermedad del higado graso no alcohólico. |
| MX2014004994A (es) * | 2011-10-26 | 2014-08-27 | Seattle Children S Res Inst | Cisteamina en el tratamiento de enfermedad fibrotica. |
| BR112014012167A2 (pt) * | 2011-11-22 | 2017-05-30 | The Regents Of The Univ Of Calefornia | métodos para tratar um indivíduo, um evento isquêmico, métodos para aumentar a razão de níveis de adiponectina e os níveis de adiponectina, e, cisteamina, derivado de cisteamina, derivado de cistamina |
| US20150086627A1 (en) * | 2012-03-29 | 2015-03-26 | Halo Therapeutics, Llc. | Dosage forms of halofuginone and methods of use |
| EP2858651B1 (en) | 2012-06-06 | 2020-11-11 | Galectin Therapeutics Inc. | Galacto-rhamnogalacturonate compositions for the treatment of diseases associated with elevated inducible nitric oxide synthase |
| US20140314841A1 (en) | 2013-04-19 | 2014-10-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Use of Cysteamine and Derivatives Thereof to Suppress Tumor Metastases |
| TWI649100B (zh) * | 2013-06-17 | 2019-02-01 | 地平線罕見醫學製藥有限責任公司 | 延遲釋放型半胱胺珠粒調配物,以及其製備及使用方法 |
| US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
| JP6490097B2 (ja) * | 2014-04-18 | 2019-03-27 | エルジー・ケム・リミテッド | 脂肪肝疾患の予防又は治療用組成物 |
| AU2016226906B2 (en) * | 2015-03-03 | 2021-06-10 | KOHJIN Life Sciences Co., Ltd. | Composition for improving or preventing nonalcoholic fatty liver |
| AU2016288230A1 (en) | 2015-07-02 | 2018-01-25 | Horizon Orphan Llc | ADO-resistant cysteamine analogs and uses thereof |
| RU2595815C1 (ru) * | 2015-07-13 | 2016-08-27 | федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации | Способ лечения больных неалкогольным стеатогепатитом на фоне метаболического синдрома |
| WO2017087532A1 (en) * | 2015-11-16 | 2017-05-26 | The Regents Of The University Of California | Methods of treating non-alcoholic steatohepatitis (nash) using cysteamine compounds |
| US10143665B2 (en) | 2015-11-17 | 2018-12-04 | Horizon Orphan Llc | Methods for storing cysteamine formulations and related methods of treatment |
| KR102414503B1 (ko) * | 2016-03-17 | 2022-06-29 | 티오제네시스 테라퓨틱스, 인크. | 시스테아민의 조절 방출을 위한 조성물 및 시스테아민 민감성 장애의 전신 치료 |
| ITUA20161799A1 (it) * | 2016-03-18 | 2017-09-18 | Recordati Ind Chimica E Farmaceutica S P A | Composizione farmaceutica a rilascio prolungato comprendente cisteamina o un suo sale |
| PT3634411T (pt) * | 2017-06-08 | 2023-11-28 | N Gene Res Laboratories Inc | Métodos para o tratamento de nash e para a prevenção de hcc induzido por nash |
| WO2019046659A1 (en) * | 2017-08-30 | 2019-03-07 | First Fruits Business Ministry, Llc | COMPOSITION AND METHOD FOR INCREASING SERIAL ADIPONECTIN AND REDUCING THE LIPID RESERVES OF THE ORGANISM |
| CN118924717A (zh) | 2017-09-20 | 2024-11-12 | 硫创治疗公司 | 用于治疗半胱胺敏感性病症的方法 |
| KR102177304B1 (ko) * | 2018-07-23 | 2020-11-10 | 제이투에이치바이오텍 (주) | 비알콜성 지방간염의 예방 또는 치료용 약학 조성물 |
| CN111544426A (zh) * | 2019-02-12 | 2020-08-18 | 复旦大学 | 炔丙基半胱氨酸及其在制备新靶点药物中的用途 |
| EP3946298A4 (en) * | 2019-03-26 | 2023-01-25 | The Regents of the University of California | Substituted amino-thiol and amino-disulfide compounds, and uses thereof |
| CA3143834A1 (en) * | 2019-07-19 | 2021-01-28 | Xiyan LI | Compositions, methods, kits and systems for cancer treatment and metabolic intervention therapy and other uses |
| CN111505099B (zh) * | 2020-04-21 | 2023-07-04 | 上海市普陀区中心医院 | Nash的诊断标志物及其应用 |
| WO2022128870A1 (en) * | 2020-12-18 | 2022-06-23 | Société des Produits Nestlé S.A. | Compositions and methods using at least one glycine or derivative thereof and/or at least one n-acetylcysteine or derivative thereof, and at least one thymol and/or carvacrol |
| CN118489805A (zh) * | 2024-05-31 | 2024-08-16 | 杭州康德权饲料有限公司 | 半胱胺或其盐在制备预防和改善蛋鸡脂肪肝的饲料添加剂中的应用 |
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| SI2535044T1 (sl) * | 2006-01-27 | 2020-06-30 | The Regents Of The University Of California | Cisteamin bitartrat in cistamin z enterično oblogo |
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| EP2636404B1 (en) * | 2007-11-30 | 2019-03-20 | The Regents of The University of California | Methods of Treating Non-Alcoholic Steatohepatitis (Nash) Using Cysteamine Products |
-
2008
- 2008-11-28 EP EP13154059.3A patent/EP2636404B1/en not_active Not-in-force
- 2008-11-28 MX MX2015010032A patent/MX360827B/es unknown
- 2008-11-28 AU AU2008329628A patent/AU2008329628B2/en not_active Ceased
- 2008-11-28 US US12/745,504 patent/US7994226B2/en active Active
- 2008-11-28 PT PT88539168T patent/PT2214480E/pt unknown
- 2008-11-28 PL PL08853916T patent/PL2214480T3/pl unknown
- 2008-11-28 MX MX2010005921A patent/MX2010005921A/es active IP Right Grant
- 2008-11-28 TW TW103146662A patent/TWI535435B/zh not_active IP Right Cessation
- 2008-11-28 DK DK08853916.8T patent/DK2214480T3/da active
- 2008-11-28 NZ NZ585732A patent/NZ585732A/en not_active IP Right Cessation
- 2008-11-28 HR HRP20130590AT patent/HRP20130590T1/hr unknown
- 2008-11-28 CN CN201510122652.7A patent/CN104825430B/zh not_active Expired - Fee Related
- 2008-11-28 CN CN200880125923.2A patent/CN101932238B/zh not_active Expired - Fee Related
- 2008-11-28 SG SG10201403200RA patent/SG10201403200RA/en unknown
- 2008-11-28 JP JP2010536206A patent/JP5583022B2/ja active Active
- 2008-11-28 ES ES08853916T patent/ES2417179T3/es active Active
- 2008-11-28 KR KR1020107013228A patent/KR20100091219A/ko not_active Ceased
- 2008-11-28 AR ARP080105211A patent/AR069500A1/es unknown
- 2008-11-28 BR BRPI0819690A patent/BRPI0819690B8/pt not_active IP Right Cessation
- 2008-11-28 WO PCT/US2008/085064 patent/WO2009070781A1/en not_active Ceased
- 2008-11-28 CA CA2706768A patent/CA2706768C/en not_active Expired - Fee Related
- 2008-11-28 EP EP08853916A patent/EP2214480B1/en not_active Not-in-force
- 2008-11-28 MY MYPI2010002498A patent/MY156316A/en unknown
- 2008-11-28 RU RU2010126631/15A patent/RU2498795C2/ru not_active IP Right Cessation
- 2008-11-28 TW TW097146491A patent/TWI478710B/zh not_active IP Right Cessation
- 2008-12-01 CL CL2008003582A patent/CL2008003582A1/es unknown
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2010
- 2010-05-23 IL IL205909A patent/IL205909B/en active IP Right Grant
- 2010-05-24 ZA ZA2010/03670A patent/ZA201003670B/en unknown
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2011
- 2011-07-15 US US13/183,990 patent/US8263662B2/en active Active
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2012
- 2012-09-10 US US13/608,134 patent/US9149448B2/en active Active
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2013
- 2013-06-27 CY CY20131100522T patent/CY1114126T1/el unknown
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2014
- 2014-07-17 JP JP2014146814A patent/JP6121951B2/ja active Active
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2015
- 2015-09-28 US US14/867,386 patent/US9511038B2/en active Active
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2016
- 2016-11-28 US US15/362,782 patent/US10307386B2/en active Active
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2017
- 2017-03-30 JP JP2017066622A patent/JP2017165735A/ja active Pending
- 2017-09-19 IL IL254586A patent/IL254586A0/en unknown
Also Published As
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