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CL2008003465A1 - Compuestos derivados de cicloalquiloxi- y heterocicloalquiloxi- piridina, moduladores del receptor de histamina h3; composicion farmaceutica; y su uso en el tratamiento de trastornos cognitivos, del sueño y psiquiatricos, tales como demencia, enfermedad de alzheimer, deficits cognitivos, insomnio, alteraciones del sueño y depresion. - Google Patents

Compuestos derivados de cicloalquiloxi- y heterocicloalquiloxi- piridina, moduladores del receptor de histamina h3; composicion farmaceutica; y su uso en el tratamiento de trastornos cognitivos, del sueño y psiquiatricos, tales como demencia, enfermedad de alzheimer, deficits cognitivos, insomnio, alteraciones del sueño y depresion.

Info

Publication number
CL2008003465A1
CL2008003465A1 CL2008003465A CL2008003465A CL2008003465A1 CL 2008003465 A1 CL2008003465 A1 CL 2008003465A1 CL 2008003465 A CL2008003465 A CL 2008003465A CL 2008003465 A CL2008003465 A CL 2008003465A CL 2008003465 A1 CL2008003465 A1 CL 2008003465A1
Authority
CL
Chile
Prior art keywords
cognitive
sleep
cycloalkyloxy
histamine
dementia
Prior art date
Application number
CL2008003465A
Other languages
English (en)
Inventor
Michael A Letavic
]
Emily M Stocking
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40297867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008003465(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2008003465A1 publication Critical patent/CL2008003465A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DERIVADOS DE CICLOALQUILOXI- Y HETEROCICLOALQUILOXI- PIRIDINA, MODULARES DEL RECEPTOR DE HISTAMINA H3; UNA COMPOSICION FARMACEUTICA QUE COMPRENDE A UNO DE DICHOS COMPUESTOS Y A SU USO EN EL TRATAMIENTO DE TRASTORNOS COGNITIVOS, DEL SUEO Y PSIQUIATRICOS, TALES COMO DEMENCIA, ENFERMEDAD DE ALZHEIMER, DEFICITS COGNITIVOS, INSOMNIO, ALTARACIONES DEL SUEÑO Y DEPRESION. EL COMPUESTO DE FORMULA (I) TIENE LA SIGUIENTE ESTRUCTURA.
CL2008003465A 2007-11-20 2008-11-20 Compuestos derivados de cicloalquiloxi- y heterocicloalquiloxi- piridina, moduladores del receptor de histamina h3; composicion farmaceutica; y su uso en el tratamiento de trastornos cognitivos, del sueño y psiquiatricos, tales como demencia, enfermedad de alzheimer, deficits cognitivos, insomnio, alteraciones del sueño y depresion. CL2008003465A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98924607P 2007-11-20 2007-11-20

Publications (1)

Publication Number Publication Date
CL2008003465A1 true CL2008003465A1 (es) 2009-03-06

Family

ID=40297867

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003465A CL2008003465A1 (es) 2007-11-20 2008-11-20 Compuestos derivados de cicloalquiloxi- y heterocicloalquiloxi- piridina, moduladores del receptor de histamina h3; composicion farmaceutica; y su uso en el tratamiento de trastornos cognitivos, del sueño y psiquiatricos, tales como demencia, enfermedad de alzheimer, deficits cognitivos, insomnio, alteraciones del sueño y depresion.

Country Status (22)

Country Link
US (1) US8883776B2 (es)
EP (1) EP2222664B1 (es)
JP (1) JP5498390B2 (es)
KR (1) KR101546712B1 (es)
CN (2) CN105712977B (es)
AR (2) AR069387A1 (es)
AU (1) AU2008326561B2 (es)
BR (1) BRPI0820481A2 (es)
CA (1) CA2706328C (es)
CL (1) CL2008003465A1 (es)
CO (1) CO6210700A2 (es)
CR (1) CR11529A (es)
EA (1) EA018582B1 (es)
EC (1) ECSP10010190A (es)
MX (1) MX2010005488A (es)
MY (1) MY158253A (es)
NI (1) NI201000086A (es)
NZ (1) NZ584998A (es)
TW (1) TWI491604B (es)
UA (1) UA103468C2 (es)
WO (1) WO2009067401A1 (es)
ZA (1) ZA201004334B (es)

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CN102015636B (zh) * 2008-05-08 2014-08-13 埃沃特克股份有限公司 作为组胺h3受体拮抗剂的氮杂环丁烷类和环丁烷类化合物
ES2625261T3 (es) * 2009-03-18 2017-07-19 Janssen Pharmaceutica, N.V. Procedimiento para la preparación de moduladores de receptores H3 de histamina
JP2013505297A (ja) * 2009-09-21 2013-02-14 ヴァンダービルト ユニバーシティー ｍＧｌｕＲ５の正のアロステリック調節因子としてのＯ−ベンジルニコチンアミド類似体
PL2729130T3 (pl) 2011-07-07 2018-02-28 Janssen Sciences Ireland Uc Preparaty kombinowane darunawiru

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Also Published As

Publication number Publication date
MY158253A (en) 2016-09-30
CA2706328C (en) 2016-04-19
AR110977A2 (es) 2019-05-22
CN105712977A (zh) 2016-06-29
CO6210700A2 (es) 2010-10-20
TW200936579A (en) 2009-09-01
NZ584998A (en) 2012-08-31
AU2008326561A1 (en) 2009-05-28
EP2222664A1 (en) 2010-09-01
JP5498390B2 (ja) 2014-05-21
HK1147994A1 (en) 2011-08-26
US8883776B2 (en) 2014-11-11
EP2222664B1 (en) 2014-10-29
EA201070637A1 (ru) 2010-12-30
BRPI0820481A2 (pt) 2015-06-16
KR101546712B1 (ko) 2015-08-24
MX2010005488A (es) 2010-06-01
KR20100098636A (ko) 2010-09-08
JP2011503233A (ja) 2011-01-27
ZA201004334B (en) 2011-10-26
CN105712977B (zh) 2021-06-29
CR11529A (es) 2012-10-25
US20090131415A1 (en) 2009-05-21
WO2009067401A1 (en) 2009-05-28
ECSP10010190A (es) 2010-06-29
AU2008326561B2 (en) 2013-12-05
NI201000086A (es) 2011-03-17
UA103468C2 (ru) 2013-10-25
CA2706328A1 (en) 2009-05-28
TWI491604B (zh) 2015-07-11
EA018582B1 (ru) 2013-09-30
AR069387A1 (es) 2010-01-20
CN101868454A (zh) 2010-10-20

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