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CL2008003002A1 - Composición farmacéutica inyectable intravenosa en forma de emulsión aceite en agua que comprende al toxoide larotaxel (xrp9881) o cabazitaxel (xrp6258) disuelto en lecitina, y al tensioactivo aniónico fosfatidilglicerol o acido fosfatidico; proeceidimiento para su preparacion, útil como antineoplástico. - Google Patents

Composición farmacéutica inyectable intravenosa en forma de emulsión aceite en agua que comprende al toxoide larotaxel (xrp9881) o cabazitaxel (xrp6258) disuelto en lecitina, y al tensioactivo aniónico fosfatidilglicerol o acido fosfatidico; proeceidimiento para su preparacion, útil como antineoplástico.

Info

Publication number
CL2008003002A1
CL2008003002A1 CL2008003002A CL2008003002A CL2008003002A1 CL 2008003002 A1 CL2008003002 A1 CL 2008003002A1 CL 2008003002 A CL2008003002 A CL 2008003002A CL 2008003002 A CL2008003002 A CL 2008003002A CL 2008003002 A1 CL2008003002 A1 CL 2008003002A1
Authority
CL
Chile
Prior art keywords
lecithin
dissolved
oil
anionic surfactant
xrp6258
Prior art date
Application number
CL2008003002A
Other languages
English (en)
Inventor
Carine Gachon
Patricia Rortais
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of CL2008003002A1 publication Critical patent/CL2008003002A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)

Abstract

Composiciones inyectables que contienen derivados de taxanos en una emulsión a base de un aceite en agua o de la composición de lecitina en que el taxano está disuelto, porque además contienen un agente tensioactivo aniónico, tal como fosfotidilglicerol o un ácido fosfatídico; procedimiento de preparación.
CL2008003002A 2007-10-10 2008-10-09 Composición farmacéutica inyectable intravenosa en forma de emulsión aceite en agua que comprende al toxoide larotaxel (xrp9881) o cabazitaxel (xrp6258) disuelto en lecitina, y al tensioactivo aniónico fosfatidilglicerol o acido fosfatidico; proeceidimiento para su preparacion, útil como antineoplástico. CL2008003002A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0707092A FR2922107B1 (fr) 2007-10-10 2007-10-10 Nouvelles compositions a base de taxoides

Publications (1)

Publication Number Publication Date
CL2008003002A1 true CL2008003002A1 (es) 2009-10-16

Family

ID=39356621

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003002A CL2008003002A1 (es) 2007-10-10 2008-10-09 Composición farmacéutica inyectable intravenosa en forma de emulsión aceite en agua que comprende al toxoide larotaxel (xrp9881) o cabazitaxel (xrp6258) disuelto en lecitina, y al tensioactivo aniónico fosfatidilglicerol o acido fosfatidico; proeceidimiento para su preparacion, útil como antineoplástico.

Country Status (38)

Country Link
US (1) US8481589B2 (es)
EP (1) EP2197492B1 (es)
JP (1) JP5574965B2 (es)
KR (1) KR20100075490A (es)
CN (1) CN101820918A (es)
AR (1) AR072333A1 (es)
AT (1) ATE534406T1 (es)
AU (1) AU2008345527A1 (es)
BR (1) BRPI0818597A2 (es)
CA (1) CA2701789A1 (es)
CL (1) CL2008003002A1 (es)
CO (1) CO6260107A2 (es)
CR (1) CR11335A (es)
CY (1) CY1112388T1 (es)
DK (1) DK2197492T3 (es)
DO (1) DOP2010000098A (es)
EA (1) EA016619B1 (es)
ES (1) ES2377352T3 (es)
FR (1) FR2922107B1 (es)
GT (1) GT201000075A (es)
HR (1) HRP20120165T1 (es)
IL (1) IL204950A0 (es)
MA (1) MA31840B1 (es)
MX (1) MX2010003914A (es)
NI (1) NI201000048A (es)
NZ (1) NZ584544A (es)
PA (1) PA8798101A1 (es)
PE (1) PE20090962A1 (es)
PL (1) PL2197492T3 (es)
PT (1) PT2197492E (es)
RS (1) RS52131B (es)
SI (1) SI2197492T1 (es)
TN (1) TN2010000129A1 (es)
TW (1) TW200922552A (es)
UA (1) UA97418C2 (es)
UY (1) UY31386A1 (es)
WO (1) WO2009083664A1 (es)
ZA (1) ZA201002504B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120065255A1 (en) * 2009-10-19 2012-03-15 Nagesh Palepu Cabazitaxel formulations and methods of preparing thereof
PL2493466T3 (pl) 2009-10-29 2021-11-15 Sanofi Mature Ip Nowe przeciwguzowe zastosowanie kabazytakselu
WO2011139899A2 (en) 2010-05-03 2011-11-10 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
JP2012051823A (ja) * 2010-08-31 2012-03-15 Fujifilm Corp 難容性薬物含有水中油型乳化組成物及びその製造方法
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
CN104225615B (zh) * 2014-09-24 2017-02-01 东南大学 一种紫杉醇类磷脂化合物、其药物组合物及应用
EP3384961B1 (en) * 2017-04-05 2021-10-13 RaySearch Laboratories AB System and method for modelling of dose calculation in radiotherapy treatment planning

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750561A (en) * 1991-07-08 1998-05-12 Rhone-Poulenc Rorer, S.A. Compositions containing taxane derivatives
FR2678833B1 (fr) 1991-07-08 1995-04-07 Rhone Poulenc Rorer Sa Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes.
JP3208517B2 (ja) * 1992-07-01 2001-09-17 ブリストル−マイヤーズ スクイブ カンパニー ７，８−シクロプロパタキサン類
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
FR2698543B1 (fr) 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
US6537579B1 (en) * 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
US5616330A (en) * 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
US6372780B2 (en) * 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
TR200100575T2 (tr) * 1998-08-20 2001-07-23 Aventis Pharma S.A. Taksoid türevlerinin yeni kullanım alanları
US20020001613A1 (en) * 2000-02-08 2002-01-03 Susan Niemiec Method of manufacturing liposomes
US20030099674A1 (en) * 2001-08-11 2003-05-29 Chen Andrew X. Lyophilized injectable formulations containing paclitaxel or other taxoid drugs
AU2004234003A1 (en) * 2003-04-29 2004-11-11 Baxter International Inc. Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
EP1498120A1 (en) * 2003-07-18 2005-01-19 Aventis Pharma S.A. Semi-solid formulations for the oral administration of taxoids
EP1498143A1 (en) * 2003-07-18 2005-01-19 Aventis Pharma S.A. Self-emulsifying and self-microemulsifying formulations for the oral administration of taxoids
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
JP5089887B2 (ja) * 2006-01-23 2012-12-05 日本精化株式会社 生理活性物質含有複合体

Also Published As

Publication number Publication date
JP5574965B2 (ja) 2014-08-20
MX2010003914A (es) 2010-05-17
FR2922107B1 (fr) 2010-02-26
HRP20120165T1 (hr) 2012-03-31
EA201070448A1 (ru) 2010-08-30
PE20090962A1 (es) 2009-08-10
UA97418C2 (ru) 2012-02-10
GT201000075A (es) 2012-04-11
JP2011500542A (ja) 2011-01-06
MA31840B1 (fr) 2010-11-01
PT2197492E (pt) 2012-02-20
WO2009083664A8 (fr) 2010-05-14
EP2197492B1 (fr) 2011-11-23
ATE534406T1 (de) 2011-12-15
WO2009083664A1 (fr) 2009-07-09
DOP2010000098A (es) 2010-04-30
CA2701789A1 (fr) 2009-07-09
AR072333A1 (es) 2010-08-25
CR11335A (es) 2010-08-13
PA8798101A1 (es) 2009-07-23
CO6260107A2 (es) 2011-03-22
TN2010000129A1 (fr) 2011-09-26
IL204950A0 (en) 2010-11-30
BRPI0818597A2 (pt) 2015-04-22
NI201000048A (es) 2010-08-20
ZA201002504B (en) 2011-06-29
RS52131B (sr) 2012-08-31
CY1112388T1 (el) 2015-12-09
FR2922107A1 (fr) 2009-04-17
CN101820918A (zh) 2010-09-01
US20100311825A1 (en) 2010-12-09
PL2197492T3 (pl) 2012-05-31
TW200922552A (en) 2009-06-01
EP2197492A1 (fr) 2010-06-23
DK2197492T3 (da) 2012-03-12
NZ584544A (en) 2012-04-27
US8481589B2 (en) 2013-07-09
SI2197492T1 (sl) 2012-03-30
AU2008345527A1 (en) 2009-07-09
ES2377352T3 (es) 2012-03-26
EA016619B1 (ru) 2012-06-29
UY31386A1 (es) 2009-05-29
KR20100075490A (ko) 2010-07-02

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