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CL2008002073A1 - Compuestos derivados de lactama tetraciclicos, inhibidores de mk-2; procedimiento de praparacion; composicion farmaceutica; y su uso en el tratamiento de artritis, sinovitis aguda, tendinitis, soriasis, miocarditis, caquexia, asma, cancer, entre otras. - Google Patents

Compuestos derivados de lactama tetraciclicos, inhibidores de mk-2; procedimiento de praparacion; composicion farmaceutica; y su uso en el tratamiento de artritis, sinovitis aguda, tendinitis, soriasis, miocarditis, caquexia, asma, cancer, entre otras.

Info

Publication number
CL2008002073A1
CL2008002073A1 CL2008002073A CL2008002073A CL2008002073A1 CL 2008002073 A1 CL2008002073 A1 CL 2008002073A1 CL 2008002073 A CL2008002073 A CL 2008002073A CL 2008002073 A CL2008002073 A CL 2008002073A CL 2008002073 A1 CL2008002073 A1 CL 2008002073A1
Authority
CL
Chile
Prior art keywords
tendonitis
myocarditis
cachexia
psoriasis
asthma
Prior art date
Application number
CL2008002073A
Other languages
English (en)
Inventor
Achim Schlapbach
Laszlo Revesz
Guido Koch
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2008002073A1 publication Critical patent/CL2008002073A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
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  • Cardiology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Ophthalmology & Optometry (AREA)
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Abstract

Compuestos derivados de lactama tetracíclicos; procedimiento de preparación; composición farmacéutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de artritis, sinovitis aguda, tendinitis, soriasis, miocarditis, caquexia, asma, cáncer, entre otras.
CL2008002073A 2007-07-16 2008-07-15 Compuestos derivados de lactama tetraciclicos, inhibidores de mk-2; procedimiento de praparacion; composicion farmaceutica; y su uso en el tratamiento de artritis, sinovitis aguda, tendinitis, soriasis, miocarditis, caquexia, asma, cancer, entre otras. CL2008002073A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07112549 2007-07-16

Publications (1)

Publication Number Publication Date
CL2008002073A1 true CL2008002073A1 (es) 2009-02-20

Family

ID=38792023

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008002073A CL2008002073A1 (es) 2007-07-16 2008-07-15 Compuestos derivados de lactama tetraciclicos, inhibidores de mk-2; procedimiento de praparacion; composicion farmaceutica; y su uso en el tratamiento de artritis, sinovitis aguda, tendinitis, soriasis, miocarditis, caquexia, asma, cancer, entre otras.

Country Status (15)

Country Link
US (2) US7838674B2 (es)
EP (1) EP2178874A1 (es)
JP (1) JP2010533674A (es)
KR (1) KR20100031619A (es)
CN (1) CN101687869A (es)
AR (1) AR067535A1 (es)
AU (1) AU2008277676A1 (es)
BR (1) BRPI0814426A2 (es)
CA (1) CA2693904A1 (es)
CL (1) CL2008002073A1 (es)
EA (1) EA201000100A1 (es)
MX (1) MX2009014247A (es)
PE (1) PE20090480A1 (es)
TW (1) TW200904818A (es)
WO (1) WO2009010488A1 (es)

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EP2641901A1 (en) 2012-03-22 2013-09-25 Syngenta Participations AG. Novel microbiocides
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CN113620981A (zh) * 2016-10-05 2021-11-09 结核病药物开发全球联盟公司 用于治疗分枝杆菌感染的杂芳基三氟硼酸盐化合物
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WO2018170200A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Heteroaryl compounds useful as mk2 inhibitors
EP3596086A4 (en) 2017-03-16 2020-12-16 Celgene CAR LLC MK2 INHIBITORS, THEIR SYNTHESIS AND THEIR INTERMEDIARIES
WO2018170201A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Deuterated analogs of mk2 inhibitors and uses thereof
CN107383026B (zh) * 2017-06-29 2019-04-30 武汉药明康德新药开发有限公司 一种7-羟甲基-2,5-二氮杂螺[3,4]辛烷-2-甲酸叔丁酯的合成方法
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用
CN109678879A (zh) * 2019-02-27 2019-04-26 陕西科技大学 一种苯并噻吩并吡喃酮类化合物及其合成方法
CN109678878A (zh) * 2019-02-27 2019-04-26 陕西科技大学 一种苯并噻吩并香豆素类化合物及其合成方法
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JP2005529850A (ja) * 2002-02-19 2005-10-06 ファルマシア・イタリア・エス・ピー・エー 三環系ピラゾール誘導体、その製造方法および抗腫瘍剤としてのその使用
AU2003297431A1 (en) * 2002-12-20 2004-07-22 Pharmacia Corporation Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds

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