CL2008000578A1 - Anticuerpo antagonista aislado anti-receptor ox40 humano; molecula de acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; su uso para tratar trastornos mediados por ox40; y metodo para detectar - Google Patents

Anticuerpo antagonista aislado anti-receptor ox40 humano; molecula de acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; su uso para tratar trastornos mediados por ox40; y metodo para detectar

Info

Publication number: CL2008000578A1
Authority: CL; Chile
Prior art keywords: codifies; understands; disorders; treat; vector
Prior art date: 2007-02-27

Application number

CL200800578A

Other languages

English (en)

Inventor

Lamhamedi-Cherrad Salah-Eddine

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-27

Filing date

2008-02-26

Publication date

2008-10-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39620235&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008000578(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-02-26 Application filed by Genentech Inc filed Critical Genentech Inc

2008-10-10 Publication of CL2008000578A1 publication Critical patent/CL2008000578A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Otolaryngology (AREA)
Psychiatry (AREA)
Cardiology (AREA)

CL200800578A 2007-02-27 2008-02-26 Anticuerpo antagonista aislado anti-receptor ox40 humano; molecula de acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; su uso para tratar trastornos mediados por ox40; y metodo para detectar CL2008000578A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US90369307P	2007-02-27	2007-02-27

Publications (1)

Publication Number	Publication Date
CL2008000578A1 true CL2008000578A1 (es)	2008-10-10

Family

ID=39620235

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200800578A CL2008000578A1 (es)	2007-02-27	2008-02-26	Anticuerpo antagonista aislado anti-receptor ox40 humano; molecula de acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; su uso para tratar trastornos mediados por ox40; y metodo para detectar

Country Status (20)

Country	Link
US (1)	US20100136030A1 (es)
EP (1)	EP2125891A2 (es)
JP (1)	JP2010518873A (es)
KR (1)	KR20100014588A (es)
CN (1)	CN101668776A (es)
AR (1)	AR065506A1 (es)
AU (1)	AU2008219666A1 (es)
BR (1)	BRPI0807269A2 (es)
CA (1)	CA2679399A1 (es)
CL (1)	CL2008000578A1 (es)
CO (1)	CO6231009A2 (es)
CR (1)	CR11042A (es)
EC (1)	ECSP099656A (es)
IL (1)	IL200572A0 (es)
MA (1)	MA31246B1 (es)
MX (1)	MX2009009194A (es)
PE (1)	PE20090689A1 (es)
RU (1)	RU2009135824A (es)
TW (1)	TW200846367A (es)
WO (1)	WO2008106116A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9163085B2 (en)	2010-08-23	2015-10-20	Board Of Regents, The University Of Texas System	Anti-OX40 antibodies and methods of treating cancer

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7291331B1 (en)	2002-09-11	2007-11-06	La Jolla Institute For Allergy And Immunology	Methods of treating OX40 medicated recall immune responses
AR057253A1 (es)	2005-12-16	2007-11-21	Genentech Inc	Anticuerpos anti-ox40l y metodos que los utilizan
MX2011007647A (es)	2009-01-21	2011-09-01	Amgen Inc	Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes.
AU2010216152B2 (en) *	2009-02-17	2015-05-14	Ucb Biopharma Sprl	Antibody molecules having specificity for human OX40
BR112014000630A2 (pt) *	2011-07-11	2017-02-14	Glenmark Pharmaceuticals Sa	anticorpo antagonista ou fragmento do mesmo que se liga a uma ox40 humana, epítopo sobre o domínio extracelular ox40 humano, ácido nucleíco isolado, vetor, célula hospedeira, método para produzir um anticorpo ou fragmento do mesmo, composição imunoconjugado, método para tratar um distúrbio mediado por ox40 em um indivíduo, uso de um anticorpo ou fragmento do mesmo, artigo de manufatura, kit e método para classificação in vitro
CA2845810C (en) *	2011-08-23	2017-03-28	Board Of Regents, The University Of Texas System	Anti-ox40 antibodies and methods of using the same
GB201116092D0 (en)	2011-09-16	2011-11-02	Bioceros B V	Antibodies and uses thereof
UA112203C2 (uk)	2011-11-11	2016-08-10	Юсб Фарма С.А.	Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
BR112015005772A2 (pt) *	2012-09-17	2017-08-08	Galectin Therapeutics Inc	método para a intensificação de imunoterapias específicas no tratamento de câncer
KR20160006168A (ko)	2013-03-18	2016-01-18	바이오서오엑스 프로덕스 비.브이.	인간화 항-cd134(ox40) 항체 및 이의 용도
GB201403775D0 (en)	2014-03-04	2014-04-16	Kymab Ltd	Antibodies, uses & methods
CN106536754B (zh)	2014-04-11	2021-04-16	诺华股份有限公司	用il-13拮抗剂选择性治疗哮喘的方法
SMT202100116T1 (it)	2014-05-28	2021-05-07	Agenus Inc	Anticorpi anti-gitr e metodi di utilizzo degli stessi
US11111284B2 (en)	2014-08-21	2021-09-07	The General Hospital Corporation	Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing
TW201619200A (zh) *	2014-10-10	2016-06-01	麥迪紐有限責任公司	人類化抗－ｏｘ４０抗體及其用途
HRP20191824T1 (hr)	2015-01-08	2020-01-24	BioNTech SE	Agonistička sredstva za vezivanje tnf receptora
US9512229B2 (en)	2015-03-03	2016-12-06	Kymab Limited	Synergistic combinations of OX40L antibodies for the treatment of GVHD
ES2937020T3 (es)	2015-03-03	2023-03-23	Kymab Ltd	Anticuerpos, usos y métodos
CA2978318A1 (en) *	2015-03-11	2016-09-15	Providence Health & Services-Oregon	Compositions and methods for enhancing the efficacy of cancer therapy
US10293059B2 (en)	2015-04-09	2019-05-21	Cornell University	Gene therapy to prevent reactions to allergens
IL304950A (en)	2015-04-10	2023-10-01	Amgen Inc	Interleukin for the expansion of myotonic control T-2 cells
TWI716405B (zh)	2015-05-07	2021-01-21	美商艾吉納斯公司	抗ox40抗體及其使用方法
LT3303396T (lt)	2015-05-29	2023-01-10	Bristol-Myers Squibb Company	Antikūnai prieš ox40 ir jų panaudojimo būdai
WO2017046746A1 (en)	2015-09-15	2017-03-23	Acerta Pharma B.V.	Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
CA2999369C (en) *	2015-09-22	2023-11-07	Spring Bioscience Corporation	Anti-ox40 antibodies and diagnostic uses thereof
CN114380908B (zh) *	2015-10-15	2023-03-17	苏州丁孚靶点生物技术有限公司	抗ox40抗体及其应用
EP3383430A4 (en) *	2015-12-02	2019-12-18	Agenus Inc.	ANTIBODIES AND METHOD FOR USE THEREOF
WO2017134292A1 (en) *	2016-02-04	2017-08-10	Glenmark Pharmaceuticals S.A.	Anti-ox40 antagonistic antibodies for the treatment of atopic dermatitis
BR112018076260A2 (pt)	2016-06-20	2019-03-26	Kymab Limited	anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina
TWI788307B (zh)	2016-10-31	2023-01-01	美商艾歐凡斯生物治療公司	用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
US11779604B2 (en)	2016-11-03	2023-10-10	Kymab Limited	Antibodies, combinations comprising antibodies, biomarkers, uses and methods
MA46770A (fr)	2016-11-09	2019-09-18	Agenus Inc	Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation
CN118638228A (zh) *	2016-12-26	2024-09-13	协和麒麟株式会社	与髓鞘少突胶质细胞糖蛋白结合的抗体
US11840565B2 (en)	2016-12-29	2023-12-12	University Of Miami	Methods and compositions for treating virus-associated inflammation
MX2019007916A (es)	2016-12-29	2019-12-05	Univ Miami	Metodo para modular la actividad de inflamasoma e inflamacion en el pulmon.
CN110462027A (zh)	2017-01-06	2019-11-15	艾欧凡斯生物治疗公司	用肿瘤坏死因子受体超家族（tnfrsf）激动剂扩增肿瘤浸润淋巴细胞（til）及til和tnfrsf激动剂的治疗组合
KR102608239B1 (ko) *	2017-02-23	2023-11-30	제리아 신야쿠 고교 가부시키 가이샤	항염증제
CN108623686A (zh) *	2017-03-25	2018-10-09	信达生物制药(苏州)有限公司	抗ox40抗体及其用途
US11819517B2 (en)	2017-06-05	2023-11-21	Iovance Biotherapeutics, Inc.	Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
KR20200100060A (ko)	2017-11-17	2020-08-25	이오반스 바이오테라퓨틱스, 인크.	미세 바늘 흡인물 및 소형 생검물로부터의 til 확장
US11713446B2 (en)	2018-01-08	2023-08-01	Iovance Biotherapeutics, Inc.	Processes for generating TIL products enriched for tumor antigen-specific T-cells
WO2019136459A1 (en)	2018-01-08	2019-07-11	Iovance Biotherapeutics, Inc.	Processes for generating til products enriched for tumor antigen-specific t-cells
JP2021509586A (ja)	2018-01-08	2021-04-01	アイオバンスバイオセラピューティクス，インコーポレイテッド	腫瘍抗原特異的ｔ細胞について濃縮されたｔｉｌ製品を生成するためのプロセス
EP3752600A1 (en)	2018-02-13	2020-12-23	Iovance Biotherapeutics, Inc.	Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists
TWI831776B (zh)	2018-04-27	2024-02-11	美商艾歐凡斯生物治療公司	腫瘤浸潤性淋巴細胞之基因編輯和彼於免疫治療之用途
JP2021528092A (ja) *	2018-07-03	2021-10-21	ユニバーシティオブマイアミ	インフラマソームに関連する疾患又は病態を治療するための組成物及び方法
WO2020016417A1 (en)	2018-07-19	2020-01-23	Ichnos Sciences S.A.	Liquid antibody formulation
TW202031273A (zh)	2018-08-31	2020-09-01	美商艾歐凡斯生物治療公司	抗ｐｄ－１抗體難治療性之非小細胞肺癌（ｎｓｃｌｃ）病患的治療
TWI862515B (zh)	2018-09-20	2024-11-21	美商艾歐凡斯生物治療公司	來自經冷凍保存之腫瘤樣本之腫瘤浸潤性淋巴細胞（ｔｉｌ）之擴增
EP3858857A1 (en) *	2018-09-26	2021-08-04	Jiangsu Hengrui Medicine Co., Ltd.	An anti-ox40 antibody, antigen-binding fragment thereof, and the pharmaceutical use
WO2020096927A1 (en)	2018-11-05	2020-05-14	Iovance Biotherapeutics, Inc.	Expansion of tils utilizing akt pathway inhibitors
AU2019375416A1 (en)	2018-11-05	2021-05-27	Iovance Biotherapeutics, Inc.	Selection of improved tumor reactive T-cells
WO2020096988A2 (en)	2018-11-05	2020-05-14	Iovance Biotherapeutics, Inc.	Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
WO2020096989A1 (en)	2018-11-05	2020-05-14	Iovance Biotherapeutics, Inc.	Treatment of nsclc patients refractory for anti-pd-1 antibody
CN113348180B (zh) *	2018-11-20	2023-05-26	上海开拓者生物医药有限公司	Ox40抗体及其制备方法和应用
CN109651510B (zh) *	2018-12-04	2023-03-24	上海长征医院	抗Eno1抗体及其用途
CA3123392A1 (en)	2018-12-19	2020-06-25	Iovance Biotherapeutics, Inc.	Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
CA3128216A1 (en) *	2019-02-01	2020-08-06	KSQ Therapeutics, Inc.	Gene-regulating compositions and methods for improved immunotherapy
EP3946437B1 (en)	2019-03-29	2025-11-19	H. Lee Moffitt Cancer Center and Research Institute, Inc.	Ex vivo methods for producing a t cell therapeutic and related compositions and methods
US20220249559A1 (en)	2019-05-13	2022-08-11	Iovance Biotherapeutics, Inc.	Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
WO2021081378A1 (en)	2019-10-25	2021-04-29	Iovance Biotherapeutics, Inc.	Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
CN115023270A (zh)	2019-11-27	2022-09-06	迈斯特治疗公司	使用调节剂产生肿瘤反应性t细胞组合物的方法
WO2021118990A1 (en)	2019-12-11	2021-06-17	Iovance Biotherapeutics, Inc.	Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
IL295990A (en)	2020-02-27	2022-11-01	Myst Therapeutics Llc	Methods for in vitro enrichment and expansion of tumor-reactive t cells and preparations related thereto
JP2023524108A (ja)	2020-05-04	2023-06-08	アイオバンスバイオセラピューティクス，インコーポレイテッド	改良された腫瘍反応性ｔ細胞の選択
JP2023523855A (ja)	2020-05-04	2023-06-07	アイオバンスバイオセラピューティクス，インコーポレイテッド	腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用
JP2023546359A (ja)	2020-10-06	2023-11-02	アイオバンスバイオセラピューティクス，インコーポレイテッド	腫瘍浸潤リンパ球療法によるｎｓｃｌｃ患者の治療
WO2022076606A1 (en)	2020-10-06	2022-04-14	Iovance Biotherapeutics, Inc.	Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
CA3187272A1 (en)	2020-10-08	2022-04-14	Thorsten Ross	Trispecific binders
WO2022125941A1 (en)	2020-12-11	2022-06-16	Iovance Biotherapeutics, Inc.	Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors
JP2023554395A (ja)	2020-12-17	2023-12-27	アイオバンスバイオセラピューティクス，インコーポレイテッド	Ｃｔｌａ－４及びｐｄ－１阻害剤と併用した腫瘍浸潤リンパ球療法による治療
JP2024500403A (ja)	2020-12-17	2024-01-09	アイオバンスバイオセラピューティクス，インコーポレイテッド	腫瘍浸潤リンパ球によるがんの治療
CA3215830A1 (en)	2021-04-19	2022-10-27	Rafael CUBAS	Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
WO2023009716A1 (en)	2021-07-28	2023-02-02	Iovance Biotherapeutics, Inc.	Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
EP4376958A1 (en)	2021-07-30	2024-06-05	Affimed GmbH	Duplexbodies
TW202323280A (zh) *	2021-10-15	2023-06-16	新加坡商創響私人有限公司	包含抗－ｏｘ４０單株抗體的藥物製劑
CA3235824A1 (en)	2021-10-27	2023-05-04	Frederick G. Vogt	Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
US20250032618A1 (en)	2021-11-10	2025-01-30	Iovance Biotherapeutics, Inc.	Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
JP2025503987A (ja)	2022-01-28	2025-02-06	アイオバンスバイオセラピューティクス，インコーポレイテッド	ペイロードを発現するように操作された腫瘍浸潤リンパ球
CA3248034A1 (en)	2022-04-15	2023-10-19	Iovance Biotherapeutics Inc	METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT
WO2024030758A1 (en)	2022-08-01	2024-02-08	Iovance Biotherapeutics, Inc.	Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
JP2025532464A (ja)	2022-09-15	2025-10-01	アビディキュアアイピービー．ブイ．	Ｎｋ細胞の腫瘍標的化のための多重特異性抗原結合タンパク質及びその使用
WO2024151885A1 (en)	2023-01-13	2024-07-18	Iovance Biotherapeutics, Inc.	Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy
WO2025076474A1 (en) *	2023-10-06	2025-04-10	Ichnos Sciences SA	Affinity matured anti-ox40 antibodies and use thereof
WO2025101484A1 (en)	2023-11-06	2025-05-15	Iovance Biotherapeutics, Inc.	Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
WO2025161898A1 (en) *	2024-02-02	2025-08-07	Biocytogen Pharmaceuticals (Beijing) Co., Ltd.	Anti-ox40 antibodies and uses thereof
WO2025191136A1 (en)	2024-03-15	2025-09-18	Avidicure Ip B.V.	Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof
WO2025191133A1 (en)	2024-03-15	2025-09-18	Avidicure Ip B.V.	Il-21 muteins, fusion proteins comprising the same and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5821332A (en) *	1993-11-03	1998-10-13	The Board Of Trustees Of The Leland Stanford Junior University	Receptor on the surface of activated CD4+ T-cells: ACT-4
US5759546A (en) *	1994-02-04	1998-06-02	Weinberg; Andrew D.	Treatment of CD4 T-cell mediated conditions
US6057421A (en) *	1994-11-30	2000-05-02	Immpheron, Inc.	Variable heavy and light chain regions of murine monoclonal antibody 1F7
CA2489004C (en) *	2002-06-13	2013-01-08	Crucell Holland B.V.	Agonistic binding molecules to the human ox40 receptor
US20040136992A1 (en) *	2002-08-28	2004-07-15	Burton Paul B. J.	Compositions and method for treating cardiovascular disease
EP1716181B1 (en) *	2004-02-19	2009-12-16	Genentech, Inc.	Cdr-repaired antibodies
AU2006236439B2 (en) *	2005-04-15	2012-05-03	Macrogenics, Inc.	Covalent diabodies and uses thereof
TWI461436B (zh) *	2005-11-25	2014-11-21	Kyowa Hakko Kirin Co Ltd	人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法
AR057253A1 (es) *	2005-12-16	2007-11-21	Genentech Inc	Anticuerpos anti-ox40l y metodos que los utilizan

2008
- 2008-02-26 AU AU2008219666A patent/AU2008219666A1/en not_active Abandoned
- 2008-02-26 RU RU2009135824/10A patent/RU2009135824A/ru not_active Application Discontinuation
- 2008-02-26 MX MX2009009194A patent/MX2009009194A/es unknown
- 2008-02-26 CA CA002679399A patent/CA2679399A1/en not_active Abandoned
- 2008-02-26 BR BRPI0807269-8A2A patent/BRPI0807269A2/pt not_active IP Right Cessation
- 2008-02-26 EP EP08726081A patent/EP2125891A2/en not_active Withdrawn
- 2008-02-26 US US12/526,550 patent/US20100136030A1/en not_active Abandoned
- 2008-02-26 JP JP2009551698A patent/JP2010518873A/ja not_active Withdrawn
- 2008-02-26 CL CL200800578A patent/CL2008000578A1/es unknown
- 2008-02-26 KR KR1020097020065A patent/KR20100014588A/ko not_active Withdrawn
- 2008-02-26 WO PCT/US2008/002498 patent/WO2008106116A2/en not_active Ceased
- 2008-02-26 CN CN200880013914A patent/CN101668776A/zh active Pending
- 2008-02-27 TW TW097106870A patent/TW200846367A/zh unknown
- 2008-02-27 PE PE2008000393A patent/PE20090689A1/es not_active Application Discontinuation
- 2008-02-27 AR ARP080100818A patent/AR065506A1/es unknown
2009
- 2009-08-25 IL IL200572A patent/IL200572A0/en unknown
- 2009-09-10 MA MA32212A patent/MA31246B1/fr unknown
- 2009-09-23 CO CO09103883A patent/CO6231009A2/es not_active Application Discontinuation
- 2009-09-24 CR CR11042A patent/CR11042A/es unknown
- 2009-09-25 EC EC2009009656A patent/ECSP099656A/es unknown

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9163085B2 (en)	2010-08-23	2015-10-20	Board Of Regents, The University Of Texas System	Anti-OX40 antibodies and methods of treating cancer
US9527917B2 (en)	2010-08-23	2016-12-27	Board Of Regents, The University Of Texas System	Nucleic acid encoding anti-OX40 antibodies
US9695246B2 (en)	2010-08-23	2017-07-04	Board Of Regents, The University Of Texas System	Anti-OX40 antibodies and methods of using the same
US10196450B2 (en)	2010-08-23	2019-02-05	Board Of Regents, The University Of Texas System	Anti-OX40 antibodies and methods of using the same
US10851173B2 (en)	2010-08-23	2020-12-01	Board Of Regents, The University Of Texas System	Anti-OX40 antibodies and methods of using the same

Also Published As

Publication number	Publication date
CA2679399A1 (en)	2008-09-04
CO6231009A2 (es)	2010-12-20
US20100136030A1 (en)	2010-06-03
AR065506A1 (es)	2009-06-10
JP2010518873A (ja)	2010-06-03
PE20090689A1 (es)	2009-06-20
BRPI0807269A2 (pt)	2014-04-29
IL200572A0 (en)	2010-05-17
MA31246B1 (fr)	2010-03-01
MX2009009194A (es)	2009-10-08
WO2008106116A2 (en)	2008-09-04
AU2008219666A1 (en)	2008-09-04
WO2008106116A3 (en)	2008-10-16
RU2009135824A (ru)	2011-04-10
KR20100014588A (ko)	2010-02-10
CN101668776A (zh)	2010-03-10
EP2125891A2 (en)	2009-12-02
TW200846367A (en)	2008-12-01
ECSP099656A (es)	2009-10-30
CR11042A (es)	2009-11-03

Publication	Publication Date	Title
CL2008000578A1 (es)	2008-10-10	Anticuerpo antagonista aislado anti-receptor ox40 humano; molecula de acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; composicion que lo comprende; su uso para tratar trastornos mediados por ox40; y metodo para detectar
CL2007003807A1 (es)	2008-05-09	Anticuerpos humanos anti-cd44 o fragmentos de los mismos; acidos nucleicos que los codifican; vector y celula huesped que los comprende; composicion farmaceutica que comprende a los anticuerpos; y su uso para tratar los sintomas de trastornos mediado
CL2007002987A1 (es)	2008-06-06	Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para tratar enfermedades relacionadas con notch3.
CL2008001129A1 (es)	2008-06-13	Variente de asparraginasa; secuencia de acido nucleico que la codifica; construccion de acidos nucleicos; vector y celula huesped; metodo para producir asparraginasa; composicion que comprende la variante; uso de la variante de asparraginasa; proceso
CL2007003623A1 (es)	2008-08-08	Proteina de enlace multivalente monocatenaria con funcion efectora; acido nucleico que la codifica; vector y celula huesped; metodo de produccion; composicion farmaceutica que la comprende; y metodo para tratar trastornos proliferativos.
CL2007002835A1 (es)	2008-05-30	Anticuerpo monoclonal especifico para el receptor cxcr4; acido nucleico que lo codifica; vector y celula que lo comprenden; metodo de produccion; inmunoconjugado y composicion que lo comprende; y su uso para tratar cancer, trastornos inflamatorios y
CL2008000839A1 (es)	2008-09-26	Anticuerpo anti-ige/m1'; acido nucleico que lo codifica; vector y celula huesped; proceso de produccion; composicion que comprende al anticuerpo; y su uso para tratar trastornos mediados por ige.
CL2008000478A1 (es)	2008-10-17	Elemento de union aislado especifico para inmunoglobulina e (ige); molecula de acido nucleico que lo codifica; metodo de produccion; composicion farmaceutica; y su uso para tratar trastornos asociados con ige.
CL2017000772A1 (es)	2017-11-03	Anticuerpo aislado que se une a mesotelina; ácido nucleico que lo codifica; célula huésped; método de producción; inmunoconjugado; formulación farmacéutica que lo comprende; su uso para tratar cáncer; y método de detección de mesotelina humana. (divisional solicitud 1776-2013)
CL2008001673A1 (es)	2008-11-21	Dominio variable simple de la inmunoglobulina del receptor tipo 1 de la anti-interleucina 1 (il-1r1); acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; antagonista de il-1r1 que lo comprende; composicion que comprende al antagonista; y uso del antagonista para tratar una condicion inflamatoria.
BRPI0915928A2 (pt)	2015-11-03	composições e métodos de uso para anticorpos terapêuticos
CL2013003336A1 (es)	2014-06-06	Anticuerpo anti-cgrp humano; acido nucleico que lo codifica; vector; celula huesped; metodo de produccion; composicion farmaceutica y diagnostica que lo comprende; y su uso terapéutico
BR112015020277A2 (pt)	2017-10-10	moléculas de ligação para bcma e cd3
CL2007002989A1 (es)	2008-05-16	Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para el diagnostico de enfermedades relacionadas con notch3.
CL2013000930A1 (es)	2014-03-28	Anticuerpo para interleuquina 17 (il-17); uso de dicho anticuerpo para tratar soriasis usando antagonistas de il-17.
CL2007002412A1 (es)	2008-06-20	Anticuerpo especifico para el dominio extracelular del receptor de prolactina (prlr); molecula de acido nucleico que lo codifica; vector de expresion y celula huesped que la comprenden; metodo de produccion; composicion farmaceutica que comprende al
BR112014010940A2 (pt)	2017-05-16	moléculas de ligação para bcma e cd3
CL2013003728A1 (es)	2014-10-17	Anticuerpo antagonista o fragmento del mismo que se une a ox40 de humano; epitope del dominio extracelular de ox40 de humano que es unido por en anticuerpo antes mencionado; acido nucleico que codifica el anticuerpo; vector y célula hospedera que comprenden dicho acido nucleico; metodo para producir el anticuerpo; composicion que comprende el anticuerpo; inmunoconjugado; uso para tratar trastornos mediados por ox40.
BR112014006390A2 (pt)	2017-03-28	anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano
BRPI0817812A2 (pt)	2015-04-14	Uso de anticorpos trkb para o tratamento de distúrbios respiratórios
CL2007002767A1 (es)	2008-05-30	Anticuerpo especifico para el receptor ccr5; acido nucleico que lo codifica; metodo de produccion; composicion farmaceutica que lo comprende; y su uso para tratar enfermedades inmunosupresoras.
CL2014000631A1 (es)	2014-09-26	Molecula de union que se une a cd134 (ox40); molecula de acido nucleico que la codifica; vector; celula huesped; proceso de preparacion; composicion farmaceutica que la comprende; y su uso para tratar cancer.
CL2014001055A1 (es)	2014-08-18	Proteina de union biespecifica que se enlaza al factor de necrosis tumoral (tnf) y la interleucina 17 (il-17); acido nucleico que la codifica; vector; celula huesped; metodo de produccion; composicion farmaceutica que la comprende; y su uso.
SMT201500047B (it)	2015-05-05	Agenti leganti il recettore notch1 e loro metodi d'uso
CL2014001888A1 (es)	2014-10-03	Anticuerpo aislado que se une a la proteina 5 relacionada con el receptor de lipoproteina de baja densidad (lrp5); acido nucleico que lo codifica; celula huesped; metodo de produccion; formulaciom farmaceutica que lo comprende; y su uso para tratar retinopatías.