[go: up one dir, main page]

CL2007002175A1 - Compuestos derivados de 2,5-difenil-1h-imidazol, moduladores de la actividad de la senda de hedgehog, util para el tratamiento de cancer de piel sin melanoma, mieloma, linfoma, soriasis, cancer pancreatico, cancer de prostata, meduloblastoma, carcino - Google Patents

Compuestos derivados de 2,5-difenil-1h-imidazol, moduladores de la actividad de la senda de hedgehog, util para el tratamiento de cancer de piel sin melanoma, mieloma, linfoma, soriasis, cancer pancreatico, cancer de prostata, meduloblastoma, carcino

Info

Publication number
CL2007002175A1
CL2007002175A1 CL200702175A CL2007002175A CL2007002175A1 CL 2007002175 A1 CL2007002175 A1 CL 2007002175A1 CL 200702175 A CL200702175 A CL 200702175A CL 2007002175 A CL2007002175 A CL 2007002175A CL 2007002175 A1 CL2007002175 A1 CL 2007002175A1
Authority
CL
Chile
Prior art keywords
cancer
prastoma
carculobo
soriasis
difenil
Prior art date
Application number
CL200702175A
Other languages
English (en)
Inventor
Dai Han Dong Gao Wenqi J Cheng
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of CL2007002175A1 publication Critical patent/CL2007002175A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CL200702175A 2006-07-25 2007-07-25 Compuestos derivados de 2,5-difenil-1h-imidazol, moduladores de la actividad de la senda de hedgehog, util para el tratamiento de cancer de piel sin melanoma, mieloma, linfoma, soriasis, cancer pancreatico, cancer de prostata, meduloblastoma, carcino CL2007002175A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83331806P 2006-07-25 2006-07-25
US94265007P 2007-06-07 2007-06-07

Publications (1)

Publication Number Publication Date
CL2007002175A1 true CL2007002175A1 (es) 2008-06-13

Family

ID=38962752

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200702175A CL2007002175A1 (es) 2006-07-25 2007-07-25 Compuestos derivados de 2,5-difenil-1h-imidazol, moduladores de la actividad de la senda de hedgehog, util para el tratamiento de cancer de piel sin melanoma, mieloma, linfoma, soriasis, cancer pancreatico, cancer de prostata, meduloblastoma, carcino

Country Status (14)

Country Link
US (1) US7928133B2 (es)
EP (1) EP2044065A2 (es)
JP (1) JP2009544730A (es)
KR (1) KR20090031789A (es)
AR (1) AR062100A1 (es)
AU (1) AU2007276788A1 (es)
BR (1) BRPI0714663A2 (es)
CA (1) CA2658782A1 (es)
CL (1) CL2007002175A1 (es)
MX (1) MX2009000947A (es)
PE (1) PE20080948A1 (es)
RU (1) RU2423354C2 (es)
TW (1) TW200817393A (es)
WO (1) WO2008014291A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA93548C2 (uk) 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
EP2066320A1 (en) * 2006-09-27 2009-06-10 Irm, Llc Methods and compositions for treating lymphoma and myeloma
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明(cyclopamine)類似物類
MX2009013273A (es) * 2007-06-07 2010-01-25 Irm Llc Derivados de bifenil-carboxamida como moduladores de la senda de hedgehog.
TW200916458A (en) * 2007-09-05 2009-04-16 Astrazeneca Ab Heterocyclic compounds and methods of use thereof
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
HUE060249T2 (hu) 2008-06-16 2023-02-28 Univ Tennessee Res Found Vegyületek rák kezelésére
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
NZ591420A (en) * 2008-09-17 2012-07-27 Novartis Ag Salts of n-[6-cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
AU2009299927B2 (en) 2008-10-01 2013-05-30 Novartis Ag Smoothened antagonism for the treatment of hedgehog pathway-related disorders
MX2011013294A (es) * 2009-06-11 2012-01-12 Siena Biotech Spa Antagonistas de la trayectoria de hedgehog y aplicaciones terapeuticas de los mismos.
JP2013516480A (ja) 2010-01-07 2013-05-13 セレクサゲン セラピューティクス,インク. ヘッジホッグ阻害剤
AU2010347233B2 (en) * 2010-03-01 2015-06-18 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
FR2967498B1 (fr) 2010-11-16 2015-01-02 Centre Nat Rech Scient Utilisation de derives de quinolinone comme outil de recherche
KR101762724B1 (ko) * 2011-01-25 2017-07-28 더 리젠츠 오브 더 유니버시티 오브 미시건 Bcl-2/bcl-xl 억제제 및 이를 이용한 치료 방법
US20120207840A1 (en) * 2011-02-10 2012-08-16 Aura Biosciences, Inc. Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For The Treatment Of Non-Melanoma Skin Cancer
EP2653464B1 (en) * 2012-04-20 2017-09-27 Rohm and Haas Company Benzylamine hydrophobe
CN106905297A (zh) * 2012-06-15 2017-06-30 加利福尼亚大学董事会 用于脑癌的新颖治疗剂
CN103570625A (zh) * 2012-07-19 2014-02-12 南京英派药业有限公司 N-(3-杂芳基芳基)-4-芳基芳基甲酰胺和类似物作为Hedgehog通路抑制剂及其应用
EP3015459A1 (en) * 2014-10-30 2016-05-04 Sanofi Benzylhydroxyde derivatives, preparation thereof and therapeutic use thereof
US10227333B2 (en) 2015-02-11 2019-03-12 Curtana Pharmaceuticals, Inc. Inhibition of OLIG2 activity
IL254007B2 (en) 2015-02-27 2024-08-01 Curtana Pharmaceuticals Inc Inhibition of olig2 activity
BR112017026103B1 (pt) 2015-06-04 2023-10-03 Sol-Gel Technologies Ltd Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos
KR20220034739A (ko) 2019-05-31 2022-03-18 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
PH12022551379A1 (en) 2019-12-06 2023-05-03 Vertex Pharma Substituted tetrahydrofurans as modulators of sodium channels
DK4347031T3 (da) 2021-06-04 2025-12-01 Vertex Pharma N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
DK0786455T3 (da) * 1994-09-26 2004-03-29 Shionogi & Co Imidazolderivater
JP4180276B2 (ja) * 1999-12-16 2008-11-12 シェーリング コーポレイション 置換イミダゾール神経ペプチドyy5レセプタアンタゴニスト
KR20050120711A (ko) 2003-04-10 2005-12-22 아바니르 파마슈티컬스 알레르기 및 세포 과다증식 질병의 치료를 위한 이미다졸유도체
WO2005113513A2 (en) * 2004-05-12 2005-12-01 Chemocentryx Aryl sulfonamides
CN101083996A (zh) * 2004-10-28 2007-12-05 Irm责任有限公司 作为hedgehog途径调节剂的化合物和组合物

Also Published As

Publication number Publication date
KR20090031789A (ko) 2009-03-27
JP2009544730A (ja) 2009-12-17
AU2007276788A1 (en) 2008-01-31
MX2009000947A (es) 2009-02-05
RU2009106167A (ru) 2010-08-27
RU2423354C2 (ru) 2011-07-10
BRPI0714663A2 (pt) 2013-05-07
TW200817393A (en) 2008-04-16
AR062100A1 (es) 2008-10-15
EP2044065A2 (en) 2009-04-08
US7928133B2 (en) 2011-04-19
CA2658782A1 (en) 2008-01-31
PE20080948A1 (es) 2008-09-10
WO2008014291A2 (en) 2008-01-31
US20090312308A1 (en) 2009-12-17
WO2008014291A3 (en) 2008-04-03

Similar Documents

Publication Publication Date Title
CL2007002175A1 (es) Compuestos derivados de 2,5-difenil-1h-imidazol, moduladores de la actividad de la senda de hedgehog, util para el tratamiento de cancer de piel sin melanoma, mieloma, linfoma, soriasis, cancer pancreatico, cancer de prostata, meduloblastoma, carcino
CL2007003758A1 (es) Compuestos derivados de aminopirimidina, inhibidores de plk1; composicion farmaceutica, util para el tratamiento de cancer.
MX2009011210A (es) Inhibidores de mcl1 de indol 7-no sustituido.
WO2010096371A3 (en) Heterocyclic compounds which modulate the cb2 receptor
CL2007002790A1 (es) Compuestos derivados de 1h-indol y 1h-bencimidazol; composicion farmaceutica; y uso para el tratamiento de hipogonadismo, osteoporosis y cancer de prostata entre otros.
CL2007003341A1 (es) Compuestos derivados de imidazotriazinas; composicion farmaceutica, util para el tratamiento del cancer, arteroesclerosis y enfermedades cardiovasculares entre otras.
BRPI0811907A2 (pt) Anticorpos monoclonais contra claudina-18 para tratamento de câncer.
SMP200900085B (it) 3-imidazolil-indoli per il trattamento di malattieproliferative.
CL2011000478A1 (es) Compuestos derivados de 2-imidazol-propanamida sustituidos, activadores de glucoquinasa; composicion farmaceutica, util para tratar o retrasar la progresion o aparacion de la diabetes tipo ii o trastornos relacionados con la diabetes.
CL2007003049A1 (es) Compuestos derivados de 2,4-diaminopirimidina; composicion farmaceutica, utiles para tratar trastornos proliferativos.
PH12013501558A1 (en) New compounds
ZA200707638B (en) Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
EA201270049A1 (ru) Дизамещенные фталазиновые антагонисты пути hedgehog
BRPI0814941A2 (pt) Composição de tratamentode semente, e, método de tratamento de semente.
WO2008131000A3 (en) 7-substituted indole mcl-1 inhibitors
MX2009004047A (es) Compuestos organicos.
BRPI1007990A2 (pt) Compostos específicos de diaril-hidantoína e diariltioidantoína.
BRPI0808775A2 (pt) compostos e composições como moduladores de atividade de gpr119
BRPI0812027A2 (pt) Composto 1,3 diona bicíclicos herbicidamente ativos.
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
DOP2011000183A (es) Polimorfos de(s)-3-amino-metil-7-(3-hidroxi-propoxi)-3h-benzo-[c][1,2-oxaborol-1-ol
EA201171063A1 (ru) Фармацевтические составы олмесартана
EA201170699A1 (ru) Тетразамещенные пиридазины в качестве антагонистов пути hedgehog
CL2007002858A1 (es) Compuestos derivados de arilo-indol, inhibidores de la glicogeno sintasa quinasa-3-beta y/o moduladores de la actividad del canal n-metil-d-aspartato; formulacion farmaceutica, util para el tratamiento o prevencion de un desorden o trauma del snc, mi
CL2008000681A1 (es) Metodo de tratamiento de melanoma mediante el uso de compuestos derivados de 4-amino-5-fluoro-(benzoimidazol sustituido)-1h-quinolin-2-ona.