CL2007001894A1 - Topical ophthalmic formulation comprising: 0.1% dexamethasone, 0.3% ciprofloxacin hydrochloride, sodium chloride, 6% hydroxypropyl beta-cyclodextrin, 0.15% sodium sulfate, 0.05% edetate disodium, 0.022% 50% benzalkonium chloride and 0.100ml / 100ml polysorbate 80; Useful for treating eye infections. - Google Patents
Topical ophthalmic formulation comprising: 0.1% dexamethasone, 0.3% ciprofloxacin hydrochloride, sodium chloride, 6% hydroxypropyl beta-cyclodextrin, 0.15% sodium sulfate, 0.05% edetate disodium, 0.022% 50% benzalkonium chloride and 0.100ml / 100ml polysorbate 80; Useful for treating eye infections.Info
- Publication number
- CL2007001894A1 CL2007001894A1 CL2007001894A CL2007001894A CL2007001894A1 CL 2007001894 A1 CL2007001894 A1 CL 2007001894A1 CL 2007001894 A CL2007001894 A CL 2007001894A CL 2007001894 A CL2007001894 A CL 2007001894A CL 2007001894 A1 CL2007001894 A1 CL 2007001894A1
- Authority
- CL
- Chile
- Prior art keywords
- dexamethasone
- polysorbate
- chloride
- cyclodextrin
- useful
- Prior art date
Links
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 title abstract 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 title abstract 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 title abstract 2
- 229960000686 benzalkonium chloride Drugs 0.000 title abstract 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 title abstract 2
- DIOIOSKKIYDRIQ-UHFFFAOYSA-N ciprofloxacin hydrochloride Chemical compound Cl.C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 DIOIOSKKIYDRIQ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001229 ciprofloxacin hydrochloride Drugs 0.000 title abstract 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 title abstract 2
- 229960003957 dexamethasone Drugs 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 title abstract 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 title abstract 2
- 229920000053 polysorbate 80 Polymers 0.000 title abstract 2
- 229940068968 polysorbate 80 Drugs 0.000 title abstract 2
- 239000011780 sodium chloride Substances 0.000 title abstract 2
- 229910052938 sodium sulfate Inorganic materials 0.000 title abstract 2
- 235000011152 sodium sulphate Nutrition 0.000 title abstract 2
- 208000001860 Eye Infections Diseases 0.000 title 1
- 229940124274 edetate disodium Drugs 0.000 title 1
- 208000011323 eye infectious disease Diseases 0.000 title 1
- 230000000699 topical effect Effects 0.000 title 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 title 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Formulación oftálmica para administración vía tópica que comprende dexametasona base micronizada, clorhidrato de ciprofloxacino, cloruro de sodio, hidroxipropilbetaciclodextrinas, sulfato de sodio, edetato disódico, cloruro de benzalconio y polisorbato 80.Ophthalmic formulation for topical administration comprising dexamethasone micronized base, ciprofloxacin hydrochloride, sodium chloride, hydroxypropylbetacyclodextrins, sodium sulfate, disodium edetate, benzalkonium chloride and polysorbate 80.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/MX2006/000062 WO2008002117A1 (en) | 2006-06-27 | 2006-06-27 | Ophthalmic solution of ciprofloxacin and dexamethasone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007001894A1 true CL2007001894A1 (en) | 2008-01-04 |
Family
ID=38845821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2007001894A CL2007001894A1 (en) | 2006-06-27 | 2007-06-27 | Topical ophthalmic formulation comprising: 0.1% dexamethasone, 0.3% ciprofloxacin hydrochloride, sodium chloride, 6% hydroxypropyl beta-cyclodextrin, 0.15% sodium sulfate, 0.05% edetate disodium, 0.022% 50% benzalkonium chloride and 0.100ml / 100ml polysorbate 80; Useful for treating eye infections. |
Country Status (3)
| Country | Link |
|---|---|
| CL (1) | CL2007001894A1 (en) |
| PE (1) | PE20080347A1 (en) |
| WO (1) | WO2008002117A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107970244B (en) * | 2016-10-21 | 2020-07-14 | 武汉武药科技有限公司 | Composition containing ciprofloxacin and dexamethasone and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6740664B2 (en) * | 1998-09-30 | 2004-05-25 | Alcon, Inc. | Methods for treating otic and ophthalmic infections |
| US20040077562A1 (en) * | 2000-11-15 | 2004-04-22 | Chandavarkar Mohan A. | Combination drug |
| WO2004069280A1 (en) * | 2003-02-06 | 2004-08-19 | Cipla Ltd | Pharmaceutical inclusion complexes containing a steroid and optionally an antibacterial agent |
| MXPA05008913A (en) * | 2003-02-21 | 2005-10-05 | Sun Pharmaceutical Ind Ltd | Stable ophthalmic formulation containing an antibiotic and a corticosteroid. |
-
2006
- 2006-06-27 WO PCT/MX2006/000062 patent/WO2008002117A1/en not_active Ceased
-
2007
- 2007-06-27 PE PE2007000833A patent/PE20080347A1/en not_active Application Discontinuation
- 2007-06-27 CL CL2007001894A patent/CL2007001894A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008002117A1 (en) | 2008-01-03 |
| PE20080347A1 (en) | 2008-04-11 |
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