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CL2007001091A1 - Compuestos derivados de ciclopropan dicarboxamida, inhibidores del factor de coagulacion xa; composiciones farmaceuticas; y su uso para tratar desordenes tromboticos, trombosis arterial o venosa, trombosis venosa profunda, enfermedad arterial periferica oclusiva y angina pectoris inestable, infarto al miocardio, entre otras. - Google Patents

Compuestos derivados de ciclopropan dicarboxamida, inhibidores del factor de coagulacion xa; composiciones farmaceuticas; y su uso para tratar desordenes tromboticos, trombosis arterial o venosa, trombosis venosa profunda, enfermedad arterial periferica oclusiva y angina pectoris inestable, infarto al miocardio, entre otras.

Info

Publication number
CL2007001091A1
CL2007001091A1 CL2007001091A CL2007001091A CL2007001091A1 CL 2007001091 A1 CL2007001091 A1 CL 2007001091A1 CL 2007001091 A CL2007001091 A CL 2007001091A CL 2007001091 A CL2007001091 A CL 2007001091A CL 2007001091 A1 CL2007001091 A1 CL 2007001091A1
Authority
CL
Chile
Prior art keywords
venous thrombosis
pharmaceutical compositions
cyclopropan
dicarboxamide
myocardial infarction
Prior art date
Application number
CL2007001091A
Other languages
English (en)
Inventor
Hilpert Hans
Panday Narendra
Haap Wolfgang
Groebke Zbinden Katrin
Ricklin Fabienne
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36942280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007001091(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2007001091A1 publication Critical patent/CL2007001091A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos derivados de dicarboxamidas, inhibidores del factor de coagulación XA; composiciones farmacéuticas; y uso para el tratamiento y/o profilaxis de trastornos trombóticos, infarto de miocardio y arteriosclerosis, entre otras.
CL2007001091A 2006-04-21 2007-04-18 Compuestos derivados de ciclopropan dicarboxamida, inhibidores del factor de coagulacion xa; composiciones farmaceuticas; y su uso para tratar desordenes tromboticos, trombosis arterial o venosa, trombosis venosa profunda, enfermedad arterial periferica oclusiva y angina pectoris inestable, infarto al miocardio, entre otras. CL2007001091A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112897A EP1847537A1 (en) 2006-04-21 2006-04-21 Dicarboxamide derivatives

Publications (1)

Publication Number Publication Date
CL2007001091A1 true CL2007001091A1 (es) 2008-01-04

Family

ID=36942280

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2007001091A CL2007001091A1 (es) 2006-04-21 2007-04-18 Compuestos derivados de ciclopropan dicarboxamida, inhibidores del factor de coagulacion xa; composiciones farmaceuticas; y su uso para tratar desordenes tromboticos, trombosis arterial o venosa, trombosis venosa profunda, enfermedad arterial periferica oclusiva y angina pectoris inestable, infarto al miocardio, entre otras.

Country Status (14)

Country Link
US (2) US20070249683A1 (es)
EP (2) EP1847537A1 (es)
JP (1) JP2009534347A (es)
KR (1) KR20080109866A (es)
CN (1) CN101421242B (es)
AR (1) AR060614A1 (es)
AU (1) AU2007242884A1 (es)
BR (1) BRPI0710539A2 (es)
CA (1) CA2649458A1 (es)
CL (1) CL2007001091A1 (es)
IL (1) IL194555A0 (es)
MX (1) MX2008013225A (es)
TW (1) TW200811136A (es)
WO (1) WO2007122104A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550487B2 (en) * 2004-03-26 2009-06-23 Hoffmann-La Roche Inc. Pyrrolidine-3,4-dicarboxamide derivatives
DE602005026047D1 (de) * 2004-11-03 2011-03-03 Hoffmann La Roche Dicarbonsäureamidderivate und deren verwendung als inhibitoren von faktor xa
ES2348122T3 (es) 2006-04-20 2010-11-30 F. Hoffmann-La Roche Ag Derivados de diazepano moduladores de receptores de quimioquina.
EP2978425B1 (en) * 2013-03-27 2017-09-27 Merck Sharp & Dohme Corp. Factor xia inhibitors
EP3078378B1 (en) 2015-04-08 2020-06-24 Vaiomer Use of factor xa inhibitors for regulating glycemia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5567000A (en) * 1999-06-24 2001-01-09 Toray Industries, Inc. Alpha1b-adrenergic receptor antagonists
US7030141B2 (en) 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
WO2004031145A2 (en) * 2002-10-02 2004-04-15 Bristol-Myers Squibb Company Lactam-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor xa inhibitors
JP2004210716A (ja) * 2002-12-27 2004-07-29 Dai Ichi Seiyaku Co Ltd ジアミド誘導体
DE602005026047D1 (de) * 2004-11-03 2011-03-03 Hoffmann La Roche Dicarbonsäureamidderivate und deren verwendung als inhibitoren von faktor xa

Also Published As

Publication number Publication date
CA2649458A1 (en) 2007-11-01
CN101421242A (zh) 2009-04-29
WO2007122104A1 (en) 2007-11-01
KR20080109866A (ko) 2008-12-17
US20110195997A1 (en) 2011-08-11
AR060614A1 (es) 2008-07-02
EP1847537A1 (en) 2007-10-24
EP2013177A1 (en) 2009-01-14
US20070249683A1 (en) 2007-10-25
CN101421242B (zh) 2011-06-01
IL194555A0 (en) 2009-08-03
BRPI0710539A2 (pt) 2011-08-16
MX2008013225A (es) 2008-10-21
AU2007242884A1 (en) 2007-11-01
TW200811136A (en) 2008-03-01
JP2009534347A (ja) 2009-09-24

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