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EA200701820A1 - Применение диосметиновых соединений при лечении и профилактике тромботических патологий - Google Patents

Применение диосметиновых соединений при лечении и профилактике тромботических патологий

Info

Publication number
EA200701820A1
EA200701820A1 EA200701820A EA200701820A EA200701820A1 EA 200701820 A1 EA200701820 A1 EA 200701820A1 EA 200701820 A EA200701820 A EA 200701820A EA 200701820 A EA200701820 A EA 200701820A EA 200701820 A1 EA200701820 A1 EA 200701820A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
prevention
application
pathologies
diosmetin compounds
Prior art date
Application number
EA200701820A
Other languages
English (en)
Other versions
EA013078B1 (ru
Inventor
Тони Вербёрен
Ален Рюпен
Патрисья Сансильвестри-Морель
Мари-Одиль Валле
Мари-Франсуа Буссар
Мишель Верзбицки
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200701820A1 publication Critical patent/EA200701820A1/ru
Publication of EA013078B1 publication Critical patent/EA013078B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Применение диосметиновых соединений в получении фармацевтических композиций, предназначенных для профилактики и/или лечения тромботических патологий и патологий с риском тромбоза.
EA200701820A 2005-03-01 2006-02-28 Применение диосметиновых соединений при лечении и профилактике тромботических патологий EA013078B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0502044A FR2882654B1 (fr) 2005-03-01 2005-03-01 Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
PCT/FR2006/000441 WO2006092490A1 (fr) 2005-03-01 2006-02-28 Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques

Publications (2)

Publication Number Publication Date
EA200701820A1 true EA200701820A1 (ru) 2008-02-28
EA013078B1 EA013078B1 (ru) 2010-02-26

Family

ID=35134198

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701820A EA013078B1 (ru) 2005-03-01 2006-02-28 Применение диосметиновых соединений при лечении и профилактике тромботических патологий

Country Status (18)

Country Link
US (1) US20080176934A1 (ru)
EP (1) EP1853253A1 (ru)
JP (1) JP2008531660A (ru)
KR (2) KR20090128581A (ru)
CN (1) CN101132788A (ru)
AR (1) AR053149A1 (ru)
AU (1) AU2006219853B2 (ru)
BR (1) BRPI0607562A2 (ru)
CA (1) CA2599658A1 (ru)
EA (1) EA013078B1 (ru)
FR (1) FR2882654B1 (ru)
MA (1) MA29316B1 (ru)
MX (1) MX2007010364A (ru)
NO (1) NO20074941L (ru)
NZ (1) NZ560749A (ru)
UA (1) UA91848C2 (ru)
WO (1) WO2006092490A1 (ru)
ZA (1) ZA200707472B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2002835A1 (en) 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
FR2929276B1 (fr) * 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR101162816B1 (ko) * 2008-04-01 2012-07-09 르 라보레또레 쎄르비에르 디오스메틴 화합물，이의 제조 방법 및 이를 함유하는 약제학적 조성물
EP2166009A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2166010A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
WO2010062681A2 (en) * 2008-10-30 2010-06-03 University Of South Florida Luteolin and diosmin/diosmetin as novel stat3 inhibitors for treating autism
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
RS60782B1 (sr) * 2011-11-23 2020-10-30 In3Bio Ltd Rekombinantni proteini i njihove terapeutske upotrebe
EP3034500A1 (en) 2014-12-17 2016-06-22 Genkyotex Sa Amido thiazole derivatives as NADPH oxidase inhibitors
KR20180120746A (ko) * 2016-03-11 2018-11-06 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 이카리인 및 이카리틴 유도체
CN110114081A (zh) * 2016-12-15 2019-08-09 泰伦基国际有限公司 一种改善心脏病变的方法
CN110167583A (zh) * 2016-12-15 2019-08-23 泰伦基国际有限公司 一种治疗冠状动脉粥样硬化及其并发症的方法
CN108210915A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 改善心脏病变的药物及其用途
JP7168990B2 (ja) 2016-12-15 2022-11-10 タレンゲン インターナショナル リミテッド 肥満症を予防および治療するための方法および薬物
TWI746581B (zh) * 2016-12-15 2021-11-21 大陸商深圳瑞健生命科學硏究院有限公司 纖溶酶原在製備預防和治療脂質腎損傷之藥劑上的用途
CN106822087A (zh) * 2017-01-12 2017-06-13 西南大学 香叶木素在制备治疗ⅱ型糖尿病的药物中的应用
CN109280067B (zh) * 2017-07-21 2022-07-05 南京正大天晴制药有限公司 香叶木苷衍生物、其制备方法以及医药用途
EP3479843A1 (en) 2017-11-01 2019-05-08 GenKyoTex Suisse SA Use of nox inhibitors for treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701261B1 (fr) * 1993-02-05 1995-03-31 Adir Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
FR2726273B1 (fr) * 1994-10-26 1996-12-06 Adir Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
EP1124815B1 (de) * 1998-10-30 2004-05-26 MERCK PATENT GmbH Verfahren zur herstellung von luteolin und luteolin-derivaten

Also Published As

Publication number Publication date
KR100971589B1 (ko) 2010-07-20
KR20090128581A (ko) 2009-12-15
AU2006219853B2 (en) 2011-06-09
EP1853253A1 (fr) 2007-11-14
FR2882654A1 (fr) 2006-09-08
EA013078B1 (ru) 2010-02-26
MA29316B1 (fr) 2008-03-03
JP2008531660A (ja) 2008-08-14
UA91848C2 (ru) 2010-09-10
CN101132788A (zh) 2008-02-27
ZA200707472B (en) 2008-11-26
MX2007010364A (es) 2007-09-25
WO2006092490A1 (fr) 2006-09-08
NO20074941L (no) 2007-10-01
KR20070110395A (ko) 2007-11-16
NZ560749A (en) 2010-11-26
AR053149A1 (es) 2007-04-25
FR2882654B1 (fr) 2007-04-27
AU2006219853A1 (en) 2006-09-08
BRPI0607562A2 (pt) 2009-09-15
US20080176934A1 (en) 2008-07-24
CA2599658A1 (fr) 2006-09-08

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU