CL2004001409A1 - Compuestos derivados de heterociclos biciclicos, sus sales; composicion farmaceutica; procedimientos de preparacion; y su uso para preparar un medicamento para tratar tumores, enfermedades de las vias respiratorias y del pulmon, del tracto gastrointe - Google Patents
Compuestos derivados de heterociclos biciclicos, sus sales; composicion farmaceutica; procedimientos de preparacion; y su uso para preparar un medicamento para tratar tumores, enfermedades de las vias respiratorias y del pulmon, del tracto gastrointeInfo
- Publication number
- CL2004001409A1 CL2004001409A1 CL200401409A CL2004001409A CL2004001409A1 CL 2004001409 A1 CL2004001409 A1 CL 2004001409A1 CL 200401409 A CL200401409 A CL 200401409A CL 2004001409 A CL2004001409 A CL 2004001409A CL 2004001409 A1 CL2004001409 A1 CL 2004001409A1
- Authority
- CL
- Chile
- Prior art keywords
- salts
- heterocicles
- lung
- diseases
- gastrointe
- Prior art date
Links
- 230000000241 respiratory effect Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000004072 lung Anatomy 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A HETEROCICLOS BICICLICOS DE LA FORMULA GENERAL EN LA CUAL R1,Rb,Rc,Rd,X,y N SE DEFINEN COMO EN LA REIVINDICACION 1. A SUS TAUTOMEROS, SUS ESTEREOISOMEROS, SUS MEZCLAS Y SUS SALES ESPECIALMENTE SUS SALES FISIOLOGICAMENTE TOLERABLES CON ACIDDO INORGANICOS U ORGANICOS, LOS CUALES PRESENTAN VALIOSAS PROPIEDADES FARMACOLOGICAS, ESPECIALMENTE UN EFECTO INHIBIDOR D ELA TRANSMISION DE SENALES QUE TIENEN LUGAR POR INTERMEDIO DE TIROSIQUINASAS, A SU UTILIZACION PARA EL TRATAMIENTO DE ENFERMEDADES, ESPECIALMENTE DE ENFERMEDADES TUMORALES, ASI COMO LA HIPERPLASIA BENIGNA DE PROSTATA (BPH) DE ENFERMEDADES DEL PULMON Y DE LAS VIAS RESPIRATORIAS Y A SU PREPARACION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10326186A DE10326186A1 (de) | 2003-06-06 | 2003-06-06 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004001409A1 true CL2004001409A1 (es) | 2005-05-06 |
Family
ID=33482765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200401409A CL2004001409A1 (es) | 2003-06-06 | 2004-06-04 | Compuestos derivados de heterociclos biciclicos, sus sales; composicion farmaceutica; procedimientos de preparacion; y su uso para preparar un medicamento para tratar tumores, enfermedades de las vias respiratorias y del pulmon, del tracto gastrointe |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7196091B2 (es) |
| EP (1) | EP1641767A2 (es) |
| JP (1) | JP2006527176A (es) |
| AR (1) | AR044604A1 (es) |
| CA (1) | CA2526995A1 (es) |
| CL (1) | CL2004001409A1 (es) |
| DE (1) | DE10326186A1 (es) |
| PE (1) | PE20050227A1 (es) |
| TW (1) | TW200510341A (es) |
| UY (1) | UY28347A1 (es) |
| WO (1) | WO2004108664A2 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE04748B1 (et) | 1999-06-21 | 2006-12-15 | Boehringer Ingelheim Pharma Kg | Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad ravimid, nende kasutamine ja meetodid nende valmistamiseks |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10204462A1 (de) * | 2002-02-05 | 2003-08-07 | Boehringer Ingelheim Pharma | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
| US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US7456189B2 (en) * | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
| US20050096332A1 (en) * | 2003-10-30 | 2005-05-05 | Boehringer Ingelheim International Gmbh | Use of tyrosine kinase inhibitors for the treatment of inflammatory processes |
| JP2009500306A (ja) * | 2005-07-04 | 2009-01-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キナゾリノン誘導体の合成方法 |
| JP5688877B2 (ja) | 2005-11-11 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌疾患の治療用キナゾリン誘導体 |
| US20090306105A1 (en) * | 2006-03-09 | 2009-12-10 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and process for preparing them |
| ES2385613T3 (es) | 2006-09-18 | 2012-07-27 | Boehringer Ingelheim International Gmbh | Método para tratar cánceres que portan mutaciones de EGFR |
| EP1921070A1 (de) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| BRPI0807234A2 (pt) * | 2007-02-06 | 2014-06-03 | Boehringer Ingelheim Int | Heterociclos bicíclicos, composições farmacêuticas que contêm estes compostos, o uso dos mesmos e processos para a preparação dos mesmos |
| KR20100111291A (ko) * | 2008-02-07 | 2010-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 스피로사이클릭 헤테로사이클, 상기 화합물을 함유하는 약제, 이의 용도 및 이의 제조 방법 |
| CA2733153C (en) * | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
| SI2451445T1 (sl) | 2009-07-06 | 2019-07-31 | Boehringer Ingelheim International Gmbh | Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| CN105399689B (zh) * | 2015-12-03 | 2017-03-01 | 中国人民解放军南京军区南京总医院 | 一种新型喹唑啉衍生物lu1503及其制备方法和应用 |
| CN105418517B (zh) * | 2015-12-03 | 2017-03-22 | 中国人民解放军南京军区南京总医院 | 一种新型喹唑啉衍生物lu1509及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| EP0824525B1 (en) * | 1995-04-27 | 2001-06-13 | AstraZeneca AB | Quinazoline derivatives |
| DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| BR0109828A (pt) * | 2000-04-07 | 2002-12-17 | Astrazeneca Ab | Composto, processo para a prepapação do mesmo ou de um sal deste, composição farmacêutica, uso do composto ou de um sal deste farmaceuticamente aceitável, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente em necessidade de tal tratamento |
| US6656946B2 (en) * | 2000-08-26 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
| DE10042058A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
-
2003
- 2003-06-06 DE DE10326186A patent/DE10326186A1/de not_active Withdrawn
-
2004
- 2004-06-02 WO PCT/EP2004/005965 patent/WO2004108664A2/de not_active Ceased
- 2004-06-02 CA CA002526995A patent/CA2526995A1/en not_active Abandoned
- 2004-06-02 JP JP2006508256A patent/JP2006527176A/ja active Pending
- 2004-06-02 EP EP04739543A patent/EP1641767A2/de not_active Withdrawn
- 2004-06-03 US US10/860,453 patent/US7196091B2/en not_active Expired - Lifetime
- 2004-06-04 UY UY28347A patent/UY28347A1/es not_active Application Discontinuation
- 2004-06-04 AR ARP040101931A patent/AR044604A1/es unknown
- 2004-06-04 PE PE2004000561A patent/PE20050227A1/es not_active Application Discontinuation
- 2004-06-04 TW TW093116265A patent/TW200510341A/zh unknown
- 2004-06-04 CL CL200401409A patent/CL2004001409A1/es unknown
-
2006
- 2006-07-28 US US11/494,926 patent/US20060264450A1/en not_active Abandoned
-
2010
- 2010-06-30 US US12/826,927 patent/US20100267718A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE10326186A1 (de) | 2004-12-23 |
| US20060264450A1 (en) | 2006-11-23 |
| EP1641767A2 (de) | 2006-04-05 |
| US7196091B2 (en) | 2007-03-27 |
| US20100267718A1 (en) | 2010-10-21 |
| US20050014772A1 (en) | 2005-01-20 |
| WO2004108664A2 (de) | 2004-12-16 |
| WO2004108664A3 (de) | 2005-05-26 |
| PE20050227A1 (es) | 2005-05-18 |
| CA2526995A1 (en) | 2004-12-16 |
| JP2006527176A (ja) | 2006-11-30 |
| AR044604A1 (es) | 2005-09-21 |
| TW200510341A (en) | 2005-03-16 |
| UY28347A1 (es) | 2005-01-31 |
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