GT200800256A - Derivados de pirazolo [3,4-d]-pirimidina útiles para tratar trastornos respiratorios - Google Patents
Derivados de pirazolo [3,4-d]-pirimidina útiles para tratar trastornos respiratoriosInfo
- Publication number
- GT200800256A GT200800256A GT200800256A GT200800256A GT200800256A GT 200800256 A GT200800256 A GT 200800256A GT 200800256 A GT200800256 A GT 200800256A GT 200800256 A GT200800256 A GT 200800256A GT 200800256 A GT200800256 A GT 200800256A
- Authority
- GT
- Guatemala
- Prior art keywords
- pirazolo
- pirimidine
- derivatives
- useful
- respiratory disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A UN COMPUESTO DE LA FÓRMULA I O UNA SAL FARMACÉUTICA ACEPATABLE O UN SOLVATO DEL MISMO DONDE R1-R3 SE DEFINEN EN LA DESCRIPCIÓN, A COMPOSICIONES Y AL USO DE LOS COMPUESTOS EN EL TRATAMIENTO DE ENFERMEDADES QUE SE ALIVIAN MEDIANTE LA INHIBICIÓN DE LA 3-CINASA DE FOSFATIDIL-INOSITOL. T2008
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0610242.0A GB0610242D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200800256A true GT200800256A (es) | 2009-05-28 |
Family
ID=36687588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200800256A GT200800256A (es) | 2006-05-23 | 2008-11-21 | Derivados de pirazolo [3,4-d]-pirimidina útiles para tratar trastornos respiratorios |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20090131457A1 (es) |
| EP (1) | EP2026811A1 (es) |
| JP (1) | JP2009537580A (es) |
| KR (1) | KR101106853B1 (es) |
| CN (1) | CN101443013A (es) |
| AR (2) | AR061057A1 (es) |
| AU (1) | AU2007253615B2 (es) |
| BR (1) | BRPI0712022A2 (es) |
| CA (1) | CA2650661A1 (es) |
| CL (1) | CL2007001455A1 (es) |
| CR (1) | CR10419A (es) |
| EC (1) | ECSP088902A (es) |
| GB (1) | GB0610242D0 (es) |
| GT (1) | GT200800256A (es) |
| IL (1) | IL195017A0 (es) |
| MA (1) | MA30433B1 (es) |
| MX (1) | MX2008014835A (es) |
| NO (1) | NO20084997L (es) |
| PE (1) | PE20080315A1 (es) |
| RU (1) | RU2008150619A (es) |
| TN (1) | TNSN08478A1 (es) |
| TW (1) | TW200806665A (es) |
| WO (1) | WO2007134828A1 (es) |
| ZA (1) | ZA200809097B (es) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
| CA2909277A1 (en) | 2006-04-04 | 2007-10-11 | Kevan M. Shokat | Kinase antagonists |
| CA2694275A1 (en) * | 2007-07-26 | 2009-01-29 | Novartis Ag | Organic compounds |
| JP5561702B2 (ja) | 2007-08-02 | 2014-07-30 | アムジエン・インコーポレーテツド | Pi3キナーゼ調節剤および使用方法 |
| WO2009046448A1 (en) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
| US7820665B2 (en) | 2007-12-19 | 2010-10-26 | Amgen Inc. | Imidazopyridazine inhibitors of PI3 kinase for cancer treatment |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| DK2240451T3 (da) | 2008-01-04 | 2017-11-20 | Intellikine Llc | Isoquinolinonderivater substitueret med en purin, der er anvendelig som pi3k-inhibitorer |
| WO2009114874A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Benzothiazole kinase inhibitors and methods of use |
| EP2252293B1 (en) | 2008-03-14 | 2018-06-27 | Intellikine, LLC | Kinase inhibitors and methods of use |
| EP2111861A1 (en) * | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
| MX315904B (es) | 2008-05-30 | 2013-11-29 | Amgen Inc | Inhibidores de fosfoinosituro-3 cinasa. |
| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
| US9096611B2 (en) * | 2008-07-08 | 2015-08-04 | Intellikine Llc | Kinase inhibitors and methods of use |
| US8220787B2 (en) * | 2008-09-19 | 2012-07-17 | Panasonic Corporation | Part mounting device |
| WO2010036380A1 (en) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
| US8697709B2 (en) | 2008-10-16 | 2014-04-15 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
| US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| US8343961B2 (en) | 2009-03-31 | 2013-01-01 | Arqule, Inc. | Substituted heterocyclic compounds |
| EP2427195B1 (en) | 2009-05-07 | 2019-05-01 | Intellikine, LLC | Heterocyclic compounds and uses thereof |
| EP2488511A1 (en) * | 2009-10-02 | 2012-08-22 | Vertex Pharmaceuticals Incorporated | Pyrazole inhibitors of phosphatidylinositol 3-kinase |
| WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
| GB201004311D0 (en) | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| WO2011146313A1 (en) | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| EP2571357B1 (en) | 2010-05-21 | 2016-07-06 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| DK2663309T3 (en) | 2011-01-10 | 2017-06-19 | Infinity Pharmaceuticals Inc | METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES |
| US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
| EP2678018A4 (en) | 2011-02-23 | 2015-09-30 | Intellikine Llc | COMBINATION OF CHINESE HEMMER AND USES THEREOF |
| KR20140063605A (ko) | 2011-07-19 | 2014-05-27 | 인피니티 파마슈티칼스, 인코포레이티드 | 헤테로사이클릭 화합물 및 그의 용도 |
| US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| AR091790A1 (es) | 2011-08-29 | 2015-03-04 | Infinity Pharmaceuticals Inc | Derivados de isoquinolin-1-ona y sus usos |
| MX370814B (es) | 2011-09-02 | 2020-01-08 | Univ California | Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas. |
| BR112014005793A2 (pt) | 2011-09-14 | 2017-03-28 | Proximagen Ltd | compostos inibidores de enzimas |
| GB201115853D0 (en) | 2011-09-14 | 2011-10-26 | Proximagen Ltd | New enzyme inhibitor compounds |
| CN103958510B (zh) | 2011-10-03 | 2016-10-19 | 北卡罗来纳大学教堂山分校 | 用于治疗癌症的吡咯并嘧啶化合物 |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN104302627A (zh) | 2012-05-22 | 2015-01-21 | 北卡罗来纳大学教堂山分校 | 用于治疗癌症的嘧啶化合物 |
| JP6301316B2 (ja) | 2012-05-23 | 2018-03-28 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 内胚葉細胞および肝実質細胞の組成物ならびにそれらの細胞を入手および使用する方法 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| AU2013323426A1 (en) | 2012-09-26 | 2015-04-23 | The Regents Of The University Of California | Modulation of ire1 |
| WO2014062774A1 (en) | 2012-10-17 | 2014-04-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| KR102229478B1 (ko) | 2012-11-01 | 2021-03-18 | 인피니티 파마슈티칼스, 인코포레이티드 | Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료 |
| US9771330B2 (en) | 2012-11-27 | 2017-09-26 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| CA2907726A1 (en) | 2013-03-22 | 2014-09-25 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinase |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PL3052485T3 (pl) | 2013-10-04 | 2022-02-28 | Infinity Pharmaceuticals, Inc. | Związki heterocykliczne i ich zastosowania |
| CA2943075C (en) | 2014-03-19 | 2023-02-28 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| US20150291606A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrrolopyrimidine compounds |
| US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CZ308056B6 (cs) * | 2015-07-20 | 2019-11-27 | Ustav Experimentalni Botaniky Av Cr V V I | 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky |
| NZ740616A (en) | 2015-09-14 | 2023-05-26 | Infinity Pharmaceuticals Inc | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017178845A1 (en) | 2016-04-15 | 2017-10-19 | Cancer Research Technology Limited | Heterocyclic compounds as ret kinase inhibitors |
| CN115650985B (zh) | 2016-04-15 | 2024-08-02 | 癌症研究科技有限公司 | 作为ret激酶抑制剂的杂环化合物 |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| IL263680B2 (en) | 2016-06-24 | 2025-10-01 | Infinity Pharmaceuticals Inc | PI3K inhibitors for use in combination with a second therapeutic agent for the treatment, management or prevention of cancer |
| JOP20180009A1 (ar) | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
| GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| JP2023508978A (ja) * | 2019-12-23 | 2023-03-06 | サンフォード バーナム プレビス メディカル ディスカバリー インスティテュート | エクトヌクレオチドピロホスファターゼ/ホスホジエステラーゼ1(enpp1)モジュレーター及びその使用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR205429A1 (es) * | 1971-04-27 | 1976-05-07 | Ciba Geigy Ag | Procedimiento para la elaboracion de nuevos derivados de 4-amino - 3-(5-nitro- 2 -furil)-1-metil - 1h - pirazol-(3,4-ol)-pirimidina |
| AR204665A1 (es) * | 1974-05-13 | 1976-02-20 | Lilly Co Eli | Procedimiento para preparar compuestos de 3-(5-nitroimidazol-2-il)pirazolo(3,4d)pirimidina |
| US4044130A (en) * | 1974-07-03 | 1977-08-23 | Ciba-Geigy Corporation | Compositions for the control of microorganisms |
| JPS5195094A (en) * | 1975-01-31 | 1976-08-20 | * ***** ****so*shi***** *o*u****** ********ne***u**** *** *** ****ne*** *************te***ku** | |
| DE60016402T2 (de) * | 1999-06-08 | 2005-10-27 | Lorantis Ltd. | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
| BR0014073A (pt) * | 1999-09-17 | 2002-07-16 | Abbott Gmbh & Co Kg | Pirazolopirimidinas como agentes terapêuticos |
| US6518277B1 (en) * | 2000-04-25 | 2003-02-11 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| AU2002341920A1 (en) * | 2001-10-02 | 2003-04-14 | Smithkline Beecham Corporation | Chemical compounds |
| AU2003225933A1 (en) | 2002-03-22 | 2003-10-13 | Cellular Genomics, Inc. | AN IMPROVED FORMULATION OF CERTAIN PYRAZOLO(3,4-d) PYRIMIDINES AS KINASE MODULATORS |
| US7429596B2 (en) * | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
| JP2007520559A (ja) * | 2004-02-03 | 2007-07-26 | アボット・ラボラトリーズ | 治療薬としてのアミノベンゾオキサゾール類 |
| WO2006068760A2 (en) * | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
| BRPI0709699A2 (pt) * | 2006-03-29 | 2011-07-26 | Foldrx Pharmaceuticals Inc | inibiÇço da toxidez da alfa-sinucleina |
-
2006
- 2006-05-23 GB GBGB0610242.0A patent/GB0610242D0/en active Pending
-
2007
- 2007-05-21 JP JP2009511393A patent/JP2009537580A/ja active Pending
- 2007-05-21 RU RU2008150619/04A patent/RU2008150619A/ru not_active Application Discontinuation
- 2007-05-21 CA CA002650661A patent/CA2650661A1/en not_active Abandoned
- 2007-05-21 MX MX2008014835A patent/MX2008014835A/es not_active Application Discontinuation
- 2007-05-21 CN CNA2007800173225A patent/CN101443013A/zh active Pending
- 2007-05-21 KR KR1020087028535A patent/KR101106853B1/ko active Active
- 2007-05-21 PE PE2007000620A patent/PE20080315A1/es not_active Application Discontinuation
- 2007-05-21 AR ARP070102192A patent/AR061057A1/es not_active Application Discontinuation
- 2007-05-21 WO PCT/EP2007/004501 patent/WO2007134828A1/en not_active Ceased
- 2007-05-21 EP EP07725407A patent/EP2026811A1/en not_active Withdrawn
- 2007-05-21 US US12/227,314 patent/US20090131457A1/en not_active Abandoned
- 2007-05-21 BR BRPI0712022-2A patent/BRPI0712022A2/pt not_active Application Discontinuation
- 2007-05-21 AU AU2007253615A patent/AU2007253615B2/en not_active Ceased
- 2007-05-22 TW TW096118225A patent/TW200806665A/zh unknown
- 2007-05-22 CL CL200701455A patent/CL2007001455A1/es unknown
-
2008
- 2008-10-23 ZA ZA200809097A patent/ZA200809097B/xx unknown
- 2008-10-30 CR CR10419A patent/CR10419A/es not_active Application Discontinuation
- 2008-10-30 IL IL195017A patent/IL195017A0/en unknown
- 2008-11-21 EC EC2008008902A patent/ECSP088902A/es unknown
- 2008-11-21 GT GT200800256A patent/GT200800256A/es unknown
- 2008-11-21 TN TNP2008000478A patent/TNSN08478A1/en unknown
- 2008-11-26 MA MA31421A patent/MA30433B1/fr unknown
- 2008-11-28 NO NO20084997A patent/NO20084997L/no not_active Application Discontinuation
-
2013
- 2013-10-09 US US14/049,706 patent/US20140051698A1/en not_active Abandoned
-
2014
- 2014-04-25 US US14/261,890 patent/US8901134B2/en active Active
-
2016
- 2016-06-27 US US15/194,373 patent/US20160303132A1/en not_active Abandoned
-
2017
- 2017-11-10 AR ARP170103136A patent/AR110051A2/es unknown
-
2018
- 2018-01-10 US US15/867,425 patent/US20180125849A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2650661A1 (en) | 2007-11-29 |
| AR110051A2 (es) | 2019-02-20 |
| US20090131457A1 (en) | 2009-05-21 |
| AU2007253615A1 (en) | 2007-11-29 |
| ZA200809097B (en) | 2009-11-25 |
| TNSN08478A1 (en) | 2010-04-14 |
| JP2009537580A (ja) | 2009-10-29 |
| RU2008150619A (ru) | 2010-06-27 |
| US20180125849A1 (en) | 2018-05-10 |
| KR20090008392A (ko) | 2009-01-21 |
| WO2007134828A1 (en) | 2007-11-29 |
| US20160303132A1 (en) | 2016-10-20 |
| AR061057A1 (es) | 2008-07-30 |
| CN101443013A (zh) | 2009-05-27 |
| EP2026811A1 (en) | 2009-02-25 |
| ECSP088902A (es) | 2008-12-30 |
| CL2007001455A1 (es) | 2008-05-16 |
| NO20084997L (no) | 2008-12-22 |
| MX2008014835A (es) | 2008-12-01 |
| CR10419A (es) | 2011-07-19 |
| MA30433B1 (fr) | 2009-05-04 |
| IL195017A0 (en) | 2009-08-03 |
| TW200806665A (en) | 2008-02-01 |
| US20140051698A1 (en) | 2014-02-20 |
| GB0610242D0 (en) | 2006-07-05 |
| US8901134B2 (en) | 2014-12-02 |
| PE20080315A1 (es) | 2008-06-11 |
| BRPI0712022A2 (pt) | 2011-12-27 |
| KR101106853B1 (ko) | 2012-01-19 |
| US20140235632A1 (en) | 2014-08-21 |
| AU2007253615B2 (en) | 2011-06-23 |
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