CH676506A5 - - Google Patents
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- Publication number
- CH676506A5 CH676506A5 CH35488A CH35488A CH676506A5 CH 676506 A5 CH676506 A5 CH 676506A5 CH 35488 A CH35488 A CH 35488A CH 35488 A CH35488 A CH 35488A CH 676506 A5 CH676506 A5 CH 676506A5
- Authority
- CH
- Switzerland
- Prior art keywords
- skin
- substances
- test
- scanning electron
- products
- Prior art date
Links
- 239000000126 substance Substances 0.000 claims description 28
- 238000012360 testing method Methods 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 15
- 230000007682 dermal toxicity Effects 0.000 claims description 8
- 231100000438 skin toxicity Toxicity 0.000 claims description 8
- 239000013543 active substance Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 239000003905 agrochemical Substances 0.000 claims description 3
- 238000002316 cosmetic surgery Methods 0.000 claims description 3
- 239000000645 desinfectant Substances 0.000 claims description 3
- 239000000975 dye Substances 0.000 claims description 3
- 239000003845 household chemical Substances 0.000 claims description 3
- 230000036541 health Effects 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 description 8
- 230000006378 damage Effects 0.000 description 7
- 230000000622 irritating effect Effects 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 241000282412 Homo Species 0.000 description 4
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000004627 transmission electron microscopy Methods 0.000 description 3
- 206010057248 Cell death Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000004626 scanning electron microscopy Methods 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 description 1
- LWWJZSNCITZYEB-UHFFFAOYSA-N 1,1,1-trichloro-4-methylpent-4-en-2-ol Chemical compound CC(=C)CC(O)C(Cl)(Cl)Cl LWWJZSNCITZYEB-UHFFFAOYSA-N 0.000 description 1
- ANHAEBWRQNIPEV-UHFFFAOYSA-N 2-chloroethyl dihydrogen phosphate Chemical compound OP(O)(=O)OCCCl ANHAEBWRQNIPEV-UHFFFAOYSA-N 0.000 description 1
- UIKQNMXWCYQNCS-UHFFFAOYSA-N 2-hydroxybutanal Chemical compound CCC(O)C=O UIKQNMXWCYQNCS-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 231100000635 Draize test Toxicity 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- COQLPRJCUIATTQ-UHFFFAOYSA-N Uranyl acetate Chemical class O.O.O=[U]=O.CC(O)=O.CC(O)=O COQLPRJCUIATTQ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 238000011206 morphological examination Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- JTFHKOYORZAXSV-UHFFFAOYSA-K trisodium phosphonoformate hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[Na+].OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O JTFHKOYORZAXSV-UHFFFAOYSA-K 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000002567 weak irritant Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD29843886A DD256760B5 (de) | 1986-12-24 | 1986-12-24 | Verfahren zur Pruefung der dermalen Toxizitaet von Substanzen oder Substanzgemischen und zur Selektion hautvertraeglicher Wirkstoffe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH676506A5 true CH676506A5 (fr) | 1991-01-31 |
Family
ID=5585657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH35488A CH676506A5 (fr) | 1986-12-24 | 1988-02-02 |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE1001434A6 (fr) |
| CH (1) | CH676506A5 (fr) |
| DD (1) | DD256760B5 (fr) |
| DE (1) | DE3802780A1 (fr) |
| GB (1) | GB2215043B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19606207A1 (de) | 1996-02-21 | 1997-08-28 | Univ Duesseldorf H Heine | Verfahren zur Bestimmung der Phototoxizität und/oder Photosensibilität von Stoffen oder Stoffgemischen sowie dessen Verwendung |
| RU2164684C2 (ru) * | 1998-01-27 | 2001-03-27 | Кировский государственный медицинский институт | Способ определения величины острой токсичности химических веществ по данным энергии связи в молекуле |
-
1986
- 1986-12-24 DD DD29843886A patent/DD256760B5/de not_active IP Right Cessation
-
1988
- 1988-01-30 DE DE19883802780 patent/DE3802780A1/de not_active Withdrawn
- 1988-02-02 CH CH35488A patent/CH676506A5/de not_active IP Right Cessation
- 1988-02-09 GB GB8802864A patent/GB2215043B/en not_active Expired - Fee Related
- 1988-02-15 BE BE8800183A patent/BE1001434A6/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE1001434A6 (fr) | 1989-10-31 |
| GB2215043B (en) | 1991-11-13 |
| GB2215043A (en) | 1989-09-13 |
| DD256760B5 (de) | 1995-11-30 |
| DD256760A1 (de) | 1988-05-18 |
| GB8802864D0 (en) | 1988-03-09 |
| DE3802780A1 (de) | 1989-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |