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CA3003652A1 - Compositions and methods for chimeric embryo-assisted organ production - Google Patents

Compositions and methods for chimeric embryo-assisted organ production Download PDF

Info

Publication number
CA3003652A1
CA3003652A1 CA3003652A CA3003652A CA3003652A1 CA 3003652 A1 CA3003652 A1 CA 3003652A1 CA 3003652 A CA3003652 A CA 3003652A CA 3003652 A CA3003652 A CA 3003652A CA 3003652 A1 CA3003652 A1 CA 3003652A1
Authority
CA
Canada
Prior art keywords
human
embryo
endogenous genes
cells
organ
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3003652A
Other languages
English (en)
French (fr)
Inventor
Atsushi Asakura
Raj ARAVALLI
Maxin CHEERAN
James Dutton
Daniel J. GARRY
Mary G. GARRY
Melanie Graham
Ling Li
Walter Low
Angela Panoskaltsis-Mortari
Timothy O'brien
Clifford Steer
Jakup TOLAR
Daniel F. Carlson
Scott C. Fahrenkrug
Naoko KOYANO-NAKAGAWA
Ann PARR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recombinetics Inc
University of Minnesota System
Original Assignee
Recombinetics Inc
University of Minnesota System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recombinetics Inc, University of Minnesota System filed Critical Recombinetics Inc
Publication of CA3003652A1 publication Critical patent/CA3003652A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
CA3003652A 2015-10-27 2016-10-27 Compositions and methods for chimeric embryo-assisted organ production Abandoned CA3003652A1 (en)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201562246926P 2015-10-27 2015-10-27
US201562246927P 2015-10-27 2015-10-27
US201562247117P 2015-10-27 2015-10-27
US201562247115P 2015-10-27 2015-10-27
US201562247122P 2015-10-27 2015-10-27
US201562247096P 2015-10-27 2015-10-27
US201562247118P 2015-10-27 2015-10-27
US201562246929P 2015-10-27 2015-10-27
US201562246947P 2015-10-27 2015-10-27
US201562247092P 2015-10-27 2015-10-27
US62/247,096 2015-10-27
US62/246,926 2015-10-27
US62/247,092 2015-10-27
US62/246,929 2015-10-27
US62/247,122 2015-10-27
US62/247,115 2015-10-27
US62/246,927 2015-10-27
US62/247,117 2015-10-27
US62/246,947 2015-10-27
US62/247,118 2015-10-27
PCT/US2016/059206 WO2017075276A2 (en) 2015-10-27 2016-10-27 Compositions and methods for chimeric embryo-assisted organ production

Publications (1)

Publication Number Publication Date
CA3003652A1 true CA3003652A1 (en) 2017-05-04

Family

ID=58631806

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3003652A Abandoned CA3003652A1 (en) 2015-10-27 2016-10-27 Compositions and methods for chimeric embryo-assisted organ production

Country Status (7)

Country Link
EP (1) EP3367785A4 (de)
JP (1) JP2019502400A (de)
KR (1) KR20180100303A (de)
CN (1) CN108697067A (de)
AU (1) AU2016344152A1 (de)
CA (1) CA3003652A1 (de)
WO (1) WO2017075276A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102684690B1 (ko) 2015-03-03 2024-07-15 리젠츠 오브 더 유니버시티 오브 미네소타 Etv2 및 그의 용도
AU2016288196A1 (en) 2015-06-30 2018-02-01 Regents Of The University Of Minnesota Humanized skeletal muscle
CN108472318A (zh) 2015-06-30 2018-08-31 明尼苏达大学校董会 人源化心脏肌肉
AU2017285206A1 (en) * 2016-06-14 2018-12-20 Riddle Institute for Regenerative Medicine Organ regeneration method using somatic cell nuclear transfer (SCNT) cell and blastocyst complementation
US20190045761A1 (en) 2017-08-11 2019-02-14 Recombinetics, Inc. Inducible disease models methods of making them and use in tissue complementation
CN109258575B (zh) * 2018-12-10 2021-07-06 广东工业大学 一种蛙类动物胚胎的孵育方法
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
EP3966316A4 (de) 2019-05-10 2023-01-25 The Regents of The University of California Modifizierte pluripotente zellen
US11859213B2 (en) 2019-05-16 2024-01-02 Regents Of The University Of Minnesota Development of superior chimerism by hiPSC engineering and embryo aggregation
AU2020307550A1 (en) 2019-06-26 2022-02-03 The Regents Of The University Of California SIRPalpha-silenced natural killer (NK) cells
US11576889B2 (en) 2019-09-23 2023-02-14 The Board Of Regents Of The University Of Texas System Methods of identifying and treating patients with HIF-2 inhibitor resistance
CN116433652B (zh) * 2023-05-11 2024-02-23 中南大学 用于确定胚胎移植的妊娠结果的方法、处理器及装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008102602A1 (ja) * 2007-02-22 2008-08-28 The University Of Tokyo Ｂｌａｓｔｏｃｙｓｔ ｃｏｍｐｌｅｍｅｎｔａｔｉｏｎを利用した臓器再生法

Also Published As

Publication number Publication date
WO2017075276A2 (en) 2017-05-04
WO2017075276A3 (en) 2017-06-01
KR20180100303A (ko) 2018-09-10
EP3367785A4 (de) 2019-08-14
CN108697067A (zh) 2018-10-23
EP3367785A2 (de) 2018-09-05
JP2019502400A (ja) 2019-01-31
AU2016344152A1 (en) 2018-05-24

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20201028