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CA2686033A1 - Procede de preparation de la (r)-2-methylpyrrolidine, de la (s)-2-methylpyrrolidine et de leurs tartrates - Google Patents

Procede de preparation de la (r)-2-methylpyrrolidine, de la (s)-2-methylpyrrolidine et de leurs tartrates Download PDF

Info

Publication number
CA2686033A1
CA2686033A1 CA002686033A CA2686033A CA2686033A1 CA 2686033 A1 CA2686033 A1 CA 2686033A1 CA 002686033 A CA002686033 A CA 002686033A CA 2686033 A CA2686033 A CA 2686033A CA 2686033 A1 CA2686033 A1 CA 2686033A1
Authority
CA
Canada
Prior art keywords
methylpyrrolidine
methyl
tartrate
pyrrolidin
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002686033A
Other languages
English (en)
Inventor
Michael Christie
Joseph J. Petraitis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2686033A1 publication Critical patent/CA2686033A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
CA002686033A 2007-05-03 2008-05-02 Procede de preparation de la (r)-2-methylpyrrolidine, de la (s)-2-methylpyrrolidine et de leurs tartrates Abandoned CA2686033A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92735607P 2007-05-03 2007-05-03
US60/927,356 2007-05-03
PCT/US2008/005702 WO2008137087A1 (fr) 2007-05-03 2008-05-02 Procédé de préparation de la (r)-2-méthylpyrrolidine, de la (s)-2-methylpyrrolidine et de leurs tartrates

Publications (1)

Publication Number Publication Date
CA2686033A1 true CA2686033A1 (fr) 2008-11-13

Family

ID=39688886

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002686033A Abandoned CA2686033A1 (fr) 2007-05-03 2008-05-02 Procede de preparation de la (r)-2-methylpyrrolidine, de la (s)-2-methylpyrrolidine et de leurs tartrates

Country Status (14)

Country Link
EP (1) EP2152669A1 (fr)
JP (1) JP5698887B2 (fr)
KR (1) KR20100017565A (fr)
CN (1) CN101679237A (fr)
AU (1) AU2008248168B2 (fr)
BR (1) BRPI0810330A2 (fr)
CA (1) CA2686033A1 (fr)
EA (1) EA019031B1 (fr)
IL (1) IL201627A (fr)
MX (1) MX2009011787A (fr)
NZ (1) NZ580948A (fr)
UA (1) UA99913C2 (fr)
WO (1) WO2008137087A1 (fr)
ZA (1) ZA200907643B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0713836A2 (pt) 2006-07-25 2013-05-28 Cephalon Inc composto, composiÇço farmacÊutica e mÉtodo para tratar distérbio
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
EP2252593B1 (fr) * 2008-01-30 2014-04-23 Cephalon, Inc. Dérivés de pyridazine substitués à activité antagoniste des récepteurs h3 de l'histamine
US10259794B2 (en) * 2014-12-23 2019-04-16 Cephalon, Inc. Methods for preparing fused bicyclic 2, 4-diaminopyrimidine derivatives
CN112638870B (zh) * 2018-09-07 2025-04-25 赛诺菲 用于制备6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329974A1 (de) 1983-08-19 1985-02-28 Bayer Ag, 5090 Leverkusen Herstellung von hydrierten nitrilkautschuken
DE3433392A1 (de) 1984-09-12 1986-03-20 Bayer Ag, 5090 Leverkusen Hydrierung nitrilgruppenhaltiger ungesaettigter polymerer
FR2714849B1 (fr) 1994-01-13 1996-04-05 Inst Francais Du Petrole Procédé de préparation d'un catalyseur d'hydrogénation soluble en phase liquide organique.
DE4403479A1 (de) 1994-02-04 1995-08-10 Basf Ag Verfahren zur Herstellung von Hydroxylammoniumsalzen
WO2004024707A2 (fr) * 2002-09-16 2004-03-25 Abbott Laboratories Procede permettant de preparer des benzofuranes a substitution amine
US7153889B2 (en) 2002-11-12 2006-12-26 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
EP1739104B1 (fr) 2004-03-08 2014-07-09 Japan Science and Technology Agency Compositions d' agglomerats de metal supportes sur polymere
US7145005B2 (en) 2004-05-12 2006-12-05 Abbott Laboratories 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation
CA2566526C (fr) 2004-06-02 2012-10-23 F. Hoffmann-La Roche Ag Derives de la naphtaline utilises comme ligands du recepteur 3 de l'histamine
WO2006059778A1 (fr) 2004-12-01 2006-06-08 Banyu Pharmaceutical Co., Ltd. Dérivé substitué de pyridone
AU2005316337A1 (en) 2004-12-17 2006-06-22 Janssen Pharmaceutica, N.V. Tetrahydroisoquinoline compounds for treatment of CNS disorders
EP1848696A1 (fr) 2005-01-21 2007-10-31 Schering Corporation Derives d'imidazole et de benzimidazole utiles en tant qu'antagonistes de l'histamine h3
AU2006228690A1 (en) 2005-03-31 2006-10-05 Ucb Pharma S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
GB0514812D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
AU2006308167A1 (en) 2005-10-27 2007-05-03 Ucb Pharma, S.A. Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses
WO2007094962A2 (fr) 2006-02-09 2007-08-23 Athersys, Inc. Pyrazoles pour le traitement de l'obésité et d'autres troubles du snc
WO2007099423A1 (fr) 2006-03-02 2007-09-07 Pfizer Products Inc. Dérivés de 1-pyrrolidine indane en tant qu'antagonistes du récepteur d'histamine 3
WO2007105053A2 (fr) 2006-03-13 2007-09-20 Pfizer Products Inc. Tétralines en tant qu'antagonistes du récepteur h-3
EP2035372A1 (fr) 2006-06-29 2009-03-18 Arena Pharmaceuticals, Inc. Modulateurs du récepteur h3 de l'histamine utiles dans le traitement de troubles liés audit récepteur
BRPI0713836A2 (pt) * 2006-07-25 2013-05-28 Cephalon Inc composto, composiÇço farmacÊutica e mÉtodo para tratar distérbio

Also Published As

Publication number Publication date
CN101679237A (zh) 2010-03-24
WO2008137087A1 (fr) 2008-11-13
JP5698887B2 (ja) 2015-04-08
MX2009011787A (es) 2009-11-13
EA200971019A1 (ru) 2010-04-30
IL201627A (en) 2014-06-30
ZA200907643B (en) 2014-03-26
NZ580948A (en) 2011-04-29
AU2008248168B2 (en) 2013-03-21
JP2010526142A (ja) 2010-07-29
EP2152669A1 (fr) 2010-02-17
AU2008248168A1 (en) 2008-11-13
KR20100017565A (ko) 2010-02-16
BRPI0810330A2 (pt) 2014-10-14
EA019031B1 (ru) 2013-12-30
UA99913C2 (ru) 2012-10-25
IL201627A0 (en) 2010-05-31

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130319

FZDE Discontinued

Effective date: 20160504