CA2673313A1 - Phyllosilicates feuilletes interagissant avec un virus, et procedes d'utilisation - Google Patents

Phyllosilicates feuilletes interagissant avec un virus, et procedes d'utilisation Download PDF

Info

Publication number: CA2673313A1
Authority: CA; Canada
Prior art keywords: virus; agent; test; layered phyllosilicate; layered
Prior art date: 2006-12-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002673313A

Other languages

English (en)

Inventor

Jerald W. Darlington

John Hughes

Panayiotis P. Constantinides

Mingming Fang

Jason Harold St. Onge

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Amcol International Corp

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-18

Filing date

2007-12-18

Publication date

2008-12-04

2007-12-18 Application filed by Individual filed Critical Individual

2008-12-04 Publication of CA2673313A1 publication Critical patent/CA2673313A1/fr

Status Abandoned legal-status Critical Current

Links

229910052615 phyllosilicate Inorganic materials 0.000 title claims abstract description 244
238000000034 method Methods 0.000 title claims abstract description 95
241000700605 Viruses Species 0.000 claims abstract description 394
241001465754 Metazoa Species 0.000 claims abstract description 58
239000003814 drug Substances 0.000 claims abstract description 50
229940124597 therapeutic agent Drugs 0.000 claims abstract description 36
230000009385 viral infection Effects 0.000 claims abstract description 18
208000036142 Viral infection Diseases 0.000 claims abstract description 16
210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 8
239000000203 mixture Substances 0.000 claims description 237
239000000463 material Substances 0.000 claims description 174
-1 protonated hydrogen cations Chemical class 0.000 claims description 89
239000003443 antiviral agent Substances 0.000 claims description 52
238000011282 treatment Methods 0.000 claims description 50
150000001768 cations Chemical class 0.000 claims description 45
239000011229 interlayer Substances 0.000 claims description 34
239000000725 suspension Substances 0.000 claims description 25
239000003085 diluting agent Substances 0.000 claims description 22
241000709661 Enterovirus Species 0.000 claims description 19
239000002245 particle Substances 0.000 claims description 15
241000725303 Human immunodeficiency virus Species 0.000 claims description 14
239000000243 solution Substances 0.000 claims description 14
239000000843 powder Substances 0.000 claims description 13
238000009472 formulation Methods 0.000 claims description 12
239000012528 membrane Substances 0.000 claims description 12
241000283707 Capra Species 0.000 claims description 11
241000282326 Felis catus Species 0.000 claims description 11
230000000699 topical effect Effects 0.000 claims description 11
241000283973 Oryctolagus cuniculus Species 0.000 claims description 10
241001494479 Pecora Species 0.000 claims description 10
229920002125 Sokalan® Polymers 0.000 claims description 10
239000003242 anti bacterial agent Substances 0.000 claims description 10
239000003937 drug carrier Substances 0.000 claims description 9
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 claims description 9
241000702670 Rotavirus Species 0.000 claims description 8
238000010521 absorption reaction Methods 0.000 claims description 8
NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 8
VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims description 8
239000007921 spray Substances 0.000 claims description 8
230000001225 therapeutic effect Effects 0.000 claims description 8
235000002198 Annona diversifolia Nutrition 0.000 claims description 7
229920002301 cellulose acetate Polymers 0.000 claims description 7
239000006071 cream Substances 0.000 claims description 7
229940039227 diagnostic agent Drugs 0.000 claims description 7
239000000032 diagnostic agent Substances 0.000 claims description 7
239000006210 lotion Substances 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 7
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 7
241000699800 Cricetinae Species 0.000 claims description 6
XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 claims description 6
241000287828 Gallus gallus Species 0.000 claims description 6
241001416177 Vicugna pacos Species 0.000 claims description 6
239000000443 aerosol Substances 0.000 claims description 6
229960001447 fomivirsen Drugs 0.000 claims description 6
XCWFZHPEARLXJI-UHFFFAOYSA-N fomivirsen Chemical compound C1C(N2C3=C(C(NC(N)=N3)=O)N=C2)OC(CO)C1OP(O)(=S)OCC1OC(N(C)C(=O)\N=C(\N)C=C)CC1OP(O)(=S)OCC1OC(N2C3=C(C(NC(N)=N3)=O)N=C2)CC1OP(O)(=S)OCC1OC(N2C(NC(=O)C(C)=C2)=O)CC1OP(O)(=S)OCC1OC(N2C(NC(=O)C(C)=C2)=O)CC1OP(O)(=S)OCC1OC(N2C(NC(=O)C(C)=C2)=O)CC1OP(O)(=S)OCC1OC(N2C3=C(C(NC(N)=N3)=O)N=C2)CC1OP(O)(=S)OCC1OC(N2C(N=C(N)C=C2)=O)CC1OP(O)(=S)OCC(C(C1)OP(S)(=O)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)O)OC1N1C=C(C)C(=O)NC1=O XCWFZHPEARLXJI-UHFFFAOYSA-N 0.000 claims description 6
229960001627 lamivudine Drugs 0.000 claims description 6
JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims description 6
NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 claims description 6
239000002674 ointment Substances 0.000 claims description 6
229960003752 oseltamivir Drugs 0.000 claims description 6
ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 claims description 6
229960000471 pleconaril Drugs 0.000 claims description 6
KQOXLKOJHVFTRN-UHFFFAOYSA-N pleconaril Chemical compound O1N=C(C)C=C1CCCOC1=C(C)C=C(C=2N=C(ON=2)C(F)(F)F)C=C1C KQOXLKOJHVFTRN-UHFFFAOYSA-N 0.000 claims description 6
241001529453 unidentified herpesvirus Species 0.000 claims description 6
241000712461 unidentified influenza virus Species 0.000 claims description 6
230000029663 wound healing Effects 0.000 claims description 6
229960001028 zanamivir Drugs 0.000 claims description 6
ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims description 6
229960002555 zidovudine Drugs 0.000 claims description 6
241000700199 Cavia porcellus Species 0.000 claims description 5
241000283073 Equus caballus Species 0.000 claims description 5
241001263478 Norovirus Species 0.000 claims description 5
241000272525 Anas platyrhynchos Species 0.000 claims description 4
102000014150 Interferons Human genes 0.000 claims description 4
108010050904 Interferons Proteins 0.000 claims description 4
OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 claims description 4
229960004150 aciclovir Drugs 0.000 claims description 4
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 4
229940121375 antifungal agent Drugs 0.000 claims description 4
239000003429 antifungal agent Substances 0.000 claims description 4
229920001525 carrageenan Polymers 0.000 claims description 4
235000010418 carrageenan Nutrition 0.000 claims description 4
239000000679 carrageenan Substances 0.000 claims description 4
229940113118 carrageenan Drugs 0.000 claims description 4
229960000735 docosanol Drugs 0.000 claims description 4
201000004946 genital herpes Diseases 0.000 claims description 4
229940047124 interferons Drugs 0.000 claims description 4
230000001737 promoting effect Effects 0.000 claims description 4
229960003636 vidarabine Drugs 0.000 claims description 4
CNPVJJQCETWNEU-CYFREDJKSA-N (4,6-dimethyl-5-pyrimidinyl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methyl-1-piperidinyl]methanone Chemical compound N([C@@H](COC)C=1C=CC(=CC=1)C(F)(F)F)([C@H](C1)C)CCN1C(CC1)(C)CCN1C(=O)C1=C(C)N=CN=C1C CNPVJJQCETWNEU-CYFREDJKSA-N 0.000 claims description 3
UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims description 3
YLDCUKJMEKGGFI-QCSRICIXSA-N 4-acetamidobenzoic acid;9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;1-(dimethylamino)propan-2-ol Chemical compound CC(O)CN(C)C.CC(O)CN(C)C.CC(O)CN(C)C.CC(=O)NC1=CC=C(C(O)=O)C=C1.CC(=O)NC1=CC=C(C(O)=O)C=C1.CC(=O)NC1=CC=C(C(O)=O)C=C1.O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(NC=NC2=O)=C2N=C1 YLDCUKJMEKGGFI-QCSRICIXSA-N 0.000 claims description 3
AXRYRYVKAWYZBR-UHFFFAOYSA-N Atazanavir Natural products C=1C=C(C=2N=CC=CC=2)C=CC=1CN(NC(=O)C(NC(=O)OC)C(C)(C)C)CC(O)C(NC(=O)C(NC(=O)OC)C(C)(C)C)CC1=CC=CC=C1 AXRYRYVKAWYZBR-UHFFFAOYSA-N 0.000 claims description 3
108010019625 Atazanavir Sulfate Proteins 0.000 claims description 3
QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 claims description 3
VWFCHDSQECPREK-LURJTMIESA-N Cidofovir Chemical compound NC=1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1 VWFCHDSQECPREK-LURJTMIESA-N 0.000 claims description 3
XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 claims description 3
108010032976 Enfuvirtide Proteins 0.000 claims description 3
229940124897 Gardasil Drugs 0.000 claims description 3
208000001688 Herpes Genitalis Diseases 0.000 claims description 3
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 3
229930010555 Inosine Natural products 0.000 claims description 3
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 3
KJHKTHWMRKYKJE-SUGCFTRWSA-N Kaletra Chemical compound N1([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=2C=CC=CC=2)NC(=O)COC=2C(=CC=CC=2C)C)CC=2C=CC=CC=2)CCCNC1=O KJHKTHWMRKYKJE-SUGCFTRWSA-N 0.000 claims description 3
KJHOZAZQWVKILO-UHFFFAOYSA-N N-(diaminomethylidene)-4-morpholinecarboximidamide Chemical compound NC(N)=NC(=N)N1CCOCC1 KJHOZAZQWVKILO-UHFFFAOYSA-N 0.000 claims description 3
206010067152 Oral herpes Diseases 0.000 claims description 3
JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims description 3
IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 3
NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims description 3
XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 claims description 3
SUJUHGSWHZTSEU-UHFFFAOYSA-N Tipranavir Natural products C1C(O)=C(C(CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)C(=O)OC1(CCC)CCC1=CC=CC=C1 SUJUHGSWHZTSEU-UHFFFAOYSA-N 0.000 claims description 3
HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 claims description 3
WPVFJKSGQUFQAP-GKAPJAKFSA-N Valcyte Chemical compound N1C(N)=NC(=O)C2=C1N(COC(CO)COC(=O)[C@@H](N)C(C)C)C=N2 WPVFJKSGQUFQAP-GKAPJAKFSA-N 0.000 claims description 3
WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 claims description 3
GLWHPRRGGYLLRV-XLPZGREQSA-N [[(2s,3s,5r)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](N=[N+]=[N-])C1 GLWHPRRGGYLLRV-XLPZGREQSA-N 0.000 claims description 3
229960004748 abacavir Drugs 0.000 claims description 3
MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 claims description 3
229960001997 adefovir Drugs 0.000 claims description 3
WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 claims description 3
239000000853 adhesive Substances 0.000 claims description 3
230000001070 adhesive effect Effects 0.000 claims description 3
229960003805 amantadine Drugs 0.000 claims description 3
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims description 3
229960001830 amprenavir Drugs 0.000 claims description 3
YMARZQAQMVYCKC-OEMFJLHTSA-N amprenavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 YMARZQAQMVYCKC-OEMFJLHTSA-N 0.000 claims description 3
229960003277 atazanavir Drugs 0.000 claims description 3
AXRYRYVKAWYZBR-GASGPIRDSA-N atazanavir Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)[C@@H](O)CN(CC=1C=CC(=CC=1)C=1N=CC=CC=1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C1=CC=CC=C1 AXRYRYVKAWYZBR-GASGPIRDSA-N 0.000 claims description 3
229940068561 atripla Drugs 0.000 claims description 3
229960001169 brivudine Drugs 0.000 claims description 3
229960000724 cidofovir Drugs 0.000 claims description 3
238000002648 combination therapy Methods 0.000 claims description 3
229940014461 combivir Drugs 0.000 claims description 3
229960002030 edoxudine Drugs 0.000 claims description 3
XACKNLSZYYIACO-DJLDLDEBSA-N edoxudine Chemical compound O=C1NC(=O)C(CC)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XACKNLSZYYIACO-DJLDLDEBSA-N 0.000 claims description 3
229960003804 efavirenz Drugs 0.000 claims description 3
XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 claims description 3
229960000366 emtricitabine Drugs 0.000 claims description 3
229960002062 enfuvirtide Drugs 0.000 claims description 3
PEASPLKKXBYDKL-FXEVSJAOSA-N enfuvirtide Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(C)=O)[C@@H](C)O)[C@@H](C)CC)C1=CN=CN1 PEASPLKKXBYDKL-FXEVSJAOSA-N 0.000 claims description 3
229960000980 entecavir Drugs 0.000 claims description 3
YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical compound O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 claims description 3
YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 claims description 3
229960004396 famciclovir Drugs 0.000 claims description 3
GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 claims description 3
229960003142 fosamprenavir Drugs 0.000 claims description 3
MLBVMOWEQCZNCC-OEMFJLHTSA-N fosamprenavir Chemical compound C([C@@H]([C@H](OP(O)(O)=O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 MLBVMOWEQCZNCC-OEMFJLHTSA-N 0.000 claims description 3
229960005102 foscarnet Drugs 0.000 claims description 3
229940112424 fosfonet Drugs 0.000 claims description 3
229960002963 ganciclovir Drugs 0.000 claims description 3
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims description 3
ODZBBRURCPAEIQ-PIXDULNESA-N helpin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(\C=C\Br)=C1 ODZBBRURCPAEIQ-PIXDULNESA-N 0.000 claims description 3
229960000374 ibacitabine Drugs 0.000 claims description 3
WEVJJMPVVFNAHZ-RRKCRQDMSA-N ibacitabine Chemical compound C1=C(I)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 WEVJJMPVVFNAHZ-RRKCRQDMSA-N 0.000 claims description 3
229960004716 idoxuridine Drugs 0.000 claims description 3
229960002751 imiquimod Drugs 0.000 claims description 3
DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims description 3
229960001936 indinavir Drugs 0.000 claims description 3
CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 claims description 3
229960003786 inosine Drugs 0.000 claims description 3
229940124524 integrase inhibitor Drugs 0.000 claims description 3
239000002850 integrase inhibitor Substances 0.000 claims description 3
229960004525 lopinavir Drugs 0.000 claims description 3
229950006243 loviride Drugs 0.000 claims description 3
CJPLEFFCVDQQFZ-UHFFFAOYSA-N loviride Chemical compound CC(=O)C1=CC=C(C)C=C1NC(C(N)=O)C1=C(Cl)C=CC=C1Cl CJPLEFFCVDQQFZ-UHFFFAOYSA-N 0.000 claims description 3
229960004710 maraviroc Drugs 0.000 claims description 3
GSNHKUDZZFZSJB-QYOOZWMWSA-N maraviroc Chemical compound CC(C)C1=NN=C(C)N1[C@@H]1C[C@H](N2CC[C@H](NC(=O)C3CCC(F)(F)CC3)C=3C=CC=CC=3)CC[C@H]2C1 GSNHKUDZZFZSJB-QYOOZWMWSA-N 0.000 claims description 3
229960005389 moroxydine Drugs 0.000 claims description 3
229960000884 nelfinavir Drugs 0.000 claims description 3
QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 claims description 3
229960000689 nevirapine Drugs 0.000 claims description 3
229940101771 nexavir Drugs 0.000 claims description 3
229940127073 nucleoside analogue Drugs 0.000 claims description 3
229960001179 penciclovir Drugs 0.000 claims description 3
229960001084 peramivir Drugs 0.000 claims description 3
XRQDFNLINLXZLB-CKIKVBCHSA-N peramivir Chemical compound CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@@H](C(O)=O)C[C@H]1NC(N)=N XRQDFNLINLXZLB-CKIKVBCHSA-N 0.000 claims description 3
XUYJLQHKOGNDPB-UHFFFAOYSA-N phosphonoacetic acid Chemical compound OC(=O)CP(O)(O)=O XUYJLQHKOGNDPB-UHFFFAOYSA-N 0.000 claims description 3
229960001237 podophyllotoxin Drugs 0.000 claims description 3
YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 claims description 3
YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 claims description 3
229960004742 raltegravir Drugs 0.000 claims description 3
CZFFBEXEKNGXKS-UHFFFAOYSA-N raltegravir Chemical compound O1C(C)=NN=C1C(=O)NC(C)(C)C1=NC(C(=O)NCC=2C=CC(F)=CC=2)=C(O)C(=O)N1C CZFFBEXEKNGXKS-UHFFFAOYSA-N 0.000 claims description 3
229960000329 ribavirin Drugs 0.000 claims description 3
HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 3
229960000888 rimantadine Drugs 0.000 claims description 3
229960000311 ritonavir Drugs 0.000 claims description 3
NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims description 3
229960001852 saquinavir Drugs 0.000 claims description 3
QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 claims description 3
229960001203 stavudine Drugs 0.000 claims description 3
229950006081 taribavirin Drugs 0.000 claims description 3
NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims description 3
229960004556 tenofovir Drugs 0.000 claims description 3
SGOIRFVFHAKUTI-ZCFIWIBFSA-N tenofovir (anhydrous) Chemical compound N1=CN=C2N(C[C@@H](C)OCP(O)(O)=O)C=NC2=C1N SGOIRFVFHAKUTI-ZCFIWIBFSA-N 0.000 claims description 3
229960001355 tenofovir disoproxil Drugs 0.000 claims description 3
JFVZFKDSXNQEJW-CQSZACIVSA-N tenofovir disoproxil Chemical compound N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N JFVZFKDSXNQEJW-CQSZACIVSA-N 0.000 claims description 3
VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims description 3
229960000838 tipranavir Drugs 0.000 claims description 3
SUJUHGSWHZTSEU-FYBSXPHGSA-N tipranavir Chemical compound C([C@@]1(CCC)OC(=O)C([C@H](CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)=C(O)C1)CC1=CC=CC=C1 SUJUHGSWHZTSEU-FYBSXPHGSA-N 0.000 claims description 3
229960003962 trifluridine Drugs 0.000 claims description 3
VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 claims description 3
229940111527 trizivir Drugs 0.000 claims description 3
229960000832 tromantadine Drugs 0.000 claims description 3
UXQDWARBDDDTKG-UHFFFAOYSA-N tromantadine Chemical compound C1C(C2)CC3CC2CC1(NC(=O)COCCN(C)C)C3 UXQDWARBDDDTKG-UHFFFAOYSA-N 0.000 claims description 3
229940008349 truvada Drugs 0.000 claims description 3
KCFYEAOKVJSACF-UHFFFAOYSA-N umifenovir Chemical compound CN1C2=CC(Br)=C(O)C(CN(C)C)=C2C(C(=O)OCC)=C1CSC1=CC=CC=C1 KCFYEAOKVJSACF-UHFFFAOYSA-N 0.000 claims description 3
229960004626 umifenovir Drugs 0.000 claims description 3
229940093257 valacyclovir Drugs 0.000 claims description 3
229960002149 valganciclovir Drugs 0.000 claims description 3
229950009860 vicriviroc Drugs 0.000 claims description 3
229960000523 zalcitabine Drugs 0.000 claims description 3
239000013060 biological fluid Substances 0.000 claims description 2
208000006454 hepatitis Diseases 0.000 claims description 2
231100000283 hepatitis Toxicity 0.000 claims description 2
241000282842 Lama glama Species 0.000 claims 2
230000000415 inactivating effect Effects 0.000 abstract description 23
238000012360 testing method Methods 0.000 description 316
239000000126 substance Substances 0.000 description 174
210000004027 cell Anatomy 0.000 description 149
239000004927 clay Substances 0.000 description 92
230000003253 viricidal effect Effects 0.000 description 90
238000003556 assay Methods 0.000 description 79
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 70
238000010790 dilution Methods 0.000 description 62
239000012895 dilution Substances 0.000 description 62
239000002609 medium Substances 0.000 description 62
239000003795 chemical substances by application Substances 0.000 description 56
150000001875 compounds Chemical class 0.000 description 56
GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 51
230000009467 reduction Effects 0.000 description 50
231100000135 cytotoxicity Toxicity 0.000 description 48
230000003013 cytotoxicity Effects 0.000 description 48
230000003612 virological effect Effects 0.000 description 47
108091003079 Bovine Serum Albumin Proteins 0.000 description 45
239000012091 fetal bovine serum Substances 0.000 description 45
208000015181 infectious disease Diseases 0.000 description 41
150000004010 onium ions Chemical class 0.000 description 40
238000004113 cell culture Methods 0.000 description 39
239000000499 gel Substances 0.000 description 39
208000025865 Ulcer Diseases 0.000 description 37
230000036269 ulceration Effects 0.000 description 36
229910052739 hydrogen Inorganic materials 0.000 description 35
239000001257 hydrogen Substances 0.000 description 34
230000000120 cytopathologic effect Effects 0.000 description 32
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 31
230000000840 anti-viral effect Effects 0.000 description 30
229940092782 bentonite Drugs 0.000 description 30
229910000278 bentonite Inorganic materials 0.000 description 30
239000000440 bentonite Substances 0.000 description 30
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 30
210000003491 skin Anatomy 0.000 description 28
229910021647 smectite Inorganic materials 0.000 description 27
230000002779 inactivation Effects 0.000 description 26
238000005342 ion exchange Methods 0.000 description 26
201000010099 disease Diseases 0.000 description 24
238000006386 neutralization reaction Methods 0.000 description 24
238000001179 sorption measurement Methods 0.000 description 24
238000002360 preparation method Methods 0.000 description 23
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 22
102000004169 proteins and genes Human genes 0.000 description 22
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 21
229910052901 montmorillonite Inorganic materials 0.000 description 21
239000002953 phosphate buffered saline Substances 0.000 description 21
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
238000009830 intercalation Methods 0.000 description 20
108090000623 proteins and genes Proteins 0.000 description 20
238000000576 coating method Methods 0.000 description 19
239000011734 sodium Substances 0.000 description 19
229920005654 Sephadex Polymers 0.000 description 18
239000012507 Sephadex™ Substances 0.000 description 18
150000002431 hydrogen Chemical class 0.000 description 18
238000013207 serial dilution Methods 0.000 description 18
239000006228 supernatant Substances 0.000 description 18
239000002002 slurry Substances 0.000 description 17
239000007787 solid Substances 0.000 description 17
239000011248 coating agent Substances 0.000 description 16
239000007788 liquid Substances 0.000 description 16
239000003826 tablet Substances 0.000 description 16
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 15
208000037797 influenza A Diseases 0.000 description 15
239000012154 double-distilled water Substances 0.000 description 14
239000013642 negative control Substances 0.000 description 14
230000000241 respiratory effect Effects 0.000 description 14
229910000280 sodium bentonite Inorganic materials 0.000 description 14
241000282412 Homo Species 0.000 description 13
241000712431 Influenza A virus Species 0.000 description 13
239000012535 impurity Substances 0.000 description 13
229940080314 sodium bentonite Drugs 0.000 description 13
241000283690 Bos taurus Species 0.000 description 12
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 12
239000012298 atmosphere Substances 0.000 description 12
239000011575 calcium Substances 0.000 description 12
ONCZQWJXONKSMM-UHFFFAOYSA-N dialuminum;disodium;oxygen(2-);silicon(4+);hydrate Chemical compound O.[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Al+3].[Al+3].[Si+4].[Si+4].[Si+4].[Si+4] ONCZQWJXONKSMM-UHFFFAOYSA-N 0.000 description 12
239000004094 surface-active agent Substances 0.000 description 12
230000001988 toxicity Effects 0.000 description 12
231100000419 toxicity Toxicity 0.000 description 12
239000002699 waste material Substances 0.000 description 12
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 11
229960003942 amphotericin b Drugs 0.000 description 11
238000011534 incubation Methods 0.000 description 11
239000004615 ingredient Substances 0.000 description 11
210000004379 membrane Anatomy 0.000 description 11
229920000642 polymer Polymers 0.000 description 11
229910052708 sodium Inorganic materials 0.000 description 11
239000003981 vehicle Substances 0.000 description 11
241000700588 Human alphaherpesvirus 1 Species 0.000 description 10
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 10
241000845082 Panama Species 0.000 description 10
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 10
229910052791 calcium Inorganic materials 0.000 description 10
230000000694 effects Effects 0.000 description 10
235000019441 ethanol Nutrition 0.000 description 10
230000003993 interaction Effects 0.000 description 10
239000002689 soil Substances 0.000 description 10
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
125000000217 alkyl group Chemical group 0.000 description 9
238000005119 centrifugation Methods 0.000 description 9
229940079593 drug Drugs 0.000 description 9
239000000706 filtrate Substances 0.000 description 9
238000001914 filtration Methods 0.000 description 9
230000003902 lesion Effects 0.000 description 9
230000000717 retained effect Effects 0.000 description 9
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 8
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 8
229930182566 Gentamicin Natural products 0.000 description 8
229930182555 Penicillin Natural products 0.000 description 8
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 8
239000004599 antimicrobial Substances 0.000 description 8
239000002734 clay mineral Substances 0.000 description 8
239000000839 emulsion Substances 0.000 description 8
230000003463 hyperproliferative effect Effects 0.000 description 8
229910052500 inorganic mineral Inorganic materials 0.000 description 8
238000012423 maintenance Methods 0.000 description 8
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 8
235000010755 mineral Nutrition 0.000 description 8
239000011707 mineral Substances 0.000 description 8
229940049954 penicillin Drugs 0.000 description 8
239000000047 product Substances 0.000 description 8
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 8
102000005962 receptors Human genes 0.000 description 8
239000000758 substrate Substances 0.000 description 8
231100000331 toxic Toxicity 0.000 description 8
230000002588 toxic effect Effects 0.000 description 8
230000001580 bacterial effect Effects 0.000 description 7
239000011324 bead Substances 0.000 description 7
210000000234 capsid Anatomy 0.000 description 7
238000006243 chemical reaction Methods 0.000 description 7
239000012531 culture fluid Substances 0.000 description 7
229960002518 gentamicin Drugs 0.000 description 7
206010022000 influenza Diseases 0.000 description 7
239000010410 layer Substances 0.000 description 7
244000144972 livestock Species 0.000 description 7
230000000813 microbial effect Effects 0.000 description 7
239000007758 minimum essential medium Substances 0.000 description 7
108020004707 nucleic acids Proteins 0.000 description 7
102000039446 nucleic acids Human genes 0.000 description 7
150000007523 nucleic acids Chemical class 0.000 description 7
239000003960 organic solvent Substances 0.000 description 7
239000013641 positive control Substances 0.000 description 7
108020003175 receptors Proteins 0.000 description 7
239000002904 solvent Substances 0.000 description 7
241000894007 species Species 0.000 description 7
239000003760 tallow Substances 0.000 description 7
210000001519 tissue Anatomy 0.000 description 7
230000035899 viability Effects 0.000 description 7
241000714201 Feline calicivirus Species 0.000 description 6
241000124008 Mammalia Species 0.000 description 6
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical class CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 6
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
241000282898 Sus scrofa Species 0.000 description 6
229940081735 acetylcellulose Drugs 0.000 description 6
230000009471 action Effects 0.000 description 6
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 6
210000004369 blood Anatomy 0.000 description 6
239000008280 blood Substances 0.000 description 6
239000002775 capsule Substances 0.000 description 6
239000001913 cellulose Substances 0.000 description 6
235000010980 cellulose Nutrition 0.000 description 6
229920002678 cellulose Polymers 0.000 description 6
230000000536 complexating effect Effects 0.000 description 6
208000035475 disorder Diseases 0.000 description 6
239000002552 dosage form Substances 0.000 description 6
239000003527 fibrinolytic agent Substances 0.000 description 6
239000011521 glass Substances 0.000 description 6
235000011187 glycerol Nutrition 0.000 description 6
239000003112 inhibitor Substances 0.000 description 6
210000003292 kidney cell Anatomy 0.000 description 6
239000011777 magnesium Substances 0.000 description 6
239000011159 matrix material Substances 0.000 description 6
229910052751 metal Inorganic materials 0.000 description 6
239000002184 metal Substances 0.000 description 6
239000003921 oil Substances 0.000 description 6
235000019198 oils Nutrition 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
235000002639 sodium chloride Nutrition 0.000 description 6
229910001415 sodium ion Inorganic materials 0.000 description 6
208000024891 symptom Diseases 0.000 description 6
238000002723 toxicity assay Methods 0.000 description 6
238000012546 transfer Methods 0.000 description 6
229960005486 vaccine Drugs 0.000 description 6
239000012873 virucide Substances 0.000 description 6
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 5
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 5
241000282472 Canis lupus familiaris Species 0.000 description 5
208000007212 Foot-and-Mouth Disease Diseases 0.000 description 5
241000710198 Foot-and-mouth disease virus Species 0.000 description 5
241000282560 Macaca mulatta Species 0.000 description 5
241000699670 Mus sp. Species 0.000 description 5
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 5
230000002745 absorbent Effects 0.000 description 5
239000002250 absorbent Substances 0.000 description 5
239000000654 additive Substances 0.000 description 5
238000001042 affinity chromatography Methods 0.000 description 5
230000000890 antigenic effect Effects 0.000 description 5
230000001363 autoimmune Effects 0.000 description 5
125000004432 carbon atom Chemical group C* 0.000 description 5
239000013553 cell monolayer Substances 0.000 description 5
239000008367 deionised water Substances 0.000 description 5
230000003111 delayed effect Effects 0.000 description 5
238000004299 exfoliation Methods 0.000 description 5
239000012530 fluid Substances 0.000 description 5
230000002538 fungal effect Effects 0.000 description 5
238000001727 in vivo Methods 0.000 description 5
230000002757 inflammatory effect Effects 0.000 description 5
230000002401 inhibitory effect Effects 0.000 description 5
150000002500 ions Chemical class 0.000 description 5
210000003734 kidney Anatomy 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
230000008569 process Effects 0.000 description 5
230000004044 response Effects 0.000 description 5
RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 5
108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 4
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 4
208000002874 Acne Vulgaris Diseases 0.000 description 4
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
241000272517 Anseriformes Species 0.000 description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
108020004414 DNA Proteins 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
241000283086 Equidae Species 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
239000000232 Lipid Bilayer Substances 0.000 description 4
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 4
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 4
201000007100 Pharyngitis Diseases 0.000 description 4
241000700159 Rattus Species 0.000 description 4
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
229920002472 Starch Polymers 0.000 description 4
239000002253 acid Substances 0.000 description 4
206010000496 acne Diseases 0.000 description 4
239000003463 adsorbent Substances 0.000 description 4
238000013019 agitation Methods 0.000 description 4
125000003282 alkyl amino group Chemical group 0.000 description 4
125000002947 alkylene group Chemical group 0.000 description 4
239000000427 antigen Substances 0.000 description 4
108091007433 antigens Proteins 0.000 description 4
102000036639 antigens Human genes 0.000 description 4
125000003118 aryl group Chemical group 0.000 description 4
125000004104 aryloxy group Chemical group 0.000 description 4
125000004429 atom Chemical group 0.000 description 4
208000010668 atopic eczema Diseases 0.000 description 4
DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 4
230000008901 benefit Effects 0.000 description 4
239000011230 binding agent Substances 0.000 description 4
230000003115 biocidal effect Effects 0.000 description 4
230000005540 biological transmission Effects 0.000 description 4
206010006451 bronchitis Diseases 0.000 description 4
VNSBYDPZHCQWNB-UHFFFAOYSA-N calcium;aluminum;dioxido(oxo)silane;sodium;hydrate Chemical compound O.[Na].[Al].[Ca+2].[O-][Si]([O-])=O VNSBYDPZHCQWNB-UHFFFAOYSA-N 0.000 description 4
230000003833 cell viability Effects 0.000 description 4
230000007253 cellular alteration Effects 0.000 description 4
235000013330 chicken meat Nutrition 0.000 description 4
229910021641 deionized water Inorganic materials 0.000 description 4
125000004663 dialkyl amino group Chemical group 0.000 description 4
230000003467 diminishing effect Effects 0.000 description 4
229940088598 enzyme Drugs 0.000 description 4
JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 description 4
150000002148 esters Chemical class 0.000 description 4
230000035931 haemagglutination Effects 0.000 description 4
229910000271 hectorite Inorganic materials 0.000 description 4
KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 4
238000003384 imaging method Methods 0.000 description 4
230000002458 infectious effect Effects 0.000 description 4
239000002054 inoculum Substances 0.000 description 4
230000002687 intercalation Effects 0.000 description 4
239000003456 ion exchange resin Substances 0.000 description 4
229920003303 ion-exchange polymer Polymers 0.000 description 4
239000000314 lubricant Substances 0.000 description 4
229920002521 macromolecule Polymers 0.000 description 4
229910052749 magnesium Inorganic materials 0.000 description 4
230000007246 mechanism Effects 0.000 description 4
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
229960002216 methylparaben Drugs 0.000 description 4
238000002156 mixing Methods 0.000 description 4
244000309711 non-enveloped viruses Species 0.000 description 4
229910000273 nontronite Inorganic materials 0.000 description 4
230000000737 periodic effect Effects 0.000 description 4
230000035699 permeability Effects 0.000 description 4
XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 4
229920003023 plastic Polymers 0.000 description 4
239000004033 plastic Substances 0.000 description 4
108090000765 processed proteins & peptides Proteins 0.000 description 4
230000000644 propagated effect Effects 0.000 description 4
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 4
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 4
229960003415 propylparaben Drugs 0.000 description 4
238000000746 purification Methods 0.000 description 4
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
229910000275 saponite Inorganic materials 0.000 description 4
229910000276 sauconite Inorganic materials 0.000 description 4
239000002356 single layer Substances 0.000 description 4
208000017520 skin disease Diseases 0.000 description 4
229940126586 small molecule drug Drugs 0.000 description 4
239000003381 stabilizer Substances 0.000 description 4
235000019698 starch Nutrition 0.000 description 4
239000011550 stock solution Substances 0.000 description 4
238000013268 sustained release Methods 0.000 description 4
239000012730 sustained-release form Substances 0.000 description 4
230000000472 traumatic effect Effects 0.000 description 4
229910052902 vermiculite Inorganic materials 0.000 description 4
239000010455 vermiculite Substances 0.000 description 4
235000019354 vermiculite Nutrition 0.000 description 4
239000001993 wax Substances 0.000 description 4
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
102100027211 Albumin Human genes 0.000 description 3
108010088751 Albumins Proteins 0.000 description 3
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
241000282465 Canis Species 0.000 description 3
241000700198 Cavia Species 0.000 description 3
208000035473 Communicable disease Diseases 0.000 description 3
206010010356 Congenital anomaly Diseases 0.000 description 3
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
201000004624 Dermatitis Diseases 0.000 description 3
239000001856 Ethyl cellulose Substances 0.000 description 3
241000282324 Felis Species 0.000 description 3
206010017918 Gastroenteritis viral Diseases 0.000 description 3
108010010803 Gelatin Proteins 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
102000003886 Glycoproteins Human genes 0.000 description 3
108090000288 Glycoproteins Proteins 0.000 description 3
208000004898 Herpes Labialis Diseases 0.000 description 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
241000282838 Lama Species 0.000 description 3
108010052285 Membrane Proteins Proteins 0.000 description 3
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 3
206010028980 Neoplasm Diseases 0.000 description 3
108091005461 Nucleic proteins Proteins 0.000 description 3
206010035664 Pneumonia Diseases 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
241000288906 Primates Species 0.000 description 3
229920001800 Shellac Polymers 0.000 description 3
206010042033 Stevens-Johnson syndrome Diseases 0.000 description 3
241000282887 Suidae Species 0.000 description 3
238000005411 Van der Waals force Methods 0.000 description 3
125000004414 alkyl thio group Chemical group 0.000 description 3
238000010171 animal model Methods 0.000 description 3
239000002260 anti-inflammatory agent Substances 0.000 description 3
239000003963 antioxidant agent Substances 0.000 description 3
235000006708 antioxidants Nutrition 0.000 description 3
125000005110 aryl thio group Chemical group 0.000 description 3
229910052788 barium Inorganic materials 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
239000010836 blood and blood product Substances 0.000 description 3
229940125691 blood product Drugs 0.000 description 3
239000000872 buffer Substances 0.000 description 3
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 3
230000009920 chelation Effects 0.000 description 3
239000011651 chromium Substances 0.000 description 3
239000007979 citrate buffer Substances 0.000 description 3
238000004140 cleaning Methods 0.000 description 3
239000008199 coating composition Substances 0.000 description 3
229920001577 copolymer Polymers 0.000 description 3
229910052802 copper Inorganic materials 0.000 description 3
239000010949 copper Substances 0.000 description 3
125000000392 cycloalkenyl group Chemical group 0.000 description 3
125000000753 cycloalkyl group Chemical group 0.000 description 3
231100000433 cytotoxic Toxicity 0.000 description 3
230000001472 cytotoxic effect Effects 0.000 description 3
238000002784 cytotoxicity assay Methods 0.000 description 3
231100000263 cytotoxicity test Toxicity 0.000 description 3
239000000645 desinfectant Substances 0.000 description 3
238000000502 dialysis Methods 0.000 description 3
238000012377 drug delivery Methods 0.000 description 3
235000019325 ethyl cellulose Nutrition 0.000 description 3
239000000835 fiber Substances 0.000 description 3
239000000945 filler Substances 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
238000002523 gelfiltration Methods 0.000 description 3
239000001963 growth medium Substances 0.000 description 3
239000008269 hand cream Substances 0.000 description 3
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
239000001863 hydroxypropyl cellulose Substances 0.000 description 3
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
229910052900 illite Inorganic materials 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
208000014674 injury Diseases 0.000 description 3
239000011630 iodine Substances 0.000 description 3
229910052740 iodine Inorganic materials 0.000 description 3
229910052742 iron Inorganic materials 0.000 description 3
239000008101 lactose Substances 0.000 description 3
229940094522 laponite Drugs 0.000 description 3
239000003446 ligand Substances 0.000 description 3
239000000865 liniment Substances 0.000 description 3
150000002632 lipids Chemical class 0.000 description 3
XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 3
229920000609 methyl cellulose Polymers 0.000 description 3
235000010981 methylcellulose Nutrition 0.000 description 3
239000001923 methylcellulose Substances 0.000 description 3
VGIBGUSAECPPNB-UHFFFAOYSA-L nonaaluminum;magnesium;tripotassium;1,3-dioxido-2,4,5-trioxa-1,3-disilabicyclo[1.1.1]pentane;iron(2+);oxygen(2-);fluoride;hydroxide Chemical compound [OH-].[O-2].[O-2].[O-2].[O-2].[O-2].[F-].[Mg+2].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[K+].[K+].[K+].[Fe+2].O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2.O1[Si]2([O-])O[Si]1([O-])O2 VGIBGUSAECPPNB-UHFFFAOYSA-L 0.000 description 3
UPHWVVKYDQHTCF-UHFFFAOYSA-N octadecylazanium;acetate Chemical compound CC(O)=O.CCCCCCCCCCCCCCCCCCN UPHWVVKYDQHTCF-UHFFFAOYSA-N 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-O oxonium Chemical compound [OH3+] XLYOFNOQVPJJNP-UHFFFAOYSA-O 0.000 description 3
230000036961 partial effect Effects 0.000 description 3
210000002640 perineum Anatomy 0.000 description 3
239000000049 pigment Substances 0.000 description 3
229920001223 polyethylene glycol Polymers 0.000 description 3
244000144977 poultry Species 0.000 description 3
235000013594 poultry meat Nutrition 0.000 description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
238000011321 prophylaxis Methods 0.000 description 3
230000002829 reductive effect Effects 0.000 description 3
230000001568 sexual effect Effects 0.000 description 3
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 3
239000004208 shellac Substances 0.000 description 3
229940113147 shellac Drugs 0.000 description 3
235000013874 shellac Nutrition 0.000 description 3
229910052709 silver Inorganic materials 0.000 description 3
239000004332 silver Substances 0.000 description 3
229940009188 silver Drugs 0.000 description 3
201000009890 sinusitis Diseases 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
238000005507 spraying Methods 0.000 description 3
230000007480 spreading Effects 0.000 description 3
238000003892 spreading Methods 0.000 description 3
239000008107 starch Substances 0.000 description 3
208000003265 stomatitis Diseases 0.000 description 3
238000007920 subcutaneous administration Methods 0.000 description 3
229910052717 sulfur Inorganic materials 0.000 description 3
208000011580 syndromic disease Diseases 0.000 description 3
239000000454 talc Substances 0.000 description 3
235000012222 talc Nutrition 0.000 description 3
229910052623 talc Inorganic materials 0.000 description 3
231100001274 therapeutic index Toxicity 0.000 description 3
239000002562 thickening agent Substances 0.000 description 3
210000002700 urine Anatomy 0.000 description 3
239000011800 void material Substances 0.000 description 3
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
229940122937 Actin inhibitor Drugs 0.000 description 2
241000251468 Actinopterygii Species 0.000 description 2
244000144927 Aloe barbadensis Species 0.000 description 2
235000002961 Aloe barbadensis Nutrition 0.000 description 2
239000005995 Aluminium silicate Substances 0.000 description 2
244000303258 Annona diversifolia Species 0.000 description 2
201000001320 Atherosclerosis Diseases 0.000 description 2
241000271566 Aves Species 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
208000035143 Bacterial infection Diseases 0.000 description 2
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
KSSJBGNOJJETTC-UHFFFAOYSA-N COC1=C(C=CC=C1)N(C1=CC=2C3(C4=CC(=CC=C4C=2C=C1)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC(=CC=C1C=1C=CC(=CC=13)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC=C(C=C1)OC Chemical compound COC1=C(C=CC=C1)N(C1=CC=2C3(C4=CC(=CC=C4C=2C=C1)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC(=CC=C1C=1C=CC(=CC=13)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)N(C1=CC=C(C=C1)OC)C1=C(C=CC=C1)OC)C1=CC=C(C=C1)OC KSSJBGNOJJETTC-UHFFFAOYSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
229940127291 Calcium channel antagonist Drugs 0.000 description 2
241000282836 Camelus dromedarius Species 0.000 description 2
101710205625 Capsid protein p24 Proteins 0.000 description 2
229940123587 Cell cycle inhibitor Drugs 0.000 description 2
229920000623 Cellulose acetate phthalate Polymers 0.000 description 2
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
208000003322 Coinfection Diseases 0.000 description 2
241000270722 Crocodylidae Species 0.000 description 2
201000003883 Cystic fibrosis Diseases 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
241000238557 Decapoda Species 0.000 description 2
206010012735 Diarrhoea Diseases 0.000 description 2
102000013138 Drug Receptors Human genes 0.000 description 2
108010065556 Drug Receptors Proteins 0.000 description 2
208000005373 Dyshidrotic Eczema Diseases 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 2
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
229940123457 Free radical scavenger Drugs 0.000 description 2
206010017533 Fungal infection Diseases 0.000 description 2
241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
206010025323 Lymphomas Diseases 0.000 description 2
PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical group [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
244000062730 Melissa officinalis Species 0.000 description 2
235000010654 Melissa officinalis Nutrition 0.000 description 2
108010090054 Membrane Glycoproteins Proteins 0.000 description 2
102000012750 Membrane Glycoproteins Human genes 0.000 description 2
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
229940122255 Microtubule inhibitor Drugs 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
208000031888 Mycoses Diseases 0.000 description 2
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
229910002651 NO3 Inorganic materials 0.000 description 2
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
206010031252 Osteomyelitis Diseases 0.000 description 2
206010033976 Paravaccinia Diseases 0.000 description 2
241000283216 Phocidae Species 0.000 description 2
101710177166 Phosphoprotein Proteins 0.000 description 2
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
239000004698 Polyethylene Substances 0.000 description 2
239000004793 Polystyrene Substances 0.000 description 2
201000004681 Psoriasis Diseases 0.000 description 2
206010039085 Rhinitis allergic Diseases 0.000 description 2
101710149279 Small delta antigen Proteins 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
101000712605 Theromyzon tessulatum Theromin Proteins 0.000 description 2
229940122388 Thrombin inhibitor Drugs 0.000 description 2
102000003978 Tissue Plasminogen Activator Human genes 0.000 description 2
108090000373 Tissue Plasminogen Activator Proteins 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
206010044223 Toxic epidermal necrolysis Diseases 0.000 description 2
231100000087 Toxic epidermal necrolysis Toxicity 0.000 description 2
XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
206010047163 Vasospasm Diseases 0.000 description 2
231100000764 actin inhibitor Toxicity 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
125000003342 alkenyl group Chemical group 0.000 description 2
125000003545 alkoxy group Chemical group 0.000 description 2
125000004453 alkoxycarbonyl group Chemical group 0.000 description 2
150000001343 alkyl silanes Chemical group 0.000 description 2
125000004644 alkyl sulfinyl group Chemical group 0.000 description 2
125000004390 alkyl sulfonyl group Chemical group 0.000 description 2
201000010105 allergic rhinitis Diseases 0.000 description 2
235000011399 aloe vera Nutrition 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
235000012211 aluminium silicate Nutrition 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 2
230000001093 anti-cancer Effects 0.000 description 2
230000003602 anti-herpes Effects 0.000 description 2
230000000340 anti-metabolite Effects 0.000 description 2
230000002927 anti-mitotic effect Effects 0.000 description 2
230000001028 anti-proliverative effect Effects 0.000 description 2
230000000692 anti-sense effect Effects 0.000 description 2
229940100197 antimetabolite Drugs 0.000 description 2
239000002256 antimetabolite Substances 0.000 description 2
239000002246 antineoplastic agent Substances 0.000 description 2
230000003078 antioxidant effect Effects 0.000 description 2
229940127218 antiplatelet drug Drugs 0.000 description 2
206010003246 arthritis Diseases 0.000 description 2
125000001691 aryl alkyl amino group Chemical group 0.000 description 2
125000003710 aryl alkyl group Chemical group 0.000 description 2
125000001769 aryl amino group Chemical group 0.000 description 2
125000005135 aryl sulfinyl group Chemical group 0.000 description 2
125000004391 aryl sulfonyl group Chemical group 0.000 description 2
235000010323 ascorbic acid Nutrition 0.000 description 2
229960005070 ascorbic acid Drugs 0.000 description 2
239000011668 ascorbic acid Substances 0.000 description 2
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 2
208000022362 bacterial infectious disease Diseases 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
239000003124 biologic agent Substances 0.000 description 2
230000004071 biological effect Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
239000000480 calcium channel blocker Substances 0.000 description 2
229910001424 calcium ion Inorganic materials 0.000 description 2
239000007894 caplet Substances 0.000 description 2
125000001589 carboacyl group Chemical group 0.000 description 2
239000000969 carrier Substances 0.000 description 2
239000012876 carrier material Substances 0.000 description 2
210000000170 cell membrane Anatomy 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
229940081734 cellulose acetate phthalate Drugs 0.000 description 2
229920001429 chelating resin Polymers 0.000 description 2
OEUUFNIKLCFNLN-LLVKDONJSA-N chembl432481 Chemical compound OC(=O)[C@@]1(C)CSC(C=2C(=CC(O)=CC=2)O)=N1 OEUUFNIKLCFNLN-LLVKDONJSA-N 0.000 description 2
229910052804 chromium Inorganic materials 0.000 description 2
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
230000002301 combined effect Effects 0.000 description 2
201000003740 cowpox Diseases 0.000 description 2
201000010549 croup Diseases 0.000 description 2
125000005724 cycloalkenylene group Chemical group 0.000 description 2
125000002993 cycloalkylene group Chemical group 0.000 description 2
231100000050 cytotoxic potential Toxicity 0.000 description 2
PWEOPMBMTXREGV-UHFFFAOYSA-N decanoic acid;octanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCC(O)=O.CCCCCCCC(O)=O.CCCCCCCCCC(O)=O.CCCCCCCCCC(O)=O PWEOPMBMTXREGV-UHFFFAOYSA-N 0.000 description 2
238000011161 development Methods 0.000 description 2
230000018109 developmental process Effects 0.000 description 2
239000008121 dextrose Substances 0.000 description 2
206010012601 diabetes mellitus Diseases 0.000 description 2
150000004985 diamines Chemical class 0.000 description 2
125000004986 diarylamino group Chemical group 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
230000037213 diet Effects 0.000 description 2
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
238000007598 dipping method Methods 0.000 description 2
238000007907 direct compression Methods 0.000 description 2
239000007884 disintegrant Substances 0.000 description 2
229910000514 dolomite Inorganic materials 0.000 description 2
231100000673 dose–response relationship Toxicity 0.000 description 2
229940000406 drug candidate Drugs 0.000 description 2
238000001035 drying Methods 0.000 description 2
208000002169 ectodermal dysplasia Diseases 0.000 description 2
230000002500 effect on skin Effects 0.000 description 2
238000010894 electron beam technology Methods 0.000 description 2
238000000921 elemental analysis Methods 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
230000007613 environmental effect Effects 0.000 description 2
210000002919 epithelial cell Anatomy 0.000 description 2
230000003628 erosive effect Effects 0.000 description 2
BLCTWBJQROOONQ-UHFFFAOYSA-N ethenyl prop-2-enoate Chemical compound C=COC(=O)C=C BLCTWBJQROOONQ-UHFFFAOYSA-N 0.000 description 2
238000007046 ethoxylation reaction Methods 0.000 description 2
229920001249 ethyl cellulose Polymers 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
210000002744 extracellular matrix Anatomy 0.000 description 2
239000004744 fabric Substances 0.000 description 2
210000003608 fece Anatomy 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
238000005189 flocculation Methods 0.000 description 2
230000016615 flocculation Effects 0.000 description 2
239000006260 foam Substances 0.000 description 2
235000013355 food flavoring agent Nutrition 0.000 description 2
239000007903 gelatin capsule Substances 0.000 description 2
230000002068 genetic effect Effects 0.000 description 2
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
239000008187 granular material Substances 0.000 description 2
230000005484 gravity Effects 0.000 description 2
229910001385 heavy metal Inorganic materials 0.000 description 2
239000003906 humectant Substances 0.000 description 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
229920001477 hydrophilic polymer Polymers 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 2
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 2
229960001680 ibuprofen Drugs 0.000 description 2
239000012216 imaging agent Substances 0.000 description 2
238000001597 immobilized metal affinity chromatography Methods 0.000 description 2
239000003018 immunosuppressive agent Substances 0.000 description 2
229940125721 immunosuppressive agent Drugs 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
230000000968 intestinal effect Effects 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
230000000302 ischemic effect Effects 0.000 description 2
238000010030 laminating Methods 0.000 description 2
208000032839 leukemia Diseases 0.000 description 2
201000011486 lichen planus Diseases 0.000 description 2
229910052744 lithium Inorganic materials 0.000 description 2
210000004072 lung Anatomy 0.000 description 2
210000005265 lung cell Anatomy 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
239000011572 manganese Substances 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
210000004779 membrane envelope Anatomy 0.000 description 2
231100000782 microtubule inhibitor Toxicity 0.000 description 2
208000020298 milker nodule Diseases 0.000 description 2
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
210000004400 mucous membrane Anatomy 0.000 description 2
230000035772 mutation Effects 0.000 description 2
210000003928 nasal cavity Anatomy 0.000 description 2
229940097496 nasal spray Drugs 0.000 description 2
201000009240 nasopharyngitis Diseases 0.000 description 2
230000002981 neuropathic effect Effects 0.000 description 2
210000002445 nipple Anatomy 0.000 description 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
210000001331 nose Anatomy 0.000 description 2
239000002773 nucleotide Substances 0.000 description 2
125000003729 nucleotide group Chemical group 0.000 description 2
229960000988 nystatin Drugs 0.000 description 2
VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 2
239000004006 olive oil Substances 0.000 description 2
235000008390 olive oil Nutrition 0.000 description 2
239000006186 oral dosage form Substances 0.000 description 2
150000002894 organic compounds Chemical class 0.000 description 2
230000008520 organization Effects 0.000 description 2
229960002194 oseltamivir phosphate Drugs 0.000 description 2
239000003973 paint Substances 0.000 description 2
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
229960005489 paracetamol Drugs 0.000 description 2
239000008188 pellet Substances 0.000 description 2
230000000149 penetrating effect Effects 0.000 description 2
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 2
239000002304 perfume Substances 0.000 description 2
235000019271 petrolatum Nutrition 0.000 description 2
229910052698 phosphorus Inorganic materials 0.000 description 2
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
229920000058 polyacrylate Polymers 0.000 description 2
229920000573 polyethylene Polymers 0.000 description 2
229920002523 polyethylene Glycol 1000 Polymers 0.000 description 2
229940113116 polyethylene glycol 1000 Drugs 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
229920002223 polystyrene Polymers 0.000 description 2
229940100467 polyvinyl acetate phthalate Drugs 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
238000000634 powder X-ray diffraction Methods 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
238000012545 processing Methods 0.000 description 2
239000003380 propellant Substances 0.000 description 2
208000009954 pyoderma gangrenosum Diseases 0.000 description 2
230000005855 radiation Effects 0.000 description 2
239000002516 radical scavenger Substances 0.000 description 2
230000003439 radiotherapeutic effect Effects 0.000 description 2
239000012066 reaction slurry Substances 0.000 description 2
230000006798 recombination Effects 0.000 description 2
238000007634 remodeling Methods 0.000 description 2
238000012552 review Methods 0.000 description 2
229960004889 salicylic acid Drugs 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
150000003384 small molecules Chemical class 0.000 description 2
229910000029 sodium carbonate Inorganic materials 0.000 description 2
235000017550 sodium carbonate Nutrition 0.000 description 2
239000007909 solid dosage form Substances 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
235000010356 sorbitol Nutrition 0.000 description 2
230000001150 spermicidal effect Effects 0.000 description 2
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
238000006467 substitution reaction Methods 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
230000008961 swelling Effects 0.000 description 2
208000006531 swine vesicular disease Diseases 0.000 description 2
208000006379 syphilis Diseases 0.000 description 2
230000008685 targeting Effects 0.000 description 2
239000003868 thrombin inhibitor Substances 0.000 description 2
229960000103 thrombolytic agent Drugs 0.000 description 2
230000036962 time dependent Effects 0.000 description 2
229960000187 tissue plasminogen activator Drugs 0.000 description 2
238000003325 tomography Methods 0.000 description 2
239000003860 topical agent Substances 0.000 description 2
229960003500 triclosan Drugs 0.000 description 2
125000005591 trimellitate group Chemical group 0.000 description 2
YWWDBCBWQNCYNR-UHFFFAOYSA-N trimethylphosphine Chemical compound CP(C)C YWWDBCBWQNCYNR-UHFFFAOYSA-N 0.000 description 2
DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
201000008827 tuberculosis Diseases 0.000 description 2
210000001215 vagina Anatomy 0.000 description 2
229940124549 vasodilator Drugs 0.000 description 2
239000003071 vasodilator agent Substances 0.000 description 2
235000015112 vegetable and seed oil Nutrition 0.000 description 2
239000008158 vegetable oil Substances 0.000 description 2
210000003462 vein Anatomy 0.000 description 2
210000002845 virion Anatomy 0.000 description 2
238000005406 washing Methods 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 description 1
MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 description 1
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 description 1
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 description 1
LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 1
CRSBERNSMYQZNG-UHFFFAOYSA-N 1-dodecene Chemical group CCCCCCCCCCC=C CRSBERNSMYQZNG-UHFFFAOYSA-N 0.000 description 1
BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical class CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical group CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
MBRHNTMUYWQHMR-UHFFFAOYSA-N 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one Chemical compound NCCO.ON1C(=O)C=C(C)C=C1C1CCCCC1 MBRHNTMUYWQHMR-UHFFFAOYSA-N 0.000 description 1
208000004998 Abdominal Pain Diseases 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
235000006491 Acacia senegal Nutrition 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
206010000507 Acne infantile Diseases 0.000 description 1
229920002126 Acrylic acid copolymer Polymers 0.000 description 1
208000030090 Acute Disease Diseases 0.000 description 1
206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
229910002012 Aerosil® Inorganic materials 0.000 description 1
108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
235000003911 Arachis Nutrition 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
241000239290 Araneae Species 0.000 description 1
241000712892 Arenaviridae Species 0.000 description 1
241000712891 Arenavirus Species 0.000 description 1
206010003210 Arteriosclerosis Diseases 0.000 description 1
241000238017 Astacoidea Species 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
206010059099 Atrophie blanche Diseases 0.000 description 1
108010001478 Bacitracin Proteins 0.000 description 1
206010004146 Basal cell carcinoma Diseases 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
208000013165 Bowen disease Diseases 0.000 description 1
208000019337 Bowen disease of the skin Diseases 0.000 description 1
206010006448 Bronchiolitis Diseases 0.000 description 1
201000004813 Bronchopneumonia Diseases 0.000 description 1
206010006811 Bursitis Diseases 0.000 description 1
208000006448 Buruli Ulcer Diseases 0.000 description 1
208000023081 Buruli ulcer disease Diseases 0.000 description 1
229910021532 Calcite Inorganic materials 0.000 description 1
206010007134 Candida infections Diseases 0.000 description 1
101710132601 Capsid protein Proteins 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
108010020326 Caspofungin Proteins 0.000 description 1
208000035484 Cellulite Diseases 0.000 description 1
206010007882 Cellulitis Diseases 0.000 description 1
229930186147 Cephalosporin Natural products 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
241000282994 Cervidae Species 0.000 description 1
208000018380 Chemical injury Diseases 0.000 description 1
208000010445 Chilblains Diseases 0.000 description 1
241000606161 Chlamydia Species 0.000 description 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
208000032544 Cicatrix Diseases 0.000 description 1
241000723346 Cinnamomum camphora Species 0.000 description 1
241000272470 Circus Species 0.000 description 1
101710094648 Coat protein Proteins 0.000 description 1
208000009084 Cold Injury Diseases 0.000 description 1
208000002881 Colic Diseases 0.000 description 1
241000272201 Columbiformes Species 0.000 description 1
206010010741 Conjunctivitis Diseases 0.000 description 1
208000008034 Contagious Ecthyma Diseases 0.000 description 1
241001507939 Cormus domestica Species 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
241000700626 Cowpox virus Species 0.000 description 1
241000709687 Coxsackievirus Species 0.000 description 1
241000938605 Crocodylia Species 0.000 description 1
206010011416 Croup infectious Diseases 0.000 description 1
241000238424 Crustacea Species 0.000 description 1
241000701022 Cytomegalovirus Species 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
206010011985 Decubitus ulcer Diseases 0.000 description 1
206010012438 Dermatitis atopic Diseases 0.000 description 1
206010012455 Dermatitis exfoliative Diseases 0.000 description 1
206010048768 Dermatosis Diseases 0.000 description 1
208000008960 Diabetic foot Diseases 0.000 description 1
238000009007 Diagnostic Kit Methods 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 1
241001115402 Ebolavirus Species 0.000 description 1
241001466953 Echovirus Species 0.000 description 1
208000006586 Ectromelia Diseases 0.000 description 1
208000005189 Embolism Diseases 0.000 description 1
206010014561 Emphysema Diseases 0.000 description 1
208000004232 Enteritis Diseases 0.000 description 1
241000991587 Enterovirus C Species 0.000 description 1
206010014989 Epidermolysis bullosa Diseases 0.000 description 1
239000004593 Epoxy Substances 0.000 description 1
206010048995 Erythrocyanosis Diseases 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
229920003152 Eudragit® RS polymer Polymers 0.000 description 1
208000001640 Fibromyalgia Diseases 0.000 description 1
206010016654 Fibrosis Diseases 0.000 description 1
206010053717 Fibrous histiocytoma Diseases 0.000 description 1
241000711950 Filoviridae Species 0.000 description 1
206010016717 Fistula Diseases 0.000 description 1
241000710781 Flaviviridae Species 0.000 description 1
208000000666 Fowlpox Diseases 0.000 description 1
229910052688 Gadolinium Inorganic materials 0.000 description 1
206010017711 Gangrene Diseases 0.000 description 1
201000000628 Gas Gangrene Diseases 0.000 description 1
208000007882 Gastritis Diseases 0.000 description 1
208000007465 Giant cell arteritis Diseases 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
206010018612 Gonorrhoea Diseases 0.000 description 1
201000005569 Gout Diseases 0.000 description 1
206010018691 Granuloma Diseases 0.000 description 1
206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
CTETYYAZBPJBHE-UHFFFAOYSA-N Haloprogin Chemical compound ClC1=CC(Cl)=C(OCC#CI)C=C1Cl CTETYYAZBPJBHE-UHFFFAOYSA-N 0.000 description 1
206010019233 Headaches Diseases 0.000 description 1
241000711549 Hepacivirus C Species 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
241000700721 Hepatitis B virus Species 0.000 description 1
208000009889 Herpes Simplex Diseases 0.000 description 1
208000007514 Herpes zoster Diseases 0.000 description 1
244000309467 Human Coronavirus Species 0.000 description 1
241000598171 Human adenovirus sp. Species 0.000 description 1
241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
241000701027 Human herpesvirus 6 Species 0.000 description 1
241000484121 Human parvovirus Species 0.000 description 1
241000726041 Human respirovirus 1 Species 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
206010020649 Hyperkeratosis Diseases 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
201000001431 Hyperuricemia Diseases 0.000 description 1
208000024781 Immune Complex disease Diseases 0.000 description 1
206010061598 Immunodeficiency Diseases 0.000 description 1
206010061217 Infestation Diseases 0.000 description 1
208000022559 Inflammatory bowel disease Diseases 0.000 description 1
208000002979 Influenza in Birds Diseases 0.000 description 1
241001500351 Influenzavirus A Species 0.000 description 1
241001500350 Influenzavirus B Species 0.000 description 1
241001500343 Influenzavirus C Species 0.000 description 1
208000006877 Insect Bites and Stings Diseases 0.000 description 1
206010022653 Intestinal haemorrhages Diseases 0.000 description 1
208000032984 Intraoperative Complications Diseases 0.000 description 1
241000701460 JC polyomavirus Species 0.000 description 1
208000007766 Kaposi sarcoma Diseases 0.000 description 1
208000002260 Keloid Diseases 0.000 description 1
206010023330 Keloid scar Diseases 0.000 description 1
208000001126 Keratosis Diseases 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
229930182816 L-glutamine Natural products 0.000 description 1
208000034693 Laceration Diseases 0.000 description 1
206010023927 Lassa fever Diseases 0.000 description 1
208000004554 Leishmaniasis Diseases 0.000 description 1
206010024229 Leprosy Diseases 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
206010024503 Limb reduction defect Diseases 0.000 description 1
206010057481 Lupus pneumonitis Diseases 0.000 description 1
101710125418 Major capsid protein Proteins 0.000 description 1
206010025476 Malabsorption Diseases 0.000 description 1
208000004155 Malabsorption Syndromes Diseases 0.000 description 1
208000002720 Malnutrition Diseases 0.000 description 1
108010021062 Micafungin Proteins 0.000 description 1
BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
241000700559 Molluscipoxvirus Species 0.000 description 1
206010028116 Mucosal inflammation Diseases 0.000 description 1
201000010927 Mucositis Diseases 0.000 description 1
208000000112 Myalgia Diseases 0.000 description 1
206010066289 Mycobacterium ulcerans infection Diseases 0.000 description 1
208000006550 Mydriasis Diseases 0.000 description 1
CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
206010028813 Nausea Diseases 0.000 description 1
206010056969 Necrobiosis lipoidica diabeticorum Diseases 0.000 description 1
DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
229940123424 Neuraminidase inhibitor Drugs 0.000 description 1
201000009053 Neurodermatitis Diseases 0.000 description 1
241000714209 Norwalk virus Species 0.000 description 1
101710141454 Nucleoprotein Proteins 0.000 description 1
206010030201 Oesophageal ulcer Diseases 0.000 description 1
208000010195 Onychomycosis Diseases 0.000 description 1
208000007027 Oral Candidiasis Diseases 0.000 description 1
206010068319 Oropharyngeal pain Diseases 0.000 description 1
241000712464 Orthomyxoviridae Species 0.000 description 1
208000005141 Otitis Diseases 0.000 description 1
206010033078 Otitis media Diseases 0.000 description 1
241000283903 Ovis aries Species 0.000 description 1
241001631646 Papillomaviridae Species 0.000 description 1
206010033799 Paralysis Diseases 0.000 description 1
241000711504 Paramyxoviridae Species 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
206010049752 Peau d'orange Diseases 0.000 description 1
206010034277 Pemphigoid Diseases 0.000 description 1
241000721454 Pemphigus Species 0.000 description 1
208000008469 Peptic Ulcer Diseases 0.000 description 1
241000150350 Peribunyaviridae Species 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
206010057249 Phagocytosis Diseases 0.000 description 1
241000286209 Phasianidae Species 0.000 description 1
NCXMLFZGDNKEPB-UHFFFAOYSA-N Pimaricin Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCC(C)OC(=O)C=CC2OC2CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 NCXMLFZGDNKEPB-UHFFFAOYSA-N 0.000 description 1
241000711902 Pneumovirus Species 0.000 description 1
208000008601 Polycythemia Diseases 0.000 description 1
108010093965 Polymyxin B Proteins 0.000 description 1
206010048591 Post thrombotic syndrome Diseases 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
241000700625 Poxviridae Species 0.000 description 1
208000004210 Pressure Ulcer Diseases 0.000 description 1
101710083689 Probable capsid protein Proteins 0.000 description 1
241000283080 Proboscidea <mammal> Species 0.000 description 1
102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 1
108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 description 1
101800004937 Protein C Proteins 0.000 description 1
102000017975 Protein C Human genes 0.000 description 1
229940096437 Protein S Drugs 0.000 description 1
102000029301 Protein S Human genes 0.000 description 1
108010066124 Protein S Proteins 0.000 description 1
241000621172 Pseudocowpox virus Species 0.000 description 1
208000007123 Pulmonary Atelectasis Diseases 0.000 description 1
206010037423 Pulmonary oedema Diseases 0.000 description 1
206010037575 Pustular psoriasis Diseases 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
108091030071 RNAI Proteins 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
241000711798 Rabies lyssavirus Species 0.000 description 1
206010037888 Rash pustular Diseases 0.000 description 1
208000033464 Reiter syndrome Diseases 0.000 description 1
241000702247 Reoviridae Species 0.000 description 1
208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
241000701037 Rhadinovirus Species 0.000 description 1
208000021326 Ritter disease Diseases 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
241001303601 Rosacea Species 0.000 description 1
108091006629 SLC13A2 Proteins 0.000 description 1
101800001700 Saposin-D Proteins 0.000 description 1
206010039710 Scleroderma Diseases 0.000 description 1
241000239226 Scorpiones Species 0.000 description 1
206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
206010040047 Sepsis Diseases 0.000 description 1
241000287219 Serinus canaria Species 0.000 description 1
241000270295 Serpentes Species 0.000 description 1
208000019802 Sexually transmitted disease Diseases 0.000 description 1
239000006087 Silane Coupling Agent Substances 0.000 description 1
241000700584 Simplexvirus Species 0.000 description 1
241000150288 Sin Nombre orthohantavirus Species 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
206010041509 Spherocytic anaemia Diseases 0.000 description 1
206010041899 Stab wound Diseases 0.000 description 1
206010041929 Staphylococcal scalded skin syndrome Diseases 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
231100000168 Stevens-Johnson syndrome Toxicity 0.000 description 1
208000007107 Stomach Ulcer Diseases 0.000 description 1
101710172711 Structural protein Proteins 0.000 description 1
206010042928 Syringomyelia Diseases 0.000 description 1
208000000389 T-cell leukemia Diseases 0.000 description 1
208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 1
210000001744 T-lymphocyte Anatomy 0.000 description 1
241000404000 Tanapox virus Species 0.000 description 1
208000000491 Tendinopathy Diseases 0.000 description 1
206010043255 Tendonitis Diseases 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
240000006474 Theobroma bicolor Species 0.000 description 1
206010053615 Thermal burn Diseases 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
208000002474 Tinea Diseases 0.000 description 1
241000130764 Tinea Species 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical group [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
241000710924 Togaviridae Species 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 1
102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 1
241000287411 Turdidae Species 0.000 description 1
206010046996 Varicose vein Diseases 0.000 description 1
206010047115 Vasculitis Diseases 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
208000007885 Vesicular Exanthema of Swine Diseases 0.000 description 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
108010015940 Viomycin Proteins 0.000 description 1
OZKXLOZHHUHGNV-UHFFFAOYSA-N Viomycin Natural products NCCCC(N)CC(=O)NC1CNC(=O)C(=CNC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC1=O)C2CC(O)NC(=N)N2 OZKXLOZHHUHGNV-UHFFFAOYSA-N 0.000 description 1
206010047642 Vitiligo Diseases 0.000 description 1
206010047700 Vomiting Diseases 0.000 description 1
208000000260 Warts Diseases 0.000 description 1
241000710886 West Nile virus Species 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
241001536558 Yaba monkey tumor virus Species 0.000 description 1
229920002494 Zein Polymers 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
TYVWBCMQECJNSK-UHFFFAOYSA-N [2-methyl-3-(2-methylprop-2-enoyloxy)butan-2-yl]azanium;chloride Chemical compound [Cl-].CC([NH3+])(C)C(C)OC(=O)C(C)=C TYVWBCMQECJNSK-UHFFFAOYSA-N 0.000 description 1
XVEUJTIZHZIHJM-UHFFFAOYSA-N a828782 Chemical compound CCOC(N)=O.CCOC(N)=O XVEUJTIZHZIHJM-UHFFFAOYSA-N 0.000 description 1
210000000683 abdominal cavity Anatomy 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
AEMQUICCWRPKDB-UHFFFAOYSA-N acetic acid;cyclohexane-1,2-dicarboxylic acid Chemical compound CC(O)=O.OC(=O)C1CCCCC1C(O)=O AEMQUICCWRPKDB-UHFFFAOYSA-N 0.000 description 1
206010000596 acrodermatitis enteropathica Diseases 0.000 description 1
208000009621 actinic keratosis Diseases 0.000 description 1
239000013543 active substance Substances 0.000 description 1
208000021240 acute bronchiolitis Diseases 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000004520 agglutination Effects 0.000 description 1
230000032683 aging Effects 0.000 description 1
238000004887 air purification Methods 0.000 description 1
229910052656 albite Inorganic materials 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
125000004450 alkenylene group Chemical group 0.000 description 1
125000002877 alkyl aryl group Chemical group 0.000 description 1
208000002029 allergic contact dermatitis Diseases 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
DLHONNLASJQAHX-UHFFFAOYSA-N aluminum;potassium;oxygen(2-);silicon(4+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Al+3].[Si+4].[Si+4].[Si+4].[K+] DLHONNLASJQAHX-UHFFFAOYSA-N 0.000 description 1
229960003204 amorolfine Drugs 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
210000003447 amputation stump Anatomy 0.000 description 1
229910052925 anhydrite Inorganic materials 0.000 description 1
239000010828 animal waste Substances 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
210000003423 ankle Anatomy 0.000 description 1
208000022531 anorexia Diseases 0.000 description 1
229910052661 anorthite Inorganic materials 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
230000003622 anti-hsv Effects 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000003096 antiparasitic agent Substances 0.000 description 1
229940125687 antiparasitic agent Drugs 0.000 description 1
229940111121 antirheumatic drug quinolines Drugs 0.000 description 1
239000000074 antisense oligonucleotide Substances 0.000 description 1
238000012230 antisense oligonucleotides Methods 0.000 description 1
229910052586 apatite Inorganic materials 0.000 description 1
206010002963 aplasia cutis congenita Diseases 0.000 description 1
208000011775 arteriosclerosis disease Diseases 0.000 description 1
210000003363 arteriovenous anastomosis Anatomy 0.000 description 1
210000001367 artery Anatomy 0.000 description 1
125000000732 arylene group Chemical group 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
238000004630 atomic force microscopy Methods 0.000 description 1
201000008937 atopic dermatitis Diseases 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
206010064097 avian influenza Diseases 0.000 description 1
229940073066 azactam Drugs 0.000 description 1
WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 1
229960003071 bacitracin Drugs 0.000 description 1
229930184125 bacitracin Natural products 0.000 description 1
CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
229960005274 benzocaine Drugs 0.000 description 1
210000003445 biliary tract Anatomy 0.000 description 1
238000006065 biodegradation reaction Methods 0.000 description 1
229960000074 biopharmaceutical Drugs 0.000 description 1
229910052626 biotite Inorganic materials 0.000 description 1
NFMAZVUSKIJEIH-UHFFFAOYSA-N bis(sulfanylidene)iron Chemical compound S=[Fe]=S NFMAZVUSKIJEIH-UHFFFAOYSA-N 0.000 description 1
230000037396 body weight Effects 0.000 description 1
229910052796 boron Inorganic materials 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
210000000621 bronchi Anatomy 0.000 description 1
201000009267 bronchiectasis Diseases 0.000 description 1
210000003123 bronchiole Anatomy 0.000 description 1
206010006475 bronchopulmonary dysplasia Diseases 0.000 description 1
229960003150 bupivacaine Drugs 0.000 description 1
VHEMBTYWURNBQQ-UHFFFAOYSA-N butanoic acid;phthalic acid Chemical compound CCCC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O VHEMBTYWURNBQQ-UHFFFAOYSA-N 0.000 description 1
ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 description 1
ULBTUVJTXULMLP-UHFFFAOYSA-N butyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCC ULBTUVJTXULMLP-UHFFFAOYSA-N 0.000 description 1
BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical group [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
229910000281 calcium bentonite Inorganic materials 0.000 description 1
235000010216 calcium carbonate Nutrition 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
229960000846 camphor Drugs 0.000 description 1
229930008380 camphor Natural products 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
201000003984 candidiasis Diseases 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
229960001631 carbomer Drugs 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
229960003034 caspofungin Drugs 0.000 description 1
JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
229960001139 cefazolin Drugs 0.000 description 1
MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 1
230000036232 cellulite Effects 0.000 description 1
229920001727 cellulose butyrate Polymers 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
229960001927 cetylpyridinium chloride Drugs 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
229910001919 chlorite Inorganic materials 0.000 description 1
229910052619 chlorite group Inorganic materials 0.000 description 1
KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
229940097572 chloromycetin Drugs 0.000 description 1
229960003677 chloroquine Drugs 0.000 description 1
WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 description 1
QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
239000012501 chromatography medium Substances 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
229960004375 ciclopirox olamine Drugs 0.000 description 1
229960002227 clindamycin Drugs 0.000 description 1
KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
238000003759 clinical diagnosis Methods 0.000 description 1
229960004022 clotrimazole Drugs 0.000 description 1
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
238000011260 co-administration Methods 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
229960003920 cocaine Drugs 0.000 description 1
230000002595 cold damage Effects 0.000 description 1
206010009887 colitis Diseases 0.000 description 1
238000001246 colloidal dispersion Methods 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000013329 compounding Methods 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
239000007859 condensation product Substances 0.000 description 1
230000001143 conditioned effect Effects 0.000 description 1
208000021779 congenital erosive and vesicular dermatosis Diseases 0.000 description 1
201000005332 contagious pustular dermatitis Diseases 0.000 description 1
238000011109 contamination Methods 0.000 description 1
239000000599 controlled substance Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
230000010485 coping Effects 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000002385 cottonseed oil Substances 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000001186 cumulative effect Effects 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
125000004977 cycloheptylene group Chemical group 0.000 description 1
QSAWQNUELGIYBC-UHFFFAOYSA-N cyclohexane-1,2-dicarboxylic acid Chemical compound OC(=O)C1CCCCC1C(O)=O QSAWQNUELGIYBC-UHFFFAOYSA-N 0.000 description 1
125000005725 cyclohexenylene group Chemical group 0.000 description 1
125000004956 cyclohexylene group Chemical group 0.000 description 1
125000004978 cyclooctylene group Chemical group 0.000 description 1
125000004979 cyclopentylene group Chemical group 0.000 description 1
230000006378 damage Effects 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
239000000850 decongestant Substances 0.000 description 1
229940124581 decongestants Drugs 0.000 description 1
206010061428 decreased appetite Diseases 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000003412 degenerative effect Effects 0.000 description 1
230000032798 delamination Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000000151 deposition Methods 0.000 description 1
210000004207 dermis Anatomy 0.000 description 1
239000003599 detergent Substances 0.000 description 1
238000002059 diagnostic imaging Methods 0.000 description 1
GWWPLLOVYSCJIO-UHFFFAOYSA-N dialuminum;calcium;disilicate Chemical compound [Al+3].[Al+3].[Ca+2].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] GWWPLLOVYSCJIO-UHFFFAOYSA-N 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
YGANSGVIUGARFR-UHFFFAOYSA-N dipotassium dioxosilane oxo(oxoalumanyloxy)alumane oxygen(2-) Chemical compound [O--].[K+].[K+].O=[Si]=O.O=[Al]O[Al]=O YGANSGVIUGARFR-UHFFFAOYSA-N 0.000 description 1
208000016097 disease of metabolism Diseases 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
229940043264 dodecyl sulfate Drugs 0.000 description 1
239000010459 dolomite Substances 0.000 description 1
229940059082 douche Drugs 0.000 description 1
229960003722 doxycycline Drugs 0.000 description 1
238000009509 drug development Methods 0.000 description 1
238000007908 dry granulation Methods 0.000 description 1
208000000718 duodenal ulcer Diseases 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
239000000428 dust Substances 0.000 description 1
238000010410 dusting Methods 0.000 description 1
208000019258 ear infection Diseases 0.000 description 1
239000002961 echo contrast media Substances 0.000 description 1
201000010582 ecthyma Diseases 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000003974 emollient agent Substances 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
230000012202 endocytosis Effects 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
239000002532 enzyme inhibitor Substances 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
125000003700 epoxy group Chemical group 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
208000028299 esophageal disease Diseases 0.000 description 1
208000019064 esophageal ulcer Diseases 0.000 description 1
210000003238 esophagus Anatomy 0.000 description 1
AKTYUTRHNMIXHM-UHFFFAOYSA-N ethenyl acetate;ethenyl prop-2-enoate Chemical compound CC(=O)OC=C.C=COC(=O)C=C AKTYUTRHNMIXHM-UHFFFAOYSA-N 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 description 1
210000002388 eustachian tube Anatomy 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000029142 excretion Effects 0.000 description 1
239000002360 explosive Substances 0.000 description 1
210000003414 extremity Anatomy 0.000 description 1
210000000887 face Anatomy 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
210000003746 feather Anatomy 0.000 description 1
239000010433 feldspar Substances 0.000 description 1
230000004761 fibrosis Effects 0.000 description 1
230000003176 fibrotic effect Effects 0.000 description 1
230000003890 fistula Effects 0.000 description 1
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
229960004884 fluconazole Drugs 0.000 description 1
229960004413 flucytosine Drugs 0.000 description 1
XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 description 1
229960002390 flurbiprofen Drugs 0.000 description 1
SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
210000002683 foot Anatomy 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
230000006870 function Effects 0.000 description 1
230000004927 fusion Effects 0.000 description 1
UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
230000009368 gene silencing by RNA Effects 0.000 description 1
210000004392 genitalia Anatomy 0.000 description 1
239000008103 glucose Substances 0.000 description 1
125000003827 glycol group Chemical group 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
239000010931 gold Substances 0.000 description 1
208000001786 gonorrhea Diseases 0.000 description 1
229960002867 griseofulvin Drugs 0.000 description 1
DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
230000012010 growth Effects 0.000 description 1
239000010440 gypsum Substances 0.000 description 1
229910052602 gypsum Inorganic materials 0.000 description 1
239000010442 halite Substances 0.000 description 1
229960001906 haloprogin Drugs 0.000 description 1
238000011597 hartley guinea pig Methods 0.000 description 1
210000003128 head Anatomy 0.000 description 1
231100000869 headache Toxicity 0.000 description 1
230000036541 health Effects 0.000 description 1
201000011066 hemangioma Diseases 0.000 description 1
239000011019 hematite Substances 0.000 description 1
229910052595 hematite Inorganic materials 0.000 description 1
208000014951 hematologic disease Diseases 0.000 description 1
208000014617 hemorrhoid Diseases 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
201000000284 histiocytoma Diseases 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
229960000890 hydrocortisone Drugs 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 description 1
208000000069 hyperpigmentation Diseases 0.000 description 1
230000003810 hyperpigmentation Effects 0.000 description 1
208000024326 hypersensitivity reaction type III disease Diseases 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000028993 immune response Effects 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
208000037798 influenza B Diseases 0.000 description 1
208000037799 influenza C Diseases 0.000 description 1
238000007641 inkjet printing Methods 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
238000007913 intrathecal administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
LIKBJVNGSGBSGK-UHFFFAOYSA-N iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Fe+3].[Fe+3] LIKBJVNGSGBSGK-UHFFFAOYSA-N 0.000 description 1
229910000015 iron(II) carbonate Inorganic materials 0.000 description 1
208000001875 irritant dermatitis Diseases 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
229930027917 kanamycin Natural products 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
229910052622 kaolinite Inorganic materials 0.000 description 1
210000001117 keloid Anatomy 0.000 description 1
230000003780 keratinization Effects 0.000 description 1
229960004125 ketoconazole Drugs 0.000 description 1
208000030175 lameness Diseases 0.000 description 1
210000002429 large intestine Anatomy 0.000 description 1
239000004816 latex Substances 0.000 description 1
229920000126 latex Polymers 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
231100000518 lethal Toxicity 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
MKXZASYAUGDDCJ-CGTJXYLNSA-N levomethorphan Chemical compound C([C@H]12)CCC[C@@]11CCN(C)[C@@H]2CC2=CC=C(OC)C=C21 MKXZASYAUGDDCJ-CGTJXYLNSA-N 0.000 description 1
229960004194 lidocaine Drugs 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
208000005592 lipodermatosclerosis Diseases 0.000 description 1
239000008206 lipophilic material Substances 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
229940057995 liquid paraffin Drugs 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
229960005015 local anesthetics Drugs 0.000 description 1
208000030208 low-grade fever Diseases 0.000 description 1
206010025135 lupus erythematosus Diseases 0.000 description 1
206010025226 lymphangitis Diseases 0.000 description 1
230000001926 lymphatic effect Effects 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
238000002595 magnetic resonance imaging Methods 0.000 description 1
206010025482 malaise Diseases 0.000 description 1
230000001071 malnutrition Effects 0.000 description 1
235000000824 malnutrition Nutrition 0.000 description 1
229910052748 manganese Inorganic materials 0.000 description 1
201000001441 melanoma Diseases 0.000 description 1
108020004084 membrane receptors Proteins 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
229960000901 mepacrine Drugs 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
229920003087 methylethyl cellulose Polymers 0.000 description 1
229960000282 metronidazole Drugs 0.000 description 1
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
229960002159 micafungin Drugs 0.000 description 1
PIEUQSKUWLMALL-YABMTYFHSA-N micafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@H](O)CC(N)=O)[C@H](O)[C@@H](O)C=2C=C(OS(O)(=O)=O)C(O)=CC=2)[C@@H](C)O)=O)=NO1 PIEUQSKUWLMALL-YABMTYFHSA-N 0.000 description 1
229960002509 miconazole Drugs 0.000 description 1
230000003641 microbiacidal effect Effects 0.000 description 1
229940124561 microbicide Drugs 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
231100000324 minimal toxicity Toxicity 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
229960005181 morphine Drugs 0.000 description 1
230000003232 mucoadhesive effect Effects 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
229910052627 muscovite Inorganic materials 0.000 description 1
201000005962 mycosis fungoides Diseases 0.000 description 1
229960004313 naftifine Drugs 0.000 description 1
OZGNYLLQHRPOBR-DHZHZOJOSA-N naftifine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)C\C=C\C1=CC=CC=C1 OZGNYLLQHRPOBR-DHZHZOJOSA-N 0.000 description 1
PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
229960002009 naproxen Drugs 0.000 description 1
CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
229940100652 nasal gel Drugs 0.000 description 1
239000007922 nasal spray Substances 0.000 description 1
229960003255 natamycin Drugs 0.000 description 1
NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 description 1
229930014626 natural product Natural products 0.000 description 1
230000008693 nausea Effects 0.000 description 1
201000008043 necrobiosis lipoidica Diseases 0.000 description 1
230000001338 necrotic effect Effects 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
230000001613 neoplastic effect Effects 0.000 description 1
WWJFFVUVFNBJTN-UHFFFAOYSA-N neopolyoxin C Natural products C=1C=C(O)C=NC=1C(O)C(C)C(N)C(=O)NC(C(O)=O)C(C(C1O)O)OC1N1C=CC(=O)NC1=O WWJFFVUVFNBJTN-UHFFFAOYSA-N 0.000 description 1
208000002040 neurosyphilis Diseases 0.000 description 1
201000000622 neurotic excoriation Diseases 0.000 description 1
239000002547 new drug Substances 0.000 description 1
229910052759 nickel Inorganic materials 0.000 description 1
WWJFFVUVFNBJTN-VHDFTHOZSA-N nikkomycin Z Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@H]2O)O)[C@H](NC(=O)[C@@H](N)[C@H](C)[C@H](O)C=2N=CC(O)=CC=2)C(O)=O)C=CC(=O)NC1=O WWJFFVUVFNBJTN-VHDFTHOZSA-N 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
239000002687 nonaqueous vehicle Substances 0.000 description 1
229940087419 nonoxynol-9 Drugs 0.000 description 1
229920004918 nonoxynol-9 Polymers 0.000 description 1
208000015380 nutritional deficiency disease Diseases 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
IOQPZZOEVPZRBK-UHFFFAOYSA-N octan-1-amine Chemical class CCCCCCCCN IOQPZZOEVPZRBK-UHFFFAOYSA-N 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
238000001543 one-way ANOVA Methods 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
229910052652 orthoclase Inorganic materials 0.000 description 1
PGZUMBJQJWIWGJ-ONAKXNSWSA-N oseltamivir phosphate Chemical group OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 PGZUMBJQJWIWGJ-ONAKXNSWSA-N 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
210000003101 oviduct Anatomy 0.000 description 1
229960003483 oxiconazole Drugs 0.000 description 1
QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
230000009984 peri-natal effect Effects 0.000 description 1
208000008494 pericarditis Diseases 0.000 description 1
230000003239 periodontal effect Effects 0.000 description 1
210000003200 peritoneal cavity Anatomy 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
230000008782 phagocytosis Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 description 1
229960003733 phenylephrine hydrochloride Drugs 0.000 description 1
150000003003 phosphines Chemical class 0.000 description 1
125000004437 phosphorous atom Chemical group 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-M phthalate(1-) Chemical compound OC(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-M 0.000 description 1
238000000053 physical method Methods 0.000 description 1
229960002702 piroxicam Drugs 0.000 description 1
QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
206010035116 pityriasis rubra pilaris Diseases 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
210000003281 pleural cavity Anatomy 0.000 description 1
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000024 polymyxin B Polymers 0.000 description 1
229960005266 polymyxin b Drugs 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
229940075065 polyvinyl acetate Drugs 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
201000011414 pompholyx Diseases 0.000 description 1
229960001589 posaconazole Drugs 0.000 description 1
RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 description 1
229920003124 powdered cellulose Polymers 0.000 description 1
235000019814 powdered cellulose Nutrition 0.000 description 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
229960004618 prednisone Drugs 0.000 description 1
230000002265 prevention Effects 0.000 description 1
238000007639 printing Methods 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
201000007094 prostatitis Diseases 0.000 description 1
229960000856 protein c Drugs 0.000 description 1
208000005333 pulmonary edema Diseases 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
208000005069 pulmonary fibrosis Diseases 0.000 description 1
208000029561 pustule Diseases 0.000 description 1
239000005297 pyrex Substances 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
GPKJTRJOBQGKQK-UHFFFAOYSA-N quinacrine Chemical compound C1=C(OC)C=C2C(NC(C)CCCN(CC)CC)=C(C=CC(Cl)=C3)C3=NC2=C1 GPKJTRJOBQGKQK-UHFFFAOYSA-N 0.000 description 1
150000003248 quinolines Chemical class 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
208000006934 radiodermatitis Diseases 0.000 description 1
229950004154 ravuconazole Drugs 0.000 description 1
OPAHEYNNJWPQPX-RCDICMHDSA-N ravuconazole Chemical compound C=1SC([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=1C1=CC=C(C#N)C=C1 OPAHEYNNJWPQPX-RCDICMHDSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
208000002574 reactive arthritis Diseases 0.000 description 1
238000009877 rendering Methods 0.000 description 1
230000010076 replication Effects 0.000 description 1
230000003362 replicative effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
230000006903 response to temperature Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
201000004700 rosacea Diseases 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
238000011012 sanitization Methods 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
230000037390 scarring Effects 0.000 description 1
230000037387 scars Effects 0.000 description 1
208000008742 seborrheic dermatitis Diseases 0.000 description 1
208000013223 septicemia Diseases 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000002453 shampoo Substances 0.000 description 1
239000002911 sialidase inhibitor Substances 0.000 description 1
208000007056 sickle cell anemia Diseases 0.000 description 1
229910021646 siderite Inorganic materials 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000002884 skin cream Substances 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
210000004894 snout Anatomy 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229960002668 sodium chloride Drugs 0.000 description 1
NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
239000002910 solid waste Substances 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
210000000278 spinal cord Anatomy 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
229910052678 stilbite Inorganic materials 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000004575 stone Substances 0.000 description 1
229940041022 streptomycins Drugs 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
229960002607 sulconazole Drugs 0.000 description 1
125000004434 sulfur atom Chemical group 0.000 description 1
229920000247 superabsorbent polymer Polymers 0.000 description 1
239000004583 superabsorbent polymers (SAPs) Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000037946 swimming pool granuloma Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
208000002025 tabes dorsalis Diseases 0.000 description 1
229940061367 tamiflu Drugs 0.000 description 1
229910052713 technetium Inorganic materials 0.000 description 1
GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
206010043207 temporal arteritis Diseases 0.000 description 1
201000004415 tendinitis Diseases 0.000 description 1
DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
229960002722 terbinafine Drugs 0.000 description 1
229960000580 terconazole Drugs 0.000 description 1
FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
229920001897 terpolymer Polymers 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229910052716 thallium Inorganic materials 0.000 description 1
BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
150000003568 thioethers Chemical class 0.000 description 1
201000005882 tinea unguium Diseases 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
229960000707 tobramycin Drugs 0.000 description 1
NLVFBUXFDBBNBW-PBSUHMDJSA-S tobramycin(5+) Chemical compound [NH3+][C@@H]1C[C@H](O)[C@@H](C[NH3+])O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H]([NH3+])[C@H](O)[C@@H](CO)O2)O)[C@H]([NH3+])C[C@@H]1[NH3+] NLVFBUXFDBBNBW-PBSUHMDJSA-S 0.000 description 1
FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
229960004880 tolnaftate Drugs 0.000 description 1
210000002105 tongue Anatomy 0.000 description 1
206010044008 tonsillitis Diseases 0.000 description 1
231100000048 toxicity data Toxicity 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
210000003437 trachea Anatomy 0.000 description 1
108091005703 transmembrane proteins Proteins 0.000 description 1
102000035160 transmembrane proteins Human genes 0.000 description 1
238000004627 transmission electron microscopy Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
208000002271 trichotillomania Diseases 0.000 description 1
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
208000025883 type III hypersensitivity disease Diseases 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
210000000626 ureter Anatomy 0.000 description 1
210000003708 urethra Anatomy 0.000 description 1
229940044950 vaginal gel Drugs 0.000 description 1
239000000029 vaginal gel Substances 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
210000001177 vas deferen Anatomy 0.000 description 1
230000002792 vascular Effects 0.000 description 1
208000019553 vascular disease Diseases 0.000 description 1
201000002282 venous insufficiency Diseases 0.000 description 1
208000005925 vesicular stomatitis Diseases 0.000 description 1
229940117958 vinyl acetate Drugs 0.000 description 1
229920006163 vinyl copolymer Polymers 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
229950001272 viomycin Drugs 0.000 description 1
GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical compound N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1
230000009278 visceral effect Effects 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
229960004740 voriconazole Drugs 0.000 description 1
BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 description 1
230000004580 weight loss Effects 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000002023 wood Substances 0.000 description 1
230000037303 wrinkles Effects 0.000 description 1
238000004876 x-ray fluorescence Methods 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
229940072358 xylocaine Drugs 0.000 description 1
201000009482 yaws Diseases 0.000 description 1
239000005019 zein Substances 0.000 description 1
229940093612 zein Drugs 0.000 description 1
239000010457 zeolite Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CA002673313A 2006-12-18 2007-12-18 Phyllosilicates feuilletes interagissant avec un virus, et procedes d'utilisation Abandoned CA2673313A1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US96653806P	2006-12-18	2006-12-18
US96653706P	2006-12-18	2006-12-18
US60/966,538		2006-12-18
US60/966,537		2006-12-18
PCT/US2007/087922 WO2008147468A2 (fr)	2006-12-18	2007-12-18	Phyllosilicates feuilletés interagissant avec un virus, et procédés d'utilisation

Publications (1)

Publication Number	Publication Date
CA2673313A1 true CA2673313A1 (fr)	2008-12-04

Family

ID=39951566

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002673313A Abandoned CA2673313A1 (fr)	2006-12-18	2007-12-18	Phyllosilicates feuilletes interagissant avec un virus, et procedes d'utilisation

Country Status (2)

Country	Link
CA (1)	CA2673313A1 (fr)
WO (1)	WO2008147468A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20100272769A1 (en) *	2005-08-03	2010-10-28	Amcol International	Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use
WO2009052090A2 (fr) *	2007-10-15	2009-04-23	7 Oaks Pharmaceutical Corporation	Compositions à base de silicate et procédé de traitement
SG181421A1 (en)	2009-12-22	2012-07-30	Marinomed Biotechnologie Gmbh	Synergistic antiviral composition and use thereof
GB201402672D0 (en)	2014-02-14	2014-04-02	Medical Res Council	Materials and methods relating to stabilised polymeric silicate compositions
CN116057158A (zh) *	2020-07-27	2023-05-02	联合利华知识产权控股有限公司	酶和表面活性剂用于抑制微生物的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
US20050202984A1 (en) *	2003-03-18	2005-09-15	Schwartz James R.	Composition comprising zinc-containing layered material with a high relative zinc lability
US20070031512A1 (en) *	2005-08-03	2007-02-08	Amcol International Corporation	Virus-interacting layered phyllosilicates and methods of inactivating viruses

2007
- 2007-12-18 WO PCT/US2007/087922 patent/WO2008147468A2/fr not_active Ceased
- 2007-12-18 CA CA002673313A patent/CA2673313A1/fr not_active Abandoned

Also Published As

Publication number	Publication date
WO2008147468A2 (fr)	2008-12-04
WO2008147468A3 (fr)	2009-02-12

Publication	Publication Date	Title
US20070231412A1 (en)	2007-10-04	Virus-interacting layered phyllosilicates and methods of inactivating viruses in the gastrointestinal tract
US20080184618A1 (en)	2008-08-07	Virus-Interacting Layered Phyllosilicates and Methods of Use
US20100272769A1 (en)	2010-10-28	Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use
López-Galindo et al.	2004	Pharmaceutical and cosmetic applications of clays
JP2007513959A (ja)	2007-05-31	抗ウイルス性薬学的組成物
EA018138B1 (ru)	2013-05-30	Применение йота-каррагенана в качестве противовирусного ингредиента
JP2000510836A (ja)	2000-08-22	いかなる感染（特にｈｉｖを含むｓｔｄ）、炎症、腫瘍、またはいかなる他の粘膜及び／または皮膚の疾患を予防及び／または治療するための方法及び処方
CA2673313A1 (fr)	2008-12-04	Phyllosilicates feuilletes interagissant avec un virus, et procedes d'utilisation
JP2002515410A (ja)	2002-05-28	広域スペクトルの殺菌用及び殺精子用の組成物、装置、及び方法
Barrera et al.	2010	In vivo evaluation of albendazole microspheres for the treatment of Toxocara canis larva migrans
AU2015211356A1 (en)	2016-09-08	Combination product for the prevention of sexually transmitted infections
JP7752675B2 (ja)	2025-10-10	ウイルスに対するタウロリジンの使用
WO2018015465A1 (fr)	2018-01-25	Composés virucides et leurs utilisations
AU772123B2 (en)	2004-04-08	Oxihumic acid and its use in the treatment of various conditions
JP2010508356A (ja)	2010-03-18	ナノ粒子を用いた酵素活性に対する阻害
TW202023948A (zh)	2020-07-01	奈米矽凝膠及其抗菌和抗病毒的應用
US11298393B2 (en)	2022-04-12	Composition comprising a mixture of an extract and bentonite
CN101998856A (zh)	2011-03-30	锌/甲氧苄啶结合治疗
KR102603469B1 (ko)	2023-11-17	퓨리톤을 포함하는 covid-19 살바이러스 조성물 및 그 용도
Ghosh et al.	2023	Clays in the Global War Against COVID-19: Why are They Preferable Over the Conventional Weaponry?
CN114903914B (zh)	2023-03-28	金纳米材料在抑制冠状病毒中的应用
CN117357558A (zh)	2024-01-09	二维纳米材料cips在抑制冠状病毒变异株中的应用
Umudi et al.	2025	Environmental and Medicinal Impacts of Clay
El-Mohamady et al.	0	International Journal of Veterinary Science and Medicine
KR20240172693A (ko)	2024-12-10	일라이트를 포함하는 항바이러스 조성물 및 이의 용도

Legal Events

Date	Code	Title	Description
2013-02-12	FZDE	Discontinued	Effective date: 20121218