CA2513130A1 - Inhalateur de poudre - Google Patents
Inhalateur de poudre Download PDFInfo
- Publication number
- CA2513130A1 CA2513130A1 CA002513130A CA2513130A CA2513130A1 CA 2513130 A1 CA2513130 A1 CA 2513130A1 CA 002513130 A CA002513130 A CA 002513130A CA 2513130 A CA2513130 A CA 2513130A CA 2513130 A1 CA2513130 A1 CA 2513130A1
- Authority
- CA
- Canada
- Prior art keywords
- capsule
- chamber
- powder
- mouthpiece
- powder inhaler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000843 powder Substances 0.000 title claims abstract description 83
- 239000002775 capsule Substances 0.000 claims abstract description 191
- 239000012528 membrane Substances 0.000 claims abstract description 12
- 238000005507 spraying Methods 0.000 claims abstract description 3
- 238000005520 cutting process Methods 0.000 claims description 26
- 239000013543 active substance Substances 0.000 claims description 23
- 239000000463 material Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- 239000000443 aerosol Substances 0.000 claims description 15
- 238000009472 formulation Methods 0.000 claims description 15
- 239000004033 plastic Substances 0.000 claims description 10
- 229920003023 plastic Polymers 0.000 claims description 10
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 5
- 238000005530 etching Methods 0.000 claims description 4
- 150000004756 silanes Chemical class 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 150000002739 metals Chemical class 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 238000000151 deposition Methods 0.000 claims description 2
- 238000000608 laser ablation Methods 0.000 claims description 2
- 238000003754 machining Methods 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 239000002245 particle Substances 0.000 description 18
- 238000003860 storage Methods 0.000 description 14
- 239000003814 drug Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 5
- 229920001600 hydrophobic polymer Polymers 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 239000005030 aluminium foil Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229960001022 fenoterol Drugs 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229920006267 polyester film Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000001828 Gelatine Substances 0.000 description 1
- 229920006360 Hostaflon Polymers 0.000 description 1
- 241000950638 Symphysodon discus Species 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000035508 accumulation Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- HOQADATXFBOEGG-UHFFFAOYSA-N isofenphos Chemical compound CCOP(=S)(NC(C)C)OC1=CC=CC=C1C(=O)OC(C)C HOQADATXFBOEGG-UHFFFAOYSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 238000007645 offset printing Methods 0.000 description 1
- 239000004482 other powder Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000004071 soot Substances 0.000 description 1
- 238000000992 sputter etching Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
- A61M15/0026—Hinged caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0222—Materials for reducing friction
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
L'invention concerne des inhalateurs de poudre dont au moins une partie des surfaces intérieures venant en contact avec l'aérosol de poudre est microstructurée. De tels inhalateurs de poudre ne présentent pas de comportement de pulvérisation plus mauvais que les inhalateurs de poudre ayant une surface intérieure lisse dans ces zones. En outre, de telles surfaces microstructurées peuvent être particulièrement bien nettoyées simplement avec de l'eau. L'invention concerne également une capsule, un emballage-coque et une membrane de transport à surface intérieure et à surface extérieure microstructurées.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2003100982 DE10300982A1 (de) | 2003-01-14 | 2003-01-14 | Pulverinhalator |
| DE10300982.5 | 2003-01-14 | ||
| PCT/EP2003/014692 WO2004062716A1 (fr) | 2003-01-14 | 2003-12-20 | Inhalateur de poudre |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2513130A1 true CA2513130A1 (fr) | 2004-07-29 |
Family
ID=32519905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002513130A Abandoned CA2513130A1 (fr) | 2003-01-14 | 2003-12-20 | Inhalateur de poudre |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1590026A1 (fr) |
| JP (1) | JP2006512958A (fr) |
| AU (1) | AU2003294927A1 (fr) |
| CA (1) | CA2513130A1 (fr) |
| DE (1) | DE10300982A1 (fr) |
| WO (1) | WO2004062716A1 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8281784B2 (en) | 2006-04-11 | 2012-10-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Mouthpiece for an inhaler |
| US8584669B2 (en) | 2006-04-13 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhaler |
| US8875701B2 (en) | 2006-04-11 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Inhaler |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005001332A1 (de) * | 2005-01-11 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| GB0503738D0 (en) | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
| DE102005022862A1 (de) * | 2005-05-18 | 2006-12-14 | Airsec S.A.S | Kapseln für Inhalatoren |
| EP2082764A1 (fr) * | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International GmbH | Inhalateur |
| DE102008014025A1 (de) | 2008-03-13 | 2009-09-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator und Sieb für einen Inhalator |
| SG170635A1 (en) * | 2009-10-22 | 2011-05-30 | Novartis Ag | Contact lens package with micro-textured interior bowl surface |
| TR201008226A2 (tr) * | 2010-10-07 | 2012-04-24 | Bi̇lgi̇ç Mahmut | Kapsül içeren bir inhalasyon cihazı. |
| WO2012078804A1 (fr) * | 2010-12-07 | 2012-06-14 | Respira Therapeutics, Inc. | Inhalateur de poudre sèche |
| WO2013174752A2 (fr) | 2012-05-21 | 2013-11-28 | Boehringer Ingelheim International Gmbh | Système composé d'un inhalateur et d'une capsule |
| EP2614848B1 (fr) | 2012-01-13 | 2020-07-01 | Boehringer Ingelheim International GmbH | Inhalateur et capsule pour inhalateur |
| PL2714162T3 (pl) | 2011-05-27 | 2020-08-24 | Boehringer Ingelheim International Gmbh | Inhalator i kapsułka do inhalatora |
| JP6365848B2 (ja) * | 2012-05-21 | 2018-08-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 吸入器及びカプセルで構成されたシステム |
| EP4646376A1 (fr) * | 2023-01-06 | 2025-11-12 | K & A Investments LLC | Capsule pour distribution de poudre dosée |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4318455A1 (de) * | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Kapselhalterung |
| ES2128071T3 (es) * | 1994-07-29 | 1999-05-01 | Wilhelm Barthlott | Superficies autolimpiables de objetos, asi como procedimiento para su produccion. |
| NZ332242A (en) * | 1996-04-25 | 2000-04-28 | Schuckmann Alfred Von | Inhaler including a suction tube, for insertion into a blister pack, and a support unit for the suction tube and blister pack |
| US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| IL127449A0 (en) * | 1996-06-10 | 1999-10-28 | Sarnoff Corp | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| GB9626233D0 (en) * | 1996-12-18 | 1997-02-05 | Chawla Brinda P S | Medicament packaging and deliveery device |
| DE20114878U1 (de) * | 2001-09-08 | 2002-03-28 | Späth, Bernd, 74248 Ellhofen | Oberfläche mit verbesserten Eigenschaften |
-
2003
- 2003-01-14 DE DE2003100982 patent/DE10300982A1/de not_active Withdrawn
- 2003-12-20 JP JP2004566012A patent/JP2006512958A/ja active Pending
- 2003-12-20 CA CA002513130A patent/CA2513130A1/fr not_active Abandoned
- 2003-12-20 WO PCT/EP2003/014692 patent/WO2004062716A1/fr not_active Ceased
- 2003-12-20 AU AU2003294927A patent/AU2003294927A1/en not_active Abandoned
- 2003-12-20 EP EP03785906A patent/EP1590026A1/fr not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8281784B2 (en) | 2006-04-11 | 2012-10-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Mouthpiece for an inhaler |
| US8875701B2 (en) | 2006-04-11 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Inhaler |
| US8584669B2 (en) | 2006-04-13 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhaler |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003294927A1 (en) | 2004-08-10 |
| JP2006512958A (ja) | 2006-04-20 |
| EP1590026A1 (fr) | 2005-11-02 |
| WO2004062716A1 (fr) | 2004-07-29 |
| DE10300982A1 (de) | 2004-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |