CA2503491A1 - Compositions, organismes et procedes faisant appel a une nouvelle proteine phosphatase humaine - Google Patents
Compositions, organismes et procedes faisant appel a une nouvelle proteine phosphatase humaine Download PDFInfo
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- CA2503491A1 CA2503491A1 CA002503491A CA2503491A CA2503491A1 CA 2503491 A1 CA2503491 A1 CA 2503491A1 CA 002503491 A CA002503491 A CA 002503491A CA 2503491 A CA2503491 A CA 2503491A CA 2503491 A1 CA2503491 A1 CA 2503491A1
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- homo sapiens
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- 238000013060 ultrafiltration and diafiltration Methods 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000009777 vacuum freeze-drying Methods 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- QAOHCFGKCWTBGC-QHOAOGIMSA-N wybutosine Chemical compound C1=NC=2C(=O)N3C(CC[C@H](NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O QAOHCFGKCWTBGC-QHOAOGIMSA-N 0.000 description 1
- QAOHCFGKCWTBGC-UHFFFAOYSA-N wybutosine Natural products C1=NC=2C(=O)N3C(CCC(NC(=O)OC)C(=O)OC)=C(C)N=C3N(C)C=2N1C1OC(CO)C(O)C1O QAOHCFGKCWTBGC-UHFFFAOYSA-N 0.000 description 1
- WCNMEQDMUYVWMJ-JPZHCBQBSA-N wybutoxosine Chemical compound C1=NC=2C(=O)N3C(CC([C@H](NC(=O)OC)C(=O)OC)OO)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WCNMEQDMUYVWMJ-JPZHCBQBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention se rapporte à des compositions, à des organismes et à des procédés faisant appel à un nouveau gène humain codant une protéine qui présente une homologie de séquence avec une séquence consensus de la famille des phosphoestérases de type calcineurine. La nouvelle protéine est codée par un gène humain comprenant 4 exons. Le gène humain est localisé dans le locus 10p15 du chromosome humain 10. Les similarités de séquence entre la nouvelle protéine humaine et la séquence de consensus des phosphoestérases de type calcineurine indiquent que la nouvelle protéine humaine peut jouer le rôle d'une protéine phosphatase de type calcineurine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42075702P | 2002-10-24 | 2002-10-24 | |
| US60/420,757 | 2002-10-24 | ||
| PCT/US2003/033703 WO2004038026A2 (fr) | 2002-10-24 | 2003-10-24 | Compositions, organismes et procedes faisant appel a une nouvelle proteine phosphatase humaine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2503491A1 true CA2503491A1 (fr) | 2004-05-06 |
Family
ID=32176624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002503491A Abandoned CA2503491A1 (fr) | 2002-10-24 | 2003-10-24 | Compositions, organismes et procedes faisant appel a une nouvelle proteine phosphatase humaine |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7208306B2 (fr) |
| EP (1) | EP1554385A2 (fr) |
| AU (1) | AU2003284887A1 (fr) |
| CA (1) | CA2503491A1 (fr) |
| WO (1) | WO2004038026A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003064621A2 (fr) * | 2002-02-01 | 2003-08-07 | Ambion, Inc. | Courts fragments d'arn interferant haute activite visant a reduire l'expression de genes cibles |
| US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| CA2474910A1 (fr) | 2002-02-01 | 2003-08-07 | Sequitur, Inc. | Compositions oligonucleotidiques presentant une efficacite amelioree |
| US20040248094A1 (en) * | 2002-06-12 | 2004-12-09 | Ford Lance P. | Methods and compositions relating to labeled RNA molecules that reduce gene expression |
| US20100075423A1 (en) * | 2002-06-12 | 2010-03-25 | Life Technologies Corporation | Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference |
| GB2406169B (en) * | 2002-06-12 | 2006-11-01 | Ambion Inc | Methods and compositions relating to labeled rna molecules that reduce gene expression |
| WO2005042705A2 (fr) * | 2003-10-22 | 2005-05-12 | The Trustees Of The University Of Pennsylvania | Composes de petits arn interferents et de micro-arn, et procede pour les concevoir, les produire et les utiliser |
| US20060142228A1 (en) * | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
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| US4489710A (en) | 1981-06-23 | 1984-12-25 | Xoma Corporation | Composition and method for transplantation therapy |
| ATE75483T1 (de) | 1981-10-23 | 1992-05-15 | Molecular Biosystems Inc | Oligonukleotides heilmittel und dessen herstellungsverfahren. |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4625014A (en) | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4638045A (en) | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| US5498531A (en) | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| JP2002508299A (ja) | 1997-09-19 | 2002-03-19 | セクイター， インク． | センスｍＲＮＡ治療 |
| FR2771422B1 (fr) | 1997-11-21 | 2001-07-27 | Centre Nat Rech Scient | Reactifs et methodes pour la detection de genes lies au complexe majeur d'histocompatibilite d'oiseaux d'elevage, tels que le poulet |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| KR20010112944A (ko) | 1999-04-21 | 2001-12-22 | 이곤 이 버그 | 폴리뉴클레오티드 서열의 기능을 억제하기 위한 방법 및조성물 |
| CA2383244A1 (fr) | 1999-05-28 | 2000-12-07 | Sugen, Inc. | Proteines kinases |
| WO2001029058A1 (fr) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Genes de voies d'interference d'arn en tant qu'outils d'interference genetique ciblee |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| JP2004504009A (ja) | 2000-03-06 | 2004-02-12 | スージェン・インコーポレーテッド | 新規ヒト蛋白質キナーゼおよび蛋白質キナーゼ様酵素 |
| JP2003526367A (ja) | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Ｒｎａ干渉の方法とｒｎａ干渉組成物 |
| AU2001240375A1 (en) | 2000-03-17 | 2001-10-03 | Benitec Australia Limited | Genetic silencing |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| JP4901051B2 (ja) | 2000-05-30 | 2012-03-21 | ジョンソン アンド ジョンソン リサーチ プロプライアトリー リミテッド | ＲＮＡｉを増強する因子を使用することによって遺伝子抑制を媒介する方法 |
| WO2002008399A2 (fr) | 2000-07-21 | 2002-01-31 | Incyte Genomics, Inc. | Kinases humaines |
| WO2002018557A2 (fr) | 2000-08-31 | 2002-03-07 | Incyte Genomics, Inc. | Kinases humaines |
| AU2001292870A1 (en) * | 2000-09-21 | 2002-04-02 | Incyte Genomics, Inc. | Protein phosphatases |
| EP1379628A2 (fr) | 2000-12-06 | 2004-01-14 | Incyte Genomics, Inc. | Sequences de kinase et phosphatase, et leur utilisation |
| US6743619B1 (en) | 2001-01-30 | 2004-06-01 | Nuvelo | Nucleic acids and polypeptides |
| US20040038881A1 (en) | 2001-08-31 | 2004-02-26 | Olga Bandman | Human kinases |
| WO2003050084A2 (fr) | 2001-12-07 | 2003-06-19 | Incyte Genomics, Inc. | Kinases and phosphatases |
-
2003
- 2003-10-24 CA CA002503491A patent/CA2503491A1/fr not_active Abandoned
- 2003-10-24 US US10/691,529 patent/US7208306B2/en not_active Expired - Fee Related
- 2003-10-24 EP EP03779208A patent/EP1554385A2/fr not_active Withdrawn
- 2003-10-24 WO PCT/US2003/033703 patent/WO2004038026A2/fr not_active Ceased
- 2003-10-24 AU AU2003284887A patent/AU2003284887A1/en not_active Abandoned
-
2007
- 2007-04-16 US US11/787,345 patent/US20080178307A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7208306B2 (en) | 2007-04-24 |
| WO2004038026A2 (fr) | 2004-05-06 |
| EP1554385A2 (fr) | 2005-07-20 |
| US20040091926A1 (en) | 2004-05-13 |
| WO2004038026A3 (fr) | 2004-07-29 |
| US20080178307A1 (en) | 2008-07-24 |
| AU2003284887A1 (en) | 2004-05-13 |
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