CA2575882A1 - Nouveaux derives 2-amino benzimidazole et utilisation de ceux-ci comme modulateurs des canaux de potassium actives par calcium a faible conductance - Google Patents
Nouveaux derives 2-amino benzimidazole et utilisation de ceux-ci comme modulateurs des canaux de potassium actives par calcium a faible conductance Download PDFInfo
- Publication number
- CA2575882A1 CA2575882A1 CA002575882A CA2575882A CA2575882A1 CA 2575882 A1 CA2575882 A1 CA 2575882A1 CA 002575882 A CA002575882 A CA 002575882A CA 2575882 A CA2575882 A CA 2575882A CA 2575882 A1 CA2575882 A1 CA 2575882A1
- Authority
- CA
- Canada
- Prior art keywords
- benzimidazol
- tetrahydro
- naphtylamine
- disease
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 102000002582 Small-Conductance Calcium-Activated Potassium Channels Human genes 0.000 title abstract description 5
- 108010093479 Small-Conductance Calcium-Activated Potassium Channels Proteins 0.000 title abstract description 5
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 15
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Abstract
La présente invention concerne de nouveaux dérivés 2-amino benzimidazole qui conviennent comme modulateurs des canaux de potassium activés par calcium à faible conductance (canaux SK). Dans d'autres aspects, cette invention concerne l'utilisation de ces composés dans une technique de thérapie et des compositions pharmaceutiques comprenant les composés de l'invention.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401191 | 2004-08-05 | ||
| DKPA200401191 | 2004-08-05 | ||
| US59902504P | 2004-08-06 | 2004-08-06 | |
| US60/599,025 | 2004-08-06 | ||
| PCT/EP2005/053792 WO2006013210A2 (fr) | 2004-08-05 | 2005-08-03 | Nouveaux derives 2-amino benzimidazole et utilisation de ceux-ci comme modulateurs des canaux de potassium actives par calcium a faible conductance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2575882A1 true CA2575882A1 (fr) | 2006-02-09 |
Family
ID=35508344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002575882A Abandoned CA2575882A1 (fr) | 2004-08-05 | 2005-08-03 | Nouveaux derives 2-amino benzimidazole et utilisation de ceux-ci comme modulateurs des canaux de potassium actives par calcium a faible conductance |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7737167B2 (fr) |
| EP (1) | EP1776348B1 (fr) |
| JP (1) | JP2008509111A (fr) |
| AT (1) | ATE396977T1 (fr) |
| AU (1) | AU2005268782A1 (fr) |
| CA (1) | CA2575882A1 (fr) |
| DE (1) | DE602005007241D1 (fr) |
| MX (1) | MX2007001325A (fr) |
| WO (1) | WO2006013210A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120309796A1 (en) | 2011-06-06 | 2012-12-06 | Fariborz Firooznia | Benzocycloheptene acetic acids |
| CN102718663A (zh) * | 2012-06-21 | 2012-10-10 | 台州市华南医化有限公司 | 一种5-氯-1-茚胺的合成方法 |
| CN109153667B (zh) * | 2016-02-24 | 2021-04-02 | 阿塞西翁制药公司 | 新型钾通道抑制剂 |
| EP3668841A1 (fr) * | 2017-08-14 | 2020-06-24 | Acesion Pharma ApS | Benzimidazoles substitués utiles en tant qu'inhibiteurs du canal potassium |
| CA3072668A1 (fr) * | 2017-08-23 | 2019-02-28 | Acesion Pharma Aps | Derives de benzimidazole utiles comme inhibiteurs de canal potassique |
| CA3211188A1 (fr) | 2021-03-22 | 2022-09-29 | Acesion Pharma Aps | Nouveaux inhibiteurs du canal potassique |
| EP4245753A1 (fr) | 2022-03-17 | 2023-09-20 | Acesion Pharma ApS | Dérivés de l'imidazole comme inhibiteurs du canal de potassium |
| WO2024040266A2 (fr) * | 2022-08-19 | 2024-02-22 | Mitokinin, Inc. | Analogues de benzoimidazole et d'indole disubstitués en tant que modulateurs de pink1 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE292120T1 (de) * | 1998-07-02 | 2005-04-15 | Neurosearch As | Kaliumkanal-blockierende mittel |
| ATE296814T1 (de) * | 1999-05-12 | 2005-06-15 | Neurosearch As | Ionenkanal modulierende mittel |
| WO2001002406A1 (fr) * | 1999-06-29 | 2001-01-11 | Neurosearch A/S | Agents bloquant les canaux potassiques |
| US7132439B2 (en) | 2002-05-13 | 2006-11-07 | Icagen, Inc. | Bis-benzimidazoles and related compounds as potassium channel modulators |
| AU2003271548A1 (en) * | 2002-10-13 | 2004-05-04 | Neurosearch A/S | Use of skca channel blocking drugs for combating parkinson's disease |
| MX2010005343A (es) * | 2007-11-16 | 2010-08-09 | Neuraxon Inc | Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina. |
-
2005
- 2005-08-03 AT AT05776133T patent/ATE396977T1/de not_active IP Right Cessation
- 2005-08-03 WO PCT/EP2005/053792 patent/WO2006013210A2/fr not_active Ceased
- 2005-08-03 DE DE602005007241T patent/DE602005007241D1/de not_active Expired - Lifetime
- 2005-08-03 JP JP2007524345A patent/JP2008509111A/ja active Pending
- 2005-08-03 EP EP05776133A patent/EP1776348B1/fr not_active Expired - Lifetime
- 2005-08-03 MX MX2007001325A patent/MX2007001325A/es not_active Application Discontinuation
- 2005-08-03 CA CA002575882A patent/CA2575882A1/fr not_active Abandoned
- 2005-08-03 US US11/628,970 patent/US7737167B2/en not_active Expired - Fee Related
- 2005-08-03 AU AU2005268782A patent/AU2005268782A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006013210A3 (fr) | 2006-05-04 |
| AU2005268782A1 (en) | 2006-02-09 |
| WO2006013210A2 (fr) | 2006-02-09 |
| EP1776348A2 (fr) | 2007-04-25 |
| JP2008509111A (ja) | 2008-03-27 |
| MX2007001325A (es) | 2008-03-13 |
| DE602005007241D1 (de) | 2008-07-10 |
| US7737167B2 (en) | 2010-06-15 |
| ATE396977T1 (de) | 2008-06-15 |
| EP1776348B1 (fr) | 2008-05-28 |
| US20070197618A1 (en) | 2007-08-23 |
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| FZDE | Discontinued |
Effective date: 20090803 |