CA2429100A1 - Microparticules destinees a l'administration parenterale - Google Patents
Microparticules destinees a l'administration parenterale Download PDFInfo
- Publication number
- CA2429100A1 CA2429100A1 CA002429100A CA2429100A CA2429100A1 CA 2429100 A1 CA2429100 A1 CA 2429100A1 CA 002429100 A CA002429100 A CA 002429100A CA 2429100 A CA2429100 A CA 2429100A CA 2429100 A1 CA2429100 A1 CA 2429100A1
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- Prior art keywords
- starch
- microparticles
- process according
- active substance
- biologically active
- Prior art date
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
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- 229920002545 silicone oil Polymers 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne un procédé permettant de produire des microparticules contenant une substance active au niveau biologique. Ce procédé consiste à préparer une solution aqueuse de ladite substance, à mélanger cette solution avec une solution aqueuse de PEG telle que la substance est concentrée et/ou solidifiée, à nettoyer éventuellement la substance, à mélanger la substance avec une solution d'amidon aqueuse, à mélanger la composition obtenue, après addition de la solution d'amidon, avec une solution polymère, de manière à former une émulsion de gouttelettes d'amidon dans la solution polymère, les gouttelettes d'amidon étant solidifiées dans des microparticules, à sécher les microparticules et appliquer éventuellement une coquille de régulation d'administration à ses microparticules. L'invention concerne également les nouvelles microparticules pouvant être obtenues à l'aide de ce procédé.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004218-4 | 2000-11-16 | ||
| SE0004218A SE518008C2 (sv) | 2000-11-16 | 2000-11-16 | Parenteralt administrerbara mikropartiklar och förfarande för framställning av desamma |
| US26049601P | 2001-01-08 | 2001-01-08 | |
| US60/260,496 | 2001-01-08 | ||
| PCT/SE2001/002166 WO2002039985A1 (fr) | 2000-11-16 | 2001-10-05 | Microparticules destinees a l'administration parenterale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2429100A1 true CA2429100A1 (fr) | 2002-05-23 |
Family
ID=26655308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002429100A Abandoned CA2429100A1 (fr) | 2000-11-16 | 2001-10-05 | Microparticules destinees a l'administration parenterale |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1333814A1 (fr) |
| JP (1) | JP2004513914A (fr) |
| AU (1) | AU2001292527A1 (fr) |
| CA (1) | CA2429100A1 (fr) |
| WO (1) | WO2002039985A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0201599D0 (sv) | 2002-03-21 | 2002-05-30 | Skyepharma Ab | Microparticles |
| EA200501422A1 (ru) * | 2003-03-04 | 2006-04-28 | Дзе Текнолоджи Девелопмент Компани Лтд. | Длительнодействующая инъецируемая композиция инсулина и способы её изготовления и применения |
| JP2007531701A (ja) * | 2003-07-18 | 2007-11-08 | バクスター・インターナショナル・インコーポレイテッド | 制御された相分離により調製される小球状粒子の作製方法、使用および組成物 |
| CA2566075A1 (fr) * | 2004-05-12 | 2005-12-01 | Baxter Healthcare S.A. | Microspheres contenant des proteines et presentant un potentiel d'injectabilite a d'importants degres de concentration de l'agent concerne |
| US20100008982A1 (en) * | 2006-04-24 | 2010-01-14 | Eyal Shimoni | Non-covalent complexes of bioactive agents with starch for oral delivery |
| EP2902783B1 (fr) * | 2012-09-28 | 2017-08-30 | Sekisui Medical Co., Ltd. | Additif permettant de mesurer un échantillon dilué au moyen d'un réactif dans le cadre d'un procédé immunochromatographique sans dilution |
| CN106535875B (zh) * | 2014-05-27 | 2022-03-18 | 港大科桥有限公司 | 全水性乳液的渗透干燥 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713249A (en) * | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| SE459005B (sv) * | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
-
2001
- 2001-10-05 WO PCT/SE2001/002166 patent/WO2002039985A1/fr not_active Ceased
- 2001-10-05 AU AU2001292527A patent/AU2001292527A1/en not_active Abandoned
- 2001-10-05 CA CA002429100A patent/CA2429100A1/fr not_active Abandoned
- 2001-10-05 EP EP01972893A patent/EP1333814A1/fr not_active Withdrawn
- 2001-10-05 JP JP2002542360A patent/JP2004513914A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1333814A1 (fr) | 2003-08-13 |
| WO2002039985A1 (fr) | 2002-05-23 |
| JP2004513914A (ja) | 2004-05-13 |
| AU2001292527A1 (en) | 2002-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |