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CA2420210A1 - Procede stereoselectif pour preparer des derives de cyclohexylamine - Google Patents

Procede stereoselectif pour preparer des derives de cyclohexylamine Download PDF

Info

Publication number
CA2420210A1
CA2420210A1 CA002420210A CA2420210A CA2420210A1 CA 2420210 A1 CA2420210 A1 CA 2420210A1 CA 002420210 A CA002420210 A CA 002420210A CA 2420210 A CA2420210 A CA 2420210A CA 2420210 A1 CA2420210 A1 CA 2420210A1
Authority
CA
Canada
Prior art keywords
compound
formula
optionally substituted
alkyl
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002420210A
Other languages
English (en)
Inventor
Michael Edward Kobierski
Rui Lin Gu
Charles Jackson Barnett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2420210A1 publication Critical patent/CA2420210A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de préparation d'acide (1R,3S)-3-(9-chloro-3-méthyl-4-oxo-5H-(isoxazoloquinoline-5-yl))cyclohexanecarboxylique et d'esters de celui-ci, représentés par les formules II et III. Dans les formules, R représente des groupes alkyle inférieurs, et A et B représentent N ou O, à condition que si A représente N, B représente O, ou si A représente O, B représente N.
CA002420210A 2000-09-22 2001-09-13 Procede stereoselectif pour preparer des derives de cyclohexylamine Abandoned CA2420210A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23464900P 2000-09-22 2000-09-22
US60/234,649 2000-09-22
PCT/US2001/026023 WO2002024705A1 (fr) 2000-09-22 2001-09-13 Procede stereoselectif pour preparer des derives de cyclohexylamine

Publications (1)

Publication Number Publication Date
CA2420210A1 true CA2420210A1 (fr) 2002-03-28

Family

ID=22882230

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002420210A Abandoned CA2420210A1 (fr) 2000-09-22 2001-09-13 Procede stereoselectif pour preparer des derives de cyclohexylamine

Country Status (5)

Country Link
EP (1) EP1322652A1 (fr)
JP (1) JP2004509897A (fr)
AU (1) AU2001294518A1 (fr)
CA (1) CA2420210A1 (fr)
WO (1) WO2002024705A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12015501678B1 (en) 2009-06-17 2022-07-06 Vertex Pharma Inhibitors of influenza viruses replication
CN102485726B (zh) * 2010-12-02 2015-07-01 天津药明康德新药开发有限公司 一种1-r-1’-螺-(哌啶-4,4’-喹啉)-2’(3’-氢)酮的制备方法
KR20130128436A (ko) 2010-12-16 2013-11-26 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
RU2013132683A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3468099A (en) * 1998-04-08 1999-10-25 Eli Lilly And Company Methods for inhibiting mrp1
US6369070B1 (en) * 1998-04-08 2002-04-09 Eli Lilly And Company Methods for inhibiting mrp1

Also Published As

Publication number Publication date
WO2002024705A1 (fr) 2002-03-28
AU2001294518A1 (en) 2002-04-02
JP2004509897A (ja) 2004-04-02
EP1322652A1 (fr) 2003-07-02

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Legal Events

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