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CA2415236A1 - Novispirines: peptides antimicrobiens - Google Patents

Novispirines: peptides antimicrobiens Download PDF

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Publication number
CA2415236A1
CA2415236A1 CA002415236A CA2415236A CA2415236A1 CA 2415236 A1 CA2415236 A1 CA 2415236A1 CA 002415236 A CA002415236 A CA 002415236A CA 2415236 A CA2415236 A CA 2415236A CA 2415236 A1 CA2415236 A1 CA 2415236A1
Authority
CA
Canada
Prior art keywords
antimicrobial
peptide
ile
isoleucine
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002415236A
Other languages
English (en)
Inventor
Robert I. Lehrer
Alan J. Waring
Brian F. Tack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Iowa Research Foundation UIRF
University of California San Diego UCSD
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/840,009 external-priority patent/US6492328B2/en
Application filed by Individual filed Critical Individual
Publication of CA2415236A1 publication Critical patent/CA2415236A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture, Treatment Of Glass Fibers (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Les peptides de novispirine sont des agents antimicrobiens avec une activité efficace contre les bactéries Gram négatif. Ces peptides sont non hémolytiques, présentent une cytotoxicité in vivo réduite par rapport à d'autres peptides antimicrobiens, et ils ont été bien tolérés in vivo après une injection intraveineuse. Ces novispirines se lient aussi avec la lipopolysaccharide (LPS), propriété qui peut atténuer les symptômes associés à l'infection par la bactérie Gram négatif. On administre une composition pharmaceutique comprenant de la novispirine comme principe actif à un patient souffrant d'une infection microbienne ou prédisposé à cette infection, et plus particulièrement aux infections par la bactérie Gram négatif.
CA002415236A 2000-06-28 2001-06-13 Novispirines: peptides antimicrobiens Abandoned CA2415236A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60685800A 2000-06-28 2000-06-28
US09/606,858 2000-06-28
US09/840,009 US6492328B2 (en) 2000-06-28 2001-04-19 Novispirins: antimicrobial peptides
US09/840,009 2001-04-19
PCT/US2001/019094 WO2002000839A2 (fr) 2000-06-28 2001-06-13 Novispirines: peptides antimicrobiens

Publications (1)

Publication Number Publication Date
CA2415236A1 true CA2415236A1 (fr) 2002-01-03

Family

ID=27085347

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002415236A Abandoned CA2415236A1 (fr) 2000-06-28 2001-06-13 Novispirines: peptides antimicrobiens

Country Status (7)

Country Link
EP (1) EP1359930A4 (fr)
JP (1) JP2004526663A (fr)
AU (1) AU2001268421A1 (fr)
BR (1) BR0112035A (fr)
CA (1) CA2415236A1 (fr)
IL (1) IL153556A0 (fr)
WO (1) WO2002000839A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7071293B1 (en) * 1999-08-18 2006-07-04 The University Of Iowa Research Foundation Alpha helical peptides with broad spectrum antimicrobial activity that are insensitive to salt
DE60326226D1 (de) * 2002-03-21 2009-04-02 Cayman Chemical Co Prostaglandin f2 alpha analoga in kombination mit einem antimikrobiellen mittel zur behandlung von glaukom
WO2005092365A2 (fr) * 2004-03-29 2005-10-06 Novozymes A/S Utilisation pharmaceutique des novispirines
US7148404B2 (en) * 2004-05-04 2006-12-12 Novozymes A/S Antimicrobial polypeptides
JP5384948B2 (ja) * 2007-02-09 2014-01-08 ジェノミディア株式会社 新規ポリペプチド及びそれを有効成分として含有する抗菌剤
GB201115910D0 (en) 2011-09-14 2011-10-26 Univ Manchester Peptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7470400A (en) * 1999-08-18 2001-03-13 Regents Of The University Of California, The Cathelicidin-derived peptides with broad spectrum antimicrobial activity

Also Published As

Publication number Publication date
EP1359930A4 (fr) 2004-07-14
IL153556A0 (en) 2003-07-06
BR0112035A (pt) 2006-02-21
WO2002000839A2 (fr) 2002-01-03
JP2004526663A (ja) 2004-09-02
WO2002000839A3 (fr) 2003-08-28
EP1359930A2 (fr) 2003-11-12
AU2001268421A1 (en) 2002-01-08

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Legal Events

Date Code Title Description
FZDE Discontinued