CA2476832A1 - Utilisation d'un inhibiteur ou antagoniste du facteur tissulaire - Google Patents
Utilisation d'un inhibiteur ou antagoniste du facteur tissulaire Download PDFInfo
- Publication number
- CA2476832A1 CA2476832A1 CA002476832A CA2476832A CA2476832A1 CA 2476832 A1 CA2476832 A1 CA 2476832A1 CA 002476832 A CA002476832 A CA 002476832A CA 2476832 A CA2476832 A CA 2476832A CA 2476832 A1 CA2476832 A1 CA 2476832A1
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- Prior art keywords
- islets
- inhibitor
- use according
- diabetes
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000003999 initiator Substances 0.000 description 1
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- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 229940112216 novoseven Drugs 0.000 description 1
- 229910052762 osmium Inorganic materials 0.000 description 1
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 1
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- 229960001476 pentoxifylline Drugs 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
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- 108010041201 prothrombin fragment 1 Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 description 1
- 229960002026 pyrithione Drugs 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Marine Sciences & Fisheries (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne l'utilisation d'un inhibiteur ou antagoniste du facteur tissulaire (TF) dans la production d'un médicament destiné au traitement ou à la prévention du diabète ou des maladies liées au diabète. Cet inhibiteur ou cet antagoniste est principalement destiné au traitement de patients diabétiques souffrant du diabète respectivement de type I ou II ainsi que du syndrome métabolique précédant le diabète de type II. Cet inhibiteur ou cet antagoniste est un agent qui inhibe complètement ou partiellement les productions TF, telles qu'un anticorps anti-TF ou une construction antisens agissant sur le gène TF.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0200545-2 | 2002-02-22 | ||
| SE0200545A SE0200545D0 (sv) | 2002-02-22 | 2002-02-22 | Use of an inhibitor or antagonist against tissue factor |
| SE0203540-0 | 2002-11-28 | ||
| SE0203540A SE0203540D0 (sv) | 2002-02-21 | 2002-11-28 | Use of an inhibilor or antagonist against lissue factor |
| PCT/SE2003/000289 WO2003070275A1 (fr) | 2002-02-22 | 2003-02-21 | Utilisation d'un inhibiteur ou antagoniste du facteur tissulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2476832A1 true CA2476832A1 (fr) | 2003-08-28 |
Family
ID=27759837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002476832A Abandoned CA2476832A1 (fr) | 2002-02-22 | 2003-02-21 | Utilisation d'un inhibiteur ou antagoniste du facteur tissulaire |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050255111A1 (fr) |
| EP (1) | EP1476186A1 (fr) |
| JP (1) | JP2005528343A (fr) |
| KR (1) | KR20050004785A (fr) |
| CN (1) | CN1646162A (fr) |
| AP (1) | AP2004003113A0 (fr) |
| AU (1) | AU2003206571A1 (fr) |
| CA (1) | CA2476832A1 (fr) |
| CO (1) | CO5611170A2 (fr) |
| IL (1) | IL163605A0 (fr) |
| MX (1) | MXPA04008061A (fr) |
| NO (1) | NO20043960L (fr) |
| NZ (1) | NZ535199A (fr) |
| RU (1) | RU2315621C2 (fr) |
| TN (1) | TNSN04160A1 (fr) |
| WO (1) | WO2003070275A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
| RS56599B1 (sr) | 2010-06-15 | 2018-02-28 | Genmab As | Konjugati humanog antitela sa lekom protiv tkivnog faktora |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| CN112739716B (zh) | 2018-05-07 | 2025-05-27 | 展马博联合股份有限公司 | 使用抗pd-1抗体与抗组织因子抗体-药物偶联物的组合治疗癌症的方法 |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| CN115944738B (zh) * | 2022-12-13 | 2024-06-18 | 华中科技大学同济医学院附属同济医院 | 补体c3裂解抑制剂在制备治疗糖尿病心肌病的药物中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506134A (en) * | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
| WO1995028167A1 (fr) * | 1994-04-13 | 1995-10-26 | Research Corporation Technologies, Inc. | Procedes de traitement de maladies a l'aide de cellules de sertoli et des allogreffes ou xenogreffes |
| EP0833911B1 (fr) * | 1995-06-07 | 2004-05-12 | Ortho Pharmaceutical Corporation | Anticorps contre la thromboplastine tissulaire comportant des regions de determination complementaire greffees et leurs methodes d'utilisation |
| GB9606452D0 (en) * | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
| US5981471A (en) * | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
| US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US6387366B1 (en) * | 1998-12-31 | 2002-05-14 | Alg Company | Methods for reducing adverse side effects associated with cellular transplantation |
| KR20070049251A (ko) * | 1999-10-27 | 2007-05-10 | 타녹스 인코퍼레이티드 | 조직 인자 길항제 및 그의 사용 방법 |
| AU5081401A (en) * | 2000-03-16 | 2001-10-03 | Genentech Inc | Anti-tissue factor antibodies with enhanced anticoagulant potency |
| US6579531B2 (en) * | 2000-06-16 | 2003-06-17 | Thomas T. Aoki | Method for treating heart disease and cardiovascular disease in diabetic and non-diabetic patients |
-
2003
- 2003-02-21 CA CA002476832A patent/CA2476832A1/fr not_active Abandoned
- 2003-02-21 AU AU2003206571A patent/AU2003206571A1/en not_active Abandoned
- 2003-02-21 US US10/505,279 patent/US20050255111A1/en not_active Abandoned
- 2003-02-21 RU RU2004128238/15A patent/RU2315621C2/ru not_active IP Right Cessation
- 2003-02-21 IL IL16360503A patent/IL163605A0/xx unknown
- 2003-02-21 EP EP03705622A patent/EP1476186A1/fr not_active Withdrawn
- 2003-02-21 WO PCT/SE2003/000289 patent/WO2003070275A1/fr not_active Ceased
- 2003-02-21 KR KR10-2004-7013097A patent/KR20050004785A/ko not_active Ceased
- 2003-02-21 MX MXPA04008061A patent/MXPA04008061A/es not_active Application Discontinuation
- 2003-02-21 AP APAP/P/2004/003113A patent/AP2004003113A0/en unknown
- 2003-02-21 CN CNA038090651A patent/CN1646162A/zh active Pending
- 2003-02-21 JP JP2003569230A patent/JP2005528343A/ja active Pending
- 2003-02-21 NZ NZ535199A patent/NZ535199A/xx unknown
-
2004
- 2004-08-20 TN TNP2004000160A patent/TNSN04160A1/en unknown
- 2004-09-21 CO CO04093610A patent/CO5611170A2/es not_active Application Discontinuation
- 2004-09-21 NO NO20043960A patent/NO20043960L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2004128238A (ru) | 2005-05-20 |
| IL163605A0 (en) | 2005-12-18 |
| NZ535199A (en) | 2006-03-31 |
| TNSN04160A1 (en) | 2007-03-12 |
| CN1646162A (zh) | 2005-07-27 |
| WO2003070275A1 (fr) | 2003-08-28 |
| CO5611170A2 (es) | 2006-02-28 |
| RU2315621C2 (ru) | 2008-01-27 |
| JP2005528343A (ja) | 2005-09-22 |
| AU2003206571A1 (en) | 2003-09-09 |
| US20050255111A1 (en) | 2005-11-17 |
| MXPA04008061A (es) | 2005-06-20 |
| EP1476186A1 (fr) | 2004-11-17 |
| AP2004003113A0 (en) | 2004-09-30 |
| NO20043960L (no) | 2004-11-10 |
| KR20050004785A (ko) | 2005-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |