CA2454246A1 - Mutants de cysteine et procedes de detection de liaison de ligands a des molecules biologiques - Google Patents

Mutants de cysteine et procedes de detection de liaison de ligands a des molecules biologiques Download PDF

Info

Publication number: CA2454246A1
Authority: CA; Canada
Prior art keywords: residue; cysteine; tbm; seq; reference value
Prior art date: 2001-08-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002454246A

Other languages

English (en)

Inventor

Robert S. Mcdowell

W. Michael Flanagan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Viracta Therapeutics Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-07

Filing date

2002-08-05

Publication date

2003-02-20

2001-10-17 Priority claimed from US09/981,547 external-priority patent/US20020022233A1/en

2001-11-21 Priority claimed from US09/990,421 external-priority patent/US6919178B2/en

2002-04-10 Priority claimed from US10/121,216 external-priority patent/US6998233B2/en

2002-08-05 Application filed by Individual filed Critical Individual

2003-02-20 Publication of CA2454246A1 publication Critical patent/CA2454246A1/fr

Status Abandoned legal-status Critical Current

Links

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RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
230000005740 tumor formation Effects 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
230000005760 tumorsuppression Effects 0.000 description 1
230000007306 turnover Effects 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
230000034512 ubiquitination Effects 0.000 description 1
238000010798 ubiquitination Methods 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
150000003721 vitamin K derivatives Chemical class 0.000 description 1
229940046010 vitamin k Drugs 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
238000002424 x-ray crystallography Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Bioinformatics & Computational Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

CA002454246A 2001-08-07 2002-08-05 Mutants de cysteine et procedes de detection de liaison de ligands a des molecules biologiques Abandoned CA2454246A1 (fr)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US31072501P	2001-08-07	2001-08-07
US60/310,725		2001-08-07
US09/981,547 US20020022233A1 (en)	1998-06-26	2001-10-17	Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
US09/981,547		2001-10-17
US09/990,421		2001-11-21
US09/990,421 US6919178B2 (en)	2000-11-21	2001-11-21	Extended tethering approach for rapid identification of ligands
US10/121,216		2002-04-10
US10/121,216 US6998233B2 (en)	1998-06-26	2002-04-10	Methods for ligand discovery
PCT/US2002/024921 WO2003014308A2 (fr)	2001-08-07	2002-08-05	Mutants de cysteine et procedes de detection de liaison de ligands a des molecules biologiques

Publications (1)

Publication Number	Publication Date
CA2454246A1 true CA2454246A1 (fr)	2003-02-20

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ID=27494353

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002454246A Abandoned CA2454246A1 (fr)	2001-08-07	2002-08-05	Mutants de cysteine et procedes de detection de liaison de ligands a des molecules biologiques

Country Status (7)

Country	Link
EP (1)	EP1421379A2 (fr)
JP (1)	JP2005503380A (fr)
CA (1)	CA2454246A1 (fr)
IL (1)	IL159900A0 (fr)
MX (1)	MXPA04001000A (fr)
NZ (1)	NZ530721A (fr)
WO (1)	WO2003014308A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7214487B2 (en)	1998-06-26	2007-05-08	Sunesis Pharmaceuticals, Inc.	Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
WO2003081210A2 (fr)	2002-03-21	2003-10-02	Sunesis Pharmaceuticals, Inc.	Identification d'inhibiteurs de kinase
AU2003270848A1 (en) *	2003-09-17	2005-04-27	Sunesis Pharmaceuticals, Inc.	Identification of kinase inhibitors
WO2025148785A1 (fr) *	2024-01-08	2025-07-17	Fbd Biologics Limited	Variants d'il-2 modifiés et leurs procédés d'utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE199109T1 (de) *	1992-03-27	2001-02-15	Akiko Itai	Verfahren zur analyse der struktur von stabilen zusammengesetzten biopolymerligandmolekuelen
US6010861A (en) *	1994-08-03	2000-01-04	Dgi Biotechnologies, Llc	Target specific screens and their use for discovering small organic molecular pharmacophores

2002
- 2002-08-05 CA CA002454246A patent/CA2454246A1/fr not_active Abandoned
- 2002-08-05 MX MXPA04001000A patent/MXPA04001000A/es not_active Application Discontinuation
- 2002-08-05 WO PCT/US2002/024921 patent/WO2003014308A2/fr not_active Ceased
- 2002-08-05 NZ NZ530721A patent/NZ530721A/en unknown
- 2002-08-05 JP JP2003519438A patent/JP2005503380A/ja not_active Withdrawn
- 2002-08-05 EP EP02761258A patent/EP1421379A2/fr not_active Withdrawn
- 2002-08-05 IL IL15990002A patent/IL159900A0/xx unknown

Also Published As

Publication number	Publication date
JP2005503380A (ja)	2005-02-03
WO2003014308A9 (fr)	2004-04-22
EP1421379A2 (fr)	2004-05-26
NZ530721A (en)	2006-09-29
IL159900A0 (en)	2004-06-20
WO2003014308A3 (fr)	2004-03-18
MXPA04001000A (es)	2004-06-25
WO2003014308A2 (fr)	2003-02-20

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Bienz	2014	Signalosome assembly by domains undergoing dynamic head-to-tail polymerization
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Hohwy et al.	2008	Novel prostaglandin D synthase inhibitors generated by fragment-based drug design
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Jenkins et al.	2003	Identification of small-molecule inhibitors of human angiogenin and characterization of their binding interactions guided by computational docking
CN1926152A (zh)	2007-03-07	改进的细胞因子设计
CA2454246A1 (fr)	2003-02-20	Mutants de cysteine et procedes de detection de liaison de ligands a des molecules biologiques
Bhandari et al.	2001	Functional inactivation of the human guanylyl cyclase C receptor: modeling and mutation of the protein kinase-like domain
Bocchinfuso et al.	2007	Structural and functional effects of disease‐causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP‐2
US20040014140A1 (en)	2004-01-22	Methods for identifying allosteric sites
Pérez et al.	2024	Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1
ZA200400342B (en)	2005-03-30	Cysteine mutants and methods for detecting ligand binding to biological molecules
AU2002326537A1 (en)	2003-02-24	Cysteine mutants and methods for detecting ligand binding to biological molecules
Saleh et al.	2002	Affinity of Stat2 for the subunits of the interferon alpha receptor
Chen et al.	2022	Structural mapping of BMP conformational epitopes and bioengineering design of osteogenic peptides to specifically target the epitope-binding sites

Legal Events

Date	Code	Title	Description
2008-08-05	FZDE	Discontinued