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CA2335598A1 - 2-fluoro-2-alkyl alkanoamides avec activite antiepileptique - Google Patents

2-fluoro-2-alkyl alkanoamides avec activite antiepileptique Download PDF

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Publication number
CA2335598A1
CA2335598A1 CA002335598A CA2335598A CA2335598A1 CA 2335598 A1 CA2335598 A1 CA 2335598A1 CA 002335598 A CA002335598 A CA 002335598A CA 2335598 A CA2335598 A CA 2335598A CA 2335598 A1 CA2335598 A1 CA 2335598A1
Authority
CA
Canada
Prior art keywords
fluoro
compound
alkyl
cyclopropyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CA002335598A
Other languages
English (en)
Inventor
Heinz Nau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2335598A1 publication Critical patent/CA2335598A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des 2-fluoro-2-alkyl alkanoamides représentés par la formule I, et les compositions pharmaceutiques les contenant. Ces composés et ces compositions sont utiles pour traiter et prévenir des crises telles que celles associées à l'épilepsie. Les composés de l'invention présentent un rapport thérapeutique amélioré par rapport à l'acide valproïque, en ce qui concerne les effets sédatifs et le potentiel tératogène. Ils présentent également une phamacocinétique et une pharmacodynamie améliorées.
CA002335598A 1998-06-22 1999-06-22 2-fluoro-2-alkyl alkanoamides avec activite antiepileptique Withdrawn CA2335598A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9028498P 1998-06-22 1998-06-22
US60/090,284 1998-06-22
PCT/US1999/013941 WO1999067199A1 (fr) 1998-06-22 1999-06-22 2-fluoro-2-alkyl alkanoamides avec activite antiepileptique

Publications (1)

Publication Number Publication Date
CA2335598A1 true CA2335598A1 (fr) 1999-12-29

Family

ID=22222110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002335598A Withdrawn CA2335598A1 (fr) 1998-06-22 1999-06-22 2-fluoro-2-alkyl alkanoamides avec activite antiepileptique

Country Status (6)

Country Link
EP (1) EP1089962A1 (fr)
JP (1) JP2002518469A (fr)
CN (1) CN1306503A (fr)
AU (1) AU4701399A (fr)
CA (1) CA2335598A1 (fr)
WO (1) WO1999067199A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004098A1 (en) 2003-07-28 2006-01-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compounds useful for treating neurological disorders

Also Published As

Publication number Publication date
JP2002518469A (ja) 2002-06-25
CN1306503A (zh) 2001-08-01
EP1089962A1 (fr) 2001-04-11
WO1999067199A1 (fr) 1999-12-29
AU4701399A (en) 2000-01-10

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Legal Events

Date Code Title Description
AZWI Withdrawn application