CA2331455A1 - Nouvelle molecule et methode diagnostique - Google Patents
Nouvelle molecule et methode diagnostique Download PDFInfo
- Publication number
- CA2331455A1 CA2331455A1 CA002331455A CA2331455A CA2331455A1 CA 2331455 A1 CA2331455 A1 CA 2331455A1 CA 002331455 A CA002331455 A CA 002331455A CA 2331455 A CA2331455 A CA 2331455A CA 2331455 A1 CA2331455 A1 CA 2331455A1
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- Prior art keywords
- dimer
- hla
- complex
- binding
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention se rapporte à un dimère sensiblement isolé comportant un premier et un second polypeptide réticulé qui comprennent les parties du domaine extracellulaire de la chaîne lourde de l'antigène HLA-B27 et sont susceptibles de se lier à un épitope de HLA-B27, ou à un analogue dimère ou multimère fonctionnel sensiblement isolé qui est susceptible de se lier audit épitope de HLA-B27 et/ou est en concurrence pour se lier à un récepteur spécifique associé audit dimère. Le dimère de cette invention peut servir à déterminer l'apparition d'une spondyloarthropathie ou la prédisposition à une telle maladie. Ce dimère peut également servir d'agent thérapeutique ou prophylactique de la spondyloarthropathie.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9810099.3A GB9810099D0 (en) | 1998-05-11 | 1998-05-11 | Novel molecule and diagnostic method |
| GB9810099.3 | 1998-05-11 | ||
| PCT/GB1999/001481 WO1999058557A2 (fr) | 1998-05-11 | 1999-05-11 | Nouvelle molecule et methode diagnostique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2331455A1 true CA2331455A1 (fr) | 1999-11-18 |
Family
ID=10831867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002331455A Abandoned CA2331455A1 (fr) | 1998-05-11 | 1999-05-11 | Nouvelle molecule et methode diagnostique |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1078055A2 (fr) |
| AU (1) | AU759065B2 (fr) |
| CA (1) | CA2331455A1 (fr) |
| GB (1) | GB9810099D0 (fr) |
| WO (1) | WO1999058557A2 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2361930A3 (fr) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimeres du complexes peptide-cmh et leur utilisation dans des maladies infectieuses de borrelia |
| EP2167537A2 (fr) | 2007-07-03 | 2010-03-31 | Dako Denmark A/S | Procedes compiles pour analyser et trier des echantillons |
| EP2197908A2 (fr) | 2007-09-27 | 2010-06-23 | Dako Denmark A/S | Multimères cmh dans le diagnostic, le vaccin et le traitement de la tuberculose |
| WO2009090651A2 (fr) * | 2008-01-15 | 2009-07-23 | Technion Research And Development Foundation Ltd. | Ligands des molécules hla-b2705 du complexe majeur d'histocompatibilité, utilisés à des fins de diagnostic et de traitement |
| DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
| US10722562B2 (en) | 2008-07-23 | 2020-07-28 | Immudex Aps | Combinatorial analysis and repair |
| GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| WO2010037402A1 (fr) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Vaccins moléculaires contre les maladies infectieuses |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
| CN104334741B (zh) | 2012-03-28 | 2018-08-17 | 歌德塔有限公司 | 组合的γ9δ2T细胞受体链交换 |
| CN107207622B (zh) * | 2015-02-04 | 2021-09-28 | 苏黎世大学 | Hla-b27同二聚体用于癌症治疗的用途 |
| KR102456666B1 (ko) | 2016-03-08 | 2022-10-19 | 유니버시타트 취리히 | ＨＬＡ-Ｂ５７ 개방 이형태체(open conformer) |
| EP3469361B1 (fr) | 2016-06-10 | 2024-07-31 | Gadeta B.V. | Nouveau procédé pour identifier des chaînes de récepteur delta t-cell ou des parties de ceux-ci qui induisent une réponse anti-infectieuse ou anti-tumorale |
| ES2949372T3 (es) * | 2016-08-10 | 2023-09-28 | Univ Zuerich | Confórmeros abiertos del CMH de clase Ia |
| CN110944658A (zh) | 2017-05-18 | 2020-03-31 | Umc乌德勒支控股有限公司 | 用于细胞靶向疗法的组合物和方法 |
| EP3898666A2 (fr) | 2018-12-17 | 2021-10-27 | Immudex ApS | Panneau comprenant des multimères de borrelia cmh |
| AU2022322029A1 (en) * | 2021-08-05 | 2024-02-15 | Immunos Therapeutics Ag | Combination medicaments comprising hla fusion proteins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489742A (en) * | 1990-10-23 | 1996-02-06 | Board Of Regents, The University Of Texas System | Transgenic rats and animal models of inflammatory disease |
| WO1997000084A1 (fr) * | 1995-06-16 | 1997-01-03 | President And Fellows Of Harvard College | Peptides non immunogenes bloquant le complexe majeur d'histocompatibilite (cmh) |
| CN1227263C (zh) * | 1996-09-18 | 2005-11-16 | 格希尔德·韦尔纳 | 用于自身免疫性疾病的诊断及治疗的肽 |
-
1998
- 1998-05-11 GB GBGB9810099.3A patent/GB9810099D0/en not_active Ceased
-
1999
- 1999-05-11 EP EP99921016A patent/EP1078055A2/fr not_active Withdrawn
- 1999-05-11 WO PCT/GB1999/001481 patent/WO1999058557A2/fr not_active Ceased
- 1999-05-11 AU AU38390/99A patent/AU759065B2/en not_active Ceased
- 1999-05-11 CA CA002331455A patent/CA2331455A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999058557A3 (fr) | 2000-02-10 |
| GB9810099D0 (en) | 1998-07-08 |
| AU3839099A (en) | 1999-11-29 |
| AU759065B2 (en) | 2003-04-03 |
| WO1999058557A2 (fr) | 1999-11-18 |
| EP1078055A2 (fr) | 2001-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |