[go: up one dir, main page]

DK2254592T3 - MHC-multimerer til Borrelia-diagnostik og sygdom - Google Patents

MHC-multimerer til Borrelia-diagnostik og sygdom

Info

Publication number
DK2254592T3
DK2254592T3 DK08872852.2T DK08872852T DK2254592T3 DK 2254592 T3 DK2254592 T3 DK 2254592T3 DK 08872852 T DK08872852 T DK 08872852T DK 2254592 T3 DK2254592 T3 DK 2254592T3
Authority
DK
Denmark
Prior art keywords
borrelia
diagnostics
disease
mhc multimers
multimers
Prior art date
Application number
DK08872852.2T
Other languages
English (en)
Inventor
Liselotte Brix
Henrik Pedersen
Jorgen Scholler
Original Assignee
Dako Denmark As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dako Denmark As filed Critical Dako Denmark As
Priority claimed from PCT/DK2008/000451 external-priority patent/WO2009106073A2/en
Application granted granted Critical
Publication of DK2254592T3 publication Critical patent/DK2254592T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK08872852.2T 2008-02-28 2008-12-30 MHC-multimerer til Borrelia-diagnostik og sygdom DK2254592T3 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6783108P 2008-02-28 2008-02-28
DKPA200800295 2008-02-28
DKPA200801011 2008-07-17
US8348108P 2008-07-24 2008-07-24
US10193108P 2008-10-01 2008-10-01
DKPA200801380 2008-10-01
PCT/DK2008/000451 WO2009106073A2 (en) 2008-02-28 2008-12-30 Mhc multimers in borrelia diagnostics and disease

Publications (1)

Publication Number Publication Date
DK2254592T3 true DK2254592T3 (da) 2019-09-09

Family

ID=67848651

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08872852.2T DK2254592T3 (da) 2008-02-28 2008-12-30 MHC-multimerer til Borrelia-diagnostik og sygdom

Country Status (2)

Country Link
US (1) US10968269B1 (da)
DK (1) DK2254592T3 (da)

Family Cites Families (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
AU530410B2 (en) 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
US4281061A (en) 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4387164A (en) 1980-11-05 1983-06-07 Fmc Corporation Method and apparatus for chemical analysis using reactive reagents dispersed in soluble film
NO155316C (no) 1982-04-23 1987-03-11 Sintef Fremgangsmaate for fremstilling av magnetiske polymerpartikler.
US4876190A (en) 1987-10-21 1989-10-24 Becton Dickinson & Company Peridinin-chlorophyll complex as fluorescent label
US5039487A (en) 1987-12-22 1991-08-13 Board Of Regents, The University Of Texas System Methods for quantifying components in liquid samples
DE68924850T2 (de) 1988-06-14 1996-10-10 Cell Med Inc Heterofunktionelle zellular immunologische reagenzien, impfstoffe daraus und verwendungsverfahren.
US6106840A (en) 1988-06-23 2000-08-22 Anergen, Inc. MHC conjugates useful in ameliorating autoimmunity
US5260422A (en) 1988-06-23 1993-11-09 Anergen, Inc. MHC conjugates useful in ameliorating autoimmunity
US5194425A (en) 1988-06-23 1993-03-16 Anergen, Inc. Mhc-mediated toxic conjugates useful in ameliorating autoimmunity
US5130297A (en) 1988-06-23 1992-07-14 Anergen, Inc. Conjugates useful in ameliorating autoimmunity MHC-II-peptide
US5468481A (en) 1988-06-23 1995-11-21 Amergen, Inc. MHC class II-peptide conjugates useful in ameliorating autoimmunity
DE3825615A1 (de) 1988-07-28 1990-02-01 Behringwerke Ag Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung
DE4015911A1 (de) 1989-09-19 1991-03-28 Max Planck Gesellschaft Impfstoff gegen die lyme-krankheit
WO1991009870A1 (de) 1989-12-22 1991-07-11 Mikrogen Molekularbiologische Entwicklungs-Gmbh Immunologisch aktive proteine von borrelia burgdorferi, zusammenhängende testkits und impfstoff
GB9007966D0 (en) 1990-04-09 1990-06-06 Dynal As Antigen/anti-antigen cleavage
CA2084413A1 (en) 1990-06-15 1991-12-16 Richard A. Flavell Compositions and methods for the prevention and diagnosis of lyme disease
IE76732B1 (en) 1990-08-07 1997-11-05 Becton Dickinson Co One step test for absolute counts
WO1994011078A1 (en) 1992-11-16 1994-05-26 Immunivest Corporation Magnetic immobilization and manipulation of biological entities
WO1992008983A1 (en) 1990-11-19 1992-05-29 Queen's University At Kingston Hiv marker/aids vaccine
CA2065658A1 (en) 1991-04-19 1992-10-20 Tse-Wen Chang Conjugates of liposomes or microbeads and antibodies specific for t lymphocytes and their use in vivo immune modulators
US6129916A (en) 1991-04-19 2000-10-10 Tanox, Inc. Method of Increasing activation on proliferation of T cells using antibody-microbead conjugates
DE69232875T2 (de) 1991-04-23 2003-08-21 Anergen, Inc. MHC-Konjugate zur Verbesserung der Autoimmunität.
WO1992021972A1 (en) 1991-06-06 1992-12-10 Immulogic Pharmaceutical Corporation Rapid screening assay for the identification of ligand-receptor interactions
DK0594772T3 (da) 1991-07-04 1997-02-24 Immunodex K S
US6872550B1 (en) 1991-07-11 2005-03-29 Baxter Vaccine Ag Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
DK0598816T3 (da) 1991-08-15 1999-11-22 Deutsches Krebsforsch Osp A-proteiner fra Borrelia Burgdorferi-undergrupper, hvilke proteiner koder for gener og vacciner
DK0650527T3 (da) 1991-10-22 2003-07-14 Symbicom Ab Forbedring af Borrelia burgdorferidiagnose og -profylakse
WO1993010220A1 (en) 1991-11-19 1993-05-27 Anergen, Inc. Soluble mhc molecules and their uses
US5583031A (en) 1992-02-06 1996-12-10 President And Fellows Of Harvard College Empty major histocompatibility class II heterodimers
EP0911036A3 (en) 1992-02-11 2001-05-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Dual carrier immunogenic construct
JP3167415B2 (ja) 1992-04-30 2001-05-21 オリンパス光学工業株式会社 固相免疫検査における抗原細胞の保存方法
DE69332268T2 (de) 1992-10-15 2003-08-14 Toray Industries, Inc. Verfahren zur herstellung von rekombinant mhcii protein in mikroorganismen
DE69332884T2 (de) 1992-10-21 2003-11-20 Stefan Miltenyi Direkte auswahl von zellen durch ein aussheidungsprodukt
WO1994012196A1 (en) 1992-11-25 1994-06-09 Tanox Biosystems, Inc. Conjugates and constructs including anti-cd28 and anti-cd3 binding molecules
US6090587A (en) 1993-10-25 2000-07-18 Corixa Corporation Prokaryotic expression of MHC proteins
EP0725838A4 (en) 1993-10-26 1997-02-26 United Biomedical Inc STRUCTURED SYNTHETIC ANTIGAN BANKS AS DIAGNOSTICS, VACCINE AND THERAPEUTIC AGENTS
WO2002016422A2 (en) 2000-08-18 2002-02-28 Research Foundation Of The State University Of New York Recombinant constructs of borrelia burgdorferi
CA2175567C (en) 1993-11-01 2010-08-10 John J. Dunn Chimeric proteins comprising borrelia polypeptides: uses therefor
US5620862A (en) 1993-11-24 1997-04-15 University Of Connecticut Methods for diagnosing early Lyme disease
CA2140591A1 (en) 1994-01-20 1995-07-21 Josef Endl Antigen-specific, activated t lymphocytes, detection and use
US7074904B2 (en) 1994-07-29 2006-07-11 Altor Bioscience Corporation MHC complexes and uses thereof
DE69534880T2 (de) 1994-07-29 2007-02-22 Sunol Molecular Corp., Miramar Mhc-komplexe und verwendungen davon
US5635363A (en) 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
US20030118594A1 (en) * 1995-06-07 2003-06-26 Bishwajit Nag Stable formulations of mhc-peptide complexes
WO1997005239A1 (en) 1995-07-25 1997-02-13 Celltherapy, Inc. Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
US5807552A (en) 1995-08-04 1998-09-15 Board Of Regents, The University Of Texas System Compositions for conferring immunogenicity to a substance and uses thereof
US6001964A (en) * 1995-09-20 1999-12-14 Albert Einstein College Of Medicine Of Yeshiva University Peptides which bind to anti-double stranded DNA antibody
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
US6458354B1 (en) 1996-03-28 2002-10-01 The Johns Hopkins University Molecular complexes which modify immune responses
US6140113A (en) 1996-03-28 2000-10-31 The Johns Hopkins University Polynucleotides encoding molecular complexes which modify immune responses
CA2250166A1 (en) 1996-03-28 1997-10-02 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
ATE232212T1 (de) 1996-05-02 2003-02-15 Dako As Verwendung von aus osp-c abgeleiteten peptidefragmenten für diagnostische methoden
AU3036597A (en) 1996-05-21 1997-12-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for using peptide complexes/major histocompatibility complex to obtain or purify antigen-specific t cells and to stimulate t cells
US5846946A (en) 1996-06-14 1998-12-08 Pasteur Merieux Serums Et Vaccins Compositions and methods for administering Borrelia DNA
US6211342B1 (en) 1996-07-18 2001-04-03 Children's Hospital Medical Center Multivalent MHC complex peptide fusion protein complex for stimulating specific T cell function
FR2751989B1 (fr) 1996-08-01 1998-10-30 Soc D Rech Et De Dev En Activa Methode d'identification de cellules eucaryotes par fixation desdites cellules sur un support et support pour mettre en oeuvre ladite methode
CA2262001C (en) 1996-08-05 2003-05-20 President And Fellows Of Harvard College Mhc binding peptide oligomers and methods of use
NZ333915A (en) 1996-08-16 2000-11-24 Harvard College Soluble monovalent and multivalent MHC class II fusion proteins
US20050003431A1 (en) 1996-08-16 2005-01-06 Wucherpfennig Kai W. Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor
US6074645A (en) 1996-11-12 2000-06-13 City Of Hope Immuno-reactive peptide CTL epitopes of human cytomegalovirus
US6562345B1 (en) 1996-11-12 2003-05-13 City Of Hope Immuno-reactive peptide CTL epitopes of human cytomegalovirus
CA2271784A1 (en) 1996-11-12 1998-05-22 City Of Hope Immuno-reactive peptide ctl epitopes of human cytomegalovirus
US6156317A (en) 1996-11-12 2000-12-05 City Of Hope Immuno-reactive peptide CTL epitopes of human cytomegalovirus
US6197928B1 (en) 1997-03-14 2001-03-06 The Regents Of The University Of California Fluorescent protein sensors for detection of analytes
US5998204A (en) 1997-03-14 1999-12-07 The Regents Of The University Of California Fluorescent protein sensors for detection of analytes
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
US5994089A (en) 1997-05-16 1999-11-30 Coulter International Corp. Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry
US5891741A (en) 1997-05-16 1999-04-06 Coulter International Corp. Antibody-aminodextran-phycobiliprotein conjugates
EP1003548B1 (en) 1997-07-10 2006-05-10 Mannkind Corporation Device for inducing a ctl response
US6248564B1 (en) 1997-08-29 2001-06-19 Harvard University Mutant MHC class I molecules
GB9718463D0 (en) 1997-08-29 1997-11-05 Dynal As Biomolecules
ES2323098T3 (es) 1997-09-16 2009-07-06 Oregon Health And Science University Moleculas de mhc recombinantes utiles para la manipulacion de celulas t especificas de antigeno.
DE19740735A1 (de) 1997-09-16 1999-03-18 Max Planck Gesellschaft Arzneimittel zur Therapie einer manifesten Lyme-Borreliose
US6232445B1 (en) 1997-10-29 2001-05-15 Sunol Molecular Corporation Soluble MHC complexes and methods of use thereof
NZ504951A (en) 1997-11-10 2001-06-29 Statens Seruminstitut Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
ES2272074T3 (es) 1998-01-19 2007-04-16 Florian Kern Procedimiento para la identificacion de fragmentos proteicos estimuladores de celulas t.
IL137706A0 (en) 1998-02-19 2001-10-31 Harvard College Mhc fusion proteins and conjugates
WO1999050637A2 (en) 1998-03-27 1999-10-07 Ludwig Institute For Cancer Research Isolated multimeric complexes useful in analysis of t cells, peptides useful in making the complexes, and uses thereof
EP0949508A1 (en) 1998-04-08 1999-10-13 Dako A/S Method, antigen complex and kit for diagnosing Lyme borreliosis
GB9810099D0 (en) 1998-05-11 1998-07-08 Isis Innovation Novel molecule and diagnostic method
WO1999060120A2 (en) 1998-05-19 1999-11-25 Avidex Limited Soluble t cell receptor
WO1999059633A1 (en) 1998-05-20 1999-11-25 Immunomedics, Inc. Therapeutics using a bispecific anti-hla class ii invariant chain x anti-pathogen antibody
DE69938183T2 (de) 1998-07-31 2009-02-19 Gundersen Lutheran Medical Foundation, Inc., La Crosse Verwendungen eines borreliaziden epitops des aussermembranproteins c von borrelia burgdorferi (ospc) als impstoff
MXPA01002674A (es) 1998-09-14 2002-06-04 Ostergaard Pedersen Lars Un metodo para producir una proteina de la superfamilia de inmunoglobulina funcional.
DE69918146T2 (de) 1998-10-05 2005-07-07 Pharmexa A/S Verfahren zur therapeutischen impfung
EP1135409A1 (en) 1998-10-09 2001-09-26 Medimmune, Inc. Decorin binding proteins dbp a and b and genes encoding them
WO2000023053A2 (en) 1998-10-20 2000-04-27 Salvatore Albani Artificial antigen-specific cells and related methods
ATE370967T1 (de) 1998-10-21 2007-09-15 Altor Bioscience Corp Polyspezifische bindemoleküle und deren verwendung
US6156514A (en) 1998-12-03 2000-12-05 Sunol Molecular Corporation Methods for making recombinant cells
US7116407B2 (en) 1998-12-15 2006-10-03 Union Biometrica, Inc. System for axial pattern analysis of multicellular organisms
US6335173B1 (en) 1999-01-12 2002-01-01 Verve, Ltd. C/O James Bell Methods for detecting an analyte of interest using tyramide coating technology
HK1041312B (en) 1999-04-16 2006-09-29 Ortho-Mcneil Pharmaceutical, Inc. Method for the detection of antigen specific t-cells
US7041442B1 (en) 1999-06-04 2006-05-09 Florian Kern Peptides for vaccinating against human CMV
WO2000078966A1 (en) 1999-06-18 2000-12-28 Research Foundation Of State University Of New York Groups of borrelia burgdorferi and borrelia afzelii that cause lyme disease in humans
US20040209314A1 (en) 1999-09-06 2004-10-21 Institut National De La Sante Et De La Recherche Medicale France Means for detection and purification of CD8+ T lymphocyte populations specific to peptides presented in the context of HLA
US20030104635A1 (en) 1999-09-21 2003-06-05 Avidex Limited Screening methods
GB9922352D0 (en) 1999-09-21 1999-11-24 Avidex Ltd Screening method
US6632435B1 (en) 1999-10-20 2003-10-14 City Of Hope CTL epitope analogs
US6605711B1 (en) 1999-11-15 2003-08-12 Ludwig Institute For Cancer Research NY-ESO-1 peptide derivatives, and uses thereof
DE10009341A1 (de) 2000-02-22 2001-09-06 Florian Kern Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten
US8609436B2 (en) 2000-03-17 2013-12-17 Guy's & St Thomas' Hospital NHS Trust (“GST”) Method
AU2001261005A1 (en) 2000-03-22 2001-10-03 Corixa Corporation Immune mediators and related methods
US6835383B2 (en) 2000-03-23 2004-12-28 City Of Hope Protein kinase deficient, immunologically active CMVpp65 mutants
AU2001249444A1 (en) 2000-03-28 2001-10-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for the simultaneous detection of multiple analytes
WO2001080833A1 (en) 2000-04-20 2001-11-01 Salvatore Albani Methods for isolation, quantification, characterization and modulation of antigen-specific t cells
WO2001090198A1 (en) 2000-05-24 2001-11-29 Ludwig Institute For Cancer Research Multicomponent conjugates which bind to target molecules and stimulate cell lysis
EP1287363A2 (en) 2000-05-25 2003-03-05 Sunol Molecular Corporation Modulation of t-cell receptor interactions
US6517838B1 (en) * 2000-06-16 2003-02-11 The Texas A&M University System Decorin binding protein essential peptides and methods of use
GB0018901D0 (en) 2000-08-03 2000-09-20 Biovation Ltd Peptides presented by cells
US7132109B1 (en) 2000-10-20 2006-11-07 University Of Connecticut Health Center Using heat shock proteins to increase immune response
EP1227321A1 (en) 2000-12-28 2002-07-31 Institut für Bioanalytik GmbH Reversible MHC multimer staining for functional purification of antigen-specific T cells
EP1349569B1 (en) 2001-01-12 2007-04-18 Becton Dickinson and Company Intrinsically fluorescent, self-multimerizing mhc fusion proteins and complexes thereof
US20020082411A1 (en) 2001-01-23 2002-06-27 Darrick Carter Immune mediators and related methods
ES2747357T3 (es) 2001-03-14 2020-03-10 Dako Denmark As Construcciones de moléculas MHC y sus usos para el diagnóstico y terapia
US7094555B2 (en) 2001-04-05 2006-08-22 Benaroya Research Institute At Virginia Mason Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
US20030199438A1 (en) 2001-04-09 2003-10-23 Shaw Allan Christian Method for identification of proteins from intracellular bacteria
DE10117858A1 (de) 2001-04-10 2002-10-24 Gsf Forschungszentrum Umwelt MHC-Tetramere
US6811785B2 (en) 2001-05-07 2004-11-02 Mount Sinai School Of Medicine Of New York University Multivalent MHC class II—peptide chimeras
US20040143094A1 (en) 2003-02-10 2004-07-22 Alena Donda Multicomponent conjugates which bind to target molecules and stimulate T cell lysis
US20040068100A1 (en) 2001-05-24 2004-04-08 Jean-Pierre Mach Multicomponent conjugates which bind to target molecules and stimulate cell lysis
AUPR593101A0 (en) 2001-06-26 2001-07-19 Council Of The Queensland Institute Of Medical Research, The Cytomegalovirus t cell epitopes
US7902121B2 (en) 2001-07-02 2011-03-08 The Board Of Trustees Of The Leland Stanford Junior University MHC-antigen arrays for detection and characterization of immune responses
GB0120042D0 (en) 2001-08-16 2001-10-10 Avidex Ltd Methods
EP1483575A2 (en) 2002-02-28 2004-12-08 Intercell AG Methods for isolating ligands e.g. t cell epitopes
US8895020B2 (en) 2002-04-19 2014-11-25 Washington University Single chain trimers and uses therefor
AU2003230366A1 (en) 2002-05-08 2003-11-11 Northwest Biotherapeutics, Inc. Quality assays for antigen presenting cells
AU2003273577A1 (en) 2002-05-30 2003-12-19 Sloan Kettering Institute For Cancer Research Suicide tetramers comprising mhc class i and uses thereof
EP1539215A2 (en) 2002-06-25 2005-06-15 City of Hope Adjuvant-free peptide vaccine
JP4619121B2 (ja) 2002-08-12 2011-01-26 ザ カウンシル オブ ザ クイーンズランド インスティテュート オブ メディカル リサーチ Tヘルパーエピトープおよび細胞傷害性tリンパ球(ctl)エピトープを含む新規な免疫原性リポペプチド
GB2392158B (en) 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof
GB0222846D0 (en) 2002-10-03 2002-11-06 Choo Yen Cell culture
EP1549748B1 (en) 2002-10-09 2014-10-01 Immunocore Ltd. Single chain recombinant t cell receptors
DE10247014A1 (de) 2002-10-09 2004-04-22 Erfle, Volker, Prof. Priv.-Doz. Dr. MHC-Multimere
US20040072262A1 (en) 2002-10-11 2004-04-15 Montero-Julian Felix A. Methods and systems for detecting MHC class I binding peptides
US20040223977A1 (en) 2003-02-03 2004-11-11 City Of Hope Fusion peptide HIV vaccines
DE10310261A1 (de) 2003-03-05 2004-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Identifizierung von Antigen-Epitopen
KR100818689B1 (ko) 2003-03-10 2008-04-02 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 간엽계 간세포의 식별방법
US20060018878A1 (en) 2003-03-11 2006-01-26 City Of Hope Dual antigen specific T cells with trafficking ability
CA2520675A1 (en) 2003-03-24 2004-10-07 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Identification, quantification, and characterization of t cells and t cell antigens
US7163685B2 (en) 2003-04-16 2007-01-16 City Of Hope Human cytomegalovirus antigens expressed in MVA and methods of use
DK1635863T3 (da) 2003-06-17 2010-11-22 Mannkind Corp Sammensætninger til udløsning, forbedring og opretholdelse af immunresponser mod MHC-klasse-i-begrænsede epitoper til profylaktiske eller terapeutiske formål
AU2004254367B2 (en) 2003-06-27 2008-06-19 Nanosphere, Inc. Bio-barcode based detection of target analytes
ATE432285T1 (de) 2003-07-11 2009-06-15 Alphavax Inc Cytomegalovirusimpfstoffe, die auf dem alphavirus basieren
US7364869B2 (en) 2003-07-29 2008-04-29 The J. David Gladstone Institutes Method of detecting antigen-specific T lymphocytes
GB0318096D0 (en) 2003-08-01 2003-09-03 Queen Mary & Westfield College Vaccine
GB2408507B (en) 2003-10-06 2005-12-14 Proimmune Ltd Chimeric MHC protein and oligomer thereof for specific targeting
RU2260047C2 (ru) 2003-10-23 2005-09-10 Государственное учреждение Научно-исследовательский институт биохимии Сибирского отделения Российской академии медицинских наук Рекомбинантная плазмидная днк, обеспечивающая синтез иммунодоминантного белка borrelia garinii, используемого для диагностики лайм-боррелиоза (варианты)
US20050095655A1 (en) 2003-11-03 2005-05-05 Montero-Julian Felix A. Solution-based methods for detecting MHC-binding peptides
US8772451B2 (en) 2003-11-10 2014-07-08 Altor Bioscience Corporation Soluble TCR molecules and methods of use
ES2323588T3 (es) 2003-11-19 2009-07-21 Merck Patent Gmbh Proteinas que pertenecen a la familia bcl-2 y fragmentos de las mismas, y su uso en pacientes con cancer.
CA2544577C (en) 2003-12-01 2013-01-08 Dako Denmark A/S Methods and compositions for immuno-histochemical detection
US7706782B1 (en) 2004-03-01 2010-04-27 Adobe Systems Incorporated System and method for developing information for a wireless information system
DE102004026135A1 (de) 2004-05-25 2006-01-05 Immatics Biotechnologies Gmbh An MHC-Moleküle bindende Tumor-assoziierte Peptide
WO2005115447A2 (en) 2004-05-25 2005-12-08 The Trustees Of The University Of Pennsylvania Human anti-cancer immunotherapy
EP1781313A4 (en) 2004-06-17 2009-08-26 Beckman Coulter Inc MYCOBACTERIUM TUBERCULOSIS EPITOPES AND METHODS OF USE
WO2006014292A2 (en) 2004-07-02 2006-02-09 Dattwyler Raymond J Oral vaccine for borrelia
US20060228758A1 (en) 2004-09-13 2006-10-12 Xencor, Inc. Analysis of MHC-peptide binding interactions
WO2006031883A2 (en) 2004-09-13 2006-03-23 Xencor, Inc. Analysis of mhc-peptide binding interactions
US20060228759A1 (en) 2004-09-13 2006-10-12 Xencor, Inc. Analysis of MHC-peptide binding interactions
DE102004054545A1 (de) 2004-09-16 2006-04-06 Max-Delbrück-Centrum für Molekulare Medizin Änderung des Beladungszustandes von MHC-Molekülen
US7976845B2 (en) 2004-11-29 2011-07-12 The Council Of The Queensland Institute Of Medical Research Human cytomegalovirus immunotherapy
EP1838342A2 (en) 2004-12-29 2007-10-03 Mannkind Corporation Methods to bypass cd+4 cells in the induction of an immune response
CA2593714C (en) 2005-02-04 2013-09-10 Survac Aps Survivin peptide vaccine
GB2422834B8 (en) 2005-02-04 2007-01-04 Proimmune Ltd MHC oligomer and method of making the same
US8541227B2 (en) 2005-02-25 2013-09-24 Dako Denmark A/S Cell counting
KR100677572B1 (ko) 2005-04-04 2007-02-02 삼성전자주식회사 전자사진방식 화상형성장치 및 현상방법
US20090130144A1 (en) 2005-04-15 2009-05-21 University Of Maryland, Baltimore Direct vaccination of the bone marrow
ATE501277T1 (de) 2005-07-01 2011-03-15 Dako Denmark As Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen
US7468186B2 (en) 2005-07-22 2008-12-23 City Of Hope Polyomavirus cellular epitopes and uses therefor
JP5390189B2 (ja) 2005-11-29 2014-01-15 ヴァージニア コモンウェルス ユニバーシティ 多価キメラospcワクシノーゲンおよび診断用抗原
US7502580B2 (en) 2005-11-30 2009-03-10 Xerox Corporation Two component development system using ion or electron charged toner
US20070134814A1 (en) 2005-12-09 2007-06-14 Kajander E O Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease
US20090061478A1 (en) 2006-01-30 2009-03-05 Lene Have Poulsen High-Speed Quantification of Antigen Specific T-Cells in Whole Blood by Flow Cytometry
US8518697B2 (en) 2006-04-04 2013-08-27 Washington University Single chain trimers and uses therefor
WO2007136778A2 (en) 2006-05-19 2007-11-29 Teva Pharmaceutical Industries, Ltd. Fusion proteins, uses thereof and processes for producing same
US20080171059A1 (en) 2006-08-07 2008-07-17 Shanshan Wu Howland Methods and compositions for increased priming of t-cells through cross-presentation of exogenous antigens
WO2008031133A2 (en) 2006-09-15 2008-03-20 Intercell Ag Borrelia antigens
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
US20090004213A1 (en) 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
WO2009003493A2 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
EP2254592B1 (en) 2008-02-28 2019-06-05 Dako Denmark A/S Mhc multimers in borrelia diagnostics and disease
US8815564B2 (en) 2008-03-14 2014-08-26 Sanofi Pasteur Biologics, Llc Replication-defective flavivirus vaccines and vaccine vectors
CN102112626A (zh) 2008-04-09 2011-06-29 加州理工学院 用于检测和/或分类靶标的捕获剂以及相关方法和系统
WO2009126816A1 (en) 2008-04-09 2009-10-15 Ventria Bioscience Production of ospa for lyme disease control
EP2281007B1 (en) 2008-04-10 2014-07-09 Thrombosis Research Institute Anti-atheroma vaccine
US20090324630A1 (en) 2008-04-21 2009-12-31 Jensen Michael C Fusion multiviral chimeric antigen
FR2931163B1 (fr) 2008-05-16 2013-01-18 Ets Francais Du Sang Lignee de cellules dendritiques plasmacytoides utilisee en therapie cellulaire active ou adoptive
EP3156069B8 (en) 2008-06-20 2020-10-21 Duke University Compositions, methods, and kits for eliciting an immune response
WO2010009735A2 (en) 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US20110318380A1 (en) 2008-10-01 2011-12-29 Dako Denmark A/S MHC Multimers in Cancer Vaccines and Immune Monitoring
WO2010037397A1 (en) 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cmv immune monitoring
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease

Also Published As

Publication number Publication date
US10968269B1 (en) 2021-04-06

Similar Documents

Publication Publication Date Title
DK2307459T3 (da) Notch1-receptorbindende midler og fremgangsmåder til anvendelse deraf
DK2304568T3 (da) Fremgangsmåde og system til fordelt raid-implementering
DK2346551T3 (da) Cylinderampul og kanylesystem til denne
DK3058875T3 (da) System til kosmetisk behandling og billedoptagelse
DK2309938T3 (da) Kryokirurgiske systemer og fremgangsmåder til anvendelse heraf
DK2337837T3 (da) Alpha-amylase-blandinger og fremgangsmåder til anvendelse heraf
DK2501890T3 (da) Kvældbart forbindelsessystem og fremgangsmåde til anvendelse af dette
DK2467173T3 (da) Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf
DK2358669T3 (da) Alpha-keto-persyrer og fremgangsmåder til fremstilling og anvendelse heraf
DK3614595T3 (da) Fremgangsmåde og indretning til forbedrede statusrapporter
DK2376519T3 (da) TGR5-modulatorer og fremgangsmåde til anvendelse deraf
EP2359230A4 (en) BACKGROUND AND PRESENTATION ARCHIVING METHOD
DK2700651T3 (da) Monovalente sammensætninger til cd28-binding og fremgangsmåder til anvendelse heraf
DK2331238T3 (da) Fremgangsmåde og enhed til fotosyntesestøttet co2-bortskaffelse
DK3622883T3 (da) Indførerer til medicinsk indretning og fremgangsmåder til at indføre og anvende medicinske indretninger
EP2351511A4 (en) MEDICAL DEVICE OF CAPSULE TYPE
DK3181134T3 (da) Bifidobakterier til behandling af diabetes og relaterede tilstande
BRPI0912622A2 (pt) poderosos peptídeos mhc da classe ii derivados de survivina
DK3128014T3 (da) Midler og fremgangsmåder til sterilisering af biofunktionelle sammensætninger
DK2270818T3 (da) Polyelektrolyt og fremgangsmåde til fremstilling af polyelektrolytten
DK2408807T3 (da) Fremgangsmåde til terapeutisk anvendelse
DK2192933T3 (da) Materialer til oftalmologisk og ortorhinolaryngologisk anordning
BRPI0915822A2 (pt) dispositivo médico
DK2222314T3 (da) Anvendelser og midler til opnåelse af bronchorelaxation
DK2326411T3 (da) Ekstraktionssystem og relateret fremgangsmåde