CA2318800C - Fluorine-containing amino acid derivatives - Google Patents
Fluorine-containing amino acid derivatives Download PDFInfo
- Publication number
- CA2318800C CA2318800C CA002318800A CA2318800A CA2318800C CA 2318800 C CA2318800 C CA 2318800C CA 002318800 A CA002318800 A CA 002318800A CA 2318800 A CA2318800 A CA 2318800A CA 2318800 C CA2318800 C CA 2318800C
- Authority
- CA
- Canada
- Prior art keywords
- group
- fluorine
- hexane
- acid
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1544498 | 1998-01-28 | ||
| JP10/15444 | 1998-01-28 | ||
| PCT/JP1999/000324 WO1999038839A1 (en) | 1998-01-28 | 1999-01-27 | Fluorine-containing amino acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2318800A1 CA2318800A1 (en) | 1999-08-25 |
| CA2318800C true CA2318800C (en) | 2005-12-20 |
Family
ID=11888991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002318800A Expired - Fee Related CA2318800C (en) | 1998-01-28 | 1999-01-27 | Fluorine-containing amino acid derivatives |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6316498B1 (ja) |
| EP (1) | EP1052246B1 (ja) |
| KR (1) | KR100446892B1 (ja) |
| CN (1) | CN1182105C (ja) |
| AT (1) | ATE236118T1 (ja) |
| AU (1) | AU734812B2 (ja) |
| CA (1) | CA2318800C (ja) |
| DE (1) | DE69906492T2 (ja) |
| DK (1) | DK1052246T3 (ja) |
| ES (1) | ES2191412T3 (ja) |
| PT (1) | PT1052246E (ja) |
| WO (1) | WO1999038839A1 (ja) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69918136T2 (de) | 1998-08-31 | 2005-07-07 | Taisho Pharmaceutical Co., Ltd. | 6-Fluorobicyclo[3.1.0]Hexan-Derivate |
| JP4399932B2 (ja) | 1998-12-18 | 2010-01-20 | 大正製薬株式会社 | 中間体及びそれを用いた含フッ素アミノ酸化合物の製造方法 |
| CA2427819A1 (en) * | 2000-10-30 | 2002-05-23 | Xue-Feng Pei | Method for modulation, stimulation, and inhibition of glutamate reuptake |
| US7038077B2 (en) | 2001-01-11 | 2006-05-02 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| EP1310480A1 (en) * | 2001-11-07 | 2003-05-14 | Eli Lilly & Company | Prodrugs of excitatory amino acids |
| CN1267407C (zh) | 2001-01-11 | 2006-08-02 | 伊莱利利公司 | 兴奋性氨基酸前体药物 |
| CA2441127A1 (en) * | 2001-03-14 | 2002-09-19 | Taisho Pharmaceutical Co., Ltd. | Process for producing bicyclocarboxylic acid derivative |
| US7456221B2 (en) | 2001-12-21 | 2008-11-25 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| JP4342437B2 (ja) | 2002-06-11 | 2009-10-14 | イーライ リリー アンド カンパニー | 興奮性アミノ酸のプロドラッグ |
| WO2006137469A1 (ja) * | 2005-06-22 | 2006-12-28 | Ajinomoto Co., Inc. | 代謝型グルタミン酸受容体活性化剤 |
| AR059898A1 (es) * | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| ATE516272T1 (de) | 2007-09-14 | 2011-07-15 | Ortho Mcneil Janssen Pharm | 1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one |
| RS51660B (sr) | 2007-09-14 | 2011-10-31 | Ortho-Mcneil-Janssen Pharmaceuticals Inc. | 1`,3`-disupstituisani-4-fenil-3,4,5,6-tetrahidro-2h, 1`h-[1,4`] bipiridinil-2`-oni |
| WO2009033703A1 (en) * | 2007-09-14 | 2009-03-19 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones |
| EP2220083B1 (en) * | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| KR20120035158A (ko) | 2009-05-12 | 2012-04-13 | 얀센 파마슈티칼즈, 인코포레이티드 | 1,２,４?트리아졸로［４,３?ａ］피리딘 유도체 및 ｍＧｌｕＲ２ 수용체의 양성 알로스테릭 조절자로서의 그의 용도 |
| US8937060B2 (en) | 2009-05-12 | 2015-01-20 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of prevention of neurological and psychiatric disorders |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CA2814996C (en) | 2010-11-08 | 2019-10-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN103298809B (zh) | 2010-11-08 | 2016-08-31 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| ES2587204T3 (es) | 2011-06-17 | 2016-10-21 | Eli Lilly And Company | Derivados de ácido biciclo (3.1.0) hexano-2,6-dicarboxílico como agonistas del receptor mGlu2 |
| EP2857385B1 (en) * | 2012-06-01 | 2017-08-02 | Taisho Pharmaceutical Co., Ltd. | Prodrug of fluorine-containing amino acid |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| CN109999033B (zh) | 2014-01-21 | 2022-12-23 | 詹森药业有限公司 | 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途 |
| HRP20191646T1 (hr) | 2014-01-21 | 2019-12-13 | Janssen Pharmaceutica Nv | Kombinacije koje sadržavaju pozitivne alosteričke modulatore ili ortosteričke agoniste metabotropnog glutamatergičnog receptora podtip 2 i njihova uporaba |
| CN105017048A (zh) * | 2015-07-01 | 2015-11-04 | 上海应用技术学院 | 一种含有四取代碳手性中心的α-氟烷基-α-氨基酸类化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL182285B1 (pl) | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| US5750566A (en) | 1994-08-12 | 1998-05-12 | Eli Lilly And Company | Synthetic excitatory amino acids |
| IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
-
1999
- 1999-01-27 DK DK99901877T patent/DK1052246T3/da active
- 1999-01-27 KR KR10-2000-7008189A patent/KR100446892B1/ko not_active Expired - Fee Related
- 1999-01-27 ES ES99901877T patent/ES2191412T3/es not_active Expired - Lifetime
- 1999-01-27 AU AU21835/99A patent/AU734812B2/en not_active Ceased
- 1999-01-27 AT AT99901877T patent/ATE236118T1/de active
- 1999-01-27 CA CA002318800A patent/CA2318800C/en not_active Expired - Fee Related
- 1999-01-27 WO PCT/JP1999/000324 patent/WO1999038839A1/ja not_active Ceased
- 1999-01-27 US US09/601,131 patent/US6316498B1/en not_active Expired - Lifetime
- 1999-01-27 DE DE69906492T patent/DE69906492T2/de not_active Expired - Lifetime
- 1999-01-27 CN CNB99804606XA patent/CN1182105C/zh not_active Expired - Fee Related
- 1999-01-27 PT PT99901877T patent/PT1052246E/pt unknown
- 1999-01-27 EP EP99901877A patent/EP1052246B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69906492D1 (de) | 2003-05-08 |
| AU2183599A (en) | 1999-08-16 |
| CN1295557A (zh) | 2001-05-16 |
| KR100446892B1 (ko) | 2004-09-04 |
| PT1052246E (pt) | 2003-06-30 |
| EP1052246B1 (en) | 2003-04-02 |
| EP1052246A4 (en) | 2001-11-07 |
| DK1052246T3 (da) | 2003-06-16 |
| HK1036792A1 (en) | 2002-01-18 |
| AU734812B2 (en) | 2001-06-21 |
| CA2318800A1 (en) | 1999-08-25 |
| US6316498B1 (en) | 2001-11-13 |
| ES2191412T3 (es) | 2003-09-01 |
| CN1182105C (zh) | 2004-12-29 |
| EP1052246A1 (en) | 2000-11-15 |
| KR20010034418A (ko) | 2001-04-25 |
| DE69906492T2 (de) | 2003-12-18 |
| WO1999038839A1 (en) | 1999-08-05 |
| ATE236118T1 (de) | 2003-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170127 |