CA2398603A1 - Molecules du facteur 23 de croissance de fibroblastes et procedes d'utilisation correspondants - Google Patents
Molecules du facteur 23 de croissance de fibroblastes et procedes d'utilisation correspondants Download PDFInfo
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- CA2398603A1 CA2398603A1 CA002398603A CA2398603A CA2398603A1 CA 2398603 A1 CA2398603 A1 CA 2398603A1 CA 002398603 A CA002398603 A CA 002398603A CA 2398603 A CA2398603 A CA 2398603A CA 2398603 A1 CA2398603 A1 CA 2398603A1
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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Abstract
L'invention concerne des polypeptides du facteur 23 de croissance de fibroblastes et des molécules d'acides nucléiques les codant. L'invention concerne aussi des agents liants sélectifs, des vecteurs, des cellules hôtes et des procédés pour produire des polypeptides FGF-23. L'invention concerne aussi des compositions pharmaceutiques et des procédés pour le diagnostic, le traitement, l'amélioration et/ou la prévention de maladies, troubles et états associés aux polypeptides FGF-23.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18244200P | 2000-02-15 | 2000-02-15 | |
| US60/182,442 | 2000-02-15 | ||
| US19890300P | 2000-04-20 | 2000-04-20 | |
| US60/198,903 | 2000-04-20 | ||
| US74858101A | 2001-02-15 | 2001-02-15 | |
| PCT/US2001/004778 WO2001061007A2 (fr) | 2000-02-15 | 2001-02-15 | Molecules du facteur 23 de croissance de fibroblastes et procedes d'utilisation correspondants |
| US09/784,581 | 2001-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2398603A1 true CA2398603A1 (fr) | 2001-08-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002398603A Abandoned CA2398603A1 (fr) | 2000-02-15 | 2001-02-15 | Molecules du facteur 23 de croissance de fibroblastes et procedes d'utilisation correspondants |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1257645A2 (fr) |
| JP (1) | JP2005508131A (fr) |
| AU (1) | AU3976701A (fr) |
| CA (1) | CA2398603A1 (fr) |
| MX (1) | MXPA02007619A (fr) |
| WO (1) | WO2001061007A2 (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001066596A2 (fr) * | 2000-03-08 | 2001-09-13 | Chiron Corporation | Gene humain fgf-23 et produits d'expression genique |
| JP2003531583A (ja) * | 2000-03-08 | 2003-10-28 | カイロン コーポレイション | ヒトｆｇｆ−２３遺伝子および遺伝子発現産物 |
| AU2001273323B2 (en) | 2000-07-19 | 2005-11-10 | Advanced Research & Technology Institute | Novel fibroblast growth factor (FGF23) and methods for use |
| US20040082506A1 (en) * | 2000-08-11 | 2004-04-29 | Takeyoshi Yamashita | Polypeptides controlling phosphoric acid metabolism, calcium metabolism, calcification and vitamin d metabolism and dnas encoding the same |
| AU2002302581A1 (en) * | 2001-04-26 | 2002-11-11 | Geneprot, Inc. | Human fibroblast growth factor-related compositions |
| CA2471656C (fr) * | 2001-12-28 | 2012-07-31 | Kirin Beer Kabushiki Kaisha | Anticorp diriges contre le facteur de croissance 23 des fibroblastes |
| US7094551B2 (en) | 2002-09-17 | 2006-08-22 | Zahradnik Richard J | Immunoassays, assay methods, antibodies and method of creating antibodies for detecting FGF-23 |
| US7883705B2 (en) | 2007-02-14 | 2011-02-08 | Kyowa Hakko Kirin Co., Ltd. | Anti FGF23 antibody and a pharmaceutical composition comprising the same |
| SG190592A1 (en) * | 2008-04-29 | 2013-06-28 | Novartis Ag | Methods of monitoring the modulation of the kinase activity of fibroblast growth factor receptor and uses of said methods |
| EP2726511B1 (fr) | 2011-07-01 | 2019-08-07 | NGM Biopharmaceuticals, Inc. | Compositions, utilisations et procédés pour le traitement de troubles et de maladies métaboliques |
| EP2925775B1 (fr) | 2012-11-28 | 2020-09-16 | NGM Biopharmaceuticals, Inc. | Compositions et méthodes de traitement de troubles et maladies métaboliques |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| KR102724421B1 (ko) | 2012-12-27 | 2024-10-30 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 담즙산 항상성의 조절 및 담즙산 질환 및 질병의 치료 방법 |
| KR102178945B1 (ko) | 2013-10-28 | 2020-11-13 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 암 모델 및 관련 방법 |
| SI3097122T1 (sl) | 2014-01-24 | 2020-07-31 | Ngm Biopharmaceuticals, Inc. | Protitelesa, ki se vežejo v domeni beta klotho 2, in metode za njihovo uporabo |
| WO2015183890A2 (fr) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Méthodes et compositions pour le traitement de maladies et de troubles métaboliques |
| CA2951153A1 (fr) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Procedes et utilisations pour la modulation de l'homeostasie de l'acide biliaire et le traitement de troubles et maladies de l'acide biliaire |
| CN107108711B (zh) | 2014-10-23 | 2021-11-23 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| EA201791238A1 (ru) | 2014-12-04 | 2018-02-28 | Новартис Аг | Способы и композиции, в которых используются варианты полипептидов klotho |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| CA3034399A1 (fr) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methodes de traitement de cancers et de tumeurs a mediation assuree par le facteur de croissance des fibroblastes 19 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU733222B2 (en) * | 1997-11-25 | 2001-05-10 | Genentech Inc. | Fibroblast growth factor-19 |
| WO2000060085A1 (fr) * | 1999-04-02 | 2000-10-12 | Millennium Pharmaceuticals, Inc. | Facteur de croissance 20 des fibroblastes |
| EP1210418B1 (fr) * | 1999-06-02 | 2010-08-18 | Genentech, Inc. | Polypeptides secretes et transmembranaires ainsi que les acides nucleiques codant pour ceux-ci |
| JP2003518944A (ja) * | 2000-01-05 | 2003-06-17 | ザイモジェネティクス，インコーポレイティド | 新規ｆｇｆ相同体ｚｆｇｆ１２ |
-
2001
- 2001-02-15 CA CA002398603A patent/CA2398603A1/fr not_active Abandoned
- 2001-02-15 AU AU39767/01A patent/AU3976701A/en not_active Abandoned
- 2001-02-15 WO PCT/US2001/004778 patent/WO2001061007A2/fr not_active Ceased
- 2001-02-15 MX MXPA02007619A patent/MXPA02007619A/es unknown
- 2001-02-15 EP EP01914373A patent/EP1257645A2/fr not_active Withdrawn
- 2001-02-15 JP JP2001560377A patent/JP2005508131A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU3976701A (en) | 2001-08-27 |
| WO2001061007A2 (fr) | 2001-08-23 |
| JP2005508131A (ja) | 2005-03-31 |
| WO2001061007A3 (fr) | 2002-03-14 |
| EP1257645A2 (fr) | 2002-11-20 |
| WO2001061007A9 (fr) | 2002-04-18 |
| MXPA02007619A (es) | 2002-12-13 |
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| FZDE | Dead |