CA2375145A1 - Proteine-tyrosine-phosphatases de piegeage de substrats - Google Patents
Proteine-tyrosine-phosphatases de piegeage de substrats Download PDFInfo
- Publication number
- CA2375145A1 CA2375145A1 CA002375145A CA2375145A CA2375145A1 CA 2375145 A1 CA2375145 A1 CA 2375145A1 CA 002375145 A CA002375145 A CA 002375145A CA 2375145 A CA2375145 A CA 2375145A CA 2375145 A1 CA2375145 A1 CA 2375145A1
- Authority
- CA
- Canada
- Prior art keywords
- ptp
- protein
- substrate
- tyrosine phosphatase
- protein tyrosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- IOVGROKTTNBUGK-SJCJKPOMSA-N ritodrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC=C(O)C=C1 IOVGROKTTNBUGK-SJCJKPOMSA-N 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- 229940005550 sodium alginate Drugs 0.000 description 1
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- 150000003457 sulfones Chemical class 0.000 description 1
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- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
L'invention concerne des compositions et des méthodes applicables à des nouvelles protéine-tyrosine-phosphatases (PTP) mutantes de piégeage de substrats, qui malgré une altération catalytique demeurent capables de lier un ou plusieurs substrats de protéines contenant de la phosphotyrosine, et qui sont également modifiées par remplacement d'au moins un résidu de tyrosine par un amino-acide ne pouvant être phosphorylé. L'invention concerne également l'utilisation de ces PTP pour l'identification de substrats de PTP et d'agents modificateurs des interactions PTP-substrat, ainsi que des méthodes destinées à modifier l'activité des PTP.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13731999P | 1999-06-03 | 1999-06-03 | |
| US60/137,319 | 1999-06-03 | ||
| US33457599A | 1999-06-16 | 1999-06-16 | |
| US09/334,575 | 1999-06-16 | ||
| PCT/US2000/014211 WO2000075339A1 (fr) | 1999-06-03 | 2000-05-24 | Proteine-tyrosine-phosphatases de piegeage de substrats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2375145A1 true CA2375145A1 (fr) | 2000-12-14 |
Family
ID=26835140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002375145A Abandoned CA2375145A1 (fr) | 1999-06-03 | 2000-05-24 | Proteine-tyrosine-phosphatases de piegeage de substrats |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1187924A1 (fr) |
| JP (1) | JP2003501098A (fr) |
| AU (1) | AU5284200A (fr) |
| CA (1) | CA2375145A1 (fr) |
| WO (1) | WO2000075339A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2326952A1 (fr) * | 2000-11-27 | 2002-05-27 | The Hospital For Sick Children | Tyrosine-phosphatase de proteines de cellules t |
| AU2002336551A1 (en) | 2001-09-18 | 2003-04-01 | Millennium Pharmaceuticals, Inc. | Mid 4460, a human tyrosine phosphatase family member and uses therefor |
| WO2004016735A2 (fr) | 2002-05-23 | 2004-02-26 | Ceptyr, Inc. | Modulation de la transduction du signal biologique par interference arn |
| US7205121B2 (en) | 2002-11-26 | 2007-04-17 | Cold Spring Harbor Laboratory | DEP-1 receptor protein tyrosine phosphatase interacting proteins and related methods |
| AU2003289947A1 (en) * | 2003-02-05 | 2004-08-30 | Grunenthal Gmbh | Identification of pain-regulated gene in the dorsal root ganglion (drg) after cfa-induced arthritis |
| US8039210B2 (en) | 2004-05-14 | 2011-10-18 | The Johns Hopkins University | Protein tyrosine phosphatase mutations in cancers |
| PL2562184T3 (pl) | 2007-07-27 | 2016-03-31 | Immatics Biotechnologies Gmbh | Nowe immunogenne epitopy do immunoterapii |
| SI2183361T1 (sl) * | 2007-07-27 | 2015-09-30 | Immatics Biotechnologies Gmbh | Nova imunoterapija proti nevronalnim in možganskim tumorjem |
| PL2105501T3 (pl) * | 2008-03-27 | 2016-03-31 | Immatics Biotechnologies Gmbh | Innowacyjna immunoterapia przeciwko nowotworom neuronów i mózgu |
| US8962277B2 (en) * | 2010-07-05 | 2015-02-24 | Univeristät für Bodenkultur Wien | Production cell line |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5912138A (en) * | 1996-07-25 | 1999-06-15 | Cold Spring Harbor Laboratory | Substrate trapping protein tyrosine phosphatases |
-
2000
- 2000-05-24 WO PCT/US2000/014211 patent/WO2000075339A1/fr not_active Ceased
- 2000-05-24 CA CA002375145A patent/CA2375145A1/fr not_active Abandoned
- 2000-05-24 JP JP2001502601A patent/JP2003501098A/ja active Pending
- 2000-05-24 AU AU52842/00A patent/AU5284200A/en not_active Abandoned
- 2000-05-24 EP EP00937706A patent/EP1187924A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000075339A1 (fr) | 2000-12-14 |
| JP2003501098A (ja) | 2003-01-14 |
| EP1187924A1 (fr) | 2002-03-20 |
| AU5284200A (en) | 2000-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |