CA2352486A1 - Methodes et reactifs d'augmentation de la capacite proliferative et de prevention de la senescence replicative - Google Patents
Methodes et reactifs d'augmentation de la capacite proliferative et de prevention de la senescence replicative Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne des méthodes et des réactifs destinés à prolonger la durée de vie, c'est-à-dire, le nombre de divisions mitotiques d'une cellule. D'une manière générale, la méthode de l'invention se base sur l'activation d'une activité de télomérase et l'inhibition d'une voie Rb/p16 et/ou d'une voie p53.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10989198P | 1998-11-25 | 1998-11-25 | |
| US60/109.891 | 1998-11-25 | ||
| US12054999P | 1999-02-17 | 1999-02-17 | |
| US60/120,549 | 1999-02-17 | ||
| PCT/US1999/027907 WO2000031238A2 (fr) | 1998-11-25 | 1999-11-24 | Methodes et reactifs d'augmentation de la capacite proliferative et de prevention de la senescence replicative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2352486A1 true CA2352486A1 (fr) | 2000-06-02 |
Family
ID=26807479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002352486A Abandoned CA2352486A1 (fr) | 1998-11-25 | 1999-11-24 | Methodes et reactifs d'augmentation de la capacite proliferative et de prevention de la senescence replicative |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1133552A2 (fr) |
| JP (1) | JP2002530436A (fr) |
| AU (1) | AU2156600A (fr) |
| CA (1) | CA2352486A1 (fr) |
| IL (1) | IL143328A0 (fr) |
| WO (1) | WO2000031238A2 (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1170378A1 (fr) * | 2000-06-26 | 2002-01-09 | Boehringer Ingelheim International GmbH | Procédé pour évaluer l'effet du thérapies de cancer |
| DE10054974A1 (de) * | 2000-11-06 | 2002-06-06 | Epigenomics Ag | Diagnose von mit Cdk4 assoziierten Krankheiten |
| AU2002242854A1 (en) | 2001-03-21 | 2002-10-03 | Geron Corporation | Use of telomerase reverse transcriptase to create homozygous knockout animals |
| AU2002342613A1 (en) | 2001-05-09 | 2002-11-25 | Geron Corporation | Treatment for wounds |
| AU2003208580A1 (en) * | 2002-02-05 | 2003-09-02 | Technion Research And Development Foundation Ltd | Lineage committed stem cells selected for telomerase promoter activity |
| SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| JPWO2004076483A1 (ja) * | 2003-02-26 | 2006-06-01 | 独立行政法人科学技術振興機構 | 癌細胞のアポトーシスを誘導する転写因子 |
| EP1626714B1 (fr) | 2003-05-20 | 2007-07-04 | Bayer Pharmaceuticals Corporation | Urees de diaryle pour des maladies mediees par le recepteur du facteur de croissance derive des plaquettes |
| EA009442B1 (ru) | 2003-06-23 | 2007-12-28 | Герон Корпорейшн | Композиции и способы увеличения активности теломеразы |
| US9248088B2 (en) | 2003-06-25 | 2016-02-02 | Telomerase Activation Sciences, Inc. | Compositions and methods for skin conditioning |
| US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
| US8710012B2 (en) | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
| US8431123B2 (en) | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
| EP1663978B1 (fr) | 2003-07-23 | 2007-11-28 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryldiphenyluree fluoro-subtituee pour le traitement et la prevention de maladies et d'etats pathologiques |
| PL1799269T3 (pl) * | 2004-09-28 | 2017-01-31 | Quark Pharmaceuticals, Inc. | Oligorybonukleotydy i sposoby ich zastosowania do leczenia łysienia, ostrej niewydolności nerek i innych chorób |
| EP1880733A4 (fr) | 2005-04-25 | 2009-08-12 | Genkin Dmitry Dmitrievich | Procede pour prolonger la duree de vie d'animaux ou de l'humain |
| JP2006325444A (ja) * | 2005-05-24 | 2006-12-07 | Toyobo Co Ltd | 細胞増殖培地 |
| AU2006311637A1 (en) * | 2005-11-07 | 2007-05-18 | The General Hospital Corporation | Methods and compositions for modulation of stem cell aging |
| JP5372769B2 (ja) | 2006-11-28 | 2013-12-18 | シーエルエス セラピューティック リミティド | 組織の細胞外間隙においてデオキシリボ核酸の量が増量することに関連するヒトの病気の治療方法及び該方法を実施するための医薬製剤 |
| US8598150B1 (en) | 2008-04-02 | 2013-12-03 | Jonathan R. Brestoff | Composition and method for affecting obesity and related conditions |
| US8987245B2 (en) | 2008-04-02 | 2015-03-24 | Jonathan R. Brestoff Parker | Composition and method for affecting obesity and related conditions |
| ES2661310T3 (es) | 2009-03-09 | 2018-03-28 | Bioatla, Llc | Proteínas mirac |
| SI2437606T1 (sl) | 2009-05-18 | 2016-10-28 | Telomerase Activation Sciences, Inc. | Sestavki in postopki za povečanje telomerazne aktivnosti |
| CN108383894A (zh) | 2010-02-16 | 2018-08-10 | 阿尔特公司 | 多肽及其应用 |
| GB201202228D0 (en) * | 2012-02-08 | 2012-03-28 | Queen Mary & Westfield College | Reversal of replicative senescence |
| US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
| ES2799515T3 (es) | 2015-05-22 | 2020-12-18 | Dmitry Dmitrievich Genkin | ADN extracelular como una diana terapéutica en la neurodegeneración |
| US11525146B2 (en) | 2017-01-09 | 2022-12-13 | Oisin Biotechnologies, Inc. | Expression constructs, fusogenic lipid-based nanoparticles and methods of use thereof |
| AU2019209770B2 (en) | 2018-01-16 | 2025-07-31 | Cls Therapeutics Limited | Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity |
| WO2019166702A1 (fr) | 2018-02-28 | 2019-09-06 | Hagalife | Utilisation d'un procédé d'irradiation flash pour augmenter la longévité et/ou pour retarder les effets du vieillissement chez les mammifères |
| JP7592493B2 (ja) | 2018-04-18 | 2024-12-02 | オイシン バイオテクノロジーズ，インク． | 治療用タンパク質の標的細胞に特異的な産生のための、および、標的細胞に関連する疾患、疾病、または障害の処置のための、融合性脂質ナノ粒子、および、融合性脂質ナノ粒子の製造方法と使用方法 |
| CN113774020B (zh) * | 2021-08-24 | 2023-04-14 | 河北朋和生物科技有限公司 | 一种脂肪间充质干细胞库的构建方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2080158A1 (fr) * | 1991-10-11 | 1993-04-12 | Scott A. Biller | Methode d'inhibition de la transformation neoplastique des cellules provoquee par les oncogenes ras au moyen de bisphosphonates ou d'analogues de ces derniers |
| CA2118985A1 (fr) * | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Inhibiteurs heterocycliques de la farnesyl proteine transferase |
| US5721236A (en) * | 1993-10-15 | 1998-02-24 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US6037136A (en) * | 1994-10-24 | 2000-03-14 | Cold Spring Harbor Laboratory | Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto |
| US5624936A (en) * | 1995-03-29 | 1997-04-29 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| WO1998037181A2 (fr) * | 1997-02-20 | 1998-08-27 | Whitehead Institute For Biomedical Research | Gene de sous-unite catalytique de telomerase et proteine codee |
| JP2002500040A (ja) * | 1998-01-12 | 2002-01-08 | コールド スプリング ハーバー ラボラトリー | 細胞の寿命の延長、方法および試薬 |
| AU760252B2 (en) * | 1998-01-30 | 2003-05-08 | Cold Spring Harbor Laboratory | Modulation of cell proliferation, methods and reagents |
-
1999
- 1999-11-24 WO PCT/US1999/027907 patent/WO2000031238A2/fr not_active Ceased
- 1999-11-24 IL IL14332899A patent/IL143328A0/xx unknown
- 1999-11-24 JP JP2000584049A patent/JP2002530436A/ja not_active Withdrawn
- 1999-11-24 AU AU21566/00A patent/AU2156600A/en not_active Abandoned
- 1999-11-24 CA CA002352486A patent/CA2352486A1/fr not_active Abandoned
- 1999-11-24 EP EP99965890A patent/EP1133552A2/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1133552A2 (fr) | 2001-09-19 |
| AU2156600A (en) | 2000-06-13 |
| WO2000031238A2 (fr) | 2000-06-02 |
| WO2000031238A3 (fr) | 2000-11-09 |
| JP2002530436A (ja) | 2002-09-17 |
| IL143328A0 (en) | 2002-04-21 |
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