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CA2348688A1 - Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive - Google Patents

Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive Download PDF

Info

Publication number
CA2348688A1
CA2348688A1 CA002348688A CA2348688A CA2348688A1 CA 2348688 A1 CA2348688 A1 CA 2348688A1 CA 002348688 A CA002348688 A CA 002348688A CA 2348688 A CA2348688 A CA 2348688A CA 2348688 A1 CA2348688 A1 CA 2348688A1
Authority
CA
Canada
Prior art keywords
leu
ala
val
ser
ile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002348688A
Other languages
English (en)
Inventor
Dominic P. Behan
Derek T. Chalmers
Ruoping Chen
Chen W. Liaw
Kevin Lowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arena Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/170,496 external-priority patent/US6555339B1/en
Application filed by Individual filed Critical Individual
Publication of CA2348688A1 publication Critical patent/CA2348688A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention se rapporte à des récepteurs transmembranaires, notamment au récepteur de la protéine G humaine pour lequel le ligand endogène est connu ("récepteurs GPCR orphelins") et, plus particulièrement, à des versions mutées (non endogènes) des GPCR humains pouvant révéler une activité constitutive.
CA002348688A 1998-10-13 1999-10-13 Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive Abandoned CA2348688A1 (fr)

Applications Claiming Priority (65)

Application Number Priority Date Filing Date Title
US09/170,496 US6555339B1 (en) 1997-04-14 1998-10-13 Non-endogenous, constitutively activated human protein-coupled receptors
US09/170,496 1998-10-13
US10802998P 1998-11-12 1998-11-12
US60/108,029 1998-11-12
US10921398P 1998-11-20 1998-11-20
US60/109,213 1998-11-20
US11006098P 1998-11-27 1998-11-27
US60/110,060 1998-11-27
US12041699P 1999-02-16 1999-02-16
US60/120,416 1999-02-16
US12185299P 1999-02-26 1999-02-26
US60/121,852 1999-02-26
US12394699P 1999-03-12 1999-03-12
US12394899P 1999-03-12 1999-03-12
US12394499P 1999-03-12 1999-03-12
US12395199P 1999-03-12 1999-03-12
US12394999P 1999-03-12 1999-03-12
US12394599P 1999-03-12 1999-03-12
US60/123,948 1999-03-12
US60/123,945 1999-03-12
US60/123,949 1999-03-12
US60/123,946 1999-03-12
US60/123,944 1999-03-12
US60/123,951 1999-03-12
US13643799P 1999-05-28 1999-05-28
US13712799P 1999-05-28 1999-05-28
US13656799P 1999-05-28 1999-05-28
US13643999P 1999-05-28 1999-05-28
US13713199P 1999-05-28 1999-05-28
US13643699P 1999-05-28 1999-05-28
US60/136,436 1999-05-28
US60/137,127 1999-05-28
US60/137,131 1999-05-28
US60/136,439 1999-05-28
US60/136,437 1999-05-28
US60/136,567 1999-05-28
US14144899P 1999-06-29 1999-06-29
US60/141,448 1999-06-29
US15111499P 1999-08-27 1999-08-27
US60/151,114 1999-08-27
US15252499P 1999-09-03 1999-09-03
US60/152,524 1999-09-03
US15655599P 1999-09-29 1999-09-29
US15663499P 1999-09-29 1999-09-29
US15663399P 1999-09-29 1999-09-29
US15665399P 1999-09-29 1999-09-29
US60/156,653 1999-09-29
US60/156,555 1999-09-29
US60/156,633 1999-09-29
US60/156,634 1999-09-29
US15728299P 1999-10-01 1999-10-01
US15729399P 1999-10-01 1999-10-01
US15728099P 1999-10-01 1999-10-01
US15729499P 1999-10-01 1999-10-01
US15728199P 1999-10-01 1999-10-01
US60/157,293 1999-10-01
US60/157,294 1999-10-01
US60/157,280 1999-10-01
US60/157,282 1999-10-01
US60/157,281 1999-10-01
US41704499A 1999-10-12 1999-10-12
US41676099A 1999-10-12 1999-10-12
US09/417,044 1999-10-12
US09/416,760 1999-10-12
PCT/US1999/024065 WO2000022131A2 (fr) 1998-10-13 1999-10-13 Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive

Publications (1)

Publication Number Publication Date
CA2348688A1 true CA2348688A1 (fr) 2000-04-20

Family

ID=27586908

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002348688A Abandoned CA2348688A1 (fr) 1998-10-13 1999-10-13 Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive

Country Status (5)

Country Link
KR (1) KR20010080882A (fr)
CA (1) CA2348688A1 (fr)
IL (1) IL142153A0 (fr)
NZ (1) NZ510712A (fr)
WO (1) WO2000022131A2 (fr)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
ATE362983T1 (de) * 1997-11-11 2007-06-15 Ono Pharmaceutical Co Menschlicher lysophosphatidsäure rezeptor und dessen verwendung
US6555344B1 (en) 1998-03-12 2003-04-29 Yamanouchi Pharmaceutical Co., Ltd. Polynucleotides encoding SRE B2 receptor
US7094593B1 (en) 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
JP2004500013A (ja) * 1998-10-16 2004-01-08 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 新規ｇタンパク質共役受容体
EP1155031A4 (fr) * 1998-11-03 2002-11-27 Smithkline Beecham Corp Recepteur couple aux proteines g, dit axor-14
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
CA2645717A1 (fr) * 1998-11-20 2000-06-02 Arena Pharmaceuticals, Inc. Recepteurs humains couples a la proteine g orphan
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
US6221660B1 (en) 1999-02-22 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding SNORF25 receptor
EP1189944A4 (fr) * 1999-06-21 2002-09-11 Smithkline Beecham Corp Axor16, r cepteur coupl une prot ine g
JP2003506040A (ja) * 1999-07-30 2003-02-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Ｇタンパク質共役型受容体およびそのｄｎａ配列
CA2391868A1 (fr) * 1999-08-27 2001-03-08 Takeda Chemical Industries, Ltd. Proteine recepteur couplee a une proteine g et adn correspondant
AU6727800A (en) * 1999-08-27 2001-03-26 Takeda Chemical Industries Ltd. Novel g protein-coupled receptor protein and dna thereof
JP2003225088A (ja) * 1999-09-10 2003-08-12 Meiji Seika Kaisha Ltd ヒト・ロイコトリエンｂ４第二受容体及びそれをコードするｄｎａ
US6998255B1 (en) 1999-09-24 2006-02-14 Solvay Pharmaceuticals B.V. Human G-protein coupled receptor
IL147889A0 (en) * 1999-09-24 2002-08-14 Solvay Pharm Bv Novel human g-protein coupled receptor
GB9923177D0 (en) * 1999-09-30 1999-12-01 Pfizer Ltd Novel polypeptide
GB9923893D0 (en) * 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
GB9923890D0 (en) * 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
GB9923888D0 (en) 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
GB9924960D0 (en) * 1999-10-21 1999-12-22 Pfizer Ltd Novel polypeptide
CA2386509A1 (fr) * 1999-10-27 2001-05-03 Pharmacia & Upjohn Company Recepteurs couples par des proteines g exprimes dans le cerveau
ATE375390T1 (de) * 1999-10-29 2007-10-15 Pfizer G-protein-gekoppelter rezeptor-ähnliche proteine
WO2001032865A1 (fr) * 1999-11-03 2001-05-10 Merck Patent Gmbh Polypeptides du type gp27 et leurs sequences d'adn
AU784543B2 (en) * 1999-11-16 2006-04-27 Pharmacia & Upjohn Company Novel G protein-coupled receptors
NZ531722A (en) * 1999-11-17 2006-06-30 Arena Pharm Inc Endogenous and non-endogenous versions of human G protein-coupled receptors
US7029857B1 (en) 1999-12-17 2006-04-18 H. Lundbeck A/S Processes for obtaining compounds employing SNORF72 receptors
AU2398501A (en) * 1999-12-20 2001-07-03 Banyu Pharmaceutical Co., Ltd. Novel guanosine triphosphate-binding protein-coupled receptor protein, bg26
EP1240350A4 (fr) 1999-12-23 2003-11-19 Millennium Pharm Inc Recepteur p2y12
GB0001700D0 (en) * 2000-01-25 2000-03-15 Glaxo Group Ltd Novel protein
US7138249B2 (en) 2000-02-04 2006-11-21 Takeda Pharmaceutical Company Limited Screening method
DE60127102T2 (de) * 2000-03-14 2007-08-23 Bayer Healthcare Aktiengesellschaft Regulation des menschliches lipoxin a4 rezeptor-ähnliches protein
US20040091863A1 (en) * 2000-03-17 2004-05-13 Shyam Ramakrishnan Regulation of human leukotriene b4-like g protein-coupled receptor
EP1270589A4 (fr) * 2000-03-21 2004-09-29 Yamanouchi Pharma Co Ltd Nouveau recepteur du leucotriene b4
AU2001242800A1 (en) * 2000-03-28 2001-10-08 Takeda Chemical Industries Ltd. Novel g protein-coupled receptor protein and dna thereof
WO2001073023A1 (fr) * 2000-03-31 2001-10-04 Helix Research Institute Nouveau recepteur gprv53 couple a une proteine se liant a la guanosine-triphosphate, gene correspondant et procede de production et d'utilisation associe
WO2001077326A1 (fr) * 2000-04-12 2001-10-18 Takeda Chemical Industries, Ltd. Proteine receptrice couplee a la proteine g et son adn
EP1178110A1 (fr) * 2000-08-01 2002-02-06 Aventis Pharma Deutschland GmbH Récepteur EDG8 de la sphingosine 1-phosphate , sa préparation et son utilisation
CA2407458A1 (fr) 2000-04-27 2001-11-01 Merck & Co., Inc. Nouveau recepteur de la neuromedine u, dit nmur2, et nucleotides codant pour lui
WO2001085786A2 (fr) * 2000-05-05 2001-11-15 Wyeth Recepteur a l'histamine h4 humain
EP1282645A2 (fr) * 2000-05-08 2003-02-12 PHARMACIA & UPJOHN COMPANY Nouveaux recepteurs couples a la proteine g
WO2001085935A2 (fr) * 2000-05-09 2001-11-15 Bayer Aktiengesellschaft Recepteur couple a une proteine g du type du gene 6 de differenciation endotheliale
ATE348162T1 (de) * 2000-05-18 2007-01-15 Bayer Healthcare Ag Regulation eines menschlichen dopamine-ähnlichen g-protein gekoppelten rezeptor.
WO2001087930A2 (fr) * 2000-05-18 2001-11-22 Bayer Aktiengesellschaft Regulation du recepteur couple a la proteine g analogue au recepteur de la galanine humaine
CA2408134A1 (fr) * 2000-05-18 2001-11-22 Incyte Genomics, Inc. Recepteurs couples aux proteines g
WO2001092485A1 (fr) 2000-05-31 2001-12-06 Ortho-Mcneil Pharmaceutical, Inc. Adn codant pour un recepteur de l'histamine de mammifere de sous-type h4
WO2002000719A2 (fr) * 2000-06-23 2002-01-03 Tularik Inc. Nouveaux recepteurs
WO2002002599A2 (fr) * 2000-06-30 2002-01-10 Ingenium Pharmaceuticals Ag Recepteur couple aux proteines g humaines igpcr17, et son utilisation
US6927041B2 (en) 2000-07-06 2005-08-09 Bayer Corporation Human neuropeptide Y-like G protein-coupled receptor
US7462457B2 (en) * 2000-08-30 2008-12-09 Johns Hopkins University School Of Medicine Identification of activated receptors and ion channels
WO2001027632A2 (fr) * 2000-10-02 2001-04-19 Biofocus Discovery Limited Procede de prediction de mutations
ES2282304T3 (es) 2000-11-01 2007-10-16 Astellas Pharma Inc. Procedimiento para seleccionar antiplaquetas.
AU1252102A (en) * 2000-11-07 2002-05-21 Paradigm Therapeutics Ltd Receptor
JP3438186B2 (ja) 2000-12-01 2003-08-18 山之内製薬株式会社 糖尿病治療剤スクリーニング方法
AU2002222681A1 (en) * 2000-12-19 2002-07-01 Takeda Chemical Industries Ltd. Novel transmembrane receptor-like proteins and dnas thereof
US7157244B2 (en) 2001-01-17 2007-01-02 Schering Corporation Adenosine receptor
ES2311601T3 (es) * 2001-04-25 2009-02-16 Astellas Pharma Inc. Receptores acoplado a proteina que se une a trifosfato de guanosina place 6002312 y su gen y produccion y uso del mismo.
US6919176B2 (en) 2001-05-07 2005-07-19 Amgen Inc. Polypeptides and nucleic acids associated with cancer
AU2002310326A1 (en) * 2001-06-05 2002-12-23 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated versions of plant g protein-coupled receptor: gcr1
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
JP4594623B2 (ja) 2002-04-12 2010-12-08 シェーリング コーポレイション Ｇタンパク質共役レセプターリガンドおよび方法
WO2003102159A2 (fr) * 2002-06-04 2003-12-11 Curagen Corporation Nouvelles proteines et nouveaux acides nucleiques codant pour ces proteines
AU2003261874A1 (en) * 2002-09-02 2004-03-29 Takeda Pharmaceutical Company Limited Adrenocortical hormone secretion controller
US20050233304A1 (en) * 2002-10-11 2005-10-20 Yamanouchi Pharmaceutical Co., Ltd. Method of screening remedy for renal failure
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
AU2003300867A1 (en) * 2002-12-19 2004-07-29 Synaptic Pharmaceutical Corporation Uses of the snorf207 receptor
US7083933B1 (en) 2003-05-09 2006-08-01 Prosidion Limited Methods for identification of modulators of OSGPR116 activity
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
WO2018087285A1 (fr) 2016-11-10 2018-05-17 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Protéines de liaison à l'antigène or10h1 et leurs utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2239293A1 (fr) * 1995-12-11 1997-06-19 New England Medical Center Hosptials, Inc. Dosage et utilisations de ligands de recepteurs d'hormones peptidiques
AU6343998A (en) * 1997-02-27 1998-09-18 Christina C. Egan Constitutively activated serotonin receptors
ATE362983T1 (de) * 1997-11-11 2007-06-15 Ono Pharmaceutical Co Menschlicher lysophosphatidsäure rezeptor und dessen verwendung

Also Published As

Publication number Publication date
KR20010080882A (ko) 2001-08-25
IL142153A0 (en) 2002-03-10
WO2000022131A3 (fr) 2001-02-22
WO2000022131A2 (fr) 2000-04-20
NZ510712A (en) 2004-11-26

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued