CA2262507A1 - Vecteurs d'expression, cellules et procedes servant a la preparation de polypeptides de thrombopoietine - Google Patents
Vecteurs d'expression, cellules et procedes servant a la preparation de polypeptides de thrombopoietine Download PDFInfo
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- CA2262507A1 CA2262507A1 CA002262507A CA2262507A CA2262507A1 CA 2262507 A1 CA2262507 A1 CA 2262507A1 CA 002262507 A CA002262507 A CA 002262507A CA 2262507 A CA2262507 A CA 2262507A CA 2262507 A1 CA2262507 A1 CA 2262507A1
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- 238000012384 transportation and delivery Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention porte sur des polypeptides de thrombopoïétine et sur les vecteurs d'expression, cellules et procédés servant à leur préparation. Lesdits polypeptides se caractérisent par leur squelette fait d'un acide aminé de type C-X-B, où C est un polypeptide humain du domaine thrombopoïétine cytokine; X est une liaison peptidique ou une liaison faite d'un ou deux résidus d'acides aminés sous réserve que X, seul ou combiné à C ou B, ne présente pas de paire d'acides aminés dibasiques; et B est un polypeptide consistant dans les résidues 1 à y de la SEQ ID NO:3, où y est un entier de 5 à 18, et où jusqu'à 35 % des résidus d'acide aminés de B sont remplacés individuellement par d'autres résidus d'acides aminés. Lesdits polypeptides entrent dans des processus in vitro et in vivo de stimulation et de développement de cellules hématopoïétiques.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69644796A | 1996-08-13 | 1996-08-13 | |
| US08/696,447 | 1996-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2262507A1 true CA2262507A1 (fr) | 1998-02-19 |
Family
ID=24797104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002262507A Abandoned CA2262507A1 (fr) | 1996-08-13 | 1997-07-30 | Vecteurs d'expression, cellules et procedes servant a la preparation de polypeptides de thrombopoietine |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0920511A1 (fr) |
| JP (1) | JP2000516465A (fr) |
| KR (1) | KR20000029998A (fr) |
| CN (1) | CN1230993A (fr) |
| AU (1) | AU728881B2 (fr) |
| CA (1) | CA2262507A1 (fr) |
| NZ (1) | NZ334103A (fr) |
| WO (1) | WO1998006849A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU750803B2 (en) | 1997-10-29 | 2002-07-25 | University Of Pittsburgh | Use of vectors such as adenoviruses and/or adeno associated viruses and/or retroviruses and/or herpes simplex viruses and/or liposomes and/or plasmids as a vehicle for genetic information enabling mammal cells to produce agents for the treatment of bone pathologies |
| KR19990081421A (ko) * | 1998-04-29 | 1999-11-15 | 성재갑 | 동물세포를 이용한 인간 혈소판 생성 촉진인자(tpo)의 제조방법 |
| AU2001280161A1 (en) * | 2000-08-24 | 2002-03-04 | Kirin Beer Kabushiki Kaisha | C-mpl ligand-containing medicinal compositions for increasing platelets and erythrocytes |
| WO2004078780A1 (fr) * | 2003-03-04 | 2004-09-16 | Pepharm R&D Limited | Composition pharmaceutique contenant l-seryl-l-leucine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG47030A1 (en) * | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
| EP0668352A1 (fr) * | 1994-02-14 | 1995-08-23 | Kirin Brewery Company, Ltd. | Protéine à activité TPO |
-
1997
- 1997-07-30 AU AU38238/97A patent/AU728881B2/en not_active Ceased
- 1997-07-30 KR KR1019997001270A patent/KR20000029998A/ko not_active Ceased
- 1997-07-30 JP JP10509794A patent/JP2000516465A/ja active Pending
- 1997-07-30 EP EP97935253A patent/EP0920511A1/fr not_active Withdrawn
- 1997-07-30 CA CA002262507A patent/CA2262507A1/fr not_active Abandoned
- 1997-07-30 WO PCT/US1997/013543 patent/WO1998006849A1/fr not_active Ceased
- 1997-07-30 CN CN97197984A patent/CN1230993A/zh active Pending
- 1997-07-30 NZ NZ334103A patent/NZ334103A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000029998A (ko) | 2000-05-25 |
| NZ334103A (en) | 2000-09-29 |
| CN1230993A (zh) | 1999-10-06 |
| WO1998006849A1 (fr) | 1998-02-19 |
| EP0920511A1 (fr) | 1999-06-09 |
| AU728881B2 (en) | 2001-01-18 |
| JP2000516465A (ja) | 2000-12-12 |
| AU3823897A (en) | 1998-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |