CA2124964C - Anticorps specifique anti-cdw52 pour le traitement de la sclerose en plaques - Google Patents
Anticorps specifique anti-cdw52 pour le traitement de la sclerose en plaques Download PDFInfo
- Publication number
- CA2124964C CA2124964C CA002124964A CA2124964A CA2124964C CA 2124964 C CA2124964 C CA 2124964C CA 002124964 A CA002124964 A CA 002124964A CA 2124964 A CA2124964 A CA 2124964A CA 2124964 C CA2124964 C CA 2124964C
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- treatment
- multiple sclerosis
- campath
- cdw52
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9125768.3 | 1991-12-04 | ||
| GB919125768A GB9125768D0 (en) | 1991-12-04 | 1991-12-04 | Therapeutic method |
| PCT/GB1992/002252 WO1993010817A1 (fr) | 1991-12-04 | 1992-12-04 | ANTICORPS SPECIFIQUE AU CDw52 UTILISE DANS LE TRAITEMENT DE LA SCLEROSE EN PLAQUES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2124964A1 CA2124964A1 (fr) | 1993-06-10 |
| CA2124964C true CA2124964C (fr) | 2005-03-15 |
Family
ID=10705671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002124964A Expired - Lifetime CA2124964C (fr) | 1991-12-04 | 1992-12-04 | Anticorps specifique anti-cdw52 pour le traitement de la sclerose en plaques |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6120766A (fr) |
| EP (1) | EP0616537B1 (fr) |
| JP (1) | JP3383303B2 (fr) |
| KR (1) | KR100271333B1 (fr) |
| AT (1) | ATE177011T1 (fr) |
| AU (1) | AU3089692A (fr) |
| CA (1) | CA2124964C (fr) |
| DE (1) | DE69228556T2 (fr) |
| DK (1) | DK0616537T3 (fr) |
| ES (1) | ES2128363T3 (fr) |
| GB (1) | GB9125768D0 (fr) |
| GR (1) | GR3029683T3 (fr) |
| IL (1) | IL103981A (fr) |
| MX (1) | MX9207032A (fr) |
| MY (1) | MY111961A (fr) |
| WO (1) | WO1993010817A1 (fr) |
| ZA (1) | ZA929446B (fr) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| GB9125768D0 (en) * | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| GB9603507D0 (en) | 1996-02-20 | 1996-04-17 | Isis Innovation | Antibody variants |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| EP1455826A2 (fr) * | 2001-12-21 | 2004-09-15 | Ilex Oncology, Inc. | Polytherapie pour la sclerose en plaques |
| WO2003067221A2 (fr) | 2002-02-08 | 2003-08-14 | Xcyte Therapies, Inc. | Compositions et procedes de restauration de reponse immune chez des patients souffrant de deficiences immunologiques |
| WO2004003142A2 (fr) | 2002-06-28 | 2004-01-08 | Xcyte Therapies, Inc. | Compositions et techniques permettant de restaurer le repertoire immunologique de patients qui presente des defauts immunologiques lies a l'auto-immunite et a un organe ou a une transplantation de cellules souche hematopoietiques multipotentes |
| EP1623017B1 (fr) * | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation et isolement de lymphocytes t specifiques de l'antigene |
| US20050118173A1 (en) * | 2003-09-22 | 2005-06-02 | Xcyte Therapies, Inc. | Compositions and methods to accelerate hematologic recovery |
| WO2005042581A2 (fr) | 2003-11-01 | 2005-05-12 | Biovation Ltd. | Anticorps anti-cd52 modifie |
| EP2016095A2 (fr) | 2006-04-13 | 2009-01-21 | Peptimmune, Inc. | Procédés de conception et de synthèse de compositions de polymères à séquence dirigée par expansion dirigée de la perméabilité épitopique |
| EP1854810A1 (fr) | 2006-05-09 | 2007-11-14 | PanGenetics B.V. | Anticorps monoclonal anti CD40 humain déimmunisé et antagoniste dérivé de l'anticorps ch5D12 |
| SI2066352T1 (sl) * | 2006-09-13 | 2016-05-31 | Alcafleu Management Gmbh & Co. Kg | Zdravljenje multiple skleroze (MS) s Campath-1 H |
| US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
| HUE031421T2 (hu) | 2007-02-16 | 2017-07-28 | Genzyme Corp | Eljárások pajzsmirigy rendellenességek kockázatának azonosítására |
| US8962273B2 (en) * | 2007-05-11 | 2015-02-24 | Genzyme Corporation | Methods of producing a secreted protein |
| KR101800467B1 (ko) | 2009-05-13 | 2017-11-22 | 젠자임 코포레이션 | 루푸스 치료 방법 및 조성물 |
| EP2429582A4 (fr) * | 2009-05-13 | 2013-01-23 | Genzyme Corp | Immunoglobulines anti-cd52 humain |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| AU2012207356A1 (en) | 2011-01-18 | 2013-08-01 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
| EA201490364A1 (ru) | 2011-07-29 | 2014-08-29 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Костимулирующие рецепторы-переключатели |
| WO2013040557A2 (fr) | 2011-09-16 | 2013-03-21 | The Trustees Of The University Of Pennsylvania | Lymphocytes t à arn modifié pour le traitement du cancer |
| US9272002B2 (en) | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
| WO2013067492A1 (fr) | 2011-11-03 | 2013-05-10 | The Trustees Of The University Of Pennsylvania | Compositions spécifiques de b7-h4 isolé et procédés d'utilisation associés |
| US20140322216A1 (en) | 2011-11-08 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
| ES2816450T3 (es) | 2012-02-22 | 2021-04-05 | Univ Pennsylvania | Uso de CAR basados en ICOS para mejorar la actividad antitumoral y la persistencia del CAR |
| ES2959443T3 (es) | 2012-02-22 | 2024-02-26 | Univ Pennsylvania | Uso del dominio de señalización de CD2 en receptores de antígenos quiméricos de segunda generación |
| EP3584256A1 (fr) | 2012-07-13 | 2019-12-25 | The Trustees Of The University Of Pennsylvania | Procédés d'évaluation de l'aptitude de lymphocytes t transduits à être administrés |
| HUE072215T2 (hu) | 2012-07-13 | 2025-10-28 | Univ Pennsylvania | Toxicitáskezelõ kiméra antigénreceptorok tumorellenes hatásának támogatására |
| CA2876730A1 (fr) | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Renforcement de l'activite des lymphocytes t car grace a la co-introduction d'un anticorps bispecifique |
| US9598489B2 (en) | 2012-10-05 | 2017-03-21 | The Trustees Of The Univeristy Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| AR095199A1 (es) | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| CN105518018B (zh) * | 2013-03-15 | 2020-04-03 | 细胞基因公司 | 修饰的t淋巴细胞 |
| US9446105B2 (en) | 2013-03-15 | 2016-09-20 | The Trustees Of The University Of Pennsylvania | Chimeric antigen receptor specific for folate receptor β |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| EP4026909A1 (fr) | 2013-12-19 | 2022-07-13 | Novartis AG | Récepteurs antigéniques chimériques de la mésothéline humaine et leurs utilisations |
| US11028143B2 (en) | 2014-01-21 | 2021-06-08 | Novartis Ag | Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules |
| EP3593812A3 (fr) | 2014-03-15 | 2020-05-27 | Novartis AG | Traitement du cancer à l'aide d'un récepteur d'antigène chimérique |
| SI3888674T1 (sl) | 2014-04-07 | 2024-08-30 | Novartis Ag | Zdravljenje raka z uporabo antigenskega himernega receptorja proti-CD19 |
| CN107074929B (zh) | 2014-05-02 | 2021-09-03 | 宾夕法尼亚大学董事会 | 嵌合自身抗体受体t细胞的组合物和方法 |
| JP6831777B2 (ja) | 2014-07-21 | 2021-02-17 | ノバルティス アーゲー | Ｃｄ３３キメラ抗原受容体を使用する癌の処置 |
| US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| WO2016019300A1 (fr) | 2014-07-31 | 2016-02-04 | Novartis Ag | Sous-ensemble optimisé de lymphocytes t contenant un récepteur d'antigène chimère |
| AU2015301460B2 (en) | 2014-08-14 | 2021-04-08 | Novartis Ag | Treatment of cancer using GFR alpha-4 chimeric antigen receptor |
| WO2016057705A1 (fr) | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarqueurs prédictifs de la réactivité thérapeutique à une thérapie par récepteurs antigéniques chimères et leurs utilisations |
| CA2966035A1 (fr) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Compositions et procedes de stimulation et de multiplication de cellules t |
| KR20170075013A (ko) | 2014-10-31 | 2017-06-30 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Cart 세포에서 유전자 발현의 변경 및 그의 용도 |
| HK1243333A1 (zh) | 2014-10-31 | 2018-07-13 | The Trustees Of The University Of Pennsylvania | 用於修饰的t细胞的方法和组合物 |
| US20180334490A1 (en) | 2014-12-03 | 2018-11-22 | Qilong H. Wu | Methods for b cell preconditioning in car therapy |
| US10828353B2 (en) | 2015-01-31 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| WO2016133779A1 (fr) | 2015-02-16 | 2016-08-25 | The Trustees Of The University Of Pennsylvania | Récepteur des cellules t entièrement humain spécifique de l'épitope 369-377 dérivé de la protéine réceptrice her2/neu (erbb2) |
| EP3089761B1 (fr) | 2015-03-02 | 2019-06-12 | Innovative Cellular Therapeutics Co., Ltd. | Réduction de la tolérance immunitaire induite par pd l1 |
| US20180140602A1 (en) | 2015-04-07 | 2018-05-24 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
| CN108473957B (zh) | 2015-04-17 | 2024-07-16 | 诺华股份有限公司 | 改善嵌合抗原受体表达细胞的功效和扩增的方法 |
| EP3286211A1 (fr) | 2015-04-23 | 2018-02-28 | Novartis AG | Traitement du cancer à l'aide de protéine récepteur antigénique chimérique et un inhibiteur de protéine kinase |
| DK3298033T4 (da) | 2015-05-18 | 2023-10-02 | Tcr2 Therapeutics Inc | Sammensætninger og medicinske anvendelser til tcr-reprogrammering under anvendelse af fusionsproteiner |
| EP3932428A1 (fr) | 2015-05-21 | 2022-01-05 | Harpoon Therapeutics, Inc. | Protéines trispécifiques de liaison et méthodes d'utilisation |
| US11890301B2 (en) | 2015-08-28 | 2024-02-06 | The Trustees Of The University Of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| US11649435B2 (en) | 2015-08-28 | 2023-05-16 | The Trustees Of The University Of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| EP3344996A2 (fr) | 2015-09-03 | 2018-07-11 | The Trustees Of The University Of Pennsylvania | Biomarqueurs prédictifs du syndrome de libération de cytokines |
| CN108138148B (zh) | 2015-10-08 | 2021-10-29 | 上海斯丹赛生物技术有限公司 | T细胞的激活和扩增 |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE95068T1 (de) * | 1988-02-12 | 1993-10-15 | British Tech Group | Modifizierte antikoerper. |
| GB9022547D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Purified immunoglobulin |
| GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| GB9125768D0 (en) * | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
-
1991
- 1991-12-04 GB GB919125768A patent/GB9125768D0/en active Pending
-
1992
- 1992-12-04 EP EP92924783A patent/EP0616537B1/fr not_active Expired - Lifetime
- 1992-12-04 CA CA002124964A patent/CA2124964C/fr not_active Expired - Lifetime
- 1992-12-04 MX MX9207032A patent/MX9207032A/es unknown
- 1992-12-04 MY MYPI92002238A patent/MY111961A/en unknown
- 1992-12-04 DK DK92924783T patent/DK0616537T3/da active
- 1992-12-04 JP JP50997393A patent/JP3383303B2/ja not_active Expired - Lifetime
- 1992-12-04 ZA ZA929446A patent/ZA929446B/xx unknown
- 1992-12-04 KR KR1019940701885A patent/KR100271333B1/ko not_active Expired - Lifetime
- 1992-12-04 ES ES92924783T patent/ES2128363T3/es not_active Expired - Lifetime
- 1992-12-04 US US08/244,316 patent/US6120766A/en not_active Expired - Lifetime
- 1992-12-04 DE DE69228556T patent/DE69228556T2/de not_active Expired - Lifetime
- 1992-12-04 IL IL103981A patent/IL103981A/xx not_active IP Right Cessation
- 1992-12-04 AT AT92924783T patent/ATE177011T1/de active
- 1992-12-04 WO PCT/GB1992/002252 patent/WO1993010817A1/fr not_active Ceased
- 1992-12-04 AU AU30896/92A patent/AU3089692A/en not_active Abandoned
-
1999
- 1999-03-12 GR GR990400767T patent/GR3029683T3/el unknown
-
2004
- 2004-09-13 US US10/938,874 patent/US20050118172A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993010817A1 (fr) | 1993-06-10 |
| MY111961A (en) | 2001-03-31 |
| JP3383303B2 (ja) | 2003-03-04 |
| DK0616537T3 (da) | 1999-09-27 |
| AU3089692A (en) | 1993-06-28 |
| EP0616537A1 (fr) | 1994-09-28 |
| IL103981A0 (en) | 1993-05-13 |
| US20050118172A1 (en) | 2005-06-02 |
| HK1011618A1 (en) | 1999-07-16 |
| MX9207032A (es) | 1993-07-01 |
| ES2128363T3 (es) | 1999-05-16 |
| EP0616537B1 (fr) | 1999-03-03 |
| DE69228556T2 (de) | 1999-07-08 |
| KR100271333B1 (ko) | 2000-11-01 |
| GB9125768D0 (en) | 1992-02-05 |
| GR3029683T3 (en) | 1999-06-30 |
| IL103981A (en) | 1997-07-13 |
| ATE177011T1 (de) | 1999-03-15 |
| ZA929446B (en) | 1993-08-19 |
| US6120766A (en) | 2000-09-19 |
| JPH07504888A (ja) | 1995-06-01 |
| CA2124964A1 (fr) | 1993-06-10 |
| DE69228556D1 (de) | 1999-04-08 |
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