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CA2181241A1 - Procede pour solubiliser des agents pharmaceutiques difficilement solubles - Google Patents

Procede pour solubiliser des agents pharmaceutiques difficilement solubles

Info

Publication number
CA2181241A1
CA2181241A1 CA2181241A CA2181241A CA2181241A1 CA 2181241 A1 CA2181241 A1 CA 2181241A1 CA 2181241 A CA2181241 A CA 2181241A CA 2181241 A CA2181241 A CA 2181241A CA 2181241 A1 CA2181241 A1 CA 2181241A1
Authority
CA
Canada
Prior art keywords
soluble pharmaceutical
pharmaceutical actives
difficultly soluble
solubilizing
solubilizing difficultly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2181241A
Other languages
English (en)
Other versions
CA2181241C (fr
Inventor
Dadi Jamshed Dhabhar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2181241A1 publication Critical patent/CA2181241A1/fr
Application granted granted Critical
Publication of CA2181241C publication Critical patent/CA2181241C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002181241A 1994-01-24 1995-01-24 Procede pour solubiliser des agents pharmaceutiques difficilement solubles Expired - Fee Related CA2181241C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18557694A 1994-01-24 1994-01-24
US185,576 1994-01-24
PCT/US1995/001018 WO1995019759A1 (fr) 1994-01-24 1995-01-24 Procede pour solubiliser des agents pharmaceutiques difficilement solubles

Publications (2)

Publication Number Publication Date
CA2181241A1 true CA2181241A1 (fr) 1995-07-27
CA2181241C CA2181241C (fr) 2000-04-25

Family

ID=22681571

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002181241A Expired - Fee Related CA2181241C (fr) 1994-01-24 1995-01-24 Procede pour solubiliser des agents pharmaceutiques difficilement solubles

Country Status (14)

Country Link
EP (1) EP0741560A1 (fr)
JP (1) JPH09508128A (fr)
CN (1) CN1138827A (fr)
AU (1) AU706890B2 (fr)
BR (1) BR9506564A (fr)
CA (1) CA2181241C (fr)
CZ (1) CZ210496A3 (fr)
FI (1) FI962948L (fr)
MX (1) MX9602955A (fr)
NO (1) NO963052L (fr)
NZ (1) NZ279443A (fr)
PL (1) PL315635A1 (fr)
SK (1) SK96196A3 (fr)
WO (1) WO1995019759A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058637A1 (fr) * 1996-06-20 1998-12-30 Mcneil-Ppc Analgesique a base d'acetaminophene et de diphenhydramine
ZA975444B (en) * 1996-06-20 1998-12-21 Mcneil Ppc Inc Acetaminophen and meclizine hydrochloride analgesics
FR2751875B1 (fr) * 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
US5763449A (en) * 1996-08-07 1998-06-09 Ascent Pediatrics, Inc. Pleasant-tasting aqueous liquid composition of a bitter-tasting drug
US6365180B1 (en) * 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
ATE429210T1 (de) * 1998-01-20 2009-05-15 Applied Analytical Ind Inc Orale flüssige zusammensetzungen
US6846495B2 (en) 1999-01-11 2005-01-25 The Procter & Gamble Company Compositions having improved delivery of actives
US20020086878A1 (en) * 1999-01-11 2002-07-04 Douglas Joseph Dobrozsi Compositions having improved stability
US20020082307A1 (en) * 1999-01-11 2002-06-27 Dobrozsi Douglas Joseph Compositions having improved stability
US6211246B1 (en) 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
FR2796843B1 (fr) * 1999-07-29 2003-05-09 So Ge Val Sa Composition antipyretique concentree et stabilisee a usage veterinaire destine a etre incorporee a l'alimentation des animaux ainsi que procede d'incorporation de cette composition a l'eau de boisson d'animaux
US6251426B1 (en) 1999-09-02 2001-06-26 Banner Pharmacaps, Inc. Ibuprofen-containing softgels
DE10011032A1 (de) * 2000-03-07 2001-09-13 Bayer Ag Acetylsalicylsäure-Lösungen
KR20020069387A (ko) * 2001-02-26 2002-09-04 진양제약주식회사 호박산독실아민 조성물 및 이 조성물을 함유한 연질캅셀제제
EP1411955A4 (fr) * 2001-07-31 2006-07-05 Wyeth Corp Preparation de sucralose permettant de masquer des gouts desagreables
US7101572B2 (en) * 2001-12-07 2006-09-05 Unilab Pharmatech, Ltd. Taste masked aqueous liquid pharmaceutical composition
CN100379406C (zh) * 2003-09-22 2008-04-09 北京德众万全药物技术开发有限公司 一种难溶性药物微丸的制备方法及包含该微丸的制剂
WO2007050975A2 (fr) * 2005-10-26 2007-05-03 Banner Pharmacaps, Inc. Systeme matriciel double a liberation lente a base d'excipients hydrophiles
DE102005053066A1 (de) 2005-11-04 2007-05-10 Basf Ag Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen
JP2009523119A (ja) * 2005-12-09 2009-06-18 ビーエーエスエフ ソシエタス・ヨーロピア 水に溶けにくい化合物のための可溶化剤としてのポリビニルラクタム−ポリオキシアルキレンブロックコポリマーの使用
US8637076B2 (en) 2006-06-01 2014-01-28 Cima Labs Inc. Prednisolone salt formulations
JP2008184430A (ja) * 2007-01-30 2008-08-14 Ss Pharmaceut Co Ltd ソフトカプセル
CA2690488C (fr) * 2010-01-19 2013-06-11 Accucaps Industries Limited Formulations pharmaceutiques de naproxen pour encapsulation molle et combinaisons associees
CA2690490C (fr) * 2010-01-19 2012-06-26 Accucaps Industries Limited Formulations pharmaceutiques de loratadine pour encapsulation et combinaisons associees
DK3158991T3 (da) 2010-01-28 2021-06-14 Eagle Pharmaceuticals Inc Formuleringer af bendamustin
ES2943668T3 (es) 2012-03-20 2023-06-15 Eagle Pharmaceuticals Inc Composiciones líquidas de bendamustina para su uso en un método para tratar afecciones que responden a la bendamustina en pacientes que requieren volúmenes reducidos para administración
HUE064884T2 (hu) 2012-03-20 2024-04-28 Eagle Pharmaceuticals Inc Bendamusztin kiszerelések
ES2792082T3 (es) * 2013-02-28 2020-11-10 Pf Consumer Healthcare 1 Llc Estabilidad mejorada de composiciones líquidas novedosas
GB201506755D0 (en) 2015-04-21 2015-06-03 Reckitt Benckiser Llc Novel pharmaceutical formulation
TWI586379B (zh) * 2015-06-29 2017-06-11 永信藥品工業股份有限公司 一種製作難溶藥物固體劑型的方法
US11278506B2 (en) 2015-10-09 2022-03-22 Rb Health (Us) Llc Pharmaceutical formulation
CN115957194B (zh) * 2021-10-08 2025-05-16 人福普克药业（武汉）有限公司 一种用于感冒软胶囊中内容物的溶剂体系及感冒软胶囊

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141961A (en) * 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives

Also Published As

Publication number Publication date
AU706890B2 (en) 1999-07-01
NZ279443A (en) 1998-04-27
PL315635A1 (en) 1996-11-25
BR9506564A (pt) 1997-09-02
SK96196A3 (en) 1997-03-05
EP0741560A1 (fr) 1996-11-13
FI962948A0 (fi) 1996-07-23
CZ210496A3 (en) 1996-12-11
NO963052D0 (no) 1996-07-22
FI962948A7 (fi) 1996-07-23
NO963052L (no) 1996-09-24
JPH09508128A (ja) 1997-08-19
MX9602955A (es) 1997-06-28
WO1995019759A1 (fr) 1995-07-27
FI962948L (fi) 1996-07-23
CA2181241C (fr) 2000-04-25
AU1607595A (en) 1995-08-08
CN1138827A (zh) 1996-12-25

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