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CA2166108C - Preparations d'insuline pour inhalation - Google Patents

Preparations d'insuline pour inhalation Download PDF

Info

Publication number
CA2166108C
CA2166108C CA002166108A CA2166108A CA2166108C CA 2166108 C CA2166108 C CA 2166108C CA 002166108 A CA002166108 A CA 002166108A CA 2166108 A CA2166108 A CA 2166108A CA 2166108 C CA2166108 C CA 2166108C
Authority
CA
Canada
Prior art keywords
insulin
pharmaceutical preparation
surfactant
particles
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002166108A
Other languages
English (en)
Other versions
CA2166108A1 (fr
Inventor
Kjell Goran Erik Backstrom
Carl Magnus Olof Dahlback
Peter Edman
Ann Charlotte Birgit Johansson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9302198A external-priority patent/SE9302198D0/xx
Priority claimed from SE9400370A external-priority patent/SE9400370L/xx
Application filed by Astra AB filed Critical Astra AB
Publication of CA2166108A1 publication Critical patent/CA2166108A1/fr
Application granted granted Critical
Publication of CA2166108C publication Critical patent/CA2166108C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Préparation thérapeutique pour inhalations comportant de l'insuline et une substance renforçant l'absorption de l'insuline par les voies respiratoires inférieures et se présentant sous la forme d'une poudre se prêtant aux inhalations.
CA002166108A 1993-06-24 1994-06-23 Preparations d'insuline pour inhalation Expired - Fee Related CA2166108C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9302198A SE9302198D0 (sv) 1993-06-24 1993-06-24 Powder preparation for inhalation
SE9302198-8 1993-06-24
SE9400370-4 1994-02-04
SE9400370A SE9400370L (sv) 1994-02-04 1994-02-04 Terapeutisk komposition för inhalation
PCT/SE1994/000633 WO1995000127A1 (fr) 1993-06-24 1994-06-23 Preparation therapeutique pour inhalations

Publications (2)

Publication Number Publication Date
CA2166108A1 CA2166108A1 (fr) 1995-01-05
CA2166108C true CA2166108C (fr) 2008-10-21

Family

ID=26661778

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002166108A Expired - Fee Related CA2166108C (fr) 1993-06-24 1994-06-23 Preparations d'insuline pour inhalation

Country Status (31)

Country Link
US (3) US5518998C1 (fr)
EP (1) EP0706382B1 (fr)
JP (2) JP3874789B2 (fr)
KR (1) KR100372673B1 (fr)
CN (1) CN1110301C (fr)
AT (1) ATE183920T1 (fr)
AU (1) AU692780B2 (fr)
BR (1) BR9406907A (fr)
CA (1) CA2166108C (fr)
CZ (1) CZ287314B6 (fr)
DE (1) DE69420412T2 (fr)
DK (1) DK0706382T3 (fr)
EE (1) EE03221B1 (fr)
EG (1) EG20599A (fr)
ES (1) ES2138087T3 (fr)
FI (1) FI111688B (fr)
GR (1) GR3031974T3 (fr)
HU (1) HU228129B1 (fr)
IL (1) IL110084A (fr)
IS (1) IS1768B (fr)
MX (1) MX9404761A (fr)
MY (1) MY112098A (fr)
NO (1) NO313657B1 (fr)
NZ (1) NZ268137A (fr)
PL (1) PL178403B1 (fr)
RU (1) RU2148398C1 (fr)
SA (1) SA94150030B1 (fr)
SK (1) SK283145B6 (fr)
TW (1) TW402506B (fr)
UA (1) UA49794C2 (fr)
WO (1) WO1995000127A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
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US7628977B2 (en) 1996-05-24 2009-12-08 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties

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EP0706382B1 (fr) 1999-09-01
MX9404761A (es) 1995-01-31
HU228129B1 (en) 2012-12-28

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