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CA2012418A1 - Methode et appareil de mesure pour les phenomenes d'electrochimiluminescence - Google Patents

Methode et appareil de mesure pour les phenomenes d'electrochimiluminescence

Info

Publication number
CA2012418A1
CA2012418A1 CA2012418A CA2012418A CA2012418A1 CA 2012418 A1 CA2012418 A1 CA 2012418A1 CA 2012418 A CA2012418 A CA 2012418A CA 2012418 A CA2012418 A CA 2012418A CA 2012418 A1 CA2012418 A1 CA 2012418A1
Authority
CA
Canada
Prior art keywords
waveform
electrode
working electrode
reference electrode
range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2012418A
Other languages
English (en)
Other versions
CA2012418C (fr
Inventor
Lee O. Hall
Glenn Zoski
Surendera K. Tyagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioveris Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2012418A1 publication Critical patent/CA2012418A1/fr
Application granted granted Critical
Publication of CA2012418C publication Critical patent/CA2012418C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03K—PULSE TECHNIQUE
    • H03K4/00—Generating pulses having essentially a finite slope or stepped portions
    • H03K4/02—Generating pulses having essentially a finite slope or stepped portions having stepped portions, e.g. staircase waveform
    • H03K4/026—Generating pulses having essentially a finite slope or stepped portions having stepped portions, e.g. staircase waveform using digital techniques
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Control Of El Displays (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
  • Geophysics And Detection Of Objects (AREA)
CA002012418A 1989-03-17 1990-03-16 Methode et appareil de mesure pour les phenomenes d'electrochimiluminescence Expired - Lifetime CA2012418C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/325,459 US5068088A (en) 1988-11-03 1989-03-17 Method and apparatus for conducting electrochemiluminescent measurements
US325,459 1989-03-17

Publications (2)

Publication Number Publication Date
CA2012418A1 true CA2012418A1 (fr) 1990-09-17
CA2012418C CA2012418C (fr) 1994-06-28

Family

ID=23267969

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002012418A Expired - Lifetime CA2012418C (fr) 1989-03-17 1990-03-16 Methode et appareil de mesure pour les phenomenes d'electrochimiluminescence

Country Status (11)

Country Link
US (1) US5068088A (fr)
EP (1) EP0496731B1 (fr)
JP (1) JP2994743B2 (fr)
KR (1) KR960016170B1 (fr)
AT (1) ATE130090T1 (fr)
AU (1) AU672711B2 (fr)
CA (1) CA2012418C (fr)
DE (1) DE69023509T2 (fr)
DK (1) DK0496731T3 (fr)
ES (1) ES2079474T3 (fr)
WO (1) WO1990011511A1 (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147806A (en) * 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US6881589B1 (en) 1987-04-30 2005-04-19 Bioveris Corporation Electrochemiluminescent localizable complexes for assay compositions
US5247243A (en) * 1988-11-03 1993-09-21 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5779976A (en) * 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5962218A (en) * 1988-11-03 1999-10-05 Igen International Inc. Methods and apparatus for improved luminescence assays
US5296191A (en) * 1988-11-03 1994-03-22 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
IL100866A (en) * 1991-02-06 1995-10-31 Igen Inc Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
IL100867A (en) * 1991-02-06 1995-12-08 Igen Inc Method and apparatus for improved luminescence assays
ZA92804B (en) 1991-02-06 1992-12-30 Igen Inc Methods and apparatus for improved luminescence assays
EP0525212A4 (en) * 1991-02-19 1993-07-14 Tdk Corporation Method of analyzing electrochemiluminescent substance and apparatus therefor
EP0594766B1 (fr) * 1991-07-10 1999-09-08 Igen International, Inc. Methodes pour dosages par luminescence ameliores utilisant une concentration particulaire et la detection par chimioluminescence
DE69215983T2 (de) * 1991-07-10 1997-05-22 Tdk Corp Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz
US5466416A (en) * 1993-05-14 1995-11-14 Ghaed; Ali Apparatus and methods for carrying out electrochemiluminescence test measurements
US5541113A (en) * 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
DE19501916A1 (de) * 1994-01-24 1995-07-27 Hitachi Ltd Verfahren und Analysator zum Immuntest unter Verwendung magnetischer Teilchen
JPH10504105A (ja) * 1994-08-15 1998-04-14 イゲン，インコーポレーテッド 電気化学ルミネセンスの試験測定を実施する装置および方法
US6852502B1 (en) 1995-06-06 2005-02-08 Bioveris Corporation Electrochemiluminescent enzyme biosensors
US5610075A (en) * 1995-01-17 1997-03-11 Stahl-Rees; Marianne Competitive electrochemiluminescence assays for endotoxins using a ruthenium label
US5993740A (en) * 1995-01-20 1999-11-30 Hitachi, Ltd. Immunoassay method and analyzer using magnetic particles
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
JPH11502617A (ja) * 1995-03-10 1999-03-02 メソ スケール テクノロジーズ，エルエルシー 多重アレイの多重特異的な電気化学発光試験
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6099760A (en) * 1995-06-07 2000-08-08 Igen, Inc. Hydrogen peroxide based ECL
US5804400A (en) * 1996-02-05 1998-09-08 Igen International, Inc. Electrochemiluminescent assay
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
WO1998029736A1 (fr) 1996-12-31 1998-07-09 Genometrix Incorporated Procede et dispositif d'analyse moleculaire multiplexee
US7314711B2 (en) * 1997-05-23 2008-01-01 Bioveris Corporation Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers
DE19803528A1 (de) * 1998-01-30 1999-08-05 Roche Diagnostics Gmbh Verfahren zur Analyse einer Probe mittels eines Elektrochemolumineszenz-Bindungsreaktion-Tests
DE19811582A1 (de) 1998-03-17 1999-09-23 Roche Diagnostics Gmbh Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen
US6200531B1 (en) * 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US7141436B2 (en) * 1999-11-03 2006-11-28 Science And Technology Corp. Immunoassay and reagents and kits for performing the same
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
US7553448B2 (en) * 2002-06-20 2009-06-30 Bioveris Corporation Electrochemiluminescence flow cell and flow cell components
US20040096368A1 (en) * 2002-06-28 2004-05-20 Igen International, Inc. Assay systems and components
US7000870B2 (en) * 2002-11-07 2006-02-21 Aerion Corporation Laminar flow wing for transonic cruise
US7238536B1 (en) 2004-03-22 2007-07-03 Florida State University Research Foundation, Inc. Controlled transport through multiple reversible interaction point membranes
US20050250173A1 (en) * 2004-05-10 2005-11-10 Davis Charles Q Detection device, components of a detection device, and methods associated therewith
WO2007040559A2 (fr) * 2004-11-17 2007-04-12 Bioveris Dosage par electrochimiluminescence
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
KR101311815B1 (ko) * 2005-06-03 2013-10-22 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 단일 패러데이 전극에서의 전기발생 화학발광 및 전기화학
KR101047207B1 (ko) 2006-03-09 2011-07-06 에프. 호프만-라 로슈 아게 항-약물 항체 분석
EP1892524B1 (fr) 2006-08-25 2011-10-26 F. Hoffmann-La Roche AG Cellule pour effectuer des mesures électroluminescentes
CA2662416C (fr) 2006-09-12 2014-12-16 F. Hoffmann-La Roche Ag Essai d'anticorps anti-medicament
CN101617228A (zh) 2007-02-27 2009-12-30 霍夫曼-拉罗奇有限公司 用于评估针对胰岛素样生长因子ⅰ受体的抗体的抑制活性的方法
US8227195B2 (en) 2007-12-15 2012-07-24 Hoffman-La Roche Inc. Distinguishing assay
US8614297B2 (en) 2008-12-22 2013-12-24 Hoffmann-La Roche Inc. Anti-idiotype antibody against an antibody against the amyloid β peptide
JP5805190B2 (ja) 2010-08-19 2015-11-04 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 療法用モノクローナル抗体に結合する抗体の測定のためのアッセイ
AU2012254169B2 (en) 2011-02-25 2016-02-25 Wellstat Diagnostics, Llc Assays for detecting enzymatic activity
WO2012143380A1 (fr) 2011-04-20 2012-10-26 F. Hoffmann-La Roche Ag Hyperfréquences pour analyse immunohistochimique
AU2012274127B2 (en) 2011-06-22 2017-06-22 F. Hoffmann-La Roche Ag Removal of target cells by circulating virus-specific cytotoxic T-cells using MHC class I comprising complexes
WO2013092611A2 (fr) 2011-12-19 2013-06-27 F. Hoffmann - La Roche Ag Procédé pour la détection d'un partenaire de liaison libre d'un liant multispéficique
BR112014017630A8 (pt) 2012-02-01 2017-07-11 Hoffmann La Roche Métodos para a determinação de presença e/ou da quantidade de um antígeno
MX352118B (es) 2012-03-08 2017-11-09 Hoffmann La Roche Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes.
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
JP6226976B2 (ja) 2012-07-13 2017-11-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性結合物を検出するための方法
WO2014096015A1 (fr) 2012-12-21 2014-06-26 F. Hoffmann-La Roche Ag Cmh multivalent à liaison disulfure de classe i comprenant des protéines multi-fonctions
CA2913687C (fr) 2013-07-04 2022-12-13 F. Hoffmann-La Roche Ag Dosage immunologique a interference supprime et pour detecter des anticorps anti-medicament dans des echantillons de serum
JP6949016B2 (ja) 2015-10-29 2021-10-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗バリアントＦｃ領域抗体および使用法
EP3384293B1 (fr) 2015-11-30 2020-07-08 H. Hoffnabb-La Roche Ag Dosage immunologique pour la détermination d'anticorps modifiés de zone fc
WO2017129803A1 (fr) 2016-01-29 2017-08-03 Roche Diagnostics Gmbh Procédé d'électrochimioluminescence et appareil pour la détection d'un analyte dans un échantillon liquide
JP7110320B2 (ja) 2017-08-01 2022-08-01 エフ．ホフマン－ラ ロシュ アーゲー 液体試料中の検体の検出の動作をモニタする方法
EP4528277A3 (fr) 2017-11-29 2025-06-18 F. Hoffmann-La Roche AG Dosage d'anticorps anti-médicament à interférence de cible supprimée
CN113272327A (zh) 2018-12-30 2021-08-17 豪夫迈·罗氏有限公司 抗兔cd19抗体及其使用方法
EP3969907B1 (fr) 2019-05-13 2025-09-24 F. Hoffmann-La Roche AG Dosage immunologique pharmacocinétique à suppression d'interférences
EP4085251B1 (fr) 2020-01-02 2024-07-31 F. Hoffmann-La Roche AG Procédé pour déterminer la quantité d'un anticorps thérapeutique dans le cerveau
WO2021254926A1 (fr) 2020-06-16 2021-12-23 F. Hoffmann-La Roche Ag Procédé de détermination de l'antigène libre d'un anticorps dans un échantillon
JP2024513474A (ja) 2021-04-09 2024-03-25 エフ． ホフマン－ラ ロシュ アーゲー 異種ポリペプチドを発現する細胞クローンを選択するための方法
JP2024534067A (ja) 2021-08-19 2024-09-18 エフ． ホフマン－ラ ロシュ アーゲー 多価抗バリアントｆｃ領域抗体および使用方法
EP4416301B1 (fr) 2021-12-21 2025-06-11 F. Hoffmann-La Roche AG Procédé de détermination de l'activité hydrolytique
JP2025528365A (ja) 2022-08-24 2025-08-28 アムジエン・インコーポレーテツド 抗薬物抗体アッセイ

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816795A (en) * 1965-10-23 1974-06-11 American Cyanamid Co Method for providing electroluminescent light from a polycyclic heterocyclic compound in an aprotic solvent under electric current
US3868534A (en) * 1972-11-29 1975-02-25 Bell Canada Northern Electric Electrochemiluminescent device having a mixed solvent
FR2247732A1 (fr) * 1973-10-16 1975-05-09 Accumulateurs Fixes
US4204037A (en) * 1978-04-04 1980-05-20 Nasa Method and automated apparatus for detecting coliform organisms
US4443713A (en) * 1978-10-30 1984-04-17 Phillips Petroleum Company Waveform generator
US4236895A (en) * 1979-06-11 1980-12-02 Meloy Laboratories, Inc. Analytical apparatus and method employing purified ozone
US4280815A (en) * 1979-06-18 1981-07-28 Technicon Instruments Corporation Electrochemiluminescent immunoassay and apparatus therefor
DE3013765A1 (de) * 1980-04-10 1981-10-15 Philips Patentverwaltung Gmbh, 2000 Hamburg Detektroranordnung, insbesondere fuer die fluessigkeitschromatografie
US4303410A (en) * 1980-11-03 1981-12-01 The United States Of America As Represented By The Secretary Of The Navy Light burst activity analyzer
EP0084323B1 (fr) * 1982-01-15 1986-07-30 TELEFUNKEN Fernseh und Rundfunk GmbH Circuit pour engendrer une tension continue de commande dépendant d'une tension alternative
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US4721601A (en) * 1984-11-23 1988-01-26 Massachusetts Institute Of Technology Molecule-based microelectronic devices
JPS6235326A (ja) * 1985-08-09 1987-02-16 Canon Inc 表示素子
US5147806A (en) * 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US5093268A (en) * 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
IL90105A (en) * 1988-04-29 1993-05-13 Igen Inc Method and apparatus for conducting electro- chemiluminescence measurements
US5132227A (en) * 1990-05-02 1992-07-21 Batelle Memorial Institute Monitoring formaldehyde

Also Published As

Publication number Publication date
DE69023509D1 (de) 1995-12-14
AU672711B2 (en) 1996-10-10
AU5335590A (en) 1990-10-22
EP0496731B1 (fr) 1995-11-08
EP0496731A4 (en) 1992-09-02
WO1990011511A1 (fr) 1990-10-04
KR920700400A (ko) 1992-02-19
JP2994743B2 (ja) 1999-12-27
DE69023509T2 (de) 1996-05-23
AU7036194A (en) 1994-10-13
ATE130090T1 (de) 1995-11-15
DK0496731T3 (da) 1996-02-26
EP0496731A1 (fr) 1992-08-05
US5068088A (en) 1991-11-26
AU649220B2 (en) 1994-05-19
KR960016170B1 (ko) 1996-12-04
JPH04505657A (ja) 1992-10-01
CA2012418C (fr) 1994-06-28
ES2079474T3 (es) 1996-01-16

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