CA1341435C - Virus recombinant, du type variole/varicelle/vaccine, servant a immuniser contre des antigenes tumoraux - Google Patents
Virus recombinant, du type variole/varicelle/vaccine, servant a immuniser contre des antigenes tumoraux Download PDFInfo
- Publication number
- CA1341435C CA1341435C CA000577071A CA577071A CA1341435C CA 1341435 C CA1341435 C CA 1341435C CA 000577071 A CA000577071 A CA 000577071A CA 577071 A CA577071 A CA 577071A CA 1341435 C CA1341435 C CA 1341435C
- Authority
- CA
- Canada
- Prior art keywords
- oncogene
- virus
- tumor
- proto
- pox
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 title claims abstract description 130
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 92
- 239000000427 antigen Substances 0.000 title claims abstract description 85
- 102000036639 antigens Human genes 0.000 title claims abstract description 85
- 108091007433 antigens Proteins 0.000 title claims abstract description 85
- 230000003053 immunization Effects 0.000 title claims description 8
- 238000002649 immunization Methods 0.000 title description 7
- 210000004027 cell Anatomy 0.000 claims description 87
- 108090000623 proteins and genes Proteins 0.000 claims description 73
- 239000013598 vector Substances 0.000 claims description 42
- 108700020796 Oncogene Proteins 0.000 claims description 41
- 230000003612 virological effect Effects 0.000 claims description 41
- 241000700618 Vaccinia virus Species 0.000 claims description 40
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 37
- 206010046865 Vaccinia virus infection Diseases 0.000 claims description 29
- 208000007089 vaccinia Diseases 0.000 claims description 28
- 108700020978 Proto-Oncogene Proteins 0.000 claims description 25
- 102000052575 Proto-Oncogene Human genes 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 22
- 230000010076 replication Effects 0.000 claims description 19
- 230000006798 recombination Effects 0.000 claims description 17
- 238000005215 recombination Methods 0.000 claims description 17
- 230000001413 cellular effect Effects 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 13
- 230000002163 immunogen Effects 0.000 claims description 11
- 210000002966 serum Anatomy 0.000 claims description 10
- 102000043276 Oncogene Human genes 0.000 claims description 8
- 108700020302 erbB-2 Genes Proteins 0.000 claims description 8
- 230000002246 oncogenic effect Effects 0.000 claims description 6
- 102000009465 Growth Factor Receptors Human genes 0.000 claims description 5
- 108010009202 Growth Factor Receptors Proteins 0.000 claims description 5
- 201000001441 melanoma Diseases 0.000 claims description 5
- 239000013612 plasmid Substances 0.000 claims description 5
- 101100118548 Drosophila melanogaster Egfr gene Proteins 0.000 claims description 3
- 101150111535 trk gene Proteins 0.000 claims description 3
- 108020003175 receptors Proteins 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 102000001253 Protein Kinase Human genes 0.000 claims 4
- 108060006633 protein kinase Proteins 0.000 claims 4
- 238000010348 incorporation Methods 0.000 claims 3
- 101150068332 KIT gene Proteins 0.000 claims 2
- 230000004075 alteration Effects 0.000 claims 1
- 210000000628 antibody-producing cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000869 mutational effect Effects 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 101150042287 ros gene Proteins 0.000 claims 1
- 101150029968 rost gene Proteins 0.000 claims 1
- 230000028993 immune response Effects 0.000 abstract description 9
- 230000000763 evoking effect Effects 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 description 40
- 241000699670 Mus sp. Species 0.000 description 37
- 101000856426 Mus musculus Cullin-7 Proteins 0.000 description 25
- 241000700159 Rattus Species 0.000 description 22
- 102000004169 proteins and genes Human genes 0.000 description 21
- 210000004881 tumor cell Anatomy 0.000 description 15
- 239000003550 marker Substances 0.000 description 12
- 238000003780 insertion Methods 0.000 description 10
- 230000037431 insertion Effects 0.000 description 10
- 230000036039 immunity Effects 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- 238000010367 cloning Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 238000011161 development Methods 0.000 description 7
- 230000018109 developmental process Effects 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 101150066555 lacZ gene Proteins 0.000 description 7
- 230000004044 response Effects 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 101150003725 TK gene Proteins 0.000 description 6
- 108020004440 Thymidine kinase Proteins 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 230000010354 integration Effects 0.000 description 6
- 230000001131 transforming effect Effects 0.000 description 6
- 229960005486 vaccine Drugs 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 5
- 101100501691 Rattus norvegicus Erbb2 gene Proteins 0.000 description 5
- 102000006601 Thymidine Kinase Human genes 0.000 description 5
- 230000005809 anti-tumor immunity Effects 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 238000009169 immunotherapy Methods 0.000 description 5
- 230000001939 inductive effect Effects 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000000543 intermediate Substances 0.000 description 5
- 239000006166 lysate Substances 0.000 description 5
- 238000011603 BDIX rat Methods 0.000 description 4
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 4
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 4
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 4
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 4
- 150000001413 amino acids Chemical group 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 230000008076 immune mechanism Effects 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 230000002516 postimmunization Effects 0.000 description 4
- 230000009257 reactivity Effects 0.000 description 4
- 238000001890 transfection Methods 0.000 description 4
- 230000009466 transformation Effects 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 235000009421 Myristica fragrans Nutrition 0.000 description 3
- 206010029260 Neuroblastoma Diseases 0.000 description 3
- 108091000080 Phosphotransferase Proteins 0.000 description 3
- 230000005875 antibody response Effects 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000012636 effector Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 102000054766 genetic haplotypes Human genes 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 230000005847 immunogenicity Effects 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 239000001115 mace Substances 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 102000020233 phosphotransferase Human genes 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 241000283707 Capra Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 239000003298 DNA probe Substances 0.000 description 2
- 102100024746 Dihydrofolate reductase Human genes 0.000 description 2
- 238000012286 ELISA Assay Methods 0.000 description 2
- 102100029974 GTPase HRas Human genes 0.000 description 2
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 description 2
- 241000726306 Irus Species 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 108090000244 Rat Proteins Proteins 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 241000700647 Variola virus Species 0.000 description 2
- 108700005077 Viral Genes Proteins 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 108020001096 dihydrofolate reductase Proteins 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 230000037433 frameshift Effects 0.000 description 2
- 230000004727 humoral immunity Effects 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000010187 selection method Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 231100000588 tumorigenic Toxicity 0.000 description 2
- 230000000381 tumorigenic effect Effects 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 101150076489 B gene Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 241000511343 Chondrostoma nasus Species 0.000 description 1
- 102100031673 Corneodesmosin Human genes 0.000 description 1
- 101710139375 Corneodesmosin Proteins 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102100036654 Dynactin subunit 1 Human genes 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 101000929626 Homo sapiens Dynactin subunit 1 Proteins 0.000 description 1
- 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 description 1
- 235000008694 Humulus lupulus Nutrition 0.000 description 1
- 244000025221 Humulus lupulus Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 241001091433 Itea Species 0.000 description 1
- 108010025815 Kanamycin Kinase Proteins 0.000 description 1
- 241000594011 Leuciscus leuciscus Species 0.000 description 1
- 102000007557 Melanoma-Specific Antigens Human genes 0.000 description 1
- 108010071463 Melanoma-Specific Antigens Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101100501690 Mus musculus Erbb2 gene Proteins 0.000 description 1
- 101100284354 Mus musculus Hr gene Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 241001505332 Polyomavirus sp. Species 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000012083 RIPA buffer Substances 0.000 description 1
- XDXHAEQXIBQUEZ-UHFFFAOYSA-N Ropinirole hydrochloride Chemical compound Cl.CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 XDXHAEQXIBQUEZ-UHFFFAOYSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 241000473945 Theria <moth genus> Species 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- FXAGBTBXSJBNMD-UHFFFAOYSA-N acetic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O FXAGBTBXSJBNMD-UHFFFAOYSA-N 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000011717 athymic nude mouse Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000010307 cell transformation Effects 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000003837 chick embryo Anatomy 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 239000003593 chromogenic compound Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- QWXYZCJEXYQNEI-OSZHWHEXSA-N intermediate I Chemical compound COC(=O)[C@@]1(C=O)[C@H]2CC=[N+](C\C2=C\C)CCc2c1[nH]c1ccccc21 QWXYZCJEXYQNEI-OSZHWHEXSA-N 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000008288 physiological mechanism Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 101150002764 purA gene Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 108700017469 rat Cdkn2c Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000010451 viral insertion Methods 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9203687A | 1987-09-02 | 1987-09-02 | |
| US092,036 | 1987-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1341435C true CA1341435C (fr) | 2003-07-29 |
Family
ID=22231039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000577071A Expired - Lifetime CA1341435C (fr) | 1987-09-02 | 1988-09-02 | Virus recombinant, du type variole/varicelle/vaccine, servant a immuniser contre des antigenes tumoraux |
Country Status (2)
| Country | Link |
|---|---|
| CA (1) | CA1341435C (fr) |
| WO (1) | WO1989001973A2 (fr) |
Families Citing this family (142)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US6241982B1 (en) | 1988-03-21 | 2001-06-05 | Chiron Corporation | Method for treating brain cancer with a conditionally lethal gene |
| US6569679B1 (en) | 1988-03-21 | 2003-05-27 | Chiron Corporation | Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene |
| ATE219519T1 (de) * | 1989-01-23 | 2002-07-15 | Chiron Corp | Rekombinanttherapien für infektionen und hyperproliferative störungen |
| WO1990014357A1 (fr) * | 1989-05-19 | 1990-11-29 | Genentech, Inc. | Domaine extracellulaire de her2 |
| US7282345B1 (en) | 1989-08-04 | 2007-10-16 | Schering Ag | C-erbB-2 external domain: GP75 |
| EP0494135B1 (fr) * | 1989-09-29 | 1996-04-10 | Oncogene Science, Inc. | Protéine humaine "neu" p100 et son utilisation pour la détection de cellules prénéoplasiques ou néoplasiques chez l'homme |
| ATE212672T1 (de) * | 1989-10-24 | 2002-02-15 | Chiron Corp | System zur freisetzung von infektiösen proteinen |
| CA2040099A1 (fr) * | 1990-05-01 | 1991-11-02 | Mariano Barbacid | Tyrosine-kinase-negative trkb |
| US5759552A (en) * | 1991-03-07 | 1998-06-02 | Virogenetics Corporation | Marek's disease virus recombinant poxvirus vaccine |
| ATE248924T1 (de) * | 1991-05-06 | 2003-09-15 | Us Gov Health & Human Serv | Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendung |
| US5545533A (en) * | 1991-05-25 | 1996-08-13 | Boehringer Mannheim Gmbh | Monoclonal antibodies against c-kit and method of detecting a malignancy using c-kit specific antibodies |
| DE4205148A1 (de) * | 1991-05-25 | 1993-01-21 | Boehringer Mannheim Gmbh | Monoklonale antikoerper gegen c-kit |
| ATE152915T1 (de) * | 1991-11-29 | 1997-05-15 | Viagene Inc | Immuntherapeutische vektorkonstrukte gegen krebs |
| KR960703172A (ko) | 1993-11-18 | 1996-06-19 | 스티븐 제이. 멘토 | 조건적으로 치사적인 유전자를 활용하기 위한 조성물 및 방법(Compositions and methods for utilizing conditionally lethal genes) |
| US5888814A (en) * | 1994-06-06 | 1999-03-30 | Chiron Corporation | Recombinant host cells encoding TNF proteins |
| US6165460A (en) * | 1995-07-10 | 2000-12-26 | Therion Biologics Corporation | Generation of immune responses to prostate-specific antigen (PSA) |
| WO1997038087A2 (fr) | 1996-04-05 | 1997-10-16 | Chiron Corporation | Vecteurs a base d'alphavirus de recombinaison, presentant une inhibition reduite de la synthese macromoleculaire cellulaire |
| AU3514197A (en) | 1996-07-03 | 1998-01-21 | Genetics Institute Inc. | Protease fmh-1, an ice/ced-like protease |
| WO1998012332A1 (fr) | 1996-09-17 | 1998-03-26 | Chiron Corporation | Compositions et procedes de traitement de maladies intracellulaires |
| US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
| US6261562B1 (en) | 1997-02-25 | 2001-07-17 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| WO2000029428A2 (fr) * | 1998-11-18 | 2000-05-25 | Oxford Biomedica (Uk) Limited | Polypeptide |
| AU8692598A (en) | 1997-08-04 | 1999-02-22 | Calydon, Inc. | A human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof |
| EP2386629A1 (fr) | 1997-10-14 | 2011-11-16 | Darwin Molecular Corporation | Mutants de kinase de thymidine et protéines de fusion ayant de la kinase de thymidine et activités de kinase de guanylate |
| DE69841807D1 (de) | 1997-11-06 | 2010-09-16 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
| EP1992640A1 (fr) | 1997-12-24 | 2008-11-19 | Corixa Corporation | Composés pour l'immunothérapie et le diagnostic du cancer du sein et leurs procédés d'utilisation |
| DE69941567D1 (de) | 1998-01-14 | 2009-12-03 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| EP2003201A3 (fr) | 1998-03-18 | 2008-12-31 | Corixa Corporation | Composés et méthodes thérapeutiques et diagnostiques du cancer du poumon |
| US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| DE69937419T2 (de) | 1998-05-01 | 2008-07-24 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Neisseria Meningitidis Antigene und Zusammenstellungen |
| TR200100373T2 (tr) | 1998-08-07 | 2001-09-21 | University Of Washington | İmünolojik uçuk virüsü antijenleri ve bunların kullanım yöntemleri |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| EP1121437B1 (fr) | 1998-10-15 | 2008-02-20 | Novartis Vaccines and Diagnostics, Inc. | Genes regules dans les cellules du cancer du sein metastatique et du cancer du colon |
| US7148035B1 (en) | 1998-11-18 | 2006-12-12 | Oxford Biomedica (Uk) Limited | Polypeptide |
| GB2370571B (en) * | 1998-11-18 | 2003-05-07 | Oxford Biomedica Ltd | A modified 5t4 antigen |
| IL143531A0 (en) | 1998-12-08 | 2002-04-21 | Corixa Corp | Polypeptides containing an antigenic portion of a chlamydia antigen, dna sequences encoding said polypeptides and pharmaceutical compositions and vaccines containing the same |
| AU2367600A (en) | 1998-12-16 | 2000-07-03 | Chiron Corporation | Human cyclin-dependent kinase ((hpnqalre)) |
| US20020119158A1 (en) | 1998-12-17 | 2002-08-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US6579973B1 (en) | 1998-12-28 | 2003-06-17 | Corixa Corporation | Compositions for the treatment and diagnosis of breast cancer and methods for their use |
| US6911429B2 (en) | 1999-04-01 | 2005-06-28 | Transition Therapeutics Inc. | Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans |
| US6864235B1 (en) | 1999-04-01 | 2005-03-08 | Eva A. Turley | Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans |
| CA2369578A1 (fr) | 1999-04-02 | 2000-10-19 | Corixa Corporation | Composes et procedes de therapie et de diagnostic du cancer du poumon |
| US7368261B1 (en) | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| PT2275554E (pt) | 1999-10-29 | 2015-06-26 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| EP2275129A3 (fr) | 2000-01-17 | 2013-11-06 | Novartis Vaccines and Diagnostics S.r.l. | Vaccin omv complèté contre la méningocoque |
| PT1650221E (pt) | 2000-02-23 | 2012-09-05 | Glaxosmithkline Biolog Sa | Novos compostos |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| AU2001255596A1 (en) | 2000-04-21 | 2001-11-07 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
| KR100829674B1 (ko) | 2000-05-19 | 2008-05-16 | 코릭사 코포레이션 | 단당류 또는 이당류계 화합물을 이용한 전염성 및 다른질병의 예방 및 치료 방법 |
| EP1950297A2 (fr) | 2000-05-31 | 2008-07-30 | Novartis Vaccines and Diagnostics, Inc. | Compositions et procédés de traitement de maladie néoplastique utilisant la chimiothérapie et des sensibilisateurs à rayonnement |
| AU6867801A (en) | 2000-06-20 | 2002-01-02 | Corixa Corp | Fusion proteins of mycobacterium tuberculosis |
| JP2004513615A (ja) | 2000-06-28 | 2004-05-13 | コリクサ コーポレイション | 肺癌の治療および診断のための組成物および方法 |
| US20020165192A1 (en) | 2000-09-19 | 2002-11-07 | Kerr William G. | Control of NK cell function and survival by modulation of ship activity |
| US7691821B2 (en) | 2001-09-19 | 2010-04-06 | University Of South Florida | Inhibition of SHIP to enhance stem cell harvest and transplantation |
| AU1412702A (en) | 2000-10-27 | 2002-05-06 | Chiron Spa | Nucleic acids and proteins from streptococcus groups a and b |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| EP2316951A1 (fr) | 2001-01-17 | 2011-05-04 | Trubion Pharmaceuticals, Inc. | Proteines de fusion d'immunoglobuline de domaine de liaison |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| JP2005504513A (ja) | 2001-05-09 | 2005-02-17 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
| CA2476755C (fr) | 2001-12-17 | 2014-08-26 | Corixa Corporation | Compositions et procedes applicables a la therapie et au diagnostic pour la maladie intestinale inflammatoire |
| GB0203419D0 (en) * | 2002-02-13 | 2002-04-03 | Oxford Biomedica Ltd | Peptide |
| US20030206916A1 (en) | 2002-05-03 | 2003-11-06 | Rush-Presbyterian-St. Luke's Medical Center | Immunogenic peptides |
| WO2004009021A2 (fr) | 2002-07-18 | 2004-01-29 | University Of Washington | Purification rapide et efficace de t-lymphocytes specifiques au hsv et antigenes a hsv identifies par ce procede |
| PT2279746E (pt) | 2002-11-15 | 2013-12-09 | Novartis Vaccines & Diagnostic | Proteínas de superfície de neisseria meningitidis |
| US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| EP1589934B1 (fr) | 2003-01-06 | 2015-09-23 | Corixa Corporation | Composés d'aminoalkyle glucosaminide phosphate et leur utilisation |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| US7812116B2 (en) | 2003-07-03 | 2010-10-12 | Rush University Medical Center | Immunogenic peptides |
| US7763592B1 (en) | 2003-11-20 | 2010-07-27 | University Of South Florida | SHIP-deficiency to increase megakaryocyte progenitor production |
| US7807646B1 (en) | 2003-11-20 | 2010-10-05 | University Of South Florida | SHIP-deficiency to increase megakaryocyte progenitor production |
| PT1736541E (pt) | 2004-03-29 | 2013-01-31 | Galpharma Co Ltd | Nova proteína galectina 9 modificada e sua utilização |
| EP2199801B1 (fr) | 2004-07-14 | 2013-05-29 | The Regents of The University of California | Biomarqueurs pour la détection précoce du cancer des ovaires |
| CA2579764A1 (fr) | 2004-08-10 | 2006-02-23 | Institute For Multiple Myeloma And Bone Cancer Research | Procedes pour reguler la differenciation et traiter le myelome multiple |
| AU2005287505A1 (en) | 2004-09-22 | 2006-03-30 | Biosynexus Incorporated | Staphylococcal immunogenic compositions |
| EP3312272B1 (fr) | 2004-10-08 | 2019-08-28 | The Government of The United States of America as represented by The Secretary of The Department of Health and Human Services | Modulation de la valeur d'adaptation réplicative par désoptimisation de codons synonymes |
| EP1701165A1 (fr) | 2005-03-07 | 2006-09-13 | Johannes Dr. Coy | Utilisation thérapeutique et diagnostique de TKTL1, ses inhibiteurs et ses activateurs |
| EP2392347A3 (fr) | 2005-03-31 | 2012-01-18 | GlaxoSmithKline Biologicals S.A. | Vaccins contre l'infection à chlamydia |
| EP1877426B1 (fr) | 2005-04-29 | 2012-02-01 | GlaxoSmithKline Biologicals SA | Méthode de prévention ou de traitement d'une infection par m tuberculosis |
| EP1907425B1 (fr) | 2005-07-22 | 2014-01-08 | Y's Therapeutics Co., Ltd. | Anticorps anti-cd26 et methodes d'utilisation de ces derniers |
| SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20 |
| EP1945247A1 (fr) | 2005-10-18 | 2008-07-23 | Novartis Vaccines and Diagnostics, Inc. | Immunisations mucosiques et systémiques avec particules de replicon d'alphavirus |
| JP2009522372A (ja) | 2006-01-09 | 2009-06-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ワクチンおよび腫瘍免疫療法のためのｔｎｆｒｓｆ、ｔｌｒ、ｎｌｒ、ｒｈｒ、プリン受容体、およびサイトカイン受容体アゴニストの組み合わせ免疫刺激剤 |
| EP1981905B1 (fr) | 2006-01-16 | 2016-08-31 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Vaccin contre chlamydia |
| WO2007117657A2 (fr) | 2006-04-07 | 2007-10-18 | The Research Foundation Of State University Of New York | Polypeptides du récepteur de la transcobalamine, acides nucléiques et modulateurs associés, procédés d'utilisation associés destinés à moduler la croissance cellulaire et à traiter le cancer et la déficience en cobalamine |
| ATE522541T1 (de) | 2006-06-09 | 2011-09-15 | Novartis Ag | Bakterielle adhäsine konformere |
| EP2418223A3 (fr) | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Protéines de liaison polyvalente à chaîne unique avec une fonction effectrice |
| ES2657392T3 (es) | 2006-09-26 | 2018-03-05 | Infectious Disease Research Institute | Composición de vacuna que contiene un adyuvante sintético |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| EP2139447A2 (fr) | 2007-03-20 | 2010-01-06 | Harold Brem | Compositions gm-csf cosméceuticales et leurs procédés d'utilisation |
| DK2170384T3 (en) | 2007-07-02 | 2016-07-25 | Etubics Corp | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF AN adenovirus vector for use in higher vaccination |
| JP2011516078A (ja) | 2008-04-10 | 2011-05-26 | セル・シグナリング・テクノロジー・インコーポレイテツド | 癌におけるｅｇｆｒ突然変異を検出する組成物および方法 |
| SG189772A1 (en) | 2008-04-11 | 2013-05-31 | Trubion Pharmaceuticals Inc | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| PT2437753T (pt) | 2009-06-05 | 2016-11-23 | Infectious Disease Res Inst | Adjuvantes lipídicos de glucopiranosilo sintéticos e composições de vacina contendo os mesmos |
| US8932600B2 (en) | 2010-01-27 | 2015-01-13 | Glaxosmithkline Biologicals S.A. | Modified tuberculosis antigens |
| EP3632463A1 (fr) | 2011-04-08 | 2020-04-08 | Immune Design Corp. | Compositions immunogènes et leurs procédés d'utilisation pour induire des réponses immunitaires humorales et cellulaires |
| US10221218B2 (en) | 2011-05-10 | 2019-03-05 | The Regents Of The University Of California | Adenovirus isolated from titi monkeys |
| US9267112B2 (en) | 2011-05-10 | 2016-02-23 | The Regents Of The University Of California | Adenovirus isolated from Titi Monkeys |
| CA2837651A1 (fr) | 2011-06-21 | 2012-12-27 | Oncofactor Corporation | Compositions et methodes pour la therapie et le diagnostic du cancer |
| WO2013033260A1 (fr) | 2011-08-29 | 2013-03-07 | The Regents Of The University Of California | Utilisation de molécules associées au hdl pour traiter et prévenir des états pro-inflammatoires |
| RS58868B1 (sr) | 2012-02-07 | 2019-08-30 | Infectious Disease Res Inst | Poboljšane adjuvansne formulacije koje sadrže agoniste tlr4 i postupci upotrebe istih |
| SG11201406592QA (en) | 2012-05-04 | 2014-11-27 | Pfizer | Prostate-associated antigens and vaccine-based immunotherapy regimens |
| SMT201800368T1 (it) | 2012-05-16 | 2018-09-13 | Immune Design Corp | Vaccini per l'infezione da virus-2 herpes simplex |
| WO2014031178A1 (fr) | 2012-08-24 | 2014-02-27 | Etubics Corporation | Vecteur adénoviral à réplication déficiente, utile en vaccination |
| WO2014144844A1 (fr) | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Petits arn dérivés d'arnt (arnts) impliqués dans la viabilité cellulaire |
| US20140296139A1 (en) | 2013-03-15 | 2014-10-02 | The Regents Of The University Of California | Mitochondrial-derived peptide mots3 regulates metabolism and cell survival |
| EP3711768A1 (fr) | 2013-04-18 | 2020-09-23 | Immune Design Corp. | Monothérapie de gla destinée à être utilisée dans le traitement du cancer |
| WO2014172661A1 (fr) | 2013-04-19 | 2014-10-23 | The Regent Of The University Of California | Virus d'amblyomma americanum |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| US10231993B2 (en) | 2013-06-27 | 2019-03-19 | University Of Washington Through Its Center For Commercialization | Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders |
| EP3016660B1 (fr) | 2013-07-01 | 2020-06-10 | The Research Foundation for the State University of New York | Inhibition de ship dans le cadre de la lutte contre l'obésité |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| EP3157530A4 (fr) | 2014-06-17 | 2018-01-17 | The Research Foundation for The State University of New York | Inhibition de ship pour induire l'expression du facteur de stimulation des colonies de granulocytes chez un sujet |
| JP2017521654A (ja) | 2014-06-27 | 2017-08-03 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | ヒトペギウイルス２（ＨＰｇＶ−２）を検出するための組成物および方法 |
| US20180071380A1 (en) | 2015-03-20 | 2018-03-15 | The Regents Of The University Of Michigan | Immunogenic compositions for use in vaccination against bordetella |
| UA126278C2 (uk) | 2015-09-21 | 2022-09-14 | Аптево Рісьорч Енд Девелопмент Ллс | Поліпептиди, які зв'язують cd3 |
| WO2017062246A1 (fr) | 2015-10-05 | 2017-04-13 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Souche de rotavirus humain g9p[6] et utilisation comme vaccin |
| TWI654302B (zh) | 2016-01-19 | 2019-03-21 | 輝瑞股份有限公司 | 癌症疫苗 |
| EP4112638A1 (fr) | 2016-05-16 | 2023-01-04 | Access to Advanced Health Institute | Formulation contenant un agoniste de tlr et procédés d'utilisation |
| WO2017210364A1 (fr) | 2016-06-01 | 2017-12-07 | Infectious Disease Research Institute | Nanoparticules d'alun contenant un agent d'encollage |
| AU2018300295A1 (en) | 2017-07-11 | 2020-01-23 | Pfizer Inc. | Immunogenic compositions comprising CEA MUC1 and TERT |
| EP4088783A1 (fr) | 2017-08-01 | 2022-11-16 | Ab Studio Inc. | Anticorps bispécifiques et leurs utilisations |
| CA3073984A1 (fr) | 2017-09-21 | 2019-03-28 | Eucure (Beijing) Biopharma Co., Ltd | Anticorps anti-ctla4 et utilisations associees |
| CA3084394A1 (fr) | 2017-11-24 | 2019-05-31 | Eucure (Beijing) Biopharma Co., Ltd | Anticorps anti-ox40 et leurs utilisations |
| JP7448954B2 (ja) | 2018-02-21 | 2024-03-13 | ザ ユニバーシティー オブ モンタナ | ジアリールトレハロース化合物及びその使用 |
| WO2019161536A1 (fr) | 2018-02-23 | 2019-08-29 | Eucure (Beijing) Biopharma Co. , Ltd | Anticorps anti-pd-1 et leurs utilisations |
| US11572381B2 (en) | 2018-03-02 | 2023-02-07 | The University Of Montana | Immunogenic trehalose compounds and uses thereof |
| EP3823987A4 (fr) | 2018-07-20 | 2022-03-02 | Eucure (Beijing) Biopharma Co., Ltd | Anticorps anti-cd40 et leurs utilisations |
| EP3850012A4 (fr) | 2018-09-12 | 2022-06-15 | Eucure (Beijing) Biopharma Co., Ltd | Anticorps anti-tnfrsf9 et leurs utilisations |
| KR102885855B1 (ko) | 2018-11-19 | 2025-11-14 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 항-pd-1 항체 및 이의 용도 |
| EP3917579A4 (fr) | 2019-01-28 | 2023-03-29 | AB Therapeutics, Inc. | Anticorps bispécifiques et leurs utilisations |
| EP3927832A4 (fr) | 2019-02-18 | 2022-11-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Animaux non humains génétiquement modifiés ayant un locus d'immunoglobuline humanisée |
| CA3138461A1 (fr) | 2019-05-23 | 2020-11-26 | Helene Bazin-Lee | Adjuvants de vaccin a base de ligands du recepteur tlr |
| IL298632A (en) | 2020-06-02 | 2023-01-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Non-human animals genetically modified with a common light chain immunoglobulin locus |
| WO2025202361A1 (fr) | 2024-03-27 | 2025-10-02 | Adcendo Aps | Anticorps anti-gpc1 et leurs utilisations |
| WO2025202359A1 (fr) | 2024-03-27 | 2025-10-02 | Adcendo Aps | Anticorps anti-gpc1 et leurs utilisations |
| WO2025223455A1 (fr) | 2024-04-24 | 2025-10-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anticorps anti-ptk7/b7h3 et leurs utilisations |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2188637B (en) * | 1986-02-07 | 1990-11-14 | Oncogen | Vaccines against melanoma |
-
1988
- 1988-09-01 WO PCT/US1988/003032 patent/WO1989001973A2/fr not_active Ceased
- 1988-09-02 CA CA000577071A patent/CA1341435C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1989001973A3 (fr) | 1989-03-23 |
| WO1989001973A2 (fr) | 1989-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1341435C (fr) | Virus recombinant, du type variole/varicelle/vaccine, servant a immuniser contre des antigenes tumoraux | |
| US6699475B1 (en) | Recombinant pox virus for immunization against tumor-associated antigens | |
| Bernards et al. | Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector. | |
| US5242829A (en) | Recombinant pseudorabies virus | |
| AU606046B2 (en) | Vaccines against melanoma | |
| CN100526331C (zh) | 来自ebv的ctl表位 | |
| JP2852515B2 (ja) | ベクターウイルスおよびベクターウイルスを含む薬用組成物 | |
| EP0652967B1 (fr) | Particules de virus hybrides a replication defectueuse et auto-assemblees | |
| WO1994017810A1 (fr) | Vaccin recombine contre le cytomegalovirus | |
| JPH09511649A (ja) | 免疫不全症組換えポックスウイルス | |
| NZ236294A (en) | Recombinant vaccines using herpes virus of turkeys against mareks disease; infectious bronchitis; newcastle disease and infectious bursal disease | |
| JP2002186494A (ja) | 組換えワクシニアウイルス | |
| JPH09503902A (ja) | 組み換えウイルス免疫治療 | |
| CA2160583A1 (fr) | Vaccin de type cytomegalovirus recombinant | |
| CA1312837C (fr) | Vaccin contre la pseudorage | |
| JP2537345B2 (ja) | 狂犬病に対するワクチン及びその製造法 | |
| US7645455B2 (en) | Chimeric lyssavirus nucleic acids and polypeptides | |
| JPH01500161A (ja) | Ａｉｄｓの原因ウィルスの糖蛋白質、該糖蛋白質の製造方法及びワクチン | |
| EP0831899B1 (fr) | Compositions a base de poxvirus-calicivirus recombinants et leurs utilisations | |
| AU731706B2 (en) | Recombinant viral pseudo-particles and vaccinal and antitumoral applications thereof | |
| CA2067469C (fr) | Vaccin recombinant contre la maladie de marek | |
| US6521236B1 (en) | Vector vaccine of recombinant feline herpesvirus | |
| US5830477A (en) | Vaccine against rabies and process for preparation thereof | |
| JPH10512151A (ja) | Ｈｔｌｖ抗原を発現する組換え弱毒化ポックスウイルスを含有する免疫原性組成物 | |
| KR100637282B1 (ko) | Ｂ형 간염 바이러스 폴리펩티드 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |
Effective date: 20200831 |