BRPI1015936A2 - cristais - Google Patents

cristais

Info

Publication number: BRPI1015936A2
Authority: BR; Brazil
Prior art keywords: crystals
Prior art date: 2009-06-26

Application number

BRPI1015936A

Other languages

English (en)

Inventor

Hideyuki Itou

Koji Nakamichi

Takashi Tosaka

Original Assignee

Nippon Shinyaku Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-26

Filing date

2010-06-25

Publication date

2016-08-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43386634&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1015936(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-06-25 Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd

2010-06-25 Priority to BR122021005510-6A priority Critical patent/BR122021005510B1/pt

2016-08-16 Publication of BRPI1015936A2 publication Critical patent/BRPI1015936A2/pt

2021-07-13 Publication of BRPI1015936B1 publication Critical patent/BRPI1015936B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C07D241/22—Benzenesulfonamido pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Gynecology & Obstetrics (AREA)
Gastroenterology & Hepatology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)

BRPI1015936-3A 2009-06-26 2010-06-25 Cristal de forma i de 2-{4-[n-(5,6-difenilpirazin-2-il)-n-isopro pilamino]butilóxi}-n (metilsulfonil)acetamida e composição farmacêutica BRPI1015936B1 (pt)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
BR122021005510-6A BR122021005510B1 (pt)	2009-06-26	2010-06-25	Forma ii do cristal de 2-{4-[n-(5,6-difenilpirazin-2-il)-n isopropilamino]butilóxi}-n- metilsulfonil)acetamida e composição farmacêutica

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
JP2009-151728		2009-06-26
JP2009151727		2009-06-26
JP2009-151729		2009-06-26
JP2009-151727		2009-06-26
JP2009151729		2009-06-26
JP2009151728		2009-06-26
PCT/JP2010/060798 WO2010150865A1 (ja)	2009-06-26	2010-06-25	結晶

Publications (2)

Publication Number	Publication Date
BRPI1015936A2 true BRPI1015936A2 (pt)	2016-08-16
BRPI1015936B1 BRPI1015936B1 (pt)	2021-07-13

Family

ID=43386634

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI1015936-3A BRPI1015936B1 (pt)	2009-06-26	2010-06-25	Cristal de forma i de 2-{4-[n-(5,6-difenilpirazin-2-il)-n-isopro pilamino]butilóxi}-n (metilsulfonil)acetamida e composição farmacêutica
BR122021005510-6A BR122021005510B1 (pt)	2009-06-26	2010-06-25	Forma ii do cristal de 2-{4-[n-(5,6-difenilpirazin-2-il)-n isopropilamino]butilóxi}-n- metilsulfonil)acetamida e composição farmacêutica

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BR122021005510-6A BR122021005510B1 (pt)	2009-06-26	2010-06-25	Forma ii do cristal de 2-{4-[n-(5,6-difenilpirazin-2-il)-n isopropilamino]butilóxi}-n- metilsulfonil)acetamida e composição farmacêutica

Country Status (33)

Country	Link
US (4)	US8791122B2 (pt)
EP (3)	EP3689855A1 (pt)
JP (1)	JPWO2010150865A1 (pt)
KR (5)	KR20250107951A (pt)
CN (2)	CN104326991A (pt)
AR (1)	AR077242A1 (pt)
AU (1)	AU2010263569B2 (pt)
BR (2)	BRPI1015936B1 (pt)
CA (1)	CA2764475C (pt)
CL (1)	CL2011003264A1 (pt)
CO (1)	CO6430432A2 (pt)
CY (3)	CY1119788T1 (pt)
DK (2)	DK3275871T3 (pt)
ES (2)	ES2797124T3 (pt)
HR (2)	HRP20180171T1 (pt)
HU (3)	HUE036721T2 (pt)
IL (3)	IL216928A (pt)
LT (3)	LT2447254T (pt)
MA (1)	MA33637B1 (pt)
MX (2)	MX2011013471A (pt)
MY (1)	MY186531A (pt)
NO (2)	NO2447254T3 (pt)
NZ (1)	NZ597352A (pt)
PH (2)	PH12015502825B1 (pt)
PL (2)	PL2447254T3 (pt)
PT (2)	PT3275871T (pt)
RU (1)	RU2556206C3 (pt)
SG (2)	SG176915A1 (pt)
SI (2)	SI3275871T1 (pt)
SM (2)	SMT201800077T1 (pt)
TW (1)	TWI531565B (pt)
WO (1)	WO2010150865A1 (pt)
ZA (1)	ZA201109099B (pt)

Families Citing this family (55)

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CN101959868A (zh) *	2008-02-28	2011-01-26	日本新药株式会社	纤维化抑制剂
US8575175B2 (en) *	2008-07-23	2013-11-05	Toray Industries, Inc.	Therapeutic agent for chronic renal failure
CN106279047B (zh)	2015-05-13	2019-05-03	普济生物科技（台州）有限公司	一种前列环素受体激动剂的制备方法
WO2016193994A1 (en)	2015-05-29	2016-12-08	Megafine Pharma (P) Ltd.	Amorphous selexipag and process for preparation thereof
WO2017029594A1 (en) *	2015-08-17	2017-02-23	Dr. Reddy's Laboratories Limited	Processes for preparation of selexipag and its amorphous form
WO2017040872A1 (en)	2015-09-03	2017-03-09	Teva Pharmaceuticals International Gmbh	Solid state forms of selexipag
WO2017042828A2 (en) *	2015-09-10	2017-03-16	Megafine Pharma (P) Ltd.	Process for the preparation of selexipag and intermediates thereof
WO2017042731A1 (en)	2015-09-10	2017-03-16	Lupin Limited	Amorphous form of selexipag and solid dispersion thereof
UA124002C2 (uk) *	2015-12-02	2021-07-07	Ніппон Сіняку Ко., Лтд.	Твердий препарат, що містить 2-{4-[n-(5,6- дифенілпіразин-2-іл)-n-ізопропіламіно]бутилокси}-n-(метилсульфоніл)ацетамід
WO2017109772A1 (en) *	2015-12-20	2017-06-29	Mapi Pharma Ltd.	Amorphous form of selexipag
EP3192502A1 (en)	2016-01-15	2017-07-19	Sandoz Ag	Pharmaceutical composition of selexipag
US10815204B2 (en)	2016-04-01	2020-10-27	Honour (R&D)	Process for the preparation of diphenylpyrazine derivatives
CN105949135A (zh) *	2016-05-10	2016-09-21	湖南欧亚生物有限公司	一种赛乐西帕的合成方法
CA3029960A1 (en) *	2016-07-05	2018-01-11	Maithri Drugs Private Limited	Novel process for the preparation of 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-n-(methylsulfonyl)acetamide and novel polymorphs thereof
WO2018015974A1 (en)	2016-07-20	2018-01-25	Mylan Laboratories Limited	Polymorphic forms and amorphous solid dispersion of selexipag
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KR102705198B1 (ko)	2024-09-11
CA2764475C (en)	2017-04-25
LTC2447254I2 (lt)	2022-04-25
CN104326991A (zh)	2015-02-04
HK1244788A1 (en)	2018-08-17
US8791122C1 (pt)	2014-07-29
LT2447254T (lt)	2018-01-10
US20120101276A1 (en)	2012-04-26
LT3275871T (lt)	2020-05-11
KR102669213B1 (ko)	2024-05-28
SMT201800077T1 (it)	2018-03-08
CN102459198B (zh)	2014-09-24
KR20240090716A (ko)	2024-06-21
PT2447254T (pt)	2018-01-04
EP3689855A1 (en)	2020-08-05
NZ597352A (en)	2013-01-25
DK3275871T3 (da)	2020-04-06
MX346318B (es)	2017-03-15
MA33637B1 (fr)	2012-10-01
CY1119788T1 (el)	2018-06-27
DK2447254T3 (en)	2018-01-15
CY1122893T1 (el)	2021-05-05
BR122021005510B1 (pt)	2022-01-11
US20150266830A1 (en)	2015-09-24
CN102459198A (zh)	2012-05-16
JPWO2010150865A1 (ja)	2012-12-10
KR20250107951A (ko)	2025-07-14
MX2011013471A (es)	2012-01-30
PH12015502825A1 (en)	2017-12-11
ES2797124T3 (es)	2020-12-01
RU2012102678A (ru)	2013-08-10
IL243293A0 (en)	2016-02-29
ES2660007T3 (es)	2018-03-20
EP2447254B1 (en)	2017-12-06
CY2018011I1 (el)	2018-09-05
SG10201403313WA (en)	2014-10-30
MY186531A (en)	2021-07-25
NO2447254T3 (pt)	2018-05-05
US20140155414A1 (en)	2014-06-05
HRP20200539T1 (hr)	2020-07-10
SI2447254T1 (en)	2018-03-30
US9284280B2 (en)	2016-03-15
EP3275871A1 (en)	2018-01-31
KR20170024165A (ko)	2017-03-06
US20140148469A1 (en)	2014-05-29
SG176915A1 (en)	2012-01-30
RU2556206C2 (ru)	2015-07-10
KR102829415B1 (ko)	2025-07-03
EP2447254A4 (en)	2012-12-19
AU2010263569B2 (en)	2016-08-18
TWI531565B (zh)	2016-05-01
IL216928A (en)	2016-10-31
ZA201109099B (en)	2012-08-29
NO2018015I1 (no)	2018-04-23
CY2018011I2 (el)	2018-09-05
CO6430432A2 (es)	2012-04-30
WO2010150865A1 (ja)	2010-12-29
AU2010263569A1 (en)	2012-02-02
SI3275871T1 (sl)	2020-06-30
US8791122B2 (en)	2014-07-29
KR20120109457A (ko)	2012-10-08
LTPA2018008I1 (lt)	2018-05-10
EP3275871B1 (en)	2020-01-15
PL2447254T3 (pl)	2018-05-30
PH12015502825B1 (en)	2017-12-11
US9340516B2 (en)	2016-05-17
SMT202000177T1 (it)	2020-05-08
PT3275871T (pt)	2020-04-21
TW201111352A (en)	2011-04-01
PL3275871T3 (pl)	2020-07-27
RU2556206C3 (ru)	2021-06-15
HUE048467T2 (hu)	2020-07-28
HUS1800015I1 (hu)	2018-05-28
IL216928A0 (en)	2012-02-29
IL243287A0 (en)	2016-02-29
EP2447254A1 (en)	2012-05-02
CL2011003264A1 (es)	2012-07-06
IL243287B (en)	2021-04-29
US9440931B2 (en)	2016-09-13
HRP20180171T1 (hr)	2018-03-09
AR077242A1 (es)	2011-08-10
HUE036721T2 (hu)	2018-07-30
CA2764475A1 (en)	2010-12-29
BRPI1015936B1 (pt)	2021-07-13
PH12015502824A1 (en)	2017-05-29
KR20240090717A (ko)	2024-06-21

Publication	Publication Date	Title
LTPA2018008I1 (lt)	2018-05-10	Kristalai
BRPI1008774A2 (pt)	2016-03-08	espiroamida substituída
DK2414015T3 (da)	2021-12-06	Laryngoskopsystem
DK2411442T4 (da)	2021-12-06	Umættet polyesterresin
DE112010004215A5 (de)	2012-08-23	Hydrostataktor
DE112010002949A5 (de)	2012-09-06	Kupplungstastpunkte
EP2469625A4 (en)	2015-11-04	OMNIBUS BAR
EP2445547A4 (en)	2012-12-12	CATHETERISM SYSTEM
EP2491340A4 (en)	2014-12-24	TELEMETRY PHOTOGRAPHIC APPARATUS
EP2407456A4 (en)	2012-08-15	CARBAZOLE ESTER-OXIME PHOTOINITIATOR
EP2440486A4 (en)	2013-09-25	CABLE RETRACTION SYSTEM
BRPI1008827A2 (pt)	2016-02-23	deisobutenizador
BRPI1014968A2 (pt)	2016-12-13	subalargador
DE112010002728A5 (de)	2012-06-21	Turboinhalator
DE112010004249A5 (de)	2012-11-29	Spindelaktor
DE112009005323A5 (de)	2012-07-26	Hebelarmprüfmaschine
DE112009005462T8 (de)	2013-03-28	Lenkungsssteuervorrichtung
EP2402744A4 (en)	2015-05-13	CARBURATION DETECTION METHOD
BR112012004964A2 (pt)	2016-04-05	girocóptero
EP2446176A4 (en)	2016-12-14	CYLINDER SEAL
EP2409976A4 (en)	2012-09-19	GLYCINE TRANSPORTER INHIBITOR
DE112010004865T8 (de)	2013-01-24	Lamellennassreibkupplung
DK2506968T3 (da)	2020-11-23	Faujasit-zeolit
EP2380788A4 (en)	2012-09-26	SAFETY BELT RETRACTOR
DE112010003255A5 (de)	2013-05-02	Fördergutverteiler

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