[go: up one dir, main page]

BRPI1007215A2 - Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes. - Google Patents

Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes.

Info

Publication number
BRPI1007215A2
BRPI1007215A2 BRPI1007215A BRPI1007215A BRPI1007215A2 BR PI1007215 A2 BRPI1007215 A2 BR PI1007215A2 BR PI1007215 A BRPI1007215 A BR PI1007215A BR PI1007215 A BRPI1007215 A BR PI1007215A BR PI1007215 A2 BRPI1007215 A2 BR PI1007215A2
Authority
BR
Brazil
Prior art keywords
linkers
pair
portions
moieties
covalent bond
Prior art date
Application number
BRPI1007215A
Other languages
English (en)
Inventor
Jayasinghe Lakmal
Milton John
Mcneill Like
Clarke James
White James
Moysey Ruth
Original Assignee
Oxford Nanopore Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Nanopore Tech Ltd filed Critical Oxford Nanopore Tech Ltd
Publication of BRPI1007215A2 publication Critical patent/BRPI1007215A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicinal Preparation (AREA)

Abstract

MÉTODO DE ACOPLAMENTO COVALENTE DE DUAS OU MAIS PORÇÕES, PRIMEIRA E SEGUNDA PORÇÕES, PRIMEIRA PORÇÃO ACOPLADA A UMA SEGUNDA PORÇÃO, PAR DE PRIMEIRO E SEGUNDO LIGANTES, E, USO DE UM PAR DE LIGANTES. A invenção fornece um método de acoplamento covalente de duas ou mais porções, o método compreendendo: a) fomecer uma primeira porção tendo anexado covalentemente à mesma (i) pelo menos um primeiro ligante compreendendo uma primeira região hibridizável e (ii) pelo menos um primeiro grupo capaz de formar uma ligação covalente; b) fornecer uma segunda porção tendo anexado covalentemente à mesma (1) pelo menos um segundo ligante compreendendo uma segunda região hibridizável capaz de hibridizar à primeira região hibridizável e (ii) pelo menos um segundo grupo capaz de formar uma ligação covalente com o primeiro grupo; c) entrar em contato com a primeira e a segunda porção sob condições que permitem que a primeira e segunda região hibridizável hibridizem e ligar as porções; e d) expor as poções ligadas às condições que permitem a formação de uma ligação covalente entre o primeiro e o segundo grupos.
BRPI1007215A 2009-01-30 2010-01-29 Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes. BRPI1007215A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14872609P 2009-01-30 2009-01-30
PCT/GB2010/000132 WO2010086602A1 (en) 2009-01-30 2010-01-29 Hybridization linkers

Publications (1)

Publication Number Publication Date
BRPI1007215A2 true BRPI1007215A2 (pt) 2017-08-29

Family

ID=42110047

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1007215A BRPI1007215A2 (pt) 2009-01-30 2010-01-29 Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes.

Country Status (9)

Country Link
US (2) US20120100530A1 (pt)
EP (2) EP2391655B1 (pt)
JP (1) JP2012516145A (pt)
KR (1) KR20110125226A (pt)
CN (2) CN102439043A (pt)
AU (1) AU2010209508C1 (pt)
BR (1) BRPI1007215A2 (pt)
CA (1) CA2750874A1 (pt)
WO (2) WO2010086602A1 (pt)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2156179B1 (en) 2007-04-04 2021-08-18 The Regents of The University of California Methods for using a nanopore
CN102144037A (zh) 2008-07-07 2011-08-03 牛津纳米孔技术有限公司 检测碱基的孔
CN102245760A (zh) 2008-07-07 2011-11-16 牛津纳米孔技术有限公司 酶-孔构建体
GB0820927D0 (en) 2008-11-14 2008-12-24 Isis Innovation Method
BRPI1007214A8 (pt) 2009-01-30 2022-12-20 Oxford Nanopore Tech Ltd Adaptador para sequenciar ácidos nucleicos, par de adaptadores, kit, construto de ácido nucleico, e, métodos para preparar um adaptador, um construto de ácido nucleico, e um construto de dequência, e para sequenciar ácido nucleico de fita dupla.
EA035311B1 (ru) 2009-02-13 2020-05-27 Икс-Чем, Инк. Способ маркировки днк-кодируемых химических библиотек
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
US8986928B2 (en) 2009-04-10 2015-03-24 Pacific Biosciences Of California, Inc. Nanopore sequencing devices and methods
US9017937B1 (en) 2009-04-10 2015-04-28 Pacific Biosciences Of California, Inc. Nanopore sequencing using ratiometric impedance
US20120149761A1 (en) * 2009-08-27 2012-06-14 Atossa Genetics, Inc. Nucleic acid molecules and uses thereof
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US8652779B2 (en) 2010-04-09 2014-02-18 Pacific Biosciences Of California, Inc. Nanopore sequencing using charge blockade labels
WO2012033524A2 (en) 2010-09-07 2012-03-15 The Regents Of The University Of California Control of dna movement in a nanopore at one nucleotide precision by a processive enzyme
GB201100516D0 (en) 2011-01-12 2011-02-23 Isis Innovation Method using fluorinated amphiphiles
BR112013020411B1 (pt) 2011-02-11 2021-09-08 Oxford Nanopore Technologies Limited Monômero de msp mutante, construto, polinucleotídeo, poro, kit e aparelho para caracterizar uma sequência de ácido nucleico alvo, e, método para caracterizar uma sequência de ácido nucleico alvo
US9347929B2 (en) 2011-03-01 2016-05-24 The Regents Of The University Of Michigan Controlling translocation through nanopores with fluid wall
JP6480183B2 (ja) 2011-05-27 2019-03-06 オックスフォード ナノポール テクノロジーズ リミテッド 結合方法
CA2843136C (en) 2011-07-25 2020-12-29 Oxford Nanopore Technologies Limited Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
US10865409B2 (en) * 2011-09-07 2020-12-15 X-Chem, Inc. Methods for tagging DNA-encoded libraries
US20160162634A1 (en) 2011-09-23 2016-06-09 Oxford Nanopore Technologies Limited Analysis of a polymer comprising polymer units
CN104039979B (zh) 2011-10-21 2016-08-24 牛津纳米孔技术公司 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法
GB201120494D0 (en) * 2011-11-29 2012-01-11 Univ Sheffield Modified exonuclease
AU2012360244B2 (en) 2011-12-29 2018-08-23 Oxford Nanopore Technologies Limited Enzyme method
CN104136631B (zh) 2011-12-29 2017-03-01 牛津纳米孔技术公司 使用xpd解旋酶表征多核苷酸的方法
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
JP6275052B2 (ja) 2012-02-15 2018-02-07 オックスフォード ナノポール テクノロジーズ リミテッド アプタマー法
CA2866587C (en) 2012-02-16 2022-07-26 Oxford Nanopore Technologies Limited Analysis of measurements of a polymer
CN112646019B (zh) 2012-04-10 2022-08-16 牛津纳米孔科技公开有限公司 突变胞溶素孔
WO2013184905A1 (en) 2012-06-06 2013-12-12 Myriad Genetics, Inc. Hereditary cancer genes
DK2872680T3 (en) 2012-07-13 2018-07-09 X Chem Inc DNA-encoded libraries with coding oligonucleotide compounds that cannot be read with polymerases
EP3741847A1 (en) 2012-07-19 2020-11-25 Oxford Nanopore Technologies Limited Modified helicases
CA2879355C (en) 2012-07-19 2021-09-21 Oxford Nanopore Technologies Limited Helicase construct and its use in characterising polynucleotides
WO2014013259A1 (en) 2012-07-19 2014-01-23 Oxford Nanopore Technologies Limited Ssb method
EP2895618B1 (en) 2012-09-14 2017-07-26 Oxford Nanopore Technologies Limited Sample preparation method
WO2014064444A1 (en) 2012-10-26 2014-05-01 Oxford Nanopore Technologies Limited Droplet interfaces
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
EP2917366B1 (en) 2012-11-06 2017-08-02 Oxford Nanopore Technologies Limited Quadruplex method
GB201222928D0 (en) 2012-12-19 2013-01-30 Oxford Nanopore Tech Ltd Analysis of a polynucleotide
WO2014122467A1 (en) 2013-02-06 2014-08-14 Loxbridge Research Llp Systems and methods for early disease detection and real-time disease monitoring
US9557292B2 (en) 2013-02-25 2017-01-31 The Regents Of The University Of Michigan Nanopore-based determination of protein charge, shape, volume, rotational diffusion coefficient, and dipole moment
CN105209634B (zh) 2013-03-08 2020-05-12 牛津纳米孔技术公司 酶停滞方法
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
GB201318465D0 (en) 2013-10-18 2013-12-04 Oxford Nanopore Tech Ltd Method
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
GB201316849D0 (en) 2013-09-23 2013-11-06 Isis Innovation Method
WO2015051378A1 (en) * 2013-10-04 2015-04-09 University Of Washington Through Its Center For Commercialization Systems and methods for nanopore-based analysis of nucleic acids
CN105899678A (zh) 2013-10-18 2016-08-24 牛津纳米孔技术公司 经修饰的酶
GB201406151D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
WO2015061409A1 (en) * 2013-10-23 2015-04-30 University Of Washington Through Its Center For Commercialization Universal protein tag for double stranded nucleic acid delivery
BR112016011061B1 (pt) 2013-11-17 2021-10-13 Quantum-Si Incorporated Dispositivo integrado com fonte de luz externa para sondar, detectar e analisar moléculas, sistema, método para formar um dispositivo integrado, método para analisar um espécime, dispositivo integrado, instrumento e métodos para sequenciar ácido nucleico
GB201406155D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
AU2015208919B9 (en) 2014-01-22 2021-04-01 Oxford Nanopore Technologies Limited Method for attaching one or more polynucleotide binding proteins to a target polynucleotide
SG11201607796TA (en) 2014-02-19 2016-11-29 Univ Washington Nanopore-based analysis of protein characteristics
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
CN106460061B (zh) 2014-04-04 2020-03-06 牛津纳米孔技术公司 在双链核酸分子的两端使用纳米孔和锚分子来表征所述双链核酸的方法
GB201417712D0 (en) 2014-10-07 2014-11-19 Oxford Nanopore Tech Ltd Method
WO2015166275A1 (en) 2014-05-02 2015-11-05 Oxford Nanopore Technologies Limited Mutant pores
EP3194933B1 (en) 2014-08-08 2024-05-01 Quantum-Si Incorporated Instrument for time resolved reading of fluorescence based assay chip
KR102585730B1 (ko) 2014-08-08 2023-10-10 퀀텀-에스아이 인코포레이티드 수신된 광자들의 시간 비닝을 위한 집적 디바이스
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
CN112903639B (zh) 2014-08-08 2022-09-13 宽腾矽公司 用于对分子进行探测、检测和分析的带外部光源的集成装置
GB201414745D0 (en) 2014-08-19 2014-10-01 Articzymes As Exonucleases
KR20250130441A (ko) 2014-09-01 2025-09-01 브이아이비 브이지더블유 돌연변이체 csgg 포어
WO2016055778A1 (en) 2014-10-07 2016-04-14 Oxford Nanopore Technologies Limited Mutant pores
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
CN115851894B (zh) 2014-10-16 2025-06-27 牛津楠路珀尔科技股份有限公司 聚合物的分析
CN113981055A (zh) 2014-10-17 2022-01-28 牛津纳米孔技术公司 纳米孔rna表征方法
GB201418469D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Method
US20170335316A1 (en) * 2014-10-21 2017-11-23 The Board of Regents of the Nevada System of Higher Education on Behalf of The Univ. of Nevada, Methods and compositions for screening molecular function comprising chimeric minimotifs
CN107533045B (zh) 2015-02-05 2020-10-09 哈佛大学校长及研究员协会 包括流体通道的纳米孔感测器
GB201502809D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Mutant pore
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
US11169138B2 (en) 2015-04-14 2021-11-09 Katholieke Universiteit Leuven Nanopores with internal protein adaptors
JP7237586B2 (ja) 2015-12-08 2023-03-13 カトリック ユニヴェルシテット ルーヴェン カーユー ルーヴェン リサーチ アンド ディベロップメント 修飾ナノポア、それを含む組成物およびその使用
US10441174B2 (en) 2016-02-17 2019-10-15 Tesseract Health, Inc. Sensor and device for lifetime imaging and detection applications
US10640822B2 (en) 2016-02-29 2020-05-05 Iridia, Inc. Systems and methods for writing, reading, and controlling data stored in a polymer
US10438662B2 (en) 2016-02-29 2019-10-08 Iridia, Inc. Methods, compositions, and devices for information storage
US10859562B2 (en) 2016-02-29 2020-12-08 Iridia, Inc. Methods, compositions, and devices for information storage
WO2017149318A1 (en) 2016-03-02 2017-09-08 Oxford Nanopore Technologies Limited Mutant pores
EP3432935B2 (en) 2016-03-24 2025-02-26 Genia Technologies, Inc. Site-specific bio-conjugation methods and compositions useful for nanopore systems
EP4122949B1 (en) 2016-04-06 2024-06-05 Oxford Nanopore Technologies plc Mutant pore
EP3464616B1 (en) 2016-05-25 2022-05-04 Oxford Nanopore Technologies plc Method
GB201609221D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
GB201616590D0 (en) 2016-09-29 2016-11-16 Oxford Nanopore Technologies Limited Method
GB201617886D0 (en) 2016-10-21 2016-12-07 Oxford Nanopore Technologies Limited Method
GB201620450D0 (en) 2016-12-01 2017-01-18 Oxford Nanopore Tech Ltd Method
US10845308B2 (en) 2016-12-22 2020-11-24 Quantum-Si Incorporated Integrated photodetector with direct binning pixel
CN119530363A (zh) 2017-02-10 2025-02-28 牛津纳米孔科技公开有限公司 修饰的纳米孔、包含其的组合物及其用途
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
GB201707138D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Machine learning analysis of nanopore measurements
GB201707140D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Method
CN117106037B (zh) 2017-06-30 2025-07-25 弗拉芒区生物技术研究所 新颖蛋白孔
KR102697139B1 (ko) 2017-07-24 2024-08-23 퀀텀-에스아이 인코포레이티드 핸드헬드 대규모 병렬 바이오 광전자 기기
GB2569630B (en) 2017-12-21 2022-10-12 Sharp Life Science Eu Ltd Droplet Interfaces in Electro-wetting Devices
GB2569977A (en) 2018-01-05 2019-07-10 Oxford Nanopore Tech Ltd Method
GB201801768D0 (en) 2018-02-02 2018-03-21 Oxford Nanopore Tech Ltd Synthesis method
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
GB201808556D0 (en) 2018-05-24 2018-07-11 Oxford Nanopore Tech Ltd Method
EP3801901A1 (en) 2018-05-24 2021-04-14 Oxford Nanopore Technologies Limited Droplet interfaces in electro-wetting devices
GB201808558D0 (en) 2018-05-24 2018-07-11 Oxford Nanopore Tech Ltd Method
GB201808554D0 (en) 2018-05-24 2018-07-11 Oxford Nanopore Tech Ltd Method
GB201809323D0 (en) 2018-06-06 2018-07-25 Oxford Nanopore Tech Ltd Method
AU2019288394B2 (en) 2018-06-22 2025-01-30 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
US20220162692A1 (en) 2018-07-30 2022-05-26 Oxford University Innovation Limited Assemblies
GB201814369D0 (en) 2018-09-04 2018-10-17 Oxford Nanopore Tech Ltd Method for determining a polymersequence
GB201818216D0 (en) 2018-11-08 2018-12-26 Oxford Nanopore Tech Ltd Pore
JP7499761B2 (ja) 2018-11-08 2024-06-14 オックスフォード ナノポール テクノロジーズ ピーエルシー 細孔
EP3887046A1 (en) 2018-11-28 2021-10-06 Oxford Nanopore Technologies Limited Sensing system and method of operation
GB201819378D0 (en) 2018-11-28 2019-01-09 Oxford Nanopore Tech Ltd Analysis of nanopore signal using a machine-learning technique
GB201821155D0 (en) 2018-12-21 2019-02-06 Oxford Nanopore Tech Ltd Method
GB201907246D0 (en) 2019-05-22 2019-07-03 Oxford Nanopore Tech Ltd Method
GB201907243D0 (en) 2019-05-22 2019-07-03 Oxford Nanopore Tech Ltd Sensing interactions between molecular entities and nanapores
GB201907244D0 (en) 2019-05-22 2019-07-03 Oxford Nanopore Tech Ltd Method
GB201917060D0 (en) 2019-11-22 2020-01-08 Oxford Nanopore Tech Ltd Method
KR20220110213A (ko) 2019-12-02 2022-08-05 옥스포드 나노포어 테크놀로지즈 피엘씨 나노포어를 사용하여 표적 폴리펩티드를 특징분석하는 방법
GB201917742D0 (en) 2019-12-04 2020-01-15 Oxford Nanopore Tech Ltd Method
GB202004944D0 (en) 2020-04-03 2020-05-20 King S College London Method
WO2021255476A2 (en) 2020-06-18 2021-12-23 Oxford Nanopore Technologies Limited Method
US20230295712A1 (en) 2020-06-18 2023-09-21 Oxford Nanopore Technologies Plc A method of selectively characterising a polynucleotide using a detector
GB202009349D0 (en) 2020-06-18 2020-08-05 Oxford Nanopore Tech Ltd Method
WO2022013551A1 (en) 2020-07-17 2022-01-20 Oxford Nanopore Technologies Limited Nanopore sensing device
US11837302B1 (en) 2020-08-07 2023-12-05 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
EP4222742A1 (en) 2020-09-29 2023-08-09 Ecole Polytechnique Federale De Lausanne (Epfl) Systems and methods for digital information decoding and data storage in hybrid macromolecules
GB202015993D0 (en) 2020-10-08 2020-11-25 Oxford Nanopore Tech Ltd Method
GB202107192D0 (en) 2021-05-19 2021-06-30 Oxford Nanopore Tech Ltd Method
US20240240248A1 (en) 2021-05-19 2024-07-18 Oxford Nanopore Technologies Plc Methods for complement strand sequencing
GB202107354D0 (en) 2021-05-24 2021-07-07 Oxford Nanopore Tech Ltd Method
GB202112235D0 (en) 2021-08-26 2021-10-13 Oxford Nanopore Tech Ltd Nanopore
US20250006308A1 (en) 2021-11-29 2025-01-02 Oxford Nanopore Technologies Plc Nanopore measurement signal analysis
GB202118939D0 (en) 2021-12-23 2022-02-09 Oxford Nanopore Tech Plc Pore
GB202118908D0 (en) 2021-12-23 2022-02-09 Oxford Nanopore Tech Ltd Method
GB202118906D0 (en) 2021-12-23 2022-02-09 Oxford Nanopore Tech Ltd Method
GB202205617D0 (en) 2022-04-14 2022-06-01 Oxford Nanopore Tech Plc Novel modified protein pores and enzymes
CN119173641A (zh) 2022-05-17 2024-12-20 牛津纳米孔科技公开有限公司 方法和衔接子
GB202207267D0 (en) 2022-05-18 2022-06-29 Oxford Nanopore Tech Plc Calibration and profiling of a nanopore array device
GB202211602D0 (en) 2022-08-09 2022-09-21 Oxford Nanopore Tech Plc Novel pore monomers and pores
GB202211607D0 (en) 2022-08-09 2022-09-21 Oxford Nanopore Tech Plc Novel pore monomers and pores
CA3262945A1 (en) 2022-08-09 2024-02-15 The Regents Of The University Of California DE NOVO PORES
EP4569330A1 (en) 2022-08-09 2025-06-18 Oxford Nanopore Technologies PLC Novel pore monomers and pores
GB202215442D0 (en) 2022-10-19 2022-11-30 Oxford Nanopore Tech Plc Analysis of a polymer
WO2024089270A2 (en) 2022-10-28 2024-05-02 Oxford Nanopore Technologies Plc Pore monomers and pores
GB202216162D0 (en) 2022-10-31 2022-12-14 Oxford Nanopore Tech Plc Method
EP4362028A1 (en) 2022-10-31 2024-05-01 Ecole Polytechnique Federale De Lausanne (Epfl) Mutant aerolysin and uses thereof
EP4612327A1 (en) 2022-11-01 2025-09-10 Oxford Nanopore Technologies PLC Biochemical analysis system and method of controlling a biochemical analysis system
GB202216905D0 (en) 2022-11-11 2022-12-28 Oxford Nanopore Tech Plc Novel pore monomers and pores
GB202301095D0 (en) 2023-01-25 2023-03-08 Oxford Nanopore Tech Plc Calibration of a nanopore array device
WO2024165853A1 (en) 2023-02-07 2024-08-15 Oxford University Innovation Limited Method of characterising a peptide, polypeptide or protein using a nanopore
GB202304324D0 (en) 2023-03-24 2023-05-10 Oxford Nanopore Tech Plc Method and kits
GB202305524D0 (en) 2023-04-14 2023-05-31 Oxford Nanopore Tech Plc Novel pore monomers and pores
GB202307141D0 (en) 2023-05-12 2023-06-28 Oxford Nanopore Tech Plc Modified helicases
GB202307486D0 (en) 2023-05-18 2023-07-05 Oxford Nanopore Tech Plc Method
WO2025003492A1 (en) 2023-06-30 2025-01-02 Ecole Polytechnique Federale De Lausanne (Epfl) Uses of aerolysin nanopores
GB202315935D0 (en) 2023-10-18 2023-11-29 Oxford Nanopore Tech Ltd Novel enzymes
GB202317028D0 (en) 2023-11-06 2023-12-20 Oxford Nanopore Tech Ltd Method
GB202401864D0 (en) 2024-02-12 2024-03-27 Fund Centre De Regulacio Genòmica A method of detecting non-canonical bases in sequencing data
GB202405960D0 (en) 2024-04-29 2024-06-12 Oxford Nanopore Tech Plc Photo-active conjugates and their uses
GB202407044D0 (en) 2024-05-17 2024-07-03 Oxford Nanopore Tech Plc Polymer analysis using transformer neural network
GB202407247D0 (en) 2024-05-21 2024-07-03 Oxford Nanopore Tech Plc Method
GB202407228D0 (en) 2024-05-21 2024-07-03 Oxford Nanopore Tech Plc Method

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI82266C (fi) 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US7569341B2 (en) * 1994-01-31 2009-08-04 Trustees Of Boston University Nucleic acid directed immobilization arrays and methods of assembly
US5561043A (en) * 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
US6362002B1 (en) 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6087099A (en) 1997-09-08 2000-07-11 Myriad Genetics, Inc. Method for sequencing both strands of a double stranded DNA in a single sequencing reaction
JPH11137260A (ja) 1997-11-06 1999-05-25 Soyaku Gijutsu Kenkyusho:Kk 抗インフルエンザウイルス環状ダンベル型ｒｎａ−ｄｎａキメラ化合物及び抗インフルエンザウイルス剤
DE19826758C1 (de) 1998-06-15 1999-10-21 Soft Gene Gmbh Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte
NO986133D0 (no) 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
US7258838B2 (en) 1999-06-22 2007-08-21 President And Fellows Of Harvard College Solid state molecular probe device
US6464842B1 (en) 1999-06-22 2002-10-15 President And Fellows Of Harvard College Control of solid state dimensional features
JP2003532380A (ja) 1999-12-02 2003-11-05 モレキュラー ステージング，インコーポレイテッド 線状自己アニーリングセグメントからの一本鎖環状ｄｎａの産出
AU2001250912B2 (en) * 2000-03-21 2007-01-04 Curagen Corporation VEGF-modulated genes and methods employing them
EP1265914B1 (en) * 2000-03-22 2007-12-26 Curagen Corporation Wnt-1 related polypeptides, and nucleic acids encoding the same
AU2002239284A1 (en) 2000-11-27 2002-06-03 The Regents Of The University Of California Methods and devices for characterizing duplex nucleic acid molecules
US20030087232A1 (en) * 2001-01-25 2003-05-08 Fred Christians Methods for screening polypeptides
US7807408B2 (en) 2001-03-19 2010-10-05 President & Fellows Of Harvard College Directed evolution of proteins
DE60221986D1 (de) * 2001-06-20 2007-10-04 Nuevolution As Eine methode zur synthese von matrizenabhängigen molekülen
WO2003003446A2 (en) 2001-06-27 2003-01-09 President And Fellows Of Harvard College Control of solid state dimensional features
AU2002320294B2 (en) * 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors
JP2004537312A (ja) * 2001-07-31 2004-12-16 フィロス インク． 核酸−蛋白質融合多量体のモジュラーアッセンブリ
IL163822A0 (en) * 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
EP1540013B1 (en) * 2002-08-19 2015-07-08 The President and Fellows of Harvard College Evolving new molecular function
US7253434B2 (en) 2002-10-29 2007-08-07 President And Fellows Of Harvard College Suspended carbon nanotube field effect transistor
WO2005000739A1 (en) 2002-10-29 2005-01-06 President And Fellows Of Harvard College Carbon nanotube device fabrication
US7344882B2 (en) * 2003-05-12 2008-03-18 Bristol-Myers Squibb Company Polynucleotides encoding variants of the TRP channel family member, LTRPC3
US20070122885A1 (en) * 2005-08-22 2007-05-31 Fermalogic, Inc. Methods of increasing production of secondary metabolites by manipulating metabolic pathways that include methylmalonyl-coa
WO2005056750A2 (en) 2003-12-11 2005-06-23 Quark Biotech, Inc. Inversion-duplication of nucleic acids and libraries prepared thereby
DE602004021033D1 (de) 2003-12-19 2009-06-18 Harvard College Analyse von molekülen durch translokation durch eine beschichtete öffnung
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
GB0505971D0 (en) 2005-03-23 2005-04-27 Isis Innovation Delivery of molecules to a lipid bilayer
US7468271B2 (en) 2005-04-06 2008-12-23 President And Fellows Of Harvard College Molecular characterization with carbon nanotube control
GB0523282D0 (en) 2005-11-15 2005-12-21 Isis Innovation Methods using pores
EP1963530B1 (en) 2005-12-22 2011-07-27 Pacific Biosciences of California, Inc. Active surface coupled polymerases
US7932029B1 (en) 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
US20110039776A1 (en) * 2006-09-06 2011-02-17 Ashutosh Chilkoti Fusion peptide therapeutic compositions
WO2008045575A2 (en) 2006-10-13 2008-04-17 J. Craig Venter Institute, Inc. Sequencing method
EP2156179B1 (en) 2007-04-04 2021-08-18 The Regents of The University of California Methods for using a nanopore
GB2453377A (en) 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
US8502972B2 (en) * 2007-12-31 2013-08-06 Fujirebio Inc. Clusters of microresonators for cavity mode optical sensing
US8231969B2 (en) * 2008-03-26 2012-07-31 University Of Utah Research Foundation Asymmetrically functionalized nanoparticles
BRPI0909212A2 (pt) 2008-03-28 2015-08-18 Pacific Biosciences California Composições e método para sequeciamento de ácido nucléico
CN102245760A (zh) * 2008-07-07 2011-11-16 牛津纳米孔技术有限公司 酶-孔构建体
CN102481341B (zh) * 2009-02-23 2017-05-17 希托马克斯医疗有限公司 蛋白原及其使用方法
FR2955773B1 (fr) * 2010-02-01 2017-05-26 Commissariat Energie Atomique Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination
TWI655213B (zh) * 2012-07-13 2019-04-01 目立康股份有限公司 自我組織化肽衍生物的製造方法
US20140206842A1 (en) * 2013-01-22 2014-07-24 Muhammed Majeed Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceutical

Also Published As

Publication number Publication date
CN102439043A (zh) 2012-05-02
CA2750874A1 (en) 2010-08-05
EP2391655A1 (en) 2011-12-07
US20120064599A1 (en) 2012-03-15
EP2391655B1 (en) 2017-10-11
JP2012516145A (ja) 2012-07-19
US9222082B2 (en) 2015-12-29
EP2391639A1 (en) 2011-12-07
AU2010209508C1 (en) 2017-10-19
KR20110125226A (ko) 2011-11-18
CN102482330A (zh) 2012-05-30
WO2010086603A1 (en) 2010-08-05
AU2010209508A1 (en) 2011-08-18
US20120100530A1 (en) 2012-04-26
AU2010209508B2 (en) 2016-11-24
WO2010086602A1 (en) 2010-08-05

Similar Documents

Publication Publication Date Title
BRPI1007215A2 (pt) Método de acoplamento covalente de duas ou mais porções, primeira e segunda porções, primeiro porção acoplada a uma segunda porção, par de primeiro e segundo ligantes, e, uso de um par de ligantes.
MA30221B1 (fr) Aryldihydro-isoquinoléinones substituées par un azacyclyle, procédé pour leur préparation et leur utilisation en tant que médicaments
CY1116264T1 (el) Αντισωματα κατα ανθρωπινης αγγειοποιητινης 2
WO2017112825A3 (en) Polymer conjugates having reduced antigenicity and methods of using the same
CY1113003T1 (el) Ευσταθη παρασκευασματα laquinimod
CY1114632T1 (el) Αντισωματα εναντι erbb3 και χρησεις εξ' αυτων
CY1123496T1 (el) Μεθοδοι για την ανιχνευση συμμετρικης διμεθυλαργινινης
BR112015023589A2 (pt) método para a produção de um conjugado de imunoligante/carga útil, conjugado, uso de um conjugado, carga útil de baixo peso molecular e uso de uma carga útil
BR112013007160A2 (pt) ligante tiazolidina para a conjugação de fármacos a anticorpos
BR0112104A (pt) Processos para tratamento de doenças reumáticas usando uma molécula de ctla4 solúvel
UY29919A1 (es) Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones
BRPI0906478B8 (pt) anticorpo anti-nr10, seu uso e composição farmacêutica que o compreende
MA30497B1 (fr) Anticorps et immunco-conjugues, et leurs utilisations.
CY1115087T1 (el) Παραγωγα αμινο-πυριδινων ως αγωνιστες των υποδοχεων s1p1/edg1
WO2017031034A3 (en) Covalent linkers in antibody-drug conjugates and methods of making and using the same
CY1112278T1 (el) Κυτταροτοξικοι παραγοντες που περιεχουν νεα παραγωγα τομαυμυciν και η θεραπευτικη χρηση τους
CY1106390T1 (el) Στepεα θepμοδιαμορφωσιμη φαρμακευτικη συνθεση για την ελεγχομενη απελευθερωση της ιβαβραδινης
MA33642B1 (fr) Composés chimiques
CY1117995T1 (el) Δευτεριωμενα παραγωγα κατεχολαμινης και φαρμακα που περιεχουν τις εν λογω ενωσεις
MX2009006410A (es) Conjugados de polimero-oligonucleotido, proteina y/o peptido.
CY1116208T1 (el) Υδατο-διαλυτη ενωση βενζοαζεπινης και η φαρμακευτικη συνθεση αυτης
CY1106824T1 (el) Σταθερες ενεσιμες συνθεσεις δικλοφενακ
DK2084325T3 (da) Biopolymerer som vådstyrkeadditiver
BR112017018778A2 (pt) conjugados anticorpo-fármaco à base de criptoficina com ligantes autodegradantes inovadores
CL2009000281A1 (es) Compuestos derivados de 5,6-dihidro-pirrolo-[2,1-a]-isoquinolinas y pirrolo-[2,1-a]-isoquinolinas; composicion farmaceutica que comprende a dichos compuestos; y uso para el tratamaiento de trastornos de la fertilidad.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2435 DE 05-09-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.