BRPI0813550B8 - composto derivado fluorescente de poliaminas, seu processo de síntese e seu uso - Google Patents
composto derivado fluorescente de poliaminas, seu processo de síntese e seu usoInfo
- Publication number
- BRPI0813550B8 BRPI0813550B8 BRPI0813550A BRPI0813550A BRPI0813550B8 BR PI0813550 B8 BRPI0813550 B8 BR PI0813550B8 BR PI0813550 A BRPI0813550 A BR PI0813550A BR PI0813550 A BRPI0813550 A BR PI0813550A BR PI0813550 B8 BRPI0813550 B8 BR PI0813550B8
- Authority
- BR
- Brazil
- Prior art keywords
- polyamines
- synthesis process
- compound derived
- fluorescent compound
- group
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229920000768 polyamine Polymers 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000007850 fluorescent dye Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- SLLFVLKNXABYGI-UHFFFAOYSA-N 1,2,3-benzoxadiazole Chemical group C1=CC=C2ON=NC2=C1 SLLFVLKNXABYGI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
composto derivado fluorescente de poiaminas, seu processo de síntese e seu uso. a presente invenção refere-se a novas derivados fluorescentes de poliaminas que possuem grupo benzoxadiazol, ao processo de preparação dos mesmos e á utilização dos mesmos a título de ferramentas de diagnóstico que permitem colocar em evidência o sistema de transporte das poliaminas nas células cancerosas e, portanto, selecionar os pacientes portadores de tais tumores tendo em vista adaptar o tratamento dos mesmos. esses derivados correspondem á fórmula (i) ou a um sal farmaceuticamente aceitável desse último, na qual: r1 representa um ou vários grupos no2 na posição 4 ou 6, ou então um grupo so2ph, so2nme2, so3h, r2 representa um hidrogênio, uma alquila com c 1-6, uma benzila, um grupo perfluoralquila, os valores de a, b, c, podem ser de 2 a 5, independentemente uns dos outros e representam encadeamentos alquilenos que separam os grupos aminados, e os valores de d e e podem ser independentemente 0 ou 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0756743 | 2007-07-26 | ||
| FR0756743A FR2919287B1 (fr) | 2007-07-26 | 2007-07-26 | Nouveaux derives fluorescents de polyamines, leur procede de preparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancereuses. |
| PCT/EP2008/059890 WO2009013360A1 (fr) | 2007-07-26 | 2008-07-28 | Nouveaux dérivés fluorescents de polyamines, leur procédé de préparation et leurs applications en tant qu'outils de diagnostic dans le traitement des tumeurs cancéreuses. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0813550A2 BRPI0813550A2 (pt) | 2014-12-23 |
| BRPI0813550B1 BRPI0813550B1 (pt) | 2019-10-15 |
| BRPI0813550B8 true BRPI0813550B8 (pt) | 2021-05-25 |
Family
ID=39048970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813550A BRPI0813550B8 (pt) | 2007-07-26 | 2008-07-28 | composto derivado fluorescente de poliaminas, seu processo de síntese e seu uso |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20100202975A1 (pt) |
| EP (1) | EP2183230B9 (pt) |
| JP (2) | JP5698533B2 (pt) |
| CN (1) | CN101809007B (pt) |
| AR (1) | AR067687A1 (pt) |
| AU (1) | AU2008278978B2 (pt) |
| BR (1) | BRPI0813550B8 (pt) |
| CA (1) | CA2694474C (pt) |
| FR (1) | FR2919287B1 (pt) |
| MX (1) | MX2010001030A (pt) |
| MY (1) | MY149523A (pt) |
| TW (1) | TWI444199B (pt) |
| WO (1) | WO2009013360A1 (pt) |
| ZA (1) | ZA201001347B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2967675B1 (fr) | 2010-11-24 | 2015-02-27 | Pf Medicament | Derives fluorescents de cyanines polyamines en tant que sonde de diagnostic |
| FR2967671A1 (fr) | 2010-11-24 | 2012-05-25 | Pf Medicament | Complexe de technetium 99m en tant qu'outil de diagnostic in vivo des tumeurs cancereuses |
| JP2014502806A (ja) * | 2010-12-15 | 2014-02-03 | エヌイーシー ヨーロッパ リミテッド | 電力線接続経由で電源装置によって少なくとも１つの電動装置を識別する方法およびシステム |
| CN108299485B (zh) * | 2018-02-09 | 2020-05-12 | 湖北大学 | 一种用于检测活细胞内过氧化氢的荧光探针及其制备方法和应用 |
| CN113929639B (zh) * | 2020-06-29 | 2023-03-21 | 东南大学 | 一类以gstp1为靶点的抗肿瘤化合物及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2407192A (en) * | 1991-08-01 | 1993-03-02 | Pharmaceutical Discovery Corporation | Characterization of specific drug receptors with fluorescent ligands |
| JPH10218871A (ja) * | 1997-02-10 | 1998-08-18 | Tokyo Kasei Kogyo Kk | 新規蛍光ラベル化剤４−〔（ω−アミノアルキル）ア ミノ〕−７−Ｎ，Ｎ−ジメチルアミノスルホニル−２， １，３−ベンゾオキサジアゾール |
| AU758570B2 (en) * | 1997-07-15 | 2003-03-27 | Mediquest Therapeutics, Inc. | Novel polyamine analogues as therapeutic and diagnostic agents |
| JP2001081082A (ja) * | 1999-09-13 | 2001-03-27 | Tokyo Kasei Kogyo Kk | 新規蛍光標識試薬４−アシルアミノ−７−メルカプト−２，１，３−ベンゾオキサジアゾール |
| JP2004061476A (ja) * | 2002-07-29 | 2004-02-26 | Tokyo Kasei Kogyo Kk | 新規蛍光キレート試薬と金属イオンの測定法 |
| GB0307855D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
| ITRM20030194A1 (it) * | 2003-04-24 | 2004-10-25 | Univ Roma | Uso di derivati del 7-nitro-2, 1, 3-benzossadiazolo per |
| FR2869035B1 (fr) * | 2004-04-16 | 2006-07-14 | Pierre Fabre Medicament Sa | Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux |
-
2007
- 2007-07-26 FR FR0756743A patent/FR2919287B1/fr not_active Expired - Fee Related
-
2008
- 2008-07-25 TW TW097128391A patent/TWI444199B/zh not_active IP Right Cessation
- 2008-07-25 AR ARP080103231A patent/AR067687A1/es active IP Right Grant
- 2008-07-28 EP EP08786531.7A patent/EP2183230B9/fr active Active
- 2008-07-28 WO PCT/EP2008/059890 patent/WO2009013360A1/fr not_active Ceased
- 2008-07-28 US US12/670,611 patent/US20100202975A1/en not_active Abandoned
- 2008-07-28 AU AU2008278978A patent/AU2008278978B2/en not_active Ceased
- 2008-07-28 MX MX2010001030A patent/MX2010001030A/es active IP Right Grant
- 2008-07-28 MY MYPI2010000386A patent/MY149523A/en unknown
- 2008-07-28 CA CA2694474A patent/CA2694474C/fr not_active Expired - Fee Related
- 2008-07-28 JP JP2010517421A patent/JP5698533B2/ja not_active Expired - Fee Related
- 2008-07-28 BR BRPI0813550A patent/BRPI0813550B8/pt not_active IP Right Cessation
- 2008-07-28 CN CN2008801002628A patent/CN101809007B/zh not_active Expired - Fee Related
-
2010
- 2010-02-24 ZA ZA2010/01347A patent/ZA201001347B/en unknown
-
2012
- 2012-06-11 US US13/493,556 patent/US8569011B2/en not_active Expired - Fee Related
-
2014
- 2014-10-03 JP JP2014204920A patent/JP5889987B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5889987B2 (ja) | 2016-03-22 |
| AU2008278978B2 (en) | 2012-12-20 |
| WO2009013360A9 (fr) | 2010-02-18 |
| TWI444199B (zh) | 2014-07-11 |
| US8569011B2 (en) | 2013-10-29 |
| CA2694474C (fr) | 2016-06-14 |
| HK1147479A1 (en) | 2011-08-12 |
| CA2694474A1 (fr) | 2009-01-29 |
| US20120252059A1 (en) | 2012-10-04 |
| EP2183230A1 (fr) | 2010-05-12 |
| TW200914053A (en) | 2009-04-01 |
| BRPI0813550A2 (pt) | 2014-12-23 |
| JP2010534638A (ja) | 2010-11-11 |
| CN101809007B (zh) | 2012-07-04 |
| BRPI0813550B1 (pt) | 2019-10-15 |
| FR2919287A1 (fr) | 2009-01-30 |
| WO2009013360A1 (fr) | 2009-01-29 |
| JP5698533B2 (ja) | 2015-04-08 |
| FR2919287B1 (fr) | 2012-10-12 |
| US20100202975A1 (en) | 2010-08-12 |
| MX2010001030A (es) | 2010-03-01 |
| ZA201001347B (en) | 2010-11-24 |
| MY149523A (en) | 2013-09-13 |
| EP2183230B1 (fr) | 2013-11-13 |
| AR067687A1 (es) | 2009-10-21 |
| CN101809007A (zh) | 2010-08-18 |
| JP2015038114A (ja) | 2015-02-26 |
| AU2008278978A1 (en) | 2009-01-29 |
| EP2183230B9 (fr) | 2015-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2495743T3 (es) | Fosfaplatinos y su uso en el tratamiento de cánceres resistentes a cisplatino y carboplatino | |
| BRPI0813550B8 (pt) | composto derivado fluorescente de poliaminas, seu processo de síntese e seu uso | |
| CY1120202T1 (el) | Χημικες ενωσεις | |
| CY1119484T1 (el) | Dbait και χρησεις αυτου | |
| BRPI0510394A (pt) | inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1 | |
| BR9909688A (pt) | Indolinonas substituìdas, a sua preparação e seu uso como composições farmacêuticas | |
| BRPI0612845A8 (pt) | composto, formulação farmacêutica, métodos para tratar câncer e para sintetizar um composto de fórmula alq-dispasador | |
| BR112013000273A2 (pt) | derivados de imidazopiridina, processo para a preparação dos mesmos e uso terapêutico dos mesmos | |
| TR201900306T4 (tr) | Mek inhibitörlerini kullanma yöntemleri. | |
| BRPI0410760A (pt) | compostos, processo para fabricação dos mesmos, composições farmacêuticas e uso deste compostos | |
| AR026036A1 (es) | Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos | |
| BRPI0917411A2 (pt) | composto de dansil-carbazol, método para tratamento de câncer em um sujeito, método para reduzir atividade de mentiltransferase de dna em uma célula, método para aumentar expressão da associação de dominio da familia 1a(rassf1a) em uma célula, métodos de identificação de célula, método de determinação se uma ou mais células de um sujeito são células cancerosas, composição farmacêutica e kit. | |
| IL213613A (en) | History of pirazine, preparations containing them and their uses | |
| AR025389A1 (es) | Indolinonas sustituidas, su preparacion y su empleo como medicamentos | |
| EA200100111A1 (ru) | Ингибиторы фарнезилпротеинтрансферазы, обладающие in vivo радиосенсибилизирующими свойствами | |
| CY1108369T1 (el) | Σωματιδια ενεργοποιησιμα με ακτινες χ και/ή uv, παρασκευη και θεραπευτικες ή διαγνωστικες χρησεις αυτων | |
| BR112014006841A2 (pt) | cartucho de grampos incluindo disposição de plano de apoio retrátil | |
| ES2196860T3 (es) | Nuevas indolinonas sustituidas con efecto inhibidor sobre diferentes cinasas y diferentes complejos ciclina/cdk. | |
| TR200003515T2 (tr) | İkame edilmiş indolinon, bunların imalatı ve ilaç olarak kullanımı | |
| BR112012010124B8 (pt) | composto derivado de cromenona ou um sal farmaceuticamente aceitavel do mesmo que possui atividade antitumor | |
| PE20050822A1 (es) | Derivados de florfenicol con mejor solubilidad en agua | |
| BRPI0913291A2 (pt) | composto, pró-droga, medicamento, métodos para diminuir a proteína 4 ou tratamento de diabete em um mamífero, e, uso do composto | |
| MA33107B1 (fr) | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met | |
| CO2019010029A2 (es) | Compuestos de tipo imidazo[4,5-c]quinolin-2-ona deuterados y su uso en el tratamiento del cáncer | |
| BRPI0409471A (pt) | processo para a preparação de 2-cianopirrolidinas n-substituìdas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/10/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/10/2019, OBSERVADAS AS CONDICOES LEGAIS |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/07/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 14A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2681 DE 24-05-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |