BRPI0818061A2 - 5,6-diaril piridinas substituídas em posição 2 e 3, preparação das mesmas e aplicação das mesmas em terapia. - Google Patents

5,6-diaril piridinas substituídas em posição 2 e 3, preparação das mesmas e aplicação das mesmas em terapia.

Info

Publication number: BRPI0818061A2
Authority: BR; Brazil
Prior art keywords: therapy; substituted; preparation; application; diaryl pyridines
Prior art date: 2007-10-12

Application number

Other languages

English (en)

Inventor

Lionel Barre

Christian Congy

Philippe Pointeau

Murielle Rinaldi-Carmona

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-12

Filing date

2008-10-10

Publication date

2015-03-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39387099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0818061(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-10-10 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2015-03-31 Publication of BRPI0818061A2 publication Critical patent/BRPI0818061A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Obesity (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BRPI0818061 2007-10-12 2008-10-10 5,6-diaril piridinas substituídas em posição 2 e 3, preparação das mesmas e aplicação das mesmas em terapia. BRPI0818061A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0707186A FR2922209B1 (fr)	2007-10-12	2007-10-12	5,6-DIARYLES PYRIDINES SUBSTITUES EN POSITION 2 et 3, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE.
PCT/FR2008/001421 WO2009087285A1 (fr)	2007-10-12	2008-10-10	5,6-diaryles pyridines substitues en position 2 et 3, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
BRPI0818061A2 true BRPI0818061A2 (pt)	2015-03-31

Family

ID=39387099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0818061 BRPI0818061A2 (pt)	2007-10-12	2008-10-10	5,6-diaril piridinas substituídas em posição 2 e 3, preparação das mesmas e aplicação das mesmas em terapia.

Country Status (20)

Country	Link
US (1)	US8362045B2 (pt)
EP (1)	EP2209768A1 (pt)
JP (1)	JP5465179B2 (pt)
KR (1)	KR20100065377A (pt)
CN (1)	CN101855208A (pt)
AR (1)	AR068778A1 (pt)
AU (1)	AU2008346293A1 (pt)
BR (1)	BRPI0818061A2 (pt)
CA (1)	CA2702012A1 (pt)
CL (1)	CL2008003027A1 (pt)
EA (1)	EA201070460A1 (pt)
FR (1)	FR2922209B1 (pt)
IL (1)	IL205016A0 (pt)
MA (1)	MA31839B1 (pt)
MX (1)	MX2010003983A (pt)
PA (1)	PA8798201A1 (pt)
PE (1)	PE20091034A1 (pt)
TW (1)	TW200922567A (pt)
UY (1)	UY31387A1 (pt)
WO (1)	WO2009087285A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201103419D0 (pt)	2011-02-28	2011-04-13	Univ Aberdeen
EP2780013A4 (en)	2011-11-18	2015-07-01	Constellation Pharmaceuticals Inc	MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
EP2780014A4 (en)	2011-11-18	2015-07-01	Constellation Pharmaceuticals Inc	MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
EP2812001B1 (en)	2012-02-10	2017-06-14	Constellation Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
WO2014151142A1 (en)	2013-03-15	2014-09-25	Constellation Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
EP3033334A1 (en)	2013-08-15	2016-06-22	Constellation Pharmaceuticals, Inc.	Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
US10577350B2 (en)	2015-08-28	2020-03-03	Constellation Pharmaceuticals, Inc.	Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
WO2018075598A1 (en)	2016-10-19	2018-04-26	Constellation Pharmaceuticals, Inc.	Synthesis of inhibitors of ezh2
US11051513B2 (en)	2017-01-26	2021-07-06	Mitsui Chemicals Agro, Inc.	Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5686470A (en) *	1995-02-10	1997-11-11	Weier; Richard M.	2, 3-substituted pyridines for the treatment of inflammation
WO2002055502A1 (en)	2001-01-02	2002-07-18	Fujisawa Pharmaceutical Co., Ltd.	Pyridine derivatives useful as cyclooxygenase inhibitor
CA2479744A1 (en) *	2002-03-28	2003-10-09	Paul E. Finke	Substituted 2,3-diphenyl pyridines
GB0314057D0 (en)	2003-06-18	2003-07-23	Astrazeneca Ab	Therapeutic agents
FR2876691B1 (fr) *	2004-10-18	2006-12-29	Sanofi Aventis Sa	Derives de pyridine, leur preparation, leur application en therapeutique
JP2008536950A (ja)	2005-04-18	2008-09-11	ニューロジェン・コーポレーション	置換ヘテロアリールのｃｂ１拮抗薬

2007
- 2007-10-12 FR FR0707186A patent/FR2922209B1/fr not_active Expired - Fee Related
2008
- 2008-10-09 PA PA20088798201A patent/PA8798201A1/es unknown
- 2008-10-09 TW TW097139016A patent/TW200922567A/zh unknown
- 2008-10-10 JP JP2010528446A patent/JP5465179B2/ja not_active Expired - Fee Related
- 2008-10-10 KR KR1020107007838A patent/KR20100065377A/ko not_active Withdrawn
- 2008-10-10 WO PCT/FR2008/001421 patent/WO2009087285A1/fr not_active Ceased
- 2008-10-10 CA CA2702012A patent/CA2702012A1/fr not_active Abandoned
- 2008-10-10 EP EP08869799A patent/EP2209768A1/fr not_active Withdrawn
- 2008-10-10 BR BRPI0818061 patent/BRPI0818061A2/pt not_active Application Discontinuation
- 2008-10-10 EA EA201070460A patent/EA201070460A1/ru unknown
- 2008-10-10 CL CL2008003027A patent/CL2008003027A1/es unknown
- 2008-10-10 AU AU2008346293A patent/AU2008346293A1/en not_active Abandoned
- 2008-10-10 MX MX2010003983A patent/MX2010003983A/es not_active Application Discontinuation
- 2008-10-10 UY UY31387A patent/UY31387A1/es not_active Application Discontinuation
- 2008-10-10 CN CN200880115604A patent/CN101855208A/zh active Pending
- 2008-10-10 AR ARP080104435A patent/AR068778A1/es unknown
- 2008-10-10 PE PE2008001755A patent/PE20091034A1/es not_active Application Discontinuation
2010
- 2010-04-07 US US12/755,883 patent/US8362045B2/en not_active Expired - Fee Related
- 2010-04-11 IL IL205016A patent/IL205016A0/en unknown
- 2010-05-10 MA MA32824A patent/MA31839B1/fr unknown

Also Published As

Publication number	Publication date
EA201070460A1 (ru)	2010-10-29
WO2009087285A4 (fr)	2009-09-24
PA8798201A1 (es)	2009-05-15
WO2009087285A1 (fr)	2009-07-16
TW200922567A (en)	2009-06-01
FR2922209B1 (fr)	2010-06-11
CN101855208A (zh)	2010-10-06
UY31387A1 (es)	2009-05-29
MX2010003983A (es)	2010-05-27
US8362045B2 (en)	2013-01-29
FR2922209A1 (fr)	2009-04-17
MA31839B1 (fr)	2010-11-01
PE20091034A1 (es)	2009-08-19
CA2702012A1 (fr)	2009-07-16
AU2008346293A1 (en)	2009-07-16
KR20100065377A (ko)	2010-06-16
CL2008003027A1 (es)	2009-10-16
AR068778A1 (es)	2009-12-02
JP5465179B2 (ja)	2014-04-09
IL205016A0 (en)	2010-11-30
US20100256202A1 (en)	2010-10-07
EP2209768A1 (fr)	2010-07-28
JP2011500543A (ja)	2011-01-06

Publication	Publication Date	Title
BRPI0818061A2 (pt)	2015-03-31	5,6-diaril piridinas substituídas em posição 2 e 3, preparação das mesmas e aplicação das mesmas em terapia.
NO2017002I1 (no)	2017-01-12	Cobicistat eller farmasøytisk akseptabelt salt derav og atazanavir eller farmasøytisk akseptabelt salt derav, spesielt atazanavirsulfat
FR2915198B1 (fr)	2009-12-18	Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
IL204663A0 (en)	2010-11-30	Nicotinamide derivatives, preparastion thereof and therapeutic use thereof
FR2915199B1 (fr)	2010-01-22	Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
BRPI0819714A2 (pt)	2015-05-26	Formulações de proteína e métodos de produção das mesmas.
FR2918061B1 (fr)	2010-10-22	Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
BRPI0907381A2 (pt)	2015-07-14	Derivados de carboxamidas azabicíclicos, o respectivo preparo e a respectiva aplicação em terapêutica.
ZA200901551B (en)	2010-06-30	2-aryl-6-phenylimidazo[1,2-alpha]pyridine derivatives, preparation thereof and therapeutic use thereof
ZA201006728B (en)	2011-11-30	Polysubstituted 2-aryl-6-phenyl-imidazo[1,2-a]pyridine derivatives,and preparation and therapeutic use thereof
BRPI0818690A2 (pt)	2015-04-14	Derivados de quinazolinediona, sua preparação e seus usos terapêuticos.
TWI350286B (en)	2011-10-11	Alkylpiperazine- and alkylhomopiperazine-carboxylate derivatives, their preparation and their application in therapy
FR2915197B1 (fr)	2009-06-12	Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
GB2455598B (en)	2012-09-19	Improvements in or relating to fires, heating apparatus and the like
DK2238110T3 (da)	2012-02-20	5.6-bisaryl-2-pyridin-carboxamid-derivater, fremstilling heraf og terapeutisk anvendelse heraf som urotensin II-receptorantagonister
BRPI0812766A2 (pt)	2014-12-02	4-cloro-4-alcóxi-1,1,1-triflúor-2-butanonas, preparação das mesmas e uso das mesmas no preparo de 4-alcóxi-1,1,1-triflúor-3-buten-2-onas
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2015-09-08	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]