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BRPI0814958A2 - Compostos de indazol ou indol, composição, e, método para preparar uma composição. - Google Patents

Compostos de indazol ou indol, composição, e, método para preparar uma composição.

Info

Publication number
BRPI0814958A2
BRPI0814958A2 BRPI0814958-5A2A BRPI0814958A BRPI0814958A2 BR PI0814958 A2 BRPI0814958 A2 BR PI0814958A2 BR PI0814958 A BRPI0814958 A BR PI0814958A BR PI0814958 A2 BRPI0814958 A2 BR PI0814958A2
Authority
BR
Brazil
Prior art keywords
composition
indazol
preparing
indol compounds
indol
Prior art date
Application number
BRPI0814958-5A2A
Other languages
English (en)
Inventor
Soon Ha Kim
Hyoung Jin Kim
Sun Young Koo
Chul Woong Chung
Sung Bae Lee
Heui Sul Park
Seung Hyun Yoon
Hyo Shin Kwak
Dong Ook Seo
Eok Park
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of BRPI0814958A2 publication Critical patent/BRPI0814958A2/pt
Publication of BRPI0814958B1 publication Critical patent/BRPI0814958B1/pt
Publication of BRPI0814958B8 publication Critical patent/BRPI0814958B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090018593A (ko) 2007-08-17 2009-02-20 주식회사 엘지생명과학 세포괴사 저해제로서의 인돌 및 인다졸 화합물
US20090142832A1 (en) 2007-11-29 2009-06-04 James Dalton Indoles, Derivatives, and Analogs Thereof and Uses Therefor
RU2450001C2 (ru) 2007-12-20 2012-05-10 Эл Джи Лайф Сайенсиз Лтд. Активаторы глюкокиназы и фармацевтические композиции, содержащие их в качестве активного ингредиента
WO2009088192A2 (ko) * 2008-01-04 2009-07-16 Lg Life Sciences Ltd. 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체
EP2276760B1 (en) * 2008-04-10 2014-04-09 Takeda Pharmaceutical Company Limited Fused ring compounds and use thereof
JPWO2010076884A1 (ja) 2008-12-29 2012-06-21 武田薬品工業株式会社 新規縮合環化合物およびその用途
TW201119651A (en) * 2009-10-26 2011-06-16 Lg Life Sciences Ltd Pharmaceutical composition comprising indole compound
KR101304772B1 (ko) * 2011-04-11 2013-09-05 인제대학교 산학협력단 ＮｅｃｒｏＸ―５를 유효성분으로 포함하는 미토콘드리아 기능 조절용 조성물
CN102766083B (zh) * 2011-05-03 2014-10-22 中国科学院上海有机化学研究所 2-氨基-3-全氟乙酰吲哚类化合物及其衍生物、制备方法和应用
WO2013077579A1 (ko) * 2011-11-25 2013-05-30 가톨릭대학교 산학협력단 안과 질환의 예방 및 치료용 약학 조성물
KR101941004B1 (ko) * 2013-03-25 2019-01-23 주식회사 엘지화학 조절 t 세포로의 분화 유도 및 증식 촉진을 통한 면역 반응 억제용 약학 조성물
KR102139338B1 (ko) * 2013-06-24 2020-07-29 주식회사 엘지생활건강 인돌 화합물을 포함하는 용해도가 개선된 화장료 조성물
KR102139339B1 (ko) * 2013-06-24 2020-07-29 주식회사 엘지생활건강 인돌 화합물을 포함하는 용해도가 개선된 화장료 조성물
KR101985886B1 (ko) * 2013-06-24 2019-06-04 주식회사 엘지생활건강 인돌 화합물 및 판테놀을 포함하는 자외선에 의한 피부손상 예방 및 개선용 조성물
EP3037418B1 (en) * 2013-08-22 2019-10-02 LG Chem, Ltd. Indole compound as inhibitor of necrosis
WO2015026172A1 (ko) * 2013-08-22 2015-02-26 주식회사 엘지생명과학 세포괴사 저해제로서의 인돌아미드 화합물
CN103601662B (zh) * 2013-11-21 2016-04-06 深圳市药品检验所 一种褪黑素半抗原、褪黑素完全抗原及其制备方法和应用
WO2015111947A1 (en) * 2014-01-24 2015-07-30 Lg Life Sciences Ltd. Composition for preventing or treating acute lung injury and acute respiratory distress syndrome
CN113967215A (zh) * 2014-04-18 2022-01-25 Lg 化学株式会社 用于预防或治疗脂肪肝疾病的组合物
TW201707707A (zh) * 2015-03-26 2017-03-01 Ｌｇ生命科學股份有限公司 包含吲哚化合物之製劑及其製備方法
JP2018515597A (ja) * 2015-04-07 2018-06-14 イーエルエイ ファーマ リミテッドＥｌａ Ｐｈａｒｍａ Ｌｔｄ カテプシンｃおよび／またはｃｅｌａ１および／またはｃｅｌａ３ａおよび／またはそれらに構造的に関連する酵素を特異的に標的とする細胞および／または組織壊死の処置および／または防止のための組成物
WO2018130537A1 (en) * 2017-01-10 2018-07-19 ETH Zürich Cell-protective compounds and their use
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
CN109884212A (zh) * 2019-03-27 2019-06-14 清华大学深圳研究生院 基于化学衍生化与hplc-ms的不饱和脂肪酸定量方法
WO2020256432A1 (ko) 2019-06-19 2020-12-24 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
WO2020256429A1 (ko) * 2019-06-19 2020-12-24 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
WO2020256437A1 (ko) 2019-06-19 2020-12-24 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
EP4046688B1 (en) * 2019-10-18 2025-04-09 Takeda Pharmaceutical Company Limited Heterocyclic compound
BR112022010561A2 (pt) 2019-12-02 2022-11-16 Storm Therapeutics Ltd Compostos poli-heterocíclicos como inibidores de mettl3
US12116343B2 (en) 2020-01-29 2024-10-15 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
US20230116201A1 (en) * 2020-01-30 2023-04-13 Anima Biotech Inc. Collagen 1 translation inhibitors and methods of use thereof
TWI865738B (zh) 2020-03-06 2024-12-11 美商維泰克斯製藥公司 治療apol-1依賴性局灶性節段性腎小球硬化之方法
KR102649355B1 (ko) 2020-03-31 2024-03-19 주식회사 엘지화학 췌도 이식 보호용 조성물
EP4165022A1 (en) 2020-06-12 2023-04-19 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and use of the same
CA3185144A1 (en) * 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and use of the same
US20240009202A1 (en) 2020-08-19 2024-01-11 Mitoimmune Therapeutics Inc. Mitochondria-targeted antioxidant as agent for treating pathologic inflammation caused by mabc-r infection
MX2023002269A (es) 2020-08-26 2023-05-16 Vertex Pharma Inhibidores de apol1 y metodos para usar los mismos.
EP4324829A4 (en) * 2021-04-12 2025-04-23 MitoImmune Therapeutics Inc. 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL]-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOL-7-AMINE SULFATE AND A NEW CRYSTALLINE FORM THEREOF
US20240043409A1 (en) * 2021-04-12 2024-02-08 Mitoimmune Therapeutics Inc. Crystalline forms of 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-n-(tetrahydro-2h-pyran-4-yl)-1h-indol-7-amine
US20240374646A1 (en) 2021-04-12 2024-11-14 Mitoimmune Therapeutics Inc. Composition for inhibiting inflammation or aging of stem cells, and method for inhibiting inflammation or aging by using same
DE102021207925A1 (de) * 2021-07-23 2023-01-26 Continental Reifen Deutschland Gmbh Verbindung, Verfahren zu deren Herstellung sowie Verwendung der Verbindung als Alterungsschutzmittel und/oder Ozonschutzmittel und/oder Farbstoff
EP4382524A4 (en) * 2021-08-02 2025-09-03 Mitoimmune Therapeutics Inc INDOLE DERIVATIVE, ITS PREPARATION PROCESS AND ITS USE
AU2022324177A1 (en) 2021-08-02 2024-02-22 Mitoimmune Therapeutics Inc. Novel indole derivative, pharmaceutical composition comprising same, and use thereof
WO2023106973A1 (ru) * 2021-12-10 2023-06-15 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новые гепатопротекторные средства
US20250082646A1 (en) * 2022-01-27 2025-03-13 Mitoimmune Therapeutics Inc. Ovarian anti-aging pharmaceutical composition and use thereof
WO2023182840A1 (ko) 2022-03-25 2023-09-28 주식회사 미토이뮨테라퓨틱스 항바이러스용 약학적 조성물 및 이의 용도
WO2024158205A1 (ko) * 2023-01-25 2024-08-02 주식회사 미토이뮨테라퓨틱스 치환기를 가지는 인돌 유도체, 및 약학적 용도
KR20240118677A (ko) 2023-01-27 2024-08-05 주식회사 미토이뮨테라퓨틱스 페롭토시스 억제제로서 인돌 화합물의 용도
WO2024191106A1 (ko) 2023-03-13 2024-09-19 주식회사 미토이뮨테라퓨틱스 뇌전증 예방 또는 치료용 약학적 조성물
WO2025188159A1 (ko) 2024-03-06 2025-09-12 주식회사 미토이뮨테라퓨틱스 신장 섬유증 예방 또는 치료용 약학적 조성물

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB599834A (en) * 1943-04-08 1948-03-22 Francolor Sa Improvements in or relating to the manufacture of azodyestuffs
US3755332A (en) * 1971-07-01 1973-08-28 Ciba Geigy Corp Substituted 4 indazolaminoquinolines
BE792078A (fr) * 1971-12-01 1973-05-29 Wander Ag Dr A Nouveaux derives de l'indazole, leur preparation et leur application comme medicaments
DE2653005A1 (de) * 1975-12-03 1977-06-08 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
JPS6160648A (ja) * 1984-08-31 1986-03-28 Teikoku Hormone Mfg Co Ltd ２−（３，５−ジアルキル−４−ヒドロキシフエニル）インド−ル誘導体
FR2659552B2 (fr) * 1989-10-20 1994-11-04 Oreal Procede de teinture des fibres keratiniques avec des aminoindoles, composition et dispositif de mise en óoeuvre.
US5254135A (en) * 1989-10-20 1993-10-19 L'oreal Methods for dyeing keratinous fibres with aminoindoles, compositions and devices for use
WO1992002500A1 (fr) * 1990-07-31 1992-02-20 Teikoku Hormone Mfg. Co., Ltd. Derive de 2-phenylindole
FI944602A0 (fi) * 1992-04-03 1994-10-03 Upjohn Co Farmaseuttisesti aktiiviset bisyklis-heterosykliset amiinit
CA2152795C (en) 1992-12-30 1999-02-16 Victor Louis King Readily available konjac glucomannan sustained release excipient
NZ273073A (en) 1993-09-10 1996-09-25 Eisai Co Ltd Bicyclic heterocyclic sulphonamide and sulphonic acid ester derivatives and pharmaceutical compositions thereof
JP3545461B2 (ja) * 1993-09-10 2004-07-21 エーザイ株式会社 二環式ヘテロ環含有スルホンアミド誘導体
US6180643B1 (en) * 1996-11-19 2001-01-30 Amgen Inc. Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents
FR2767475A1 (fr) * 1997-08-25 1999-02-26 Oreal Compositions de teinture des fibres keratiniques contenant des derives d'indazoles et procede
US6858577B1 (en) * 1999-06-29 2005-02-22 Ortho-Mcneil Pharmaceutical, Inc. Indole peptidomimetics as thrombin receptor antagonists
DE60004685T2 (de) * 1999-09-17 2004-07-29 Abbott Gmbh & Co. Kg Pyrazolopyrimidine als arzneimittel
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
KR100767000B1 (ko) * 2000-02-03 2007-10-15 에자이 알앤드디 매니지먼트 가부시키가이샤 인테그린 발현 저해제
WO2002018335A1 (en) * 2000-08-28 2002-03-07 Yamanouchi Pharmaceutical Co., Ltd. Cyclic amine derivatives
UA82827C2 (en) * 2000-12-18 2008-05-26 Inhibitors against the production and release of inflammatory cytokines
CA2440842A1 (en) * 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
JPWO2002100833A1 (ja) * 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
TW200306819A (en) * 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
BR0313000A (pt) 2002-07-19 2005-07-12 Memory Pharm Corp Compostos, composição farmacêutica e método para efetuar a inibição da enzima pde4, realçar a cognição e/ou tratar a psicose em um paciente
ATE451104T1 (de) * 2002-07-29 2009-12-15 Rigel Pharmaceuticals Inc Verfahren zur behandlung oder pruvention von autoimmunkrankheiten mit 2,4-pyrimidindiamin- verbindungen
DE10237722A1 (de) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
US20040110802A1 (en) * 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
SK288115B6 (sk) * 2002-09-25 2013-09-03 Memory Pharmaceuticals Corporation Indazoles, pharmaceutical compositions comprising them and their use
CN1742007A (zh) * 2003-01-22 2006-03-01 伊莱利利公司 甾族激素核受体的吲哚衍生物调控剂
US7563748B2 (en) * 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
EP2468729B1 (en) * 2003-10-15 2013-12-25 Ube Industries, Ltd. Novel indazole derivative
EP1723105B1 (en) * 2004-03-03 2013-05-15 Eli Lilly And Company Bicyclic substituted indole-derivative steroid hormone nuclear receptor modulators
WO2006000020A1 (en) 2004-06-29 2006-01-05 European Nickel Plc Improved leaching of base metals
EP1632491A1 (en) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
WO2006058338A2 (en) * 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
US7741479B2 (en) * 2004-12-07 2010-06-22 Locus Pharmaceuticals, Inc. Urea inhibitors of MAP kinases
WO2006112549A1 (ja) 2005-04-20 2006-10-26 Takeda Pharmaceutical Company Limited 縮合複素環化合物
WO2007076161A2 (en) * 2005-12-27 2007-07-05 Myriad Genetics, Inc Compounds with therapeutic activity
TW200736232A (en) * 2006-01-26 2007-10-01 Astrazeneca Ab Pyrimidine derivatives
MY158052A (en) * 2006-10-19 2016-08-30 Takeda Pharmaceutical Indole compound
KR20090018593A (ko) * 2007-08-17 2009-02-20 주식회사 엘지생명과학 세포괴사 저해제로서의 인돌 및 인다졸 화합물
RU2450001C2 (ru) * 2007-12-20 2012-05-10 Эл Джи Лайф Сайенсиз Лтд. Активаторы глюкокиназы и фармацевтические композиции, содержащие их в качестве активного ингредиента
WO2009088192A2 (ko) * 2008-01-04 2009-07-16 Lg Life Sciences Ltd. 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체

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CN101784543B (zh) 2013-10-16
US8222414B2 (en) 2012-07-17
KR20090018594A (ko) 2009-02-20
US8889691B2 (en) 2014-11-18
CN101784543A (zh) 2010-07-21
SI2178870T1 (sl) 2018-11-30
BRPI0814958B1 (pt) 2021-05-11
ES2426641T3 (es) 2013-10-24
PT2178870T (pt) 2018-11-09
BRPI0815154A2 (pt) 2015-03-31
WO2009025477A1 (en) 2009-02-26
US8569307B2 (en) 2013-10-29
EP2178869A4 (en) 2012-03-21
EP2178870A4 (en) 2012-04-11
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BRPI0815154B1 (pt) 2024-01-30
JP5323834B2 (ja) 2013-10-23
CN101801965A (zh) 2010-08-11
US20140024618A1 (en) 2014-01-23
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